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Current Drug Discovery Technologies

,

Volume 15

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Number 4



Biography   Open Access



Review Article



Review Article

An Evidence-based Review of Medicinal Herbs for the Treatment of Gastroesophageal Reflux Disease (GERD)

, 15(4): 305 - 314

Ayda Hosseinkhani, Kamran Bagheri Lankarani, Abdolali Mohagheghzadeh, Chunlin Long and Mehdi Pasalar*


DOI: 10.2174/1570163814666171010113517




Research Article

Molecular Docking, Synthesis and Biological Evaluation of Sulphonylureas/ Guanidine Derivatives as Promising Antidiabetic Agent

, 15(4): 315 - 325

Ishan I. Panchal*, Dhrubo Jyoti Sen, Ashish D. Patel, Umang Shah, Mehul Patel, Archana Navale and Vashisth Bhavsar


DOI: 10.2174/1570163814666171002102904




Research Article



Research Article   Open Access

The Development of New Factor Xa Inhibitors Based on Amide Synthesis

, 15(4): 335 - 350

Dmitry N. Tarasov, Dmitry G. Tovbin, Dmitry V. Malakhov, Arseniy V. Aybush, Natalia A. Tserkovnikova, Marina I. Savelyeva, Dmitry A. Sychev, Natalia N. Drozd* and Alla Y. Savchenko


DOI: 10.2174/1570163815666180215114732




Research Article



Acknowledgement   Open Access



Articles Ahead of Print







Cancer Cell Metabolism Featuring Nrf2


Payal Chatterjee*, Mukesh Yadav, Namrata Chauhan, Ying Huang and Yun Luo


View Abstract View on PubMed


Identification and Characterization of Chemical Compounds that Inhibit Leucyl-tRNA Synthetase from Pseudomonas aeruginosa


Regina Zamacona, Pamela N. Chavero, Eduardo Medellin, Yanmei Hu, Casey A. Hughes, Nathalie Quach, Megan Keniry and James M. Bullard*


View Abstract View on PubMed



OralAcute and Repeated-Doses Toxicity Study of Valepotriates from Valeriana glechomifolia (Meyer) in Mice


Tielle Moraes de Almeida, Gilsane Lino von Poser*, Liz Girardi Muller, Paula Reis Pereira, Eduardo Cassel, Rubem M.F. Vargas, Nilson Junior da Silva Nunes, David Driemeier, Eliane Dallegrave and Stella de Faria Valle


View Abstract View on PubMed


Abstracts Ahead of Print



Chemistry And Pharmacological Activities Of Biginelli Product- A Brief Overview


Namy George, M Asha Asokan, A Ajish, M Surya, V Vishnu, Rajasree G Pai and Subin Mary Zachariah*


View Abstract



Herbal Drug Use In Sickle Cell Disease Management; Trends And Perspectives In Sub-Saharan Africa


Michael P. Okoh*, Lukman A. Alli, Martti E.E. Tolvanen and Maxwell Nwegbu


View Abstract


Design, synthesis, characterization of novel linomide analogues and their evaluation for anticancer activity


Rudrax N.S. Priolkar, Sunil Shingade*, Mahesh Palkar and Shivalingrao Mamle Desai


View Abstract






Editor's Choice

Molecular Docking, Synthesis and Biological Evaluation of Sulphonylureas/ Guanidine Derivatives as Promising Antidiabetic Agent

, 2018; 15(4): 315 - 325

Ishan I. Panchal*, Dhrubo Jyoti Sen, Ashish D. Patel, Umang Shah, Mehul Patel, Archana Navale and Vashisth Bhavsar


DOI: 10.2174/1570163814666171002102904





Affinity Crystallography Reveals the Bioactive Compounds of Industrial Juicing Byproducts of Punica granatum for Glycogen Phosphorylase

, 2018; 15(1): 41 - 53

George A. Stravodimos, Anastassia L. Kantsadi, Anna Apostolou, Efthimios Kyriakis, Vassiliki-Nafsika Kafaski-Kanelli, Theodora Solovou, Pagona Gatzona, Panagiota G.V. Liggri, Stavroula Theofanous, Vyron A. Gorgogietas, Apostolia Kissa, Chariklia Psachoula, Angelos Lemonakis, Demetra S.M. Chatzileontiadou, Anna-Maria G. Psarra, Vassiliki T. Skamnaki, Serkos A. Haroutounian* and Demetres. D. Leonidas*


DOI: 10.2174/1570163814666170619091736






QSAR Studies, Synthesis and Antibacterial Assessment of New Inhibitors Against Multidrug-Resistant Mycobacterium tuberculosis

, 2017; 14(1): 25 - 38

Vasyl Kovalishyn, Volodymyr Brovarets, Volodymyr Blagodatnyi, Iryna Kopernyk, Diana Hodyna, Svitlana Chumachenko, Oleg Shablykin, Oleksandr Kozachenko, Myhailo Vovk, Marianna Barus, Myhailo Bratenko and Larysa Metelytsia


