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Current Drug Metabolism

Volume 22, 14 Issues, 2021
ISSN: 1875-5453 (Online)
ISSN: 1389-2002 (Print)
This journal supports open access

Aims & Scope

Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism.

More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.

Current Drug Metabolism

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Volume 22

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Number 5



Biography   Open Access











Research Article





Research Article

Comparison of the Inhibitory Effects of Clotrimazole and Ketoconazole against Human Carboxylesterase 2

, 22(5): 391 - 398

Tingting Zhao, Dalong Wang, Shan Zhao, Jing Chen, Tongyi Dou, Guangbo Ge, Changyuan Wang, Qiang Meng, Huijun Sun, Kexin Liu and Jingjing Wu*


DOI: 10.2174/1389200222666210210115509


Current Drug Metabolism, Volume 22 (2021) - Number 6


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print


The Role of Biotransformation in the Activity of Endocrine Disruptors


Elif Ince Erguc, Alev Tascioglu-Aliyev, Bita Entezari and Hande Gurer-Orhan *


DOI: 10.2174/1389200222666210603114617
View Abstract View on PubMed


Design and Evaluation of Sustained Release of Ornidazole by Dental Inserts


Sunchu Harika*, Y. Shravan Kumar*, Y. Madhusudhan Rao, Pavani Sriram and Umasankar


DOI: 10.2174/1389200222666210222152940
View Abstract View on PubMed






Deciphering the Role of Nanoparticle-Based Treatment for Parkinson’s Disease


Md. Marufur Rahman Moni, Mst. Marium Begum, Md. Sahab Uddin* and Ghulam Md Ashraf*


DOI: 10.2174/1389200222666210202110129
View Abstract View on PubMed




Abstracts Ahead of Print




ADMET Profiling in Drug Discovery and Development: Perspectives of in silico, in vitro and integrated approaches


Nour El-Huda Daoud, Pobitra Borah, Pran Kishore Deb, Katharigatta N. Venugopala*, Wafa Hourani, Muhammed Alzweiri, Sanaa K. Bardaweel and Vinod Tiwari


DOI: 10.2174/1389200222666210705122913
View Abstract


Evaluation and Clinical Implication of Zhenwu Decoction on Seven Cytochrome P450 Enzyme in Chronic Heart Failure Rats


Li-li Hong, Hong-Song Wang*, Xiao-Yu Cheng*, Sheng Zhang, Yan Zhao, Qian Wang, Ya-TIng Zhao, Lei Wang, Lan Ge, Jun Su and Wei-Dong Chen


DOI: 10.2174/1389200222666210701171047
View Abstract



Oxypeucedanin is a mechanism-based inactivator of CYP2B6 and CYP2D6


Kehan Zhang, Yilin Li, Yao Fu, Tiantian Cui, Qian Wang, Xu Mao, Ying Peng and Jiang Zheng*


DOI: 10.2174/1389200222666210629114830
View Abstract



A Review on Pharmacokinetic and Pharmacodynamic Drug Interactions of Adrenergic β-blockers with Clinically Relevant Drugs-An Overview


Naina Mohamed Pakkir Maideen*, Balasubramanian Rajkapoor, Sudha Muthusamy, Sambathkumar Ramanathan, Ananda Thangadurai Subramaniam and Abdussalam A Sughir


DOI: 10.2174/1389200222666210614112529
View Abstract


New horizons in the treatment of neurological disorders with tailorable gold nanoparticles


Farheen Danish, Md. Asad Khan*, Ghulam Md Ashraf, Anwar L. Bilgrami and M. Moshahid A. Rizvi


DOI: 10.2174/1389200222666210525123416
View Abstract


Published Contents

Editor's Choice



Topical Capsaicin for the Treatment of Neuropathic Pain

, 2021; 22(3): 198 - 207

Adiba Sultana, Rajeev K. Singla, Xuefei He, Yan Sun, Md. Shahin Alam and Bairong Shen*


