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Current Drug Metabolism

Volume 21, 14 Issues, 2020
ISSN: 1875-5453 (Online)
ISSN: 1389-2002 (Print)
This journal supports open access
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In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Aims & Scope

Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism.

More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.

Current Drug Metabolism

,

Volume 21

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Number 4



Biography   Open Access



Editorial   Open Access



Review Article



Review Article



Review Article



General Research Article



General Research Article

Evaluation of the Effects of Maytenus ilicifolia on the Activities of Cytochrome P450 3A and P-glycoprotein

, 21(4): 281 - 290

Sara Batista do Nascimento, Mariana de Lima Nascimento, Laís Lobato de Araújo, Flávio Martins de Oliveira, Maria do Carmo Vieira, Joaquim Maurício Duarte-Almeida, João Máximo Siqueira, Isabela da Costa César, Hartmut Derendorf and Whocely Victor de Castro*


DOI: 10.2174/1389200221666200512112718


General Research Article

Pharmacogenetic Evaluation of Metformin and Sulphonylurea Response in Mexican Mestizos with Type 2 Diabetes

, 21(4): 291 - 300

Menjivar Marta, Katy Sánchez-Pozos, Joel Jaimes-Santoyo, Jazmin Monroy-Escutia, Carolina Rivera- Santiago, María de los Ángeles Granados-Silvestre and María Guadalupe Ortiz-López*


DOI: 10.2174/1389200221666200514125443


Current Drug Metabolism, Volume 21 (2020) - Number 5


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Annonaceae Family Alkaloids as Agents Against Leishmaniasis: A Review and Molecular Docking Evaluation


Vitor Prates Lorenzo, Luciana Scotti, Jackson Roberto Guedes da Silva Almeida and Marcus Tullius Scotti*


DOI: 10.2174/1389200221666200702124046
View Abstract View on PubMed



The Recent Advancement in the Field of Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) for Aiming Breast Cancer


Debalina Maity, Sankha Bhattacharya*, Yudhishtir Singh Baghel, Sushilkumar Singh, Shweta Rai, Ritika S, Shubham Shrestha, Neeraj Singh and Akhil Kumar


DOI: 10.2174/1573399816666200627213646
View Abstract



Preclinical Evidence for the Pharmacological Actions of Glycyrrhizic Acid: A Comprehensive Review


Muneeb U Rehman, Adil Farooq, Rayeesa Ali, Sana Bashir, Nazirah Bashir, Samia Majeed, Syed Taifa, Sheikh Bilal Ahmad, Azher Arafah, Aga Syed Sameer*, Rehan Khan, Wajhul Qamar, Saiema Rasool and Anas Ahmad


DOI: 10.2174/1389200221666200620204914
View Abstract View on PubMed




Salidroside – Can it be a Multifunctional Drug?


Sri Krishna Jayadev Magani, Sri Durgambica Mupparthi, Bhanu Prakash Gollapalli, Dhananjay Shukla, AK Tiwari, Jyotsna Gorantala, Nagendra Sastry Yarla and Srinivasan Tantravahi*


DOI: 10.2174/1389200221666200610172105
View Abstract View on PubMed




Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Published Contents

Editor's Choice


Human Papillomavirus Induced Cervical and Oropharyngeal Cancers: From Mechanisms to Potential Immuno-therapeutic Strategies

, 2020; 21(3): 167 - 177

Mohd. Saeed*, Syed Mohd Faisal, Firoz Akhtar, Saheem Ahmad, Mousa M. Alreshidi, Mohd. Adnan Kausar, Shadab Kazmi, Amir Saeed, Mohd. Adnan and Ghulam Md Ashraf*


DOI: 10.2174/1389200221666200421121228



Has the Time Come to Employ Population and Individual Bioequivalence for the Evaluation of Generics?

, 2020; 21(2): 112 - 125

Francis Micheal*, Mohanlal Sayana, Rajendra Prasad and Balamurali Musuvathi Motilal


DOI: 10.2174/1389200221666200401105119




Effect of Environmental Exposure and Pharmacogenomics on Drug Metabolism

, 2019; 20(14): 1103 - 1113

Basu Dev Banerjee*, Ranjeet Kumar, Krishna Latha Thamineni, Harendra Shah, Gaurav Kumar Thakur and Tusha Sharma


DOI: 10.2174/1389200221666200110153304



Therapeutic Study of Phytochemicals Against Cancer and Alzheimer’s Disease Management

