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Current Alzheimer Research

Volume 16, 14 Issues, 2019
ISSN: 1875-5828 (Online)
ISSN: 1567-2050 (Print)
This journal supports open access

Ranking and Category

  • 65th of 197 in

    Clinical Neurology

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Aims & Scope

Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer's disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive 'bird's-eye view' of the current state of Alzheimer's research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.

Current Alzheimer Research

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Volume 16

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Number 4



Editorial   Open Access



Research Article

The Role of MAPK's Signaling in Mediating ApoE4-Driven Pathology In Vivo

, 16(4): 281 - 292

Shiran Salomon-Zimri, Amit Koren, Ariel Angel, Tali Ben-Zur, Daniel Offen and Daniel M. Michaelson*


DOI: 10.2174/1567205016666190228120254


Research Article

Abnormal Saccadic Intrusions with Alzheimer's Disease in Darkness

, 16(4): 293 - 301

Kiyotaka Nakamagoe*, Shiori Yamada, Rio Kawakami, Tadachika Koganezawa and Akira Tamaoka


DOI: 10.2174/1567205016666190311102130


Research Article



Research Article



Research Article

N-alkylated Tacrine Derivatives as Potential Agents in Alzheimer’s Disease Therapy

, 16(4): 333 - 343

Eugenie Nepovimova, Jan Korabecny, Vendula Hepnarova, Daniel Jun, Rafael Dolezal, Lubica Muckova, Petr Jost, Ondrej Soukup, Jana Janockova, Ngoc Lam Pham, Thuy Duong Nguyen, Martin Valis and Kamil Kuca*


DOI: 10.2174/1567205016666190314163942


Review Article

Is Brain-Derived Neurotrophic Factor: A Common Link Between Neurodegenerative Disorders and Cancer?

, 16(4): 344 - 352

Radhika Khosla, Avijit Banik, Sushant Kaushal, Priya Battu, Deepti Gupta and Akshay Anand*


DOI: 10.2174/1567205016666190408123947


Systemic Review Article

Lead (Pb) in Alzheimer’s Dementia: A Systematic Review of Human Case- Control Studies

, 16(4): 353 - 361

Eric E. Brown, Parita Shah, Bruce G. Pollock, Philip Gerretsen and Ariel Graff-Guerrero*


DOI: 10.2174/1567205016666190311101445


Articles Ahead of Print


Monoamines and their Derivatives on GPCRs: Potential Therapy for Alzheimer’s Disease


Eunice D. Farfán-García, Ricardo Gómez-Marques, Mónica Barrón-González, Teresa Pérez-Capistran, Martha C. Rosales-Hernández, Rodolfo Pinto-Almazán and Marvin A. Soriano-Ursúa*


View Abstract View on PubMed


Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer’s Disease


Martina Kaniakova, Eugenie Nepovimova, Lenka Kleteckova, Kristyna Skrenkova, Kristina Holubova, Zofia Chrienova, Vendula Hepnarova, Tomas Kucera, Tereza Kobrlova, Karel Vales, Jan Korabecny, Ondrej Soukup and Martin Horak*


View Abstract View on PubMed




Donepezil Derivatives Targeting Amyloid-β Cascade in Alzheimer's Disease


Eva Mezeiova, Katarina Chalupova, Eugenie Nepovimova, Lukas Gorecki, Lukas Prchal, David Malinak, Kamil Kuca, Ondrej Soukup and Jan Korabecny*


View Abstract View on PubMed





Characterization of Serum Exosomes from a Transgenic Mouse Model of Alzheimer’s Disease


Hector Rosas-Hernandez, Elvis Cuevas, James B. Raymick, Bonnie L. Robinson, Syed F. Ali, Joseph Hanig and Sumit Sarkar*


View Abstract View on PubMed


Abstracts Ahead of Print

Connected Speech Deficit as an Early Hallmark of CSF-defined Alzheimer’s Disease and Correlation with Cerebral Hypoperfusion Pattern


Giulia Mazzon*, Miloš Ajčević, Tatiana Cattaruzza, Alina Menichelli, Michele Guerriero, Selene Capitanio, Valentina Pesavento, Franca Dore, Sandro Sorbi, Paolo Manganotti and Andrea Marini


View Abstract


Neuropeptides in Alzheimer’s disease: An update


Petrella Carla, Di Certo Maria Grazia, Barbato Christian, Gabanella Francesca, Ralli Massimo, Greco Antonio, Possenti Roberta and Severini Cinzia*


View Abstract



Neuroinflammation in Alzheimer’s Disease: Microglia, Molecular Participants and Therapeutic Choices


