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Current Drug Targets

Volume 22, 17 Issues, 2021
ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)
This journal supports open access

Aims & Scope

Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes.

Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication full-length/mini review articles and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

Current Drug Targets

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Volume 22

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Number 6









Review Article

Artificial Intelligence, Big Data and Machine Learning Approaches in Precision Medicine & Drug Discovery

, 22(6): 631 - 655

Anuraj Nayarisseri*, Ravina Khandelwal, Poonam Tanwar, Maddala Madhavi, Diksha Sharma, Garima Thakur, Alejandro Speck-Planche and Sanjeev Kumar Singh*


DOI: 10.2174/1389450122999210104205732


Review Article

Curcumin and its Multi-target Function Against Pain and Inflammation: An Update of Pre-clinical Data

, 22(6): 656 - 671

Shaikh Jamal Uddin*, Md. Fahim Hasan, Mohasana Afroz, Dipto Kumer Sarker, Razina Rouf, Muhammad Torequl Islam, Jamil A. Shilpi and Mohammad S. Mubarak*


DOI: 10.2174/1389450121666200925150022


Review Article

Progress in Detection of Insomnia Sleep Disorder: A Comprehensive Review

, 22(6): 672 - 684

Md Belal Bin Heyat, Faijan Akhtar, M.A. Ansari, Asif Khan, Fahed Alkahtani, Haroon Khan* and Dakun Lai*


DOI: 10.2174/1389450121666201027125828


Review Article

Current Quest in Natural Bioactive Compounds for Alzheimer’s Disease: Multi-Targeted-Designed-Ligand Based Approach with Preclinical and Clinical Based Evidence

, 22(6): 685 - 720

Ashif Iqubal, Syed Obaidur Rahman, Musheer Ahmed, Pratichi Bansal, Md Rafi Haider, Mohammad Kashif Iqubal, Abul Kalam Najmi, Faheem Hyder Pottoo and Syed Ehtaishamul Haque*


DOI: 10.2174/1389450121999201209201004


Current Drug Targets, Volume 22 (2021) - Number 8


This issue is in progress but contains articles that are final and fully citable.

Current Drug Targets, Volume 22 (2021) - Number 7


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print




GSK-3 Inhibitors as New Leads to Treat Type-II Diabetes


Gowru Srivani, Ramyakrishna Sharvirala, Prabhakar Reddy Veerareddy, Dilipkumar Pal and Gangarapu Kiran*


DOI: 10.2174/1389450122666210120144428
View Abstract View on PubMed



The Role of Non-coding Genome in Cancer-associated Fibroblasts; Stateof- the-Art and Perspectives in Cancer Targeted Therapy


Arezoo Gowhari Shabgah, Hamed Mohammadi, Pouya Goleij, Mahdiyeh Hedayati-Moghadam, Arash Salmaninejad and Jamshid Gholizadeh Navashenaq*


DOI: 10.2174/1389450122666210216091953
View Abstract View on PubMed


Antiplatelet Effects of Bioactive Compounds Present in Tomato Pomace


Eduardo Fuentes, Andrés Trostchansky*, Lívia Mateus Reguengo, Mario Roberto Maróstica Jr. and Iván Palomo


DOI: 10.2174/1389450122999210128180456
View Abstract View on PubMed





Abstracts Ahead of Print

Revealing Insights into Natural Products Against mcr-1-Producing Bacteria


Ana Beatriz Souza Flor dos Santos, Manuele Figueiredo da Silva, João Xavier de Araújo-Júnior and Edeildo Ferreira da Silva-Júnior *


DOI: 10.2174/1389450122666210415102413
View Abstract



New Trends On Biological Activities And Clinical Studies Of Quinolinic Analogues: A Review


Sandra Elizabeth Barbosa da Silva, José Arion da Silva Moura , Tiago Rafael de Sousa Nunes , Ivan da Rocha Pitta and Marina Galdino da Rocha Pitta*


DOI: 10.2174/1389450122666210415100151
View Abstract


The gut microbiota and traditional Chinese medicine: a new clinical frontier on cancer


Yan-Zhen Chen, Meng-Yun Yuan, Ya Ling Chen, Xingxing Zhang, Xin-Tian Xu, Shen-Lin Liu, Xi Zou, Jia-Lei Tao, Yong-Hu Qiang, Jian Wu* and Qing-Min Sun*


DOI: 10.2174/1389450122666210412141304
View Abstract


Triazole-containing heterocycles: Privileged scaffolds in anti-Trypanosoma cruzi drug development.