DOI: 10.2174/1389200221999201116143701





Current Treatment Options for HCC: From Pharmacokinetics to Efficacy and Adverse Events in Liver Cirrhosis

, 2020; 21(11): 866 - 884

Giovanni Galati*, Antonio Fabio Massimo Vainieri*, Claudia Angela Maria Fulgenzi, Stefano Di Donato, Marianna Silletta, Paolo Gallo, Angelo Onorato, Umberto Vespasiani-Gentilucci and Antonio Picardi


DOI: 10.2174/1389200221999200918141239




Polymeric Nanoparticles for Brain Drug Delivery - A Review

, 2020; 21(9): 649 - 660

Subashini Raman, Syed Mahmood*, Ayah R. Hilles, Md Noushad Javed, Motia Azmana and Khater Ahmed Saeed Al-Japairai


DOI: 10.2174/1389200221666200508074348





Open Access Articles



Dysregulation of lncRNA and circRNA Expression in Mouse Testes after Exposure to Triptolide

, 2019; 20(8): 665 - 673

Suping Xiong, Yanting Li, Yang Xiang, Na Peng, Chunmiao Shen, Yanqiu Cai, Dandan Song, Peng Zhang, Xiaolong Wang, Xuihui Zeng and Xiaoning Zhang*




Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients

, 2019; 20(7): 592 - 600

Zhiqi Wang, Nan Zhang, Chaoyang Chen, Shuqing Chen, Junyu Xu, Ying Zhou, Xia Zhao* and Yimin Cui*




Nanogels for Skin Cancer Therapy via Transdermal Delivery: Current Designs

, 2019; 20(7): 575 - 582

Phuong H.L. Tran, Wei Duan, Beom-Jin Lee and Thao T.D. Tran*




Decreased Disposition of Anticancer Drugs Predominantly Eliminated via the Liver in Patients with Renal Failure

, 2019; 20(5): 361 - 376

Ken-ichi Fujita *, Natsumi Matsumoto, Hiroo Ishida, Yutaro Kubota, Shinichi Iwai, Motoko Shibanuma and Yukio Kato




Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis

, 2019; 20(4): 266 - 274

Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*






Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model

, 2019; 20(2): 103 - 113

Shotaro Uehara, Toru Oshio, Kazuyuki Nakanishi, Etsuko Tomioka, Miyu Suzuki, Takashi Inoue, Yasuhiro Uno, Erika Sasaki and Hiroshi Yamazaki*





Thiazide Therapy in Chronic Kidney Disease: Renal and Extra Renal Targets

, 2018; 19(12): 1012 - 1020

Negiin Pourafshar*, Saeed Alshahrani, Ashkan Karimi and Manoocher Soleimani*




Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives

, 2018; 19(10): 830 - 838

Lucija Kuna, Ivana Bozic, Tomislav Kizivat, Kristina Bojanic, Margareta Mrso, Edgar Kralj, Robert Smolic, George Y. Wu and Martina Smolic*







Most Cited Articles

Review Article

Recent advances in machine learning methods for predicting heat shock proteins

, 2019; 20(3): 224-228.

Wei Chen*, Pengmian Feng, Tao Liu and Dianchuan Jin


DOI: 10.2174/1389200219666181031105916


Review Article

Survey of machine learning techniques in drug discovery

, 2019; 20(3): 185-193.

Natalie Stephenson, Emily Shane, Jessica Chase, Jason Rowland, David Ries, Nicola Justice, Jie Zhang, Leong Chan and Renzhi Cao*


DOI: 10.2174/1389200219666180820112457




Review Article

Cancer nanotechnology: A new revolution for cancer diagnosis and therapy

, 2019; 20(6): 416-429.

Vivek K Chaturvedi, Anshuman Singh, Vinay K. Singh and Mohan P. Singh*


DOI: 10.2174/1389200219666180918111528


Review Article

Magnetic nanoparticles: Current trends and future aspects in diagnostics and nanomedicine

, 2019; 20(6): 457-472.

