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Current Drug Metabolism

Volume 22, 14 Issues, 2021
ISSN: 1875-5453 (Online)
ISSN: 1389-2002 (Print)
This journal supports open access

Aims & Scope

Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism.

More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.

Current Drug Metabolism


Volume 22


Number 2

Biography   Open Access

Review Article

Effectiveness and Tolerability of Very-low Volume Preparation for Colonoscopy: A Narrative Review

, 22(2): 85 - 88

Emanuele Sinagra*, Sandro Sferrazza, Alessandro Vitello, Gaetano Morreale, Francesca Rossi, Giuseppe Conoscenti, Socrate Pallio, Dario Raimondo and Marcello Maida

DOI: 10.2174/1389200221999201208212007

Review Article

Metabolism of Direct-acting Antiviral Agents (DAAs) in Hepatitis C Therapy: A Review of the Literature

, 22(2): 89 - 98

Ivana Mikolasevic*, Tajana F. Kanizaj, Dorotea Bozic, Petra Puz, Sanja S. Shapeski, Zeljko Puljiz, Delfa Radic-Kristo, Milos Lalovac, Maja Mijic, Bozena Delija, Toni Juric, Ivan Bogadi and Lucija Virovic-Jukic

DOI: 10.2174/1389200221999201214224126

Review Article

Drug Induced Cutaneous Manifestations due to Treatment of Gastrointestinal Disorders

, 22(2): 99 - 107

Milica S. Lalosevic, Jovan Lalosevic*, Mihailo Stjepanovic, Marija Stojanovic and Mirjana Stojkovic

DOI: 10.2174/1389200221999201116143109

Research Article

Modulation of Drug Resistance by Limonene: Inhibition of Efflux Pumps in Staphylococcus aureus Strains RN-4220 and IS-58

, 22(2): 110 - 113

Ana C.J. de Araújo, Priscilla R. Freitas, Cristina R. dos Santos Barbosa, Débora F. Muniz, Jaime Ribeiro-Filho, Saulo R. Tintino, José P.S. Júnior, José M.B. Filho, Gabriela R. de Sousa and Henrique D.M. Coutinho*

DOI: 10.2174/1389200221999210104204718

Research Article

Modulation of the Drug Resistance by Platonia insignis Mart. Extract, Ethyl Acetate Fraction and Morelloflavone/Volkensiflavone (Biflavonoids) in Staphylococcus aureus Strains Overexpressing Efflux Pump Genes

, 22(2): 114 - 122

Andressa K.F. e Silva, Antonielly C. dos Reis, Emanuelly E.A. Pinheiro, Jonas N. de Sousa, Felipe A. de Alcântara Oliveira, Arkellau K.S. Moura, José de Sousa L. Neto, Antonia M. das Graças L. Citó, José P. Siqueira-Júnior, Glenn W. Kaatz and Humberto M. Barreto*

DOI: 10.2174/1389200221666200523155617

Current Drug Metabolism, Volume 22 (2021) - Number 3

This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Comparison of the Inhibitory Effects of Clotrimazole and Ketoconazole Against Human Carboxylesterase 2

Tingting Zhao, Dalong Wang, Zhao Shan, Jing Chen, Tongyi Dou, Guangbo Ge, Changyuan Wang, Qiang Meng, Huijun Sun, Kexin Liu and Jingjing Wu*

DOI: 10.2174/1389200222666210210115509
View Abstract View on PubMed

Recent Patents, Regulatory Issues, and Toxicity of Nanoparticles in Neuronal Disorders

Abdul Muheem, Mohammed Asadullah Jahangir, Chandra Prakash Jaiswal, Mohammed Jafar, Mohammad Zaki Ahmad, Javed Ahmad and Musarrat Husain Warsi*

DOI: 10.2174/1389200221999201210213036
View Abstract View on PubMed

Anticancer Activity and In Silico ADMET Properties of 2,4,5-Trisubstitutedthiazole Derivatives

Bilal A. Al-Jaidi*, Soha Taher Telfah, Sanaa K. Bardaweel, Pran Kishore Deb*, Pobitra Borah, Katharigatta N. Venugopala, Yazan A. Bataineh and Qutaiba Ahmed Al Khames Aga