Kamdem Boniface Pone*, Sadou Dalhatou , Hugues Kamdem Paumo, Lebogang Maureen Katata-Seru and Elizabeth Igne Ferreira


DOI: 10.2174/1389450122666210412125643
View Abstract


Role of ATP-binding Cassette Transporters in Sorafenib Therapy for Hepatocellular Carcinoma: an overview


Maria Manuela Estevinho*, Carlos Fernandes, João Carlos Silva, Ana Catarina Gomes, Edgar Afecto, João Correia and João Carvalho


DOI: 10.2174/1389450122666210412125018
View Abstract






Published Contents

Editor's Choice


Anti-platelet Drug-loaded Targeted Technologies for the Effective Treatment of Atherothrombosis

, 2021; 22(4): 399 - 419

Selvakumar Muruganantham, Venkateshwaran Krishnaswami, Shanmugarathinam Alagarsamy and Ruckmani Kandasamy*


DOI: 10.2174/1389450121666201027125303



Downregulation of Membrane-bound Angiotensin Converting Enzyme 2 (ACE2) Receptor has a Pivotal Role in COVID-19 Immunopathology

, 2021; 22(3): 254 - 281

Cristina Vieira, Lucas Nery, Ludimila Martins, Luiz Jabour, Raphael Dias and Ana Cristina Simões e Silva*


DOI: 10.2174/1389450121666201020154033



Fibrotic Strictures in Crohn’s Disease: Mechanisms and Predictive Factors

, 2021; 22(2): 241 - 251

Riccardo Mager, Giulia Roda, Mohammad Khaled Shalaby and Stefania Vetrano*


DOI: 10.2174/1389450121666201020160803



Neoadjuvant Chemotherapy Before Radical Cystectomy: Why We Must Adhere?

, 2021; 22(1): 14 - 21

Beppe Calò*, Michele Marchioni, Francesca Sanguedolce, Ugo Giovanni Falagario, Marco Chirico, Giuseppe Carrieri and Luigi Cormio


DOI: 10.2174/1389450121666200802022150



The Activating Receptors of Natural Killer Cells and Their Inter-Switching Potentials

, 2020; 21(16): 1733 - 1751

Adekunle Babajide Rowaiye, Titilayo Asala, Angus Nnamdi Oli*, Ikemefuna Chijioke Uzochukwu, Alex Akpa and Charles Okechukwu Esimone


DOI: 10.2174/1389450121666200910160929




Exosomes in Inflammatory Bowel Disease: What Have We Learned So Far?

, 2020; 21(14): 1448 - 1455

Haichao Wang, Chen Ye, Yaling Wu, Pengyu Yang, Chunqiu Chen, Zhanju Liu and Xiaolei Wang*


DOI: 10.2174/1389450121666200428102330



PD1/PD-L1 Axis in Uro-oncology

, 2020; 21(13): 1293 - 1300

Kerstin Junker*, Markus Eckstein, Michelangelo Fiorentino and Rodolfo Montironi


DOI: 10.2174/1389450121666200326123700



Anti-VEGF Treatment in Corneal Diseases

, 2020; 21(12): 1159 - 1180

Giuseppe Giannaccare, Marco Pellegrini, Cristina Bovone, Rossella Spena, Carlotta Senni, Vincenzo Scorcia and Massimo Busin*


DOI: 10.2174/1389450121666200319111710



Open Access Articles

Recognition of Plasminogen Activator Inhibitor Type 1 as the Primary Regulator of Fibrinolysis

, 2019; 20(16): 1695 - 1701

Tetsumei Urano*, Yuko Suzuki, Takayuki Iwaki, Hideto Sano, Naoki Honkura and Francis J. Castellino




Current Understanding of Group A Streptococcal Biofilms

, 2019; 20(9): 982 - 993

Heema K.N. Vyas, Emma-Jayne Proctor, Jason McArthur, Jody Gorman and Martina Sanderson-Smith*








