Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research
Volume 22, 10 Issues, 2019
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access
Ranking and Category
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67th of 79 in
Biochemical Research Methods
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39th of 71 in
Chemistry, Applied
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220th of 267 in
Pharmacology & Pharmacy
Aims & Scope
Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:
- Target identification and validation
- Assay design, development, miniaturization and comparison
- High throughput/high content/in silico screening and associated technologies
- Label-free detection technologies and applications
- Stem cell technologies
- Biomarkers
- ADMET/PK/PD methodologies and screening
- Probe discovery and development, hit to lead optimization
- Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
- Chemical library design and chemical diversity
- Chemo/bio-informatics, data mining
- Compound management
- Pharmacognosy
- Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products)
- Natural Product Analytical Studies
- Bipharmaceutical studies of Natural products
- Drug repurposing
- Data management and statistical analysis
- Laboratory automation, robotics, microfluidics, signal detection technologies
- Current & Future Institutional Research Profile
- Technology transfer, legal and licensing issues
- Patents
In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.
Combinatorial Chemistry & High Throughput Screening
,Volume 22
-Number 6
Biography Open Access
Meet Our Editorial Board Member
Current Frontiers Open Access
Protein Glycation: An Old Villain is Shedding Secrets
, 22(6): 362 - 369Gerald H. Lushington* and Anthony C. Barnes
DOI: 10.2174/1386207322666190704094356
Protein Glycation: An Old Villain is Shedding Secrets
Research Article
Molecular Docking Supplements an In vitro Determination of the Leading CYP Isoform for Arylpiperazine Derivatives
, 22(6): 370 - 378Szymon Ulenberg, Tomasz Bączek*, Joanna Zieliñska, Mariusz Belka, Marek Król and Franciszek Herold
DOI: 10.2174/1386207322666190705143322
Molecular Docking Supplements an In vitro Determination of the Leading CYP Isoform for Arylpiperazine Derivatives
Research Article Open Access
Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development
, 22(6): 379 - 386Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*
DOI: 10.2174/1386207322666190704095602
Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development
Research Article
Quantitative Structure-Activity Relationship Study of Camptothecin Derivatives as Anticancer Drugs Using Molecular Descriptors
, 22(6): 387 - 399Neda Ahmadinejad and Fatemeh Shafiei*
DOI: 10.2174/1386207322666190708112251
Quantitative Structure-Activity Relationship Study of Camptothecin Derivatives as Anticancer Drugs Using Molecular Descriptors
Research Article
Substituted Furanocoumarins as Novel Class of Antibacterial Translation Inhibitors
, 22(6): 400 - 410Yan A. Ivanenkov, Renat S. Yamidanov, Ilya A. Osterman, Petr V. Sergiev, Andrey A. Ayginin*, Vladimir A. Aladinskiy, Anastasia V. Aladinskaya, Victor A. Terentiev, Mark S. Veselov, Dmitry A. Skvortsov, Katerina S. Komarova, Alexey V. Chemeris, Liana F. Zainullina, Marina A. Maximova, Zulfiya R. Zileeva, Yulia V. Vakhitova, Alexey Kh. Baymiev, Andrey Kh. Baymiev, Alina A. Sofronova, Alexey E. Machulkin, Rostislav A. Petrov, Dmitry S. Bezrukov, Maria M. Puchinina, Dmitrii A. Lukianov and Olga A. Dontsova
DOI: 10.2174/1386207322666190723110539
Substituted Furanocoumarins as Novel Class of Antibacterial Translation Inhibitors
Research Article
Systematic Investigation of Quercetin for Treating Cardiovascular Disease Based on Network Pharmacology
, 22(6): 411 - 420Xian-Jun Wu, Xin-Bin Zhou, Chen Chen and Wei Mao *
DOI: 10.2174/1386207322666190717124507
Systematic Investigation of Quercetin for Treating Cardiovascular Disease Based on Network Pharmacology
Research Article
Green Chemistry Preparation of thiochromeno[4,3-b]pyran and benzo[h]thiazolo[2,3-b]quinazoline Derivatives using HSBM Technique over ZnAl2O4 Nano-Powders
, 22(6): 421 - 427Seyyed Jalal Roudbaraki, Sadaf Janghorban and Majid Ghashang *
DOI: 10.2174/1386207322666190617164617
Green Chemistry Preparation of thiochromeno[4,3-b]pyran and benzo[h]thiazolo[2,3-b]quinazoline Derivatives using HSBM Technique over ZnAl2O4 Nano-Powders
Combinatorial Chemistry & High Throughput Screening, Volume 22 (2019) - Number 8
This issue is in progress but contains articles that are final and fully citable.
