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Current Drug Metabolism

Volume 22, 14 Issues, 2021
ISSN: 1875-5453 (Online)
ISSN: 1389-2002 (Print)
This journal supports open access

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Aims & Scope

Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism.

More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.

Current Drug Metabolism

,

Volume 21

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Number 14



Biography   Open Access



Editorial



Review Article

Recent Advances in Treatment of Childhood Obesity

, 21(14): 1072 - 1078

Walter Milano, Paola Ambrosio, Francesca Carizzone, Walter Di Munzio, Valeria De Biasio and Anna Capasso*


DOI: 10.2174/1389200221666200817112311


Review Article

Germacrone: A Potent Secondary Metabolite with Therapeutic Potential in Metabolic Diseases, Cancer and Viral Infections

, 21(14): 1079 - 1090

Ammara Riaz, Azhar Rasul*, Nazia Kanwal, Ghulam Hussain, Muhammad Ajmal Shah*, Iqra Sarfraz, Rubab Ishfaq, Rabia Batool, Fariha Rukhsar and Şevki Adem


DOI: 10.2174/1389200221999200728144801


Review Article (Mini-Review)



Review Article



Review Article



Review Article

Nanostructured Lipid Carriers (NLCs): Nose-to-Brain Delivery and Theranostic Application

, 21(14): 1136 - 1143

Javed Ahmad*, Md. Rizwanullah, Saima Amin, Musarrat Husain Warsi, Mohammad Zaki Ahmad and Md. Abul Barkat


DOI: 10.2174/1389200221666200719003304


Articles Ahead of Print

Metabolism and Mechanism of Human Cytochrome P450 Enzyme 1A2


Jingchao Guo, Xiaohui Zhu, Sara Badawy, Awais Ihsan, Zhenli Liu, Changqing Xie and Xu Wang*


DOI: 10.2174/1389200221999210101233135
View Abstract View on PubMed




Effectiveness and Tolerability of Very-Low Volume Preparation for Colonoscopy: A Narrative Review


Emanuele Sinagra*, Sandro Sferrazza, Alessandro Vitello, Gaetano Morreale, Francesca Rossi, Giuseppe Conoscenti, Socrate Pallio, Dario Raimondo and Marcello Maida


DOI: 10.2174/1389200221999201208212007
View Abstract View on PubMed


Modulation of Drug Resistance by Limonene: Inhibition of Efflux Pumps in Staphylococcus aureus Strains RN-4220 and IS-58


Ana Carolina Justino de Araújo, Priscilla Ramos Freitas, Cristina Rodrigues dos Santos Barbosa, Débora Feitosa Muniz, Jaime Jaime Ribeiro-Filho, Saulo Relison Tintino, José Pinto Siqueira Júnior, José Maria Barbosa Filho, Gabriela Ribeiro de Sousa and Henrique Douglas Melo Coutinho*


DOI: 10.2174/1389200221999210104204718
View Abstract







Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Published Contents

Editor's Choice

Current Treatment Options for HCC: From Pharmacokinetics to Efficacy and Adverse Events in Liver Cirrhosis

, 2020; 21(11): 866 - 884

Giovanni Galati*, Antonio Fabio Massimo Vainieri*, Claudia Angela Maria Fulgenzi, Stefano Di Donato, Marianna Silletta, Paolo Gallo, Angelo Onorato, Umberto Vespasiani-Gentilucci and Antonio Picardi


DOI: 10.2174/1389200221999200918141239




Polymeric Nanoparticles for Brain Drug Delivery - A Review

, 2020; 21(9): 649 - 660

Subashini Raman, Syed Mahmood*, Ayah R. Hilles, Md Noushad Javed, Motia Azmana and Khater Ahmed Saeed Al-Japairai


DOI: 10.2174/1389200221666200508074348






Exosome-based Tumor Therapy: Opportunities and Challenges

, 2020; 21(5): 339 - 351

Chunmei Li, Xiaoming Hou, Peng Zhang, Juan Li, Xiaoguang Liu, Yuping Wang, Quanlin Guan and Yongning Zhou*


DOI: 10.2174/1389200221666200515103354




Human Papillomavirus Induced Cervical and Oropharyngeal Cancers: From Mechanisms to Potential Immuno-therapeutic Strategies

, 2020; 21(3): 167 - 177

Mohd. Saeed*, Syed Mohd Faisal, Firoz Akhtar, Saheem Ahmad, Mousa M. Alreshidi, Mohd. Adnan Kausar, Shadab Kazmi, Amir Saeed, Mohd. Adnan and Ghulam Md Ashraf*


DOI: 10.2174/1389200221666200421121228



Has the Time Come to Employ Population and Individual Bioequivalence for the Evaluation of Generics?