Opportunities of Bacterial Cellulose to Treat Epithelial Tissues

, 2019; 20(8): 808 - 822

Irene Anton-Sales, Uwe Beekmann, Anna Laromaine*, Anna Roig* and Dana Kralisch





Blood Eosinophils as Biomarkers to Drive Treatment Choices in Asthma and COPD

, 2018; 19(16): 1882 - 1896

Konstantinos Kostikas, Caterina Brindicci and Francesco Patalano*




Current Status and Perspectives on Pharmacologic Therapy for Abdominal Aortic Aneurysm

, 2018; 19(11): 1265 - 1275

Koichi Yoshimura*, Noriyasu Morikage, Shizuka Nishino-Fujimoto, Akira Furutani, Bungo Shirasawa and Kimikazu Hamano





TXNIP in Metabolic Regulation: Physiological Role and Therapeutic Outlook

, 2017; 18(9): 1095 - 1103

Naif Mohammad Alhawiti, Saeed Al Mahri, Mohammad Azhar Aziz, Shuja Shafi Malik and Sameer Mohammad*






Structural and Functional Aspects of Class A Carbapenemases

, 2016; 17(9): 1006 - 1028

Thierry Naas, Laurent Dortet and Bogdan I. Iorga





Most Cited Articles

Review Article

Bioinformatics approaches for anti-cancer drug discovery

, 2020; 21(1): 3-17.

Kening Li, Yuxin Du, Lu Li and Dong-Qing Wei*


DOI: 10.2174/1389450120666190923162203



Review Article

Targeting cancer stem cells pathways for the effective treatment of cancer

, 2020; 21(3): 258-278.

Ashish Ranjan Dwivedi, Amandeep Thakur, Vijay Kumar, Ira Skvortsova and Vinod Kumar*


DOI: 10.2174/1389450120666190821160730


Review Article (Mini-Review)

The therapeutic potential of chemokines in the treatment of chemotherapy-induced peripheral neuropathy

, 2020; 21(3): 288-301.

Lin Zhou, Luyao Ao, Yunyi Yan, Wanting Li, Anqi Ye, Yahui Hu*, Weirong Fang* and Yunman Li*


DOI: 10.2174/1389450120666190906153652


Review Article

ACE2/angiotensin-(1-7)/mas receptor axis in human cancer: Potential role for pediatric tumors

, 2020; 21(9): 892-901.

Ana Luiza Ataide Carneiro de Paula Gonzaga , Vitória Andrade Palmeira , Thomas Felipe Silva Ribeiro , Larissa Braga Costa , Karla Emília de Sá Rodrigues and Ana Cristina Simões-e-Silva *


DOI: 10.2174/1389450121666200210124217



Review Article (Mini-Review)

Antiviral drug targets of single-stranded rna viruses causing chronic human diseases

, 2020; 21(2): 105-124.

Dhurvas Chandrasekaran Dinesh*, Selvaraj Tamilarasan, Kaushik Rajaram and Evžen Bouřa*


DOI: 10.2174/1389450119666190920153247



Review Article

The potential of pi3k/akt/mtor signaling as a druggable target for endometrial and ovarian carcinomas

, 2020; 21(10): 946-961.

Csongor György Lengyel*, Sara Cecilia Altuna, Baker Shalal Habeeb, Dario Trapani and Shah Zeb Khan


DOI: 10.2174/1389450120666191120123612


Review Article

IL-37 as a potential biotherapeutics of inflammatory diseases

, 2020; 21(9): 855-863.

Junhui Bai, Yukun Li, Meixiang Li, Sijie Tan* and Daichao Wu*


DOI: 10.2174/1389450121666200429114926



Review Article

Medicinal perspective of indole derivatives: Recent developments and structure-activity relationship studies

, 2020; 21(9): 864-891.

Devendra Kumar, Sahil Sharma, Sourav Kalra, Gurpreet Singh, Vikramdeep Monga and Bhupinder Kumar*


DOI: 10.2174/1389450121666200310115327


Review Article

Understanding the pharmaceutical aspects of dendrimers for the delivery of anticancer drugs

, 2020; 21(6): 528-540.