Biography Open Access
Meet Our Editorial Board Member
Review Article (Mini-Review)
Current Approaches to Drug Discovery for Chagas Disease: Methodological Advances
, 22(8): 509 - 520Cauê B. Scarim* and Chung M. Chin
DOI: 10.2174/1386207322666191010144111
Current Approaches to Drug Discovery for Chagas Disease: Methodological Advances
Research Article
Same Target, Different Therapeutic Outcomes: The Case of CAY10471 and Fevipiprant on CRTh2 Receptor in Treatment of Allergic Rhinitis and Asthma
, 22(8): 521 - 533Abdul R. Issahaku, Clement Agoni, Opeyemi S. Soremekun, Patrick A. Kubi, Ransford O. Kumi, Fisayo A. Olotu and Mahmoud E.S. Soliman*
DOI: 10.2174/1386207322666190919113006
Same Target, Different Therapeutic Outcomes: The Case of CAY10471 and Fevipiprant on CRTh2 Receptor in Treatment of Allergic Rhinitis and Asthma
Research Article
Enrichment of Up-regulated and Down-regulated Gene Clusters using Gene Ontology, miRNAs and lncRNAs in Colorectal Cancer
, 22(8): 534 - 545Fahimeh Fattahi, Jafar Kiani, Mohsen Khosravi, Somayeh Vafaei, Asghar Mohammadi, Zahra Madjd* and Mohammad Najafi*
DOI: 10.2174/1386207321666191010114149
Enrichment of Up-regulated and Down-regulated Gene Clusters using Gene Ontology, miRNAs and lncRNAs in Colorectal Cancer
Research Article
The Effect of Temperature on the Interaction of Phenanthroline-based Ligands with G-quadruplex: In Silico Viewpoint
, 22(8): 546 - 554Mohadeseh Bazoobandi, Mohammad R. Bozorgmehr*, Ali Mahmoudi and Ali Morsali
DOI: 10.2174/1386207322666191022142629
The Effect of Temperature on the Interaction of Phenanthroline-based Ligands with G-quadruplex: In Silico Viewpoint
Research Article
A Random Forest Model to Predict the Activity of a Large Set of Soluble Epoxide Hydrolase Inhibitors Solely Based on a Set of Simple Fragmental Descriptors
, 22(8): 555 - 569Jamal Shamsara*
DOI: 10.2174/1386207322666191016110232
A Random Forest Model to Predict the Activity of a Large Set of Soluble Epoxide Hydrolase Inhibitors Solely Based on a Set of Simple Fragmental Descriptors
Research Article
New Amine and Aromatic Substituted Analogues of Phencyclidine: Synthesis and Determination of Acute and Chronic Pain Activities
, 22(8): 570 - 576Maryam Shokrollahi, Marjaneh Samadizadeh, Mohsen Khalili, Seyed A. Sobhanian and Abbas Ahmadi*
DOI: 10.2174/1386207322666191016152157
New Amine and Aromatic Substituted Analogues of Phencyclidine: Synthesis and Determination of Acute and Chronic Pain Activities
Clinical Trial
Role of Ischemia Modified Albumin Serum Levels as an Oxidative Stress Marker in Children with Diabetic Ketoacidosis
, 22(8): 577 - 581Mutlu U. Yazıcı*, Ganime Ayar, Senay Savas-Erdeve, Ebru Azapağası, Salim Neşelioğlu, Özcan Erel and Semra Çetinkaya
DOI: 10.2174/1386207322666191008214919
Role of Ischemia Modified Albumin Serum Levels as an Oxidative Stress Marker in Children with Diabetic Ketoacidosis
Combinatorial Chemistry & High Throughput Screening, Volume 22 (2019) - Number 7
This issue is in progress but contains articles that are final and fully citable.