Haijun Wang, Yin Shen, Haoyu Chuang, Chengdi Chiu de, Youfan Ye and Lei Zhao*


View Abstract


Published Contents

Editor's Choice

The Role of MAPK's Signaling in Mediating ApoE4-Driven Pathology In Vivo

, 2019; 16(4): 281 - 292

Shiran Salomon-Zimri, Amit Koren, Ariel Angel, Tali Ben-Zur, Daniel Offen and Daniel M. Michaelson*


DOI: 10.2174/1567205016666190228120254



Lead (Pb) in Alzheimer’s Dementia: A Systematic Review of Human Case- Control Studies

, 2019; 16(4): 353 - 361

Eric E. Brown, Parita Shah, Bruce G. Pollock, Philip Gerretsen and Ariel Graff-Guerrero*


DOI: 10.2174/1567205016666190311101445




Synthesis of New Galanthamine-Peptide Derivatives Designed for Prevention and Treatment of Alzheimer’s Disease

, 2019; 16(3): 183 - 192

Lyubomir T. Vezenkov*, Daniela S. Tsekova*, Ivanka Kostadinova, Rositsa Mihaylova, Nikolay G. Vassilev and Nikolai D. Danchev


DOI: 10.2174/1567205016666190228123923




The Temporal Relationship between Pain Intensity and Pain Interference and Incident Dementia

, 2019; 16(2): 109 - 115

Ali Ezzati*, Cuiling Wang, Mindy J. Katz, Carol A. Derby, Andrea R. Zammit, Molly E. Zimmerman, Jelena M. Pavlovic, Martin J. Sliwinski and Richard B. Lipton


DOI: 10.2174/1567205016666181212162424



Impact of a Clinical Decision Support Tool on Dementia Diagnostics in Memory Clinics: The PredictND Validation Study

, 2019; 16(2): 91 - 101

Marie Bruun*, Kristian S. Frederiksen, Hanneke F.M. Rhodius-Meester, Marta Baroni, Le Gjerum, Juha Koikkalainen, Timo Urhemaa, Antti Tolonen, Mark van Gils, Tong Tong, Ricardo Guerrero, Daniel Rueckert, Nadia Dyremose, Birgitte Bo Andersen, Anja H. Simonsen, Afina Lemstra, Merja Hallikainen, Sudhir Kurl, Sanna-Kaisa Herukka, Anne M. Remes, Gunhild Waldemar, Hilkka Soininen, Patrizia Mecocci, Wiesje M. van der Flier, Jyrki Lötjönen and Steen G. Hasselbalch


DOI: 10.2174/1567205016666190103152425



Visual Event-Related Potentials in Mild Cognitive Impairment and Alzheimer’s Disease: A Literature Review

, 2019; 16(1): 67 - 89

Cassandra Morrison*, Sheida Rabipour, Vanessa Taler, Christine Sheppard and Frank Knoefel


DOI: 10.2174/1567205015666181022101036



Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice

, 2019; 16(1): 8 - 18

Xing Li, Xiaoqin Run*, Zhen Wei, Kuan Zeng, Zhihou Liang, Fang Huang, Dan Ke, Qun Wang, Jian-Zhi Wang, Rong Liu, Bin Zhang* and Xiaochuan Wang*


DOI: 10.2174/1567205015666181031145045




Open Access Articles

Impact of a Clinical Decision Support Tool on Dementia Diagnostics in Memory Clinics: The PredictND Validation Study

, 2019; 16(2): 91 - 101

Marie Bruun*, Kristian S. Frederiksen, Hanneke F.M. Rhodius-Meester, Marta Baroni, Le Gjerum, Juha Koikkalainen, Timo Urhemaa, Antti Tolonen, Mark van Gils, Tong Tong, Ricardo Guerrero, Daniel Rueckert, Nadia Dyremose, Birgitte Bo Andersen, Anja H. Simonsen, Afina Lemstra, Merja Hallikainen, Sudhir Kurl, Sanna-Kaisa Herukka, Anne M. Remes, Gunhild Waldemar, Hilkka Soininen, Patrizia Mecocci, Wiesje M. van der Flier, Jyrki Lötjönen and Steen G. Hasselbalch




Stroke as a Cause of Death in Death Certificates of Patients with Dementia: A Cohort Study from the Swedish Dementia Registry

, 2018; 15(14): 1322 - 1330

Ana Subic*, Eva Zupanic, Mia von Euler, Bo Norrving, Pavla Cermakova, Dorota Religa, Bengt Winblad, Milica G. Kramberger, Maria Eriksdotter and Sara Garcia-Ptacek





Probiotic Supplementation in Patients with Alzheimer’s Dementia - An Explorative Intervention Study

, 2018; 15(12): 1106 - 1113

Friedrich Leblhuber, Kostja Steiner, Burkhard Schuetz, Dietmar Fuchs* and Johanna M. Gostner