, 2019; 20(13): 1006 - 1013

Syed Sayeed Ahmad, Tayyaba Waheed, Sayed Rozeen, Sufia Mahmood and Mohammad Amjad Kamal*


DOI: 10.2174/1389200221666200103092719



A Retrospective Look at Anti-EGFR Agents in Pancreatic Cancer Therapy

, 2019; 20(12): 958 - 966

Henu K. Verma, Praveen K. Kampalli, Saikrishna Lakkakula, Gayathri Chalikonda, Lakkakula V.K.S. Bhaskar* and Smaranika Pattnaik*


DOI: 10.2174/1389200220666191122104955




Assessment of miR-212 and Other Biomarkers in the Diagnosis and Treatment of HBV-infection-related Liver Diseases

, 2019; 20(10): 785 - 798

Yigan Zhang, Huaze Xi, Xin Nie, Peng Zhang, Ning Lan, Ying Lu, Jinrong Liu and Wenzhen Yuan*


DOI: 10.2174/1389200220666191011120434




Open Access Articles

Dysregulation of lncRNA and circRNA Expression in Mouse Testes after Exposure to Triptolide

, 2019; 20(8): 665 - 673

Suping Xiong, Yanting Li, Yang Xiang, Na Peng, Chunmiao Shen, Yanqiu Cai, Dandan Song, Peng Zhang, Xiaolong Wang, Xuihui Zeng and Xiaoning Zhang*




Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients

, 2019; 20(7): 592 - 600

Zhiqi Wang, Nan Zhang, Chaoyang Chen, Shuqing Chen, Junyu Xu, Ying Zhou, Xia Zhao* and Yimin Cui*




Decreased Disposition of Anticancer Drugs Predominantly Eliminated via the Liver in Patients with Renal Failure

, 2019; 20(5): 361 - 376

Ken-ichi Fujita *, Natsumi Matsumoto, Hiroo Ishida, Yutaro Kubota, Shinichi Iwai, Motoko Shibanuma and Yukio Kato




Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis

, 2019; 20(4): 266 - 274

Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*






Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model

, 2019; 20(2): 103 - 113

Shotaro Uehara, Toru Oshio, Kazuyuki Nakanishi, Etsuko Tomioka, Miyu Suzuki, Takashi Inoue, Yasuhiro Uno, Erika Sasaki and Hiroshi Yamazaki*





Thiazide Therapy in Chronic Kidney Disease: Renal and Extra Renal Targets

, 2018; 19(12): 1012 - 1020

Negiin Pourafshar*, Saeed Alshahrani, Ashkan Karimi and Manoocher Soleimani*




Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives

, 2018; 19(10): 830 - 838

Lucija Kuna, Ivana Bozic, Tomislav Kizivat, Kristina Bojanic, Margareta Mrso, Edgar Kralj, Robert Smolic, George Y. Wu and Martina Smolic*






Digestive Enzyme Supplementation in Gastrointestinal Diseases

, 2016; 17(2): 187 - 193

Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini and Giovanni Cammarota




Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines

, 2015; 16(6): 412 - 426

Derek W. Edwardson, Rashmi Narendrula, Simon Chewchuk, Kyle Mispel-Beyer, Jonathan P.J. Mapletoft and Amadeo M. Parissenti




Preclinical Pharmacokinetics, Pharmacodynamics and Safety of Sucroferric Oxyhydroxide

, 2014; 15(10): 953 - 965

Mario Cozzolino, Felix Funk, Viatcheslav Rakov, Olivier Phan and Isaac Teitelbaum





Most Cited Articles

Review Article

Recent advances in machine learning methods for predicting heat shock proteins

, 2019; 20(3): 224-228.

Wei Chen*, Pengmian Feng, Tao Liu and Dianchuan Jin


DOI: 10.2174/1389200219666181031105916


Review Article

Survey of machine learning techniques in drug discovery

, 2019; 20(3): 185-193.

Natalie Stephenson, Emily Shane, Jessica Chase, Jason Rowland, David Ries, Nicola Justice, Jie Zhang, Leong Chan and Renzhi Cao*


DOI: 10.2174/1389200219666180820112457




Review Article

Magnetic nanoparticles: Current trends and future aspects in diagnostics and nanomedicine

, 2019; 20(6): 457-472.

Naga Veera Srikanth Vallabani, Sanjay Singh* and Ajay Singh Karakoti*


DOI: 10.2174/1389200220666181122124458



Review Article

Survey of machine learning techniques for prediction of the isoform specificity of cytochrome P450 substrates

, 2019; 20(3): 229-235.