, 2020; 21(2): 112 - 125

Francis Micheal*, Mohanlal Sayana, Rajendra Prasad and Balamurali Musuvathi Motilal


DOI: 10.2174/1389200221666200401105119



Open Access Articles

Dysregulation of lncRNA and circRNA Expression in Mouse Testes after Exposure to Triptolide

, 2019; 20(8): 665 - 673

Suping Xiong, Yanting Li, Yang Xiang, Na Peng, Chunmiao Shen, Yanqiu Cai, Dandan Song, Peng Zhang, Xiaolong Wang, Xuihui Zeng and Xiaoning Zhang*




Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients

, 2019; 20(7): 592 - 600

Zhiqi Wang, Nan Zhang, Chaoyang Chen, Shuqing Chen, Junyu Xu, Ying Zhou, Xia Zhao* and Yimin Cui*




Decreased Disposition of Anticancer Drugs Predominantly Eliminated via the Liver in Patients with Renal Failure

, 2019; 20(5): 361 - 376

Ken-ichi Fujita *, Natsumi Matsumoto, Hiroo Ishida, Yutaro Kubota, Shinichi Iwai, Motoko Shibanuma and Yukio Kato




Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis

, 2019; 20(4): 266 - 274

Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*






Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model

, 2019; 20(2): 103 - 113

Shotaro Uehara, Toru Oshio, Kazuyuki Nakanishi, Etsuko Tomioka, Miyu Suzuki, Takashi Inoue, Yasuhiro Uno, Erika Sasaki and Hiroshi Yamazaki*





Thiazide Therapy in Chronic Kidney Disease: Renal and Extra Renal Targets

, 2018; 19(12): 1012 - 1020

Negiin Pourafshar*, Saeed Alshahrani, Ashkan Karimi and Manoocher Soleimani*




Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives

, 2018; 19(10): 830 - 838

Lucija Kuna, Ivana Bozic, Tomislav Kizivat, Kristina Bojanic, Margareta Mrso, Edgar Kralj, Robert Smolic, George Y. Wu and Martina Smolic*






Digestive Enzyme Supplementation in Gastrointestinal Diseases

, 2016; 17(2): 187 - 193

Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini and Giovanni Cammarota




Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines

, 2015; 16(6): 412 - 426

Derek W. Edwardson, Rashmi Narendrula, Simon Chewchuk, Kyle Mispel-Beyer, Jonathan P.J. Mapletoft and Amadeo M. Parissenti




Preclinical Pharmacokinetics, Pharmacodynamics and Safety of Sucroferric Oxyhydroxide

, 2014; 15(10): 953 - 965

Mario Cozzolino, Felix Funk, Viatcheslav Rakov, Olivier Phan and Isaac Teitelbaum





Most Cited Articles

Review Article

Decoding novel mechanisms and emerging therapeutic strategies in breast cancer resistance

, 2020; 21(3): 199-210.

Sadat Shafi, Sana Khan, Farazul Hoda, Faizana Fayaz, Archu Singh, Mohammad Ahmed Khan*, Ruhi Ali, Faheem Hyder Pottoo, Sana Tariq and Abul Kalam Najmi


DOI: 10.2174/1389200221666200303124946


Review Article

Stem cells in tumour microenvironment aid in prolonged survival rate of cancer cells and developed drug resistance: major challenge in osteosarcoma treatment

, 2020; 21(1): 44-52.

Bhaskar Birru, ChandraSai Potla Durthi*, Santhosh Kacham, Madhuri Pola, Satish Babu Rajulapati, Sreenivasa Rao Parcha and Mohammad Amjad Kamal


DOI: 10.2174/1389200221666200214120226


Review Article

The current state of potential therapeutic modalities for glioblastoma multiforme: A clinical review

, 2020; 21(8): 564-578.