Biography Open Access
Meet Our Editorial Board Member
Review Article
From the Explored to the Unexplored: Computer-Tailored Drug Design Attempts in the Discovery of Selective Caspase Inhibitors
, 22(7): 432 - 444Ransford Kumi Oduro, Abdul Rashid Issahakua, Opeyemi S. Soremekun, Clement Agoni, Fisayo A. Olotu and Mahmoud E. S. Soliman*
DOI: 10.2174/1386207322666190927143026
From the Explored to the Unexplored: Computer-Tailored Drug Design Attempts in the Discovery of Selective Caspase Inhibitors
Review Article
Screening GLP-1 Receptor Ligands from Natural Products in Herbs through High-Content Technique
, 22(7): 445 - 454Kunhao Qin, Shengting Zhang, Jie Wang, Dongbo Liu, Yingying Xiang, Xiuling Ji and Yunlin Wei*
DOI: 10.2174/1386207322666190919143735
Screening GLP-1 Receptor Ligands from Natural Products in Herbs through High-Content Technique
Research Article
Boosting Granular Support Vector Machines for the Accurate Prediction of Protein-Nucleotide Binding Sites
, 22(7): 455 - 469Yi-Heng Zhu, Jun Hu, Yong Qi, Xiao-Ning Song and Dong-Jun Yu*
DOI: 10.2174/1386207322666190925125524
Boosting Granular Support Vector Machines for the Accurate Prediction of Protein-Nucleotide Binding Sites
Research Article
Density Functional Theory Study of Antioxidant Adsorption onto Singlewall Boron Nitride Nanotubes: Design of New Antioxidant Delivery Systems
, 22(7): 470 - 482Samereh Ghazanfary, Fatemeh Oroojalian*, Rezvan Yazdian-Robati, Mehdi Dadmehr and Amirhossein Sahebkar*
DOI: 10.2174/1386207322666190930113200
Density Functional Theory Study of Antioxidant Adsorption onto Singlewall Boron Nitride Nanotubes: Design of New Antioxidant Delivery Systems
Research Article
Drug Repurposing Screen Identifies Novel Classes of Drugs with Anticancer Activity in Mantle Cell Lymphoma
, 22(7): 483 - 495Chengwu Han, Xueying Yu, Chunxia Zhang, Yongyue Cao, Ying Cai, Sijie Wang and Jun Shen*
DOI: 10.2174/1386207322666190916120128
Drug Repurposing Screen Identifies Novel Classes of Drugs with Anticancer Activity in Mantle Cell Lymphoma
Research Article
Evaluation of Salivary Antioxidants and Oxidative Stress Markers in Male Smokers
, 22(7): 496 - 501Fatemeh Ahmadi-Motamayel*, Parisa Falsafi, Hamidreza Abolsamadi, Mohammad Taghi Goodarzi and Jalal Poorolajal
DOI: 10.2174/1386207322666190806123616
Evaluation of Salivary Antioxidants and Oxidative Stress Markers in Male Smokers
Case Report
Measurement of the Cellular Hemoglobin Concentration by Laser Scatter Method from Excessive Lipemic Sample: CASE REPORT
, 22(7): 502 - 505Ataman Gönel* and Ismail Koyuncu
DOI: 10.2174/1386207322666190925130114
Measurement of the Cellular Hemoglobin Concentration by Laser Scatter Method from Excessive Lipemic Sample: CASE REPORT
Articles Ahead of Print
Clustering and Sampling of the c-Met Conformational Space: A Computational Drug Discovery Study
Korosh Mashayekh, Shahrzad Sharifi, Tahereh Damghani, Maryam Elyasi, Mohammad Sadegh Avestan and Somayeh Pirhadi*