DOI: 10.2174/1389200221666201217094602
View Abstract View on PubMed

A Novel Nanoformulation of Ellagic Acid is Promising in Restoring Oxidative Homeostasis in Rat Brains with Alzheimer’s Disease

Steve Harakeh*, Mohamad H. Qari, Wafaa S. Ramadan, Soad K. Al Jaouni, Mohammed S. Al Muhayawi, Turki Al Amri, Ghulam Md Ashraf, Dhruba J Bharali and Shaker A Mousa*

DOI: 10.2174/1389200221666201216170851
View Abstract View on PubMed

Abstracts Ahead of Print

Role of Natural Products in the Treatment of Obesity: Nanotechnological perspectives

Kashish Kapoor, Reecha Madaan*, Suresh Kumar, Rajni Bala and Raman Preet Walia

DOI: 10.2174/1389200222666210324150738
View Abstract

Absorption, Metabolism, Distribution, and Excretion of Letermovir

Karsten Menzel*, Prajakti Kothare, Jacqueline B. McCrea, Xiaoyan Chu and Dirk Kropeit

DOI: 10.2174/1389200222666210223112826
View Abstract

Design and Evaluation of Ornidazole Sustained release Dental Inserts

Sunchu Harika*, Y. Shravan Kumar*, Y. Madhusudhan Rao, Pavani Sriram and Uma Shankar

DOI: 10.2174/1389200222666210222152940
View Abstract

Evaluation of dermorphin metabolism using zebrafish water tank model and human liver microsomes

Juliana de L. Castro*, Henrique M. G. Pereira, Valéria P. de Sousa and Maria Elvira P. Martucci

DOI: 10.2174/1389200222666210216095753
View Abstract

Published Contents

Editor's Choice

Current Treatment Options for HCC: From Pharmacokinetics to Efficacy and Adverse Events in Liver Cirrhosis

, 2020; 21(11): 866 - 884

Giovanni Galati*, Antonio Fabio Massimo Vainieri*, Claudia Angela Maria Fulgenzi, Stefano Di Donato, Marianna Silletta, Paolo Gallo, Angelo Onorato, Umberto Vespasiani-Gentilucci and Antonio Picardi

DOI: 10.2174/1389200221999200918141239

Polymeric Nanoparticles for Brain Drug Delivery - A Review

, 2020; 21(9): 649 - 660

Subashini Raman, Syed Mahmood*, Ayah R. Hilles, Md Noushad Javed, Motia Azmana and Khater Ahmed Saeed Al-Japairai

DOI: 10.2174/1389200221666200508074348

Exosome-based Tumor Therapy: Opportunities and Challenges

, 2020; 21(5): 339 - 351

Chunmei Li, Xiaoming Hou, Peng Zhang, Juan Li, Xiaoguang Liu, Yuping Wang, Quanlin Guan and Yongning Zhou*

DOI: 10.2174/1389200221666200515103354

Open Access Articles

Dysregulation of lncRNA and circRNA Expression in Mouse Testes after Exposure to Triptolide

, 2019; 20(8): 665 - 673

Suping Xiong, Yanting Li, Yang Xiang, Na Peng, Chunmiao Shen, Yanqiu Cai, Dandan Song, Peng Zhang, Xiaolong Wang, Xuihui Zeng and Xiaoning Zhang*

Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients

, 2019; 20(7): 592 - 600

Zhiqi Wang, Nan Zhang, Chaoyang Chen, Shuqing Chen, Junyu Xu, Ying Zhou, Xia Zhao* and Yimin Cui*

Decreased Disposition of Anticancer Drugs Predominantly Eliminated via the Liver in Patients with Renal Failure

, 2019; 20(5): 361 - 376

Ken-ichi Fujita *, Natsumi Matsumoto, Hiroo Ishida, Yutaro Kubota, Shinichi Iwai, Motoko Shibanuma and Yukio Kato

Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis

, 2019; 20(4): 266 - 274

Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*

Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model

, 2019; 20(2): 103 - 113

Shotaro Uehara, Toru Oshio, Kazuyuki Nakanishi, Etsuko Tomioka, Miyu Suzuki, Takashi Inoue, Yasuhiro Uno, Erika Sasaki and Hiroshi Yamazaki*