Naga Veera Srikanth Vallabani, Sanjay Singh* and Ajay Singh Karakoti*


DOI: 10.2174/1389200220666181122124458


Review Article

Herb-drug interactions and hepatotoxicity

, 2019; 20(4): 275-282.

Mohammad K. Parvez* and Vikas Rishi


DOI: 10.2174/1389200220666190325141422



Review Article

Recent advances in the machine learning-based drug-target interaction prediction

, 2019; 20(3): 194-202.

Wen Zhang*, Weiran Lin, Ding Zhang, Siman Wang, Jingwen Shi and Yanqing Niu


DOI: 10.2174/1389200219666180821094047




Review Article

Survey of machine learning techniques for prediction of the isoform specificity of cytochrome P450 substrates

, 2019; 20(3): 229-235.

Yi Xiong, Yanhua Qiao, Daisuke Kihara, Hui-Yuan Zhang, Xiaolei Zhu* and Dong-Qing Wei*


DOI: 10.2174/1389200219666181019094526


General Review Article

Advanced glycation end products (AGEs), glutathione and breast cancer: Factors, mechanism and therapeutic interventions

, 2019; 20(1): 65-71.

Anil K. Sharma, Var R. Sharma, Girish K. Gupta, Ghulam Md. Ashraf and Mohammad A. Kamal*


DOI: 10.2174/1389200219666180912104342



Review Article

A review of recent advances and research on drug target identification methods

, 2019; 20(3): 209-216.

Yang Hu*, Tianyi Zhao, Ningyi Zhang, Ying Zhang* and Liang Cheng*


DOI: 10.2174/1389200219666180925091851



Most Accessed Articles





Role of Natural Products in the Treatment of Obesity: Nanotechnological Perspectives

, 2021; 22(6): 451-480.

Kashish Kapoor, Reecha Madaan*, Suresh Kumar, Rajni Bala and Raman P. Walia


DOI: 10.2174/1389200222666210324150738



Advances in Understanding the Metabolites and Metabolomics of Polygonum multiflorum Thunb: A Mini-review

, 2021; 22(3): 165-172.

Jian-Bo Yang, Hui-Yu Gao, Yun-Fei Song, Yue Liu, Qi Wang, Ying Wang, Shuang-Cheng Ma*, Xian-Long Cheng and Feng Wei*


DOI: 10.2174/1389200221666201201091345


Metabolism and Mechanism of Human Cytochrome P450 Enzyme 1A2

, 2021; 22(1): 40-49.

Jingchao Guo, Xiaohui Zhu, Sara Badawy, Awais Ihsan, Zhenli Liu, Changqing Xie and Xu Wang*


DOI: 10.2174/1389200221999210101233135






Comparison of the Inhibitory Effects of Clotrimazole and Ketoconazole against Human Carboxylesterase 2

, 2021; 22(5): 391-398.

Tingting Zhao, Dalong Wang, Shan Zhao, Jing Chen, Tongyi Dou, Guangbo Ge, Changyuan Wang, Qiang Meng, Huijun Sun, Kexin Liu and Jingjing Wu*


DOI: 10.2174/1389200222666210210115509



Stem Cells in Tumour Microenvironment Aid in Prolonged Survival Rate of Cancer Cells and Developed Drug Resistance: Major Challenge in Osteosarcoma Treatment

, 2020; 21(1): 44-52.

Bhaskar Birru, ChandraSai Potla Durthi*, Santhosh Kacham, Madhuri Pola, Satish Babu Rajulapati, Sreenivasa Rao Parcha and Mohammad Amjad Kamal


DOI: 10.2174/1389200221666200214120226




Editor-in-Chief

graphic
Ming Hu
College of Pharmacy
University of Houston
Houston, TX
(USA)
Biography
View Full Editorial Board

COPE Compliant

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Journal History

Current Drug Metabolism was launched in 2000. Dr. Ming Hu serves as the Editor-in-Chief of the journal.

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