DOI: 10.2174/1386207322666191024103902
View Abstract
Synthesis of 2-substituted 4-arylidene-5(4H)-oxazolones as potential cytotoxic agents in the presence of lemon juice as a biocatalyst
Malavattu Giri Prasad, C. Vijaya Lakshmi, Naresh Kumar Katari*, K. Anand, Manojit Pal* and Sreekantha B. Jonnalagadda*
DOI: 10.2174/1386207322666191024105150
View Abstract
Identification of the Active Constituents and Significant Pathways of Guizhi-Shaoyao-Zhimu Decoction for the Treatment of Diabetes Mellitus Based on Molecular Docking and Network Pharmacology
Qing Zhang, Ruolan Li, Wei Peng, Mengmeng Zhang, Jia Liu, Shujun Wei, Jiaolong Wang, Chunjie Wu, Yongxiang Gao* and Xufeng Pu*
DOI: 10.2174/1386207322666191022101613
View Abstract View on PubMed
Green Synthesis of 4H-pyran Derivatives using Fe3O4-MNPs as Efficient Nanocatalyst: Study of Antioxidant Activity
Faezeh Shafaei* and Asef Hajipour Najar
DOI: 10.2174/1386207322666191022130235
View Abstract View on PubMed
The Use of Texture Features to Extract and Analyze Useful Information from Retinal Images
Xiaobo Zhang, Weiyang Chen*, Gang Li and Weiwei Li
DOI: 10.2174/1386207322666191022123445
View Abstract View on PubMed
High Expression of miR-206 Predicts Adverse Outcomes: A Potential Therapeutic Target for Esophageal Cancer
Guobo Du, Jing Zhou, Long Cheng, Xiaojie Ma, Yan Gui and Bangxian Tan*
DOI: 10.2174/1386207322666191018145825
View Abstract
Plasma-free Amino Acid Profiling of Nasal Polyposis Patients
Mustafa Celik*, Alper Şen, İsmail Koyuncu and Ataman Gönel
DOI: 10.2174/1386207322666190920110324
View Abstract View on PubMed
Drug Target Group Prediction with Multiple Drug Networks
Jingang Che, Lei Chen*, Zi-Han Guo, Shuaiqun Wang and Aorigele
DOI: 10.2174/1386207322666190702103927
View Abstract View on PubMed
Relating Substructures and Side Effects of Drugs with Chemical-Chemical Interactions
Bo Zhou*, Xian Zhao, Jing Lu, Zuntao Sun, Min Liu, Yilu Zhou, Rongzhi Liu and Yihua Wang
DOI: 10.2174/1386207322666190702102752
View Abstract
Computational Method for Identifying Malonylation Sites by Using Random Forest Algorithm
ShaoPeng Wang, JiaRui Li, Xijun Sun, Yu-Hang Zhang, Tao Huang* and Yudong Cai*
DOI: 10.2174/1386207322666181227144318
View Abstract View on PubMed
Abstracts Ahead of Print
Virtual Screening of Potential Anti-fatigue Mechanism for Polygonati Rhizoma Based on Network Pharmacology
Yeqing hu, Zefeng wang, Qiguo Wu* and R Zhang
DOI: 10.2174/1386207322666191106110615
View Abstract
Exploration of the Hepatoprotective Effect and Mechanism of Swertia mussotii Franch in an Acute Liver Injury Rat Model
Haixia Yun, Xianglan Duan, Wendou Xiong, Yiwei Ding, Xinyu Wu, Junhua Kang, Xiaoyan Pu, Yingzhong Yang and Zhi Chen*
DOI: 10.2174/1386207322666191106105725
View Abstract
Published Contents
- Combinatorial Chemistry & High Throughput Screening, Volume 22, 2019
- Combinatorial Chemistry & High Throughput Screening, Volume 21, 2018