Technological Solutions for Older People with Alzheimer’s Disease: Review

, 2018; 15(10): 975 - 983

Petra Maresova*, Signe Tomsone, Petre Lameski, Joana Madureira, Ana Mendes, Eftim Zdravevski, Ivan Chorbev, Vladimir Trajkovik, Moriah Ellen and Kasper Rodile





Interplay between the APOE Genotype and Possible Plasma Biomarkers in Alzheimer’s Disease

, 2018; 15(10): 938 - 950

Martina Zverova, Eva Kitzlerova, Zdenek Fisar*, Roman Jirak, Jana Hroudova, Hana Benakova, Petra Lelkova, Pavel Martasek and Jiri Raboch





Up-regulation of DMN Connectivity in Mild Cognitive Impairment Via Network-based Cognitive Training

, 2018; 15(6): 578 - 589

Matteo De Marco, Francesca Meneghello, Cristina Pilosio, Jessica Rigon and Annalena Venneri*





Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment

, 2018; 15(5): 482 - 492

Kiyomi Nishimaki, Takashi Asada*, Ikuroh Ohsawa, Etsuko Nakajima, Chiaki Ikejima, Takashi Yokota, Naomi Kamimura and Shigeo Ohta*




Evaluation of Metabolic and Synaptic Dysfunction Hypotheses of Alzheimer's Disease (AD): A Meta-Analysis of CSF Markers

, 2018; 15(2): 164 - 181

Roni Manyevitch, Matthew Protas, Sean Scarpiello, Marisa Deliso, Brittany Bass, Anthony Nanajian, Matthew Chang, Stefani M. Thompson, Neil Khoury, Rachel Gonnella, Margit Trotz, D. Blaine Moore, Emily Harms, George Perry, Lucy Clunes, Angelica Ortiz, Jan O. Friedrich and Ian V.J. Murray*




A Speech Recognition-based Solution for the Automatic Detection of Mild Cognitive Impairment from Spontaneous Speech

, 2018; 15(2): 130 - 138

Laszlo Toth*, Ildiko Hoffmann, Gabor Gosztolya, Veronika Vincze, Greta Szatloczki, Zoltan Banreti, Magdolna Pakaski and Janos Kalman




Biomarkers for Alzheimer's Disease Diagnosis

, 2017; 14(11): 1149 - 1154

Vasileios Mantzavinos and Athanasios Alexiou*




iTRAQ-based Proteomic Analysis of APPSw,Ind Mice Provides Insights into the Early Changes in Alzheimer’s Disease

, 2017; 14(10): 1109 - 1122

Nan Li, Pinghong Hu, Tiantian Xu, Huan Chen, Xiaoying Chen, Jianwen Hu, Xifei Yang, Lei Shi, Jian-hong Luo and Junyu Xu*





Most Cited Articles

Research Article

A speech recognition-based solution for the automatic detection of mild cognitive impairment from spontaneous speech

, 2018; 15(2): 130-138.

Laszlo Toth*, Ildiko Hoffmann, Gabor Gosztolya, Veronika Vincze, Greta Szatloczki, Zoltan Banreti, Magdolna Pakaski and Janos Kalman


DOI: 10.2174/1567205014666171121114930


Research Article

Pharmacogenetics of angiotensin-converting enzyme inhibitors in patients with Alzheimer’s disease dementia

, 2018; 15(4): 386-398.

Fabricio Ferreira de Oliveira*, Elizabeth Suchi Chen, Marilia Cardoso Smith and Paulo Henrique Ferreira Bertolucci


DOI: 10.2174/1567205014666171016101816


Review Article

Modulation of inflammation as a way of delaying alzheimer’s disease progression: The diet’s role

, 2018; 15(4): 363-380.

R. Businaro*, M. Corsi, R. Asprino, C. Di Lorenzo, D. Laskin, R.M. Corbo, S. Ricci and A. Pinto


DOI: 10.2174/1567205014666170829100100


Research Article

Ginkgo biloba extract EGb761 attenuates hyperhomocysteinemia-induced AD like tau hyperphosphorylation and cognitive impairment in rats

, 1 January 2018; 15(1): 89-99.

Kuan Zeng, Mengzhu Li, Jichang Hu, Yacoubou Abdoul Razak Mahaman, Jian Bao, Fang Huang, Yiyuan Xia, Xinghua Liu, Qun Wang, Jian-Zhi Wang, Yang Yang, Rong Liu and Xiaochuan Wang*


DOI: 10.2174/1567205014666170829102135


Research Article

Alzheimer’s disease and NQO1: Is there a link?

, 1 January 2018; 15(1): 56-66.

Jamuna Chhetri*, Anna E. King and Nuri Gueven


DOI: 10.2174/1567205014666170203095802



Research Article

Voice markers of lexical access in mild cognitive impairment and Alzheimer’s disease

, 2018; 15(2): 111-119.