Elmira Mohtashami, Negar Shafaei-Bajestani, Hamid Mollazadeh, Seyed Hadi Mousavi, Mohammad Jalili-Nik, Amirhossein Sahebkar* and Amir R. Afshari*


DOI: 10.2174/1389200221666200714101038


Review Article

Prognostic role of hedgehog-gli1 signaling pathway in aggressive and metastatic breast cancers

, 2020; 21(1): 33-43.

Prasuja Rokkam, Shailender Gugalavath, Deepak Kakara Gift Kumar, Rahul Kumar Vempati and Rama Rao Malla*


DOI: 10.2174/1389200221666200122120625


Review Article

Versatile and valuable utilization of amidohydrolase l-glutaminase in pharma and food industries: A review

, 2020; 21(1): 11-24.

Chandrasai Potla Durthi*, Madhuri Pola, Satish Babu Rajulapati*, Anand Kishore Kola and Mohammad Amjad Kamal


DOI: 10.2174/1574884715666200116110542


Research Article

Using reduced amino acid alphabet and biological properties to analyze and predict animal neurotoxin protein

, 2020; 21(10): 810-817.

Yao Yu, Shiyuan Wang, Yakun Wang, Yiyin Cao, Chunlu Yu, Yi Pan, Dongqing Su, Qianzi Lu, Yongchun Zuo* and Lei Yang*


DOI: 10.2174/1389200221666200520090555


Review Article

Lipid nanoformulations in the treatment of neuropsychiatric diseases: An approach to overcome the blood brain barrier

, 2020; 21(9): 674-684.

Saleha Rehman, Bushra Nabi, Faheem Hyder Pottoo, Sanjula Baboota and Javed Ali*


DOI: 10.2174/1573399816666200627214129


Research Article

Dietary baicalin zinc supplementation alleviates oxidative stress and enhances nutrition absorption in deoxynivalenol challenged pigs

, 2020; 21(8): 614-625.

Andong Zha, Zhijuan Cui, Ming Qi, Simeng Liao, Lixin Chen, Peng Liao* and Bie Tan*


DOI: 10.2174/1389200221666200302124102


Review Article (Mini-Review)

Exosome-based tumor therapy: Opportunities and challenges

, 2020; 21(5): 339-351.

Chunmei Li, Xiaoming Hou, Peng Zhang, Juan Li, Xiaoguang Liu, Yuping Wang, Quanlin Guan and Yongning Zhou*


DOI: 10.2174/1389200221666200515103354


Review Article

A review: Effects of macrolides on cyp450 enzymes

, 2020; 21(12): 928-937.

Liyun Zhang, Xiaoqing Xu, Sara Badawy, Awais Ihsan, Zhenli Liu, Changqing Xie, Xu Wang* and Yanfei Tao*


DOI: 10.2174/1389200221666200817113920


Review Article

The metabolism and pharmacokinetics of rhein and aurantio-obtusin

, 2020; 21(12): 960-968.

Shun-Li Xiao, Liang-Jun Guan, Ren-Feng Jiang, Xiang-Gen Wang, Xing Li and Wei Cai*


DOI: 10.2174/1389200221666200719002128


Review Article

Role of glucose transporters in drug membrane transport

, 2020; 21(12): 947-958.

Xin Wang, Kunkun Guo, Baolin Huang, Zimin Lin and Zheng Cai*


DOI: 10.2174/1389200221666200810125924


Review Article

Research progress of herbal medicines on drug metabolizing enzymes: Consideration based on toxicology

, 2020; 21(12): 913-927.

Shuting Wang, Wanfang Li, Jianbo Yang, Zengyan Yang, Cuiping Yang* and Hongtao Jin*


DOI: 10.2174/1389200221999200819144204



Review Article

The influence of different disease states on rituximab pharmacokinetics

, 2020; 21(12): 938-946.