- Combinatorial Chemistry & High Throughput Screening, Volume 20, 2017
- Combinatorial Chemistry & High Throughput Screening, Volume 19, 2016
- Combinatorial Chemistry & High Throughput Screening, Volume 18, 2015
- Combinatorial Chemistry & High Throughput Screening, Volume 17, 2014
- Combinatorial Chemistry & High Throughput Screening, Volume 16, 2013
- Combinatorial Chemistry & High Throughput Screening, Volume 15, 2012
- Combinatorial Chemistry & High Throughput Screening, Volume 14, 2011
- Combinatorial Chemistry & High Throughput Screening, Volume 13, 2010
- Combinatorial Chemistry & High Throughput Screening, Volume 12, 2009
- Combinatorial Chemistry & High Throughput Screening, Volume 11, 2008
- Combinatorial Chemistry & High Throughput Screening, Volume 10, 2007
- Combinatorial Chemistry & High Throughput Screening, Volume 9, 2006
- Combinatorial Chemistry & High Throughput Screening, Volume 8, 2005
- Combinatorial Chemistry & High Throughput Screening, Volume 7, 2004
- Combinatorial Chemistry & High Throughput Screening, Volume 6, 2003
- Combinatorial Chemistry & High Throughput Screening, Volume 5, 2002
- Combinatorial Chemistry & High Throughput Screening, Volume 4, 2001
- Combinatorial Chemistry & High Throughput Screening, Volume 3, 2000
Editor's Choice
Systematic Investigation of Quercetin for Treating Cardiovascular Disease Based on Network Pharmacology
, 2019; 22(6): 411 - 420Xian-Jun Wu, Xin-Bin Zhou, Chen Chen and Wei Mao *
DOI: 10.2174/1386207322666190717124507
Biochemometrics and Required Tools in Botanical Natural Products Research: A Review
, 2019; 22(5): 290 - 306Kevin M. Wyss, Graham C. Llivina and Angela I. Calderón*
DOI: 10.2174/1386207322666190704094003
Recognition of Lung Adenocarcinoma-specific Gene Pairs Based on Genetic Algorithm and Establishment of a Deep Learning Prediction Model
, 2019; 22(4): 256 - 265Zhongwei Zhao, Xiaoxi Fan, Lili Yang, Jingjing Song, Shiji Fang, Jianfei Tu, Minjiang Chen, Jie Li, Liyun Zheng, Fazong Wu, Dengke Zhang, Xihui Ying and Jiansong Ji*
DOI: 10.2174/1386207322666190530102245
Expression and Significance of LncRNA-MINCR and CDK2 mRNA in Primary Hepatocellular Carcinoma
, 2019; 22(3): 201 - 206Jiangshan Lian, Xiaolin Zhang, Yingfeng Lu, Shaorui Hao, Zhe Zhang and Yida Yang*
DOI: 10.2174/1386207322666190404151020
Progress in Molecularly Imprinted Polymers for Biomedical Applications
, 2019; 22(2): 78 - 88Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi and Alistair C. Cowie
DOI: 10.2174/1386207322666190325115526
Comparison of the Full-Length and 152~528 Truncate of Human Cyclic Nucleotide Phosphodiesterase 4B2 for the Characterization of Inhibitors
, 2019; 22(1): 49 - 58Xiang Zhang, Shu He, Xiaolei Hu, Jing Wu, Xinpeng Li, Fei Liao* and Xiaolan Yang*
DOI: 10.2174/1386207322666190306142810
Maxillary Metastasis of Esophageal Cancer: Report of the First Case and Literature Review