DOI: 10.2174/1570163813666161108125227





Open Access Articles

The Development of New Factor Xa Inhibitors Based on Amide Synthesis

, 2018; 15(4): 335 - 350

Dmitry N. Tarasov, Dmitry G. Tovbin, Dmitry V. Malakhov, Arseniy V. Aybush, Natalia A. Tserkovnikova, Marina I. Savelyeva, Dmitry A. Sychev, Natalia N. Drozd* and Alla Y. Savchenko




The Modulatory Effect of Lead Drug Candidates on Inflammatory Gene Expression in Sepsis: A Mini-Review

, 2018; 15: 1 - 11 (E-Pub Ahead of Print)

Samuel Mawuli Adadey*, Michael Bright Yakass, Seth Agyemang and Samuel Duodu




Date Palm (Phoenix dactylifera): Novel Findings and Future Direc-tions for Food and Drug Discovery

, 2018; 15: 1 - 11 (E-Pub Ahead of Print)

Ali H. El-Far*, Babatunji Emmanuel Oyinloye, Masood Sepehrimanesh, Mahmoud A. Gab Allah, Ibrahim Abu Reidah, Hazem M. Shaheen, Iman Razeghian-Jahromi, Abd el-wahab A. Alsenosy, Ahmed E. Noreldin, Soad K. Al Jaouni and Shaker A. Mousa




Structure-Based Docking Studies of GLUT4 Towards Exploring Selected Phytochemicals from Somalia xanthocarpum as a Therapeutic Target for the Treatment of Cancer

, 2018; 15: 1 - 10 (E-Pub Ahead of Print)

Babatunji Emmanuel Oyinloye*, Tayo Alex Adekiya, Raphael Taiwo Aruleba, Oluwafemi Adeleke Ojo and Basiru Olaitan Ajiboye






Can EGFR-Tyrosine Kinase Inhibitors (TKI) Alone Without Talc Pleurodesis Prevent Recurrence of Malignant Pleural Effusion (MPE) in Lung Adenocarcinoma

, 2016; 13(2): 68 - 76

Akash Verma, Akhil Chopra, Yeo W. Lee, Lavina D. Bharwani, Atasha B. Asmat, Dokeu B.A Aneez, Fazuludeen A. Akbar, Albert Y.H. Lim, Sanjay H. Chotirmall and John Abisheganaden




Quantitative Structure-Cytotoxic Activity Relationship 1-(Benzoyloxy)urea and Its Derivative

, 2016; 13(2): 101 - 108

Suko Hardjono, Siswandono Siswodihardjo, Purwanto Pramono and Win Darmanto









Most Cited Articles





Can EGFR-Tyrosine Kinase Inhibitors (TKI) Alone Without Talc Pleurodesis Prevent Recurrence of Malignant Pleural Effusion (MPE) in Lung Adenocarcinoma

, 2016; 13(2): 68-76.

Akash Verma, Akhil Chopra, Yeo W. Lee, Lavina D. Bharwani, Atasha B. Asmat, Dokeu B.A Aneez, Fazuludeen A. Akbar, Albert Y.H. Lim, Sanjay H. Chotirmall and John Abisheganaden


DOI: 10.2174/1570163813666160524142846




Phytochemistry and Phytotherapeutic Aspects of Elaeagnus angustifolia L.

, 2016; 13(4): 199-210.

Farid Niknam, Amir Azadi, Alireza Barzegar, Pouya Faridi, Nader Tanideh and Mohammad M. Zarshenas


DOI: 10.2174/1570163813666160905115325





Most Accessed Articles




Anti-Carcinogenic Effects of Carnosol-An Updated Review

, 2018; 15(1): 32-40.

Saeed Samarghandian, Mohsen Azimi-Nezhad and Tahereh Farkhondeh*


DOI: 10.2174/1570163814666170413121732


Affinity Crystallography Reveals the Bioactive Compounds of Industrial Juicing Byproducts of Punica granatum for Glycogen Phosphorylase

, 2018; 15(1): 41-53.

George A. Stravodimos, Anastassia L. Kantsadi, Anna Apostolou, Efthimios Kyriakis, Vassiliki-Nafsika Kafaski-Kanelli, Theodora Solovou, Pagona Gatzona, Panagiota G.V. Liggri, Stavroula Theofanous, Vyron A. Gorgogietas, Apostolia Kissa, Chariklia Psachoula, Angelos Lemonakis, Demetra S.M. Chatzileontiadou, Anna-Maria G. Psarra, Vassiliki T. Skamnaki, Serkos A. Haroutounian* and Demetres. D. Leonidas*


DOI: 10.2174/1570163814666170619091736


Compound Libraries: Recent Advances and Their Applications in Drug Discovery

, 2017; 14(4): 216-228.

Zhen Gong, Guoping Hu, Qiang Li, Zhiguo Liu, Fei Wang, Xuejin Zhang, Jian Xiong, Peng Li, Yan Xu, Rujian Ma, Shuhui Chen and Jian Li*


DOI: 10.2174/1570163814666170425155154






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