Xiaoxing Wang, Wenwen Du, Xianglin Zhang* and Pengmei Li*


DOI: 10.2174/1389200221666200719004035



Most Accessed Articles


Stem Cells in Tumour Microenvironment Aid in Prolonged Survival Rate of Cancer Cells and Developed Drug Resistance: Major Challenge in Osteosarcoma Treatment

, 2020; 21(1): 44-52.

Bhaskar Birru, ChandraSai Potla Durthi*, Santhosh Kacham, Madhuri Pola, Satish Babu Rajulapati, Sreenivasa Rao Parcha and Mohammad Amjad Kamal


DOI: 10.2174/1389200221666200214120226


A Review: Effects of Macrolides on CYP450 Enzymes

, 2020; 21(12): 928-937.

Liyun Zhang, Xiaoqing Xu, Sara Badawy, Awais Ihsan, Zhenli Liu, Changqing Xie, Xu Wang* and Yanfei Tao*


DOI: 10.2174/1389200221666200817113920





Current Treatment Options for HCC: From Pharmacokinetics to Efficacy and Adverse Events in Liver Cirrhosis

, 2020; 21(11): 866-884.

Giovanni Galati*, Antonio Fabio Massimo Vainieri*, Claudia Angela Maria Fulgenzi, Stefano Di Donato, Marianna Silletta, Paolo Gallo, Angelo Onorato, Umberto Vespasiani-Gentilucci and Antonio Picardi


DOI: 10.2174/1389200221999200918141239


Changes of Transporters and Drug-metabolizing Enzymes in Nephrotic Syndrome

, 2020; 21(5): 368-378.

Yaqian Dong, Linna Gong, Xianyuan Lu, Mingguang Ye, Yu Lin, Shuting Xie, Jiaxing Zhang, Fenghua Zhou, Lan Tang, Wei Zou* and Menghua Liu*


DOI: 10.2174/1389200221666200512113731


Toward Greater Insights on Applications of Modeling and Simulation in Pregnancy

, 2020; 21(9): 722-741.

Ling Song, Cheng Cui, Ying Zhou, Zhongqi Dong, Zhiheng Yu, Yifan Xu, Tianyan Zhou, Khaled Abduljalil, Hongcan Han, Li Li, Jinbo Yang, Yangyu Zhao*, Haiyan Li and Dongyang Liu*


DOI: 10.2174/1389200221666200907143941



Prognostic Role of Hedgehog-GLI1 Signaling Pathway in Aggressive and Metastatic Breast Cancers

, 2020; 21(1): 33-43.

Prasuja Rokkam, Shailender Gugalavath, Deepak Kakara Gift Kumar, Rahul Kumar Vempati and Rama Rao Malla*


DOI: 10.2174/1389200221666200122120625


The Metabolism and Pharmacokinetics of Rhein and Aurantio-Obtusin

, 2020; 21(12): 960-968.

Shun-Li Xiao, Liang-Jun Guan, Ren-Feng Jiang, Xiang-Gen Wang, Xing Li and Wei Cai*


DOI: 10.2174/1389200221666200719002128


The Potential Role of Serum Exosomes in Preeclampsia

, 2020; 21(5): 352-356.

Xuelin Gao, Lulu Shao, Xinying Ge, Long Zhang , Dexin Chen and Rongxia He*


DOI: 10.2174/1389200221666200525152441


Review on the Clinical Pharmacology of Hydroxychloroquine Sulfate for the Treatment of COVID-19

, 2020; 21(6): 427-435.

Cheng Cui, Siqi Tu, Valerie Sia Jie En, Xiaobei Li, Xueting Yao, Haiyan Li* and Dongyang Liu*


DOI: 10.2174/1389200221666200610172929


Further Considerations Towards an Effective and Efficient Oncology Drug Discovery DMPK Strategy

, 2020; 21(2): 145-162.

Beth Williamson , Nicola Colclough, Adrian John Fretland, Barry Christopher Jones, Rhys Dafydd Owen Jones and Dermot Francis McGinnity *


DOI: 10.2174/1389200221666200312104837



Editor-in-Chief

Ming Hu
University of Houston
College of Pharmacy
Houston, TX
(USA)
Biography
View Full Editorial Board

COPE Compliant

Journal History

Current Drug Metabolism was launched in 2000. Dr. Ming Hu serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 2.75

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