Thiazide Therapy in Chronic Kidney Disease: Renal and Extra Renal Targets

, 2018; 19(12): 1012 - 1020

Negiin Pourafshar*, Saeed Alshahrani, Ashkan Karimi and Manoocher Soleimani*

Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives

, 2018; 19(10): 830 - 838

Lucija Kuna, Ivana Bozic, Tomislav Kizivat, Kristina Bojanic, Margareta Mrso, Edgar Kralj, Robert Smolic, George Y. Wu and Martina Smolic*

Digestive Enzyme Supplementation in Gastrointestinal Diseases

, 2016; 17(2): 187 - 193

Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini and Giovanni Cammarota

Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines

, 2015; 16(6): 412 - 426

Derek W. Edwardson, Rashmi Narendrula, Simon Chewchuk, Kyle Mispel-Beyer, Jonathan P.J. Mapletoft and Amadeo M. Parissenti

Most Cited Articles

Review Article

Decoding novel mechanisms and emerging therapeutic strategies in breast cancer resistance

, 2020; 21(3): 199-210.

Sadat Shafi, Sana Khan, Farazul Hoda, Faizana Fayaz, Archu Singh, Mohammad Ahmed Khan*, Ruhi Ali, Faheem Hyder Pottoo, Sana Tariq and Abul Kalam Najmi

DOI: 10.2174/1389200221666200303124946

Research Article

Dietary baicalin zinc supplementation alleviates oxidative stress and enhances nutrition absorption in deoxynivalenol challenged pigs

, 2020; 21(8): 614-625.

Andong Zha, Zhijuan Cui, Ming Qi, Simeng Liao, Lixin Chen, Peng Liao* and Bie Tan*

DOI: 10.2174/1389200221666200302124102

Review Article

The current state of potential therapeutic modalities for glioblastoma multiforme: A clinical review

, 2020; 21(8): 564-578.

Elmira Mohtashami, Negar Shafaei-Bajestani, Hamid Mollazadeh, Seyed Hadi Mousavi, Mohammad Jalili-Nik, Amirhossein Sahebkar* and Amir R. Afshari*

DOI: 10.2174/1389200221666200714101038

Review Article

Stem cells in tumour microenvironment aid in prolonged survival rate of cancer cells and developed drug resistance: major challenge in osteosarcoma treatment

, 2020; 21(1): 44-52.

Bhaskar Birru, ChandraSai Potla Durthi*, Santhosh Kacham, Madhuri Pola, Satish Babu Rajulapati, Sreenivasa Rao Parcha and Mohammad Amjad Kamal

DOI: 10.2174/1389200221666200214120226

Review Article

Nanostructured lipid carriers (NLCs): Nose-to-brain delivery and theranostic application

, 2020; 21(14): 1136-1143.

Javed Ahmad*, Md. Rizwanullah, Saima Amin, Musarrat Husain Warsi, Mohammad Zaki Ahmad and Md. Abul Barkat

DOI: 10.2174/1389200221666200719003304

Review Article

Chemical metabolism of xenobiotics by gut microbiota

, 2020; 21(4): 260-269.

Radislav Nakov* and Tsvetelina Velikova

DOI: 10.2174/1389200221666200303113830

Review Article

Prognostic role of hedgehog-gli1 signaling pathway in aggressive and metastatic breast cancers

, 2020; 21(1): 33-43.

Prasuja Rokkam, Shailender Gugalavath, Deepak Kakara Gift Kumar, Rahul Kumar Vempati and Rama Rao Malla*

DOI: 10.2174/1389200221666200122120625

Review Article

Versatile and valuable utilization of amidohydrolase l-glutaminase in pharma and food industries: A review

, 2020; 21(1): 11-24.

Chandrasai Potla Durthi*, Madhuri Pola, Satish Babu Rajulapati*, Anand Kishore Kola and Mohammad Amjad Kamal

DOI: 10.2174/1574884715666200116110542

Review Article

Talin: A potential drug target for cancer therapy

, 2020; 21(1): 25-32.