, 2018; 21(10): 801 - 805Hong Hu, Jing Wang, Xiao-Yun Zhou, Meng-Ting Tong, Chong-Ya Zhai, Xin-Bing Sui, Yan-Hua Zhang, Xiao-Xi Xie, Hao Liu, Jian-Sheng Xie, Hong-Ming Pan* and Da Li*
DOI: 10.2174/1386207322666190103105938
Catalytic Conversion of Biorenewable Sugar Feedstocks into Market Chemicals
, 2018; 21(9): 616 - 630Gary Diamond, Alfred Hagemeyer*, Vince Murphy and Valery Sokolovskii
DOI: 10.2174/1386207322666181219155050
Prognostic Impact of Lymphadenectomy in Different Stages of Malignant Germ Cell Tumor of the Ovary Based on Propensity Score Matching
, 2018; 21(9): 652 - 661Ying Chen, Yang Ning, Qinghua Zhang and Ying Xie*
DOI: 10.2174/1386207322666181220121836
Synthesis of Novel α-amidino Carboxylic Acids and their Use as H-Bond Catalysts in Strecker Reaction
, 2018; 21(8): 609 - 614Zahra Zaghari and Javad Azizian*
DOI: 10.2174/1386207321666181114110039
Open Access Articles
Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development
, 2019; 22(6): 379 - 386Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*
Effect of the Phragmitis Rhizoma Aqueous Extract on the Pharmacokinetics of Docetaxel in Rats
, 2019; 22(5): 326 - 332Sarah Shin, No Soo Kim, Young Ah Kim, Hea Ry Oh and Ok-Sun Bang*
Integrative Analysis of Dysfunctional Modules Driven by Genomic Alterations at System Level Across 11 Cancer Types
, 2018; 21(10): 771 - 783Yin Wang, Zhenhao Liu, Baofeng Lian*, Lei Liu* and Lu Xie*
A Network Integration Method for Deciphering the Types of Metabolic Pathway of Chemicals with Heterogeneous Information
, 2018; 21(9): 670 - 680Zi-Han Guo, Lei Chen* and Xian Zhao
Protein Sequence Comparison and DNA-binding Protein Identification with Generalized PseAAC and Graphical Representation
, 2018; 21(2): 100 - 110Chun Li*, Jialing Zhao, Changzhong Wang and Yuhua Yao
High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review
, 2016; 19(8): 605 - 615Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*
An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever
, 2016; 19(7): 516 - 536Chelsea N. Powers and William N. Setzer*
Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library
, 2016; 19(4): 262 - 274Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh G. Santos, Marc A. Giulianotti and Robert J. Deschenes*
Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP
, 2015; 18(1): 3 - 17Arjan J. van Adrichem, Annika Fagerholm, Laura Turunen, Anna Lehto, Jani Saarela, Ari Koskinen, Gretchen A. Repasky and Krister Wennerberg*
Digital Holographic Microscopy: A Quantitative Label-Free Microscopy Technique for Phenotypic Screening
, 2014; 17(1): 80 - 88Benjamin Rappaz, Billy Breton, Etienne Shaffer and Gerardo Turcatti*
Chemical Informatics and the Drug Discovery Knowledge Pyramid
, 2013; 16(10): 764 - 776Gerald H. Lushington*, Yinghua Dong and Bhargav Theertham
A Generalized Model and High Throughput Data Analysis System for Functional Modulation of Receptor-Agonist Systems Suitable for use in Drug Discovery
, 2013; 16(3): 199 - 209Aaron C. Pawlyk*, R. Kyle Palmer, Dennis Sprous and Chip Allee
A Simple Method for Analyzing Actives in Random RNAi Screens: Introducing the “H Score” for Hit Nomination & Gene Prioritization
, 2012; 15(9): 686 - 704Bhavneet Bhinder and Hakim Djaballah*
Application of NMR Metabolomics to Search for Human Disease Biomarkers
, 2012; 15(8): 595 - 610Teklab Gebregiworgis and Robert Powers*
Alternative Medicine Safety: Agaricus blazei and Propolis
, 2011; 14(7): 616 - 621Kenji Sorimachi* and Takaaki Nakamoto
Most Cited Articles
Research Article
Prediction of nitrated tyrosine residues in protein sequences by extreme learning machine and feature selection methods
, 2018; 21(6): 393-402.Lei Chen*, ShaoPeng Wang, Yu-Hang Zhang , Lai Wei , XianLing Xu, Tao Huang * and Yu-Dong Cai *
DOI: 10.2174/1386207321666180531091619
Research Article
Synthesis of some novel imidazoles catalyzed by Co <inf>3</inf> O <inf>4</inf> nanoparticles and evaluation of their antibacterial activities
, 2018; 21(4): 271-280.Mohammad A. Ghasemzadeh*, Mohammad H. Abdollahi-Basir and Zahra Elyasi
DOI: 10.2174/1386207321666180330164942
Research Article
One-pot synthesis of novel 2-pyrazolo-3-phenyl-1,3-thiazolidine-4-ones using DSDABCOC as an effective media
, 1 January 2018; 21(1): 271-280.Mohammad A. Ghasemzadeh*, Mohammad H. Abdollahi-Basir and Zahra Elyasi
DOI: 10.2174/138620732166618012409405
Research Article
A network integration method for deciphering the types of metabolic pathway of chemicals with heterogeneous information
, 2018; 21(9): 670-680.Zi-Han Guo, Lei Chen* and Xian Zhao
DOI: 10.2174/1386207322666181206112641
Research Article
Pyrazole schiff base hybrids as anti-malarial agents: Synthesis, in vitro screening and computational study
, 2018; 21(3): 194-203.Shilpy Aggarwal, Deepika Paliwal, Dhirender Kaushik, Girish Kumar Gupta and Ajay Kumar*
DOI: 10.2174/1386207321666180213092911
Review Article
Efficacy and toxicity of addition of bevacizumab to chemotherapy in patients with metastatic colorectal cancer
, 2018; 21(10): 718-724.Wen-Cong Ruan, Yue-Ping Che, Li Ding and Hai-Feng Li*
DOI: 10.2174/1386207322666190119162352
Research Article
Prediction of drug combinations with a network embedding method
, 2018; 21(10): 789-797.Tianyun Wang, Lei Chen* and Xian Zhao
DOI: 10.2174/1386207322666181226170140
Research Article
An integrated feature selection algorithm for cancer classification using gene expression data
, 2018; 21(9): 631-645.Saeed Ahmed*, Muhammad Kabir, Zakir Ali, Muhammad Arif, Farman Ali and Dong-Jun Yu
DOI: 10.2174/1386207322666181220124756
Research Article
Application of QSAR analysis and different quantum chemical calculation methods in activity evaluation of selected fluoroquinolones
, 2018; 21(7): 468-475.Piotr Kawczak*, Leszek Bober and Tomasz Bączek
DOI: 10.2174/1386207321666180827105856
General Research Article
Synergistic interplay of the co-administration of rifampin and newly developed anti-TB drug: Could it be a promising new line of TB therapy?