Juan J.G. Meilan*, Francisco Martinez-Sanchez, Juan Carro, Nuria Carcavilla and Olga Ivanova


DOI: 10.2174/1567205014666170829112439


Research Article

Use of speech analyses within a mobile application for the assessment of cognitive impairment in elderly people

, 2018; 15(2): 120-129.

Alexandra Konig*, Aharon Satt, Alex Sorin, Ran Hoory, Alexandre Derreumaux, Renaud David and Phillippe H. Robert


DOI: 10.2174/1567205014666170829111942


Research Article

Advances on automatic speech analysis for early detection of alzheimer disease: A non-linear multi-task approach

, 2018; 15(2): 139-148.

Karmele Lopez-de-Ipina *, Unai Martinez-de-Lizarduy*, Pilar M. Calvo, Jiri Mekyska, Blanca Beitia, Nora Barroso, Ainara Estanga, Milkel Tainta and Mirian Ecay-Torres


DOI: 10.2174/1567205014666171120143800


Research Article

Effects of molecular hydrogen assessed by an animal model and a randomized clinical study on mild cognitive impairment

, 2018; 15(5): 482-492.

Kiyomi Nishimaki, Takashi Asada*, Ikuroh Ohsawa, Etsuko Nakajima, Chiaki Ikejima, Takashi Yokota, Naomi Kamimura and Shigeo Ohta*


DOI: 10.2174/1567205014666171106145017



Research Article

Probiotic supplementation in patients with alzheimer’s dementia-An explorative intervention study

, 2018; 15(12): 1106-1113.

Friedrich Leblhuber, Kostja Steiner, Burkhard Schuetz, Dietmar Fuchs* and Johanna M. Gostner


DOI: 10.2174/1389200219666180813144834






Most Accessed Articles

Impact of a Clinical Decision Support Tool on Dementia Diagnostics in Memory Clinics: The PredictND Validation Study

, 2019; 16(2): 91-101.

Marie Bruun*, Kristian S. Frederiksen, Hanneke F.M. Rhodius-Meester, Marta Baroni, Le Gjerum, Juha Koikkalainen, Timo Urhemaa, Antti Tolonen, Mark van Gils, Tong Tong, Ricardo Guerrero, Daniel Rueckert, Nadia Dyremose, Birgitte Bo Andersen, Anja H. Simonsen, Afina Lemstra, Merja Hallikainen, Sudhir Kurl, Sanna-Kaisa Herukka, Anne M. Remes, Gunhild Waldemar, Hilkka Soininen, Patrizia Mecocci, Wiesje M. van der Flier, Jyrki Lötjönen and Steen G. Hasselbalch


DOI: 10.2174/1567205016666190103152425


Probiotic Supplementation in Patients with Alzheimer’s Dementia - An Explorative Intervention Study

, 2018; 15(12): 1106-1113.

Friedrich Leblhuber, Kostja Steiner, Burkhard Schuetz, Dietmar Fuchs* and Johanna M. Gostner


DOI: 10.2174/1389200219666180813144834


The Implications of Autophagy in Alzheimer’s Disease

, 2018; 15(14): 1283-1296.

Tadanori Hamano*, Kouji Hayashi, Norimichi Shirafuji and Yasunari Nakamoto


DOI: 10.2174/1567205015666181004143432


Alterations in the Expression of Amyloid Precursor Protein Cleaving Enzymes mRNA in Alzheimer Peripheral Blood

, 2019; 16(1): 29-38.

Prapimpun Wongchitrat*, Nattaporn Pakpian, Kuntida Kitidee, Kamonrat Phopin, Pornpatr A. Dharmasaroja and Piyarat Govitrapong


DOI: 10.2174/1567205015666181109103742



Current State of Saliva Biomarkers for Aging and Alzheimer’s Disease

, 2019; 16(1): 56-66.

Maxime François*, Caroline F. Bull, Michael F. Fenech and Wayne R. Leifert


DOI: 10.2174/1567205015666181022094924



Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice

, 2019; 16(1): 8-18.

Xing Li, Xiaoqin Run*, Zhen Wei, Kuan Zeng, Zhihou Liang, Fang Huang, Dan Ke, Qun Wang, Jian-Zhi Wang, Rong Liu, Bin Zhang* and Xiaochuan Wang*


DOI: 10.2174/1567205015666181031145045


Stroke as a Cause of Death in Death Certificates of Patients with Dementia: A Cohort Study from the Swedish Dementia Registry

, 2018; 15(14): 1322-1330.

Ana Subic*, Eva Zupanic, Mia von Euler, Bo Norrving, Pavla Cermakova, Dorota Religa, Bengt Winblad, Milica G. Kramberger, Maria Eriksdotter and Sara Garcia-Ptacek


DOI: 10.2174/1567205015666181002134155




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