Rama Rao Malla and Rahul Kumar Vempati *

DOI: 10.2174/1389200221666200214114018

Review Article (Mini-Review)

Natural compounds as source of aldose reductase (Ar) inhibitors for the treatment of diabetic complications: A mini review

, 2020; 21(14): 1091-1116.

Ajmer Singh Grewal, Komal Thapa, Neha Kanojia, Neelam Sharma and Sukhbir Singh*

DOI: 10.2174/1389200221666201016124125

Review Article

The metabolism and pharmacokinetics of rhein and aurantio-obtusin

, 2020; 21(12): 960-968.

Shun-Li Xiao, Liang-Jun Guan, Ren-Feng Jiang, Xiang-Gen Wang, Xing Li and Wei Cai*

DOI: 10.2174/1389200221666200719002128

Research Article

Using reduced amino acid alphabet and biological properties to analyze and predict animal neurotoxin protein

, 2020; 21(10): 810-817.

Yao Yu, Shiyuan Wang, Yakun Wang, Yiyin Cao, Chunlu Yu, Yi Pan, Dongqing Su, Qianzi Lu, Yongchun Zuo* and Lei Yang*

DOI: 10.2174/1389200221666200520090555

Review Article

Applications of machine learning in drug target discovery

, 2020; 21(10): 790-803.

Dongrui Gao, Qingyuan Chen, Yuanqi Zeng, Meng Jiang and Yongqing Zhang*

DOI: 10.2174/1567201817999200728142023

Most Accessed Articles

Toward Greater Insights on Applications of Modeling and Simulation in Pregnancy

, 2020; 21(9): 722-741.

Ling Song, Cheng Cui, Ying Zhou, Zhongqi Dong, Zhiheng Yu, Yifan Xu, Tianyan Zhou, Khaled Abduljalil, Hongcan Han, Li Li, Jinbo Yang, Yangyu Zhao*, Haiyan Li and Dongyang Liu*

DOI: 10.2174/1389200221666200907143941

A Review: Effects of Macrolides on CYP450 Enzymes

, 2020; 21(12): 928-937.

Liyun Zhang, Xiaoqing Xu, Sara Badawy, Awais Ihsan, Zhenli Liu, Changqing Xie, Xu Wang* and Yanfei Tao*

DOI: 10.2174/1389200221666200817113920

Stem Cells in Tumour Microenvironment Aid in Prolonged Survival Rate of Cancer Cells and Developed Drug Resistance: Major Challenge in Osteosarcoma Treatment

, 2020; 21(1): 44-52.

Bhaskar Birru, ChandraSai Potla Durthi*, Santhosh Kacham, Madhuri Pola, Satish Babu Rajulapati, Sreenivasa Rao Parcha and Mohammad Amjad Kamal

DOI: 10.2174/1389200221666200214120226

Metabolism and Distribution of Novel Tumor Targeting Drugs In Vivo

, 2020; 21(13): 996-1008.

Mengli Wang, Qiuzheng Du, Lihua Zuo, Peng Xue, Chao Lan* and Zhi Sun*

DOI: 10.2174/1389200221666201112110638

The Metabolism and Pharmacokinetics of Rhein and Aurantio-Obtusin

, 2020; 21(12): 960-968.

Shun-Li Xiao, Liang-Jun Guan, Ren-Feng Jiang, Xiang-Gen Wang, Xing Li and Wei Cai*

DOI: 10.2174/1389200221666200719002128

Metabolism of Direct-acting Antiviral Agents (DAAs) in Hepatitis C Therapy: A Review of the Literature

, 2021; 22(2): 89-98.

Ivana Mikolasevic*, Tajana F. Kanizaj, Dorotea Bozic, Petra Puz, Sanja S. Shapeski, Zeljko Puljiz, Delfa Radic-Kristo, Milos Lalovac, Maja Mijic, Bozena Delija, Toni Juric, Ivan Bogadi and Lucija Virovic-Jukic

DOI: 10.2174/1389200221999201214224126


Ming Hu
University of Houston
College of Pharmacy
Houston, TX
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Journal History

Current Drug Metabolism was launched in 2000. Dr. Ming Hu serves as the Editor-in-Chief of the journal.

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