Sunil Kumar Dubey*, Shubham Salunkhe, Mukta Agrawal, Maithili Kali, Gautam Singhvi, Sanjay Tiwari, Swarnlata Saraf, Shailendra Saraf and Amit Alexander*


DOI: 10.2174/1389450120666191031092259


Review Article

Nanosized modification strategies for improving the antitumor efficacy of MEK inhibitors

, 2020; 21(3): 228-251.

Yanan Li, Qingrong Dong, Ting Mei, Meichen Zheng, Ramasamy Raj Kumar, Bin Yu, Chunsheng Wu, Hui Zhang* and Feifei An*


DOI: 10.2174/1389450120666190807143245


General Review Article

Advances in the treatment of ovarian cancer using PARP inhibitors and the underlying mechanism of resistance

, 2020; 21(2): 167-178.

Ling Wang, Qi Wang, Yangchun Xu, Manhua Cui and Liying Han*


DOI: 10.2174/1389450120666190925123507



Most Accessed Articles


Targeting Cancer Stem Cells Pathways for the Effective Treatment of Cancer

, 2020; 21(3): 258-278.

Ashish Ranjan Dwivedi, Amandeep Thakur, Vijay Kumar, Ira Skvortsova and Vinod Kumar*


DOI: 10.2174/1389450120666190821160730





COVID-19 and Renal Diseases: An Update

, 2021; 22(1): 52-67.

Letícia Bitencourt, Ana Luisa Pedrosa, Stephanie Bruna Camilo Soares de Brito, Ana Cláudia Fontoura Fróes, Sarah Tayná de Carvalho, Giulio Gori Fonseca, Guilherme Costa Ferreira, Pollyanna Faria Fradico and Ana Cristina Simões e Silva*


DOI: 10.2174/1389450121999201013151300



Targeting Host Cell Proteases to Prevent SARS-CoV-2 Invasion

, 2021; 22(2): 192-201.

Upinder Kaur, Sankha Shubhra Chakrabarti*, Bisweswar Ojha, Bhairav Kumar Pathak, Amit Singh, Luciano Saso and Sasanka Chakrabarti


DOI: 10.2174/1389450121666200924113243


Edaravone May Prevent Ferroptosis in ALS

, 2020; 21(8): 776-780.

Snežana Spasić*, Aleksandra Nikolić-Kokić, Srđan Miletić, Zorana Oreščanin-Dušić, Mihajlo B. Spasić, Duško Blagojević and Zorica Stević


DOI: 10.2174/1389450121666200220123305


Downregulation of Membrane-bound Angiotensin Converting Enzyme 2 (ACE2) Receptor has a Pivotal Role in COVID-19 Immunopathology

, 2021; 22(3): 254-281.

Cristina Vieira, Lucas Nery, Ludimila Martins, Luiz Jabour, Raphael Dias and Ana Cristina Simões e Silva*


DOI: 10.2174/1389450121666201020154033


Targeting Drugs Against Fibroblast Growth Factor(s)-Induced Cell Signaling

, 2021; 22(2): 214-240.

Shilpi Agrawal, Sanhita Maity, Zeina AlRaawi, Musaab Al-Ameer and Thallapuranam Krishnaswamy Suresh Kumar*


DOI: 10.2174/1389450121999201012201926


Fluoroquinolones: Blessings Or Curses

, 2020; 21(13): 1354-1370.

Priyanka P. Majalekar* and Pramodkumar J. Shirote


DOI: 10.2174/1389450121666200621193355


Exosomes: A Novel Therapeutic Paradigm for the Treatment of Depression

, 2021; 22(2): 183-191.

Shvetank Bhatt*, Jovita Kanoujia, Arghya Kusum Dhar, Surendar Arumugam, Amanda K. A. Silva and Neeraj Mishra


DOI: 10.2174/1389450121999201006193005


Post-menopausal Osteoporosis and Probiotics

, 2021; 22(7): 816-822.

Sangeeta Huidrom*, Mirza Atif Beg and Tariq Masood


DOI: 10.2174/1389450121666201027124947





Editor-in-Chief

graphic
Francis J. Castellino
(14643 citations)
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
(USA)
View Full Editorial Board

COPE Compliant

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Journal History

Current Drug Targets Journal was launched in 2000. Dr. Francis J. Castellino serves as the Editor-in-Chief of the journal.

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