, 2018; 21(6): 453-460.Clement Agoni, Pritika Ramharack and Mahmoud E.S. Soliman*
DOI: 10.2174/1386207321666180716093617
Research Article
A clean, mild, and efficient preparation of aryl 14H-benzo[a,j]xanthene leuco-dye derivatives via nanocatalytic MCM-41-SO<inf>3</inf>h under ultrasonic irradiation in aqueous media
, 1 January 2018; 21(1): 5-13.Mostafa Fathollahi, Shahnaz Rostamizadeh* and Ali M. Amani
DOI: 10.2174/1386207321666180104111508
Research Article
Identification of human acetylcholinesterase inhibitors from the constituents of EGb761 by modeling docking and molecular dynamics simulations
, 1 January 2018; 21(1): 41-49.Lihu Zhang, Dongdong Li, Fuliang Cao, Wei Xiao*, Linguo Zhao*, Gang Ding and Zhen zhong Wang
DOI: 10.2174/1386207320666171123201910
Research Article
Predictive and descriptive CoMFA models: The effect of variable selection
, 2018; 21(2): 117-124.Bakhtyar Sepehri, Nematollah Omidikia, Mohsen Kompany-Zareh and Raouf Ghavami*
DOI: 10.2174/1386207321666180212162028
Review Article
Herbal products for common auto-inflammatory disorders - Novel approaches
, 2018; 21(3): 161-174.Shanoo Suroowan and Fawzi Mahomoodally*
DOI: 10.2174/1386207321666180213093449
Research Article
Pharmacoinformatics and molecular docking studies reveal potential novel compounds against schizophrenia by target SYN II
, 2018; 21(3): 175-181.Rana Adnan Tahir and Sheikh Arslan Sehgal*
DOI: 10.2174/1386207321666180213092018
Most Accessed Articles
Systematic Investigation of Quercetin for Treating Cardiovascular Disease Based on Network Pharmacology
, 2019; 22(6): 411-420.Xian-Jun Wu, Xin-Bin Zhou, Chen Chen and Wei Mao *
DOI: 10.2174/1386207322666190717124507
Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development
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DOI: 10.2174/1386207322666190704095602
Progress in Molecularly Imprinted Polymers for Biomedical Applications
, 2019; 22(2): 78-88.Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi and Alistair C. Cowie
DOI: 10.2174/1386207322666190325115526
False Negative D Vitamin Measurement in LC-MS/MS Method Due to Hyperlipidemia: Case Report
, 2019; 22(6): 428-430.Ataman Gonel* and Alparslan Yetisgin
DOI: 10.2174/1386207322666190722155106
Facile Synthesis and Cytotoxicity of Phenazine-Chromene Hybrid Molecules Derived from Phenazine Natural Product
, 2019; 22(1): 35-40.Mei-Chen Zhang, Shu-Hui Gu, Guang-Pan Liu, Chen-Cheng Li, Han-Mei Xu*, Zhong-Xi Wu, Bo-Ping Ye, Yuan-Yuan Lu, De-Chun Huang, Zhi-Xiang Wang and Feng Jiang*
DOI: 10.2174/1386207322666190307125015
Comparison of the Full-Length and 152~528 Truncate of Human Cyclic Nucleotide Phosphodiesterase 4B2 for the Characterization of Inhibitors
, 2019; 22(1): 49-58.Xiang Zhang, Shu He, Xiaolei Hu, Jing Wu, Xinpeng Li, Fei Liao* and Xiaolan Yang*
DOI: 10.2174/1386207322666190306142810
Green Chemistry Preparation of thiochromeno[4,3-b]pyran and benzo[h]thiazolo[2,3-b]quinazoline Derivatives using HSBM Technique over ZnAl2O4 Nano-Powders
, 2019; 22(6): 421-427.Seyyed Jalal Roudbaraki, Sadaf Janghorban and Majid Ghashang *
DOI: 10.2174/1386207322666190617164617
Reynoutria Japonica from Traditional Chinese Medicine: A Source of Competitive Adenosine Deaminase Inhibitors for Anticancer
, 2019; 22(2): 113-122.Xin-guo Zhang*, Guo-Yan Ma, Fei Kou, Wen-Jie Liu, Qiao-Yun Sun, Guang-Jun Guo, Xiao-Di Ma, Si-Jia Guo and Zhu Jian-Ning
DOI: 10.2174/1386207322666190415100618
Activity Evaluation and Selection of Some Classes of Antibiotics with the use of Semi-Empirical