Yi Xiong, Yanhua Qiao, Daisuke Kihara, Hui-Yuan Zhang, Xiaolei Zhu* and Dong-Qing Wei*


DOI: 10.2174/1389200219666181019094526


Review Article

Herb-drug interactions and hepatotoxicity

, 2019; 20(4): 275-282.

Mohammad K. Parvez* and Vikas Rishi


DOI: 10.2174/1389200220666190325141422


Review Article

Recent advances in the machine learning-based drug-target interaction prediction

, 2019; 20(3): 194-202.

Wen Zhang*, Weiran Lin, Ding Zhang, Siman Wang, Jingwen Shi and Yanqing Niu


DOI: 10.2174/1389200219666180821094047


Review Article

Iron oxide nanoparticles for breast cancer theranostics

, 2019; 20(6): 446-456.

Md. Salman Shakil, Md. Ashraful Hasan* and Satya Ranjan Sarker*


DOI: 10.2174/1389200220666181122105043



Review Article

Drug-drug interactions of P-gp substrates unrelated to CYP metabolism

, 2019; 20(2): 124-129.

Yumiko Akamine, Norio Yasui-Furukori and Tsukasa Uno*


DOI: 10.2174/1389200219666181003142036



Review Article

Curcumin-a novel therapeutic agent in the prevention of colorectal cancer

, 2019; 20(12): 977-987.

Manoj K. Gupta, Ramakrishna Vadde and Vemula Sarojamma*


DOI: 10.2174/1389200220666191007153238


General Review Article

Iron and Vitamin D/Calcium deficiency after gastric bypass: Mechanisms involved and strategies to improve oral supplement disposition

, 2019; 20(3): 244-252.

Aisling Mangan*, Carel W. Le Roux, Nana Gletsu Miller and Neil G. Docherty


DOI: 10.2174/1389200219666181026160242



Most Accessed Articles


Essential Oils: Extraction Techniques, Pharmaceutical And Therapeutic Potential - A Review

, 2018; 19(13): 1100-1110.

Zarith Asyikin Abdul Aziz, Akil Ahmad, Siti Hamidah Mohd Setapar*, Alptug Karakucuk, Muhammad Mohsin Azim, David Lokhat, Mohd. Rafatullah, Magdah Ganash, Mohammad A. Kamal and Ghulam Md Ashraf*


DOI: 10.2174/1389200219666180723144850


Cannabinoids and Cytochrome P450 Interactions

, 2016; 17(3): 206-226.

Ondřej Zendulka, Gabriela Dovrtělová, Kristýna Nosková, Miroslav Turjap, Alexandra Šulcová, Lumír Hanuš and Jan Juřica


DOI: 10.2174/1389200217666151210142051


Use of Non-steroidal Anti-inflammatory Drugs in Pregnancy: Impact on the Fetus and Newborn

, 2012; 13(4): 474-490.

Roberto Antonucci, Marco Zaffanello, Elisabetta Puxeddu, Annalisa Porcella, Laura Cuzzolin, Maria Dolores Pilloni and Vassilios Fanos


DOI: 10.2174/138920012800166607



Medicinal and Therapeutic Potential of Herbs and Plant Metabolites / Extracts Countering Viral Pathogens - Current Knowledge and Future Prospects

, 2018; 19(3): 236-263.

Kuldeep Dhama*, Kumaragurubaran Karthik, Rekha Khandia, Ashok Munjal, Ruchi Tiwari, Rajneesh Rana, Sandip Kumar Khurana, Sana Ullah, Rifat Ullah Khan, Mahmoud Alagawany, Mayada Ragab Farag, Maryam Dadar and Sunil Kumar Joshi


DOI: 10.2174/1389200219666180129145252



Neuroblastoma: An Updated Review on Biology and Treatment

, 2019; 20(13): 1014-1022.

Suresh Mallepalli, Manoj Kumar Gupta and Ramakrishna Vadde*


DOI: 10.2174/1389200221666191226102231


Pharmacokinetic and Pharmacodynamic Properties of Anti-VEGF Drugs After Intravitreal Injection

, 2015; 16(7): 572-584.

Francesco Semeraro, Francesco Morescalchi, Sarah Duse, Elena Gambicorti, Anna Cancarini and Ciro Costagliola


DOI: 10.2174/1389200216666151001120831



Editor-in-Chief

Ming Hu
University of Houston College of Pharmacy
Houston, TX
(USA)
Biography View Full Editorial Board

Journal History

Current Drug Metabolism was launched in 2000. Dr. Michael Sinz serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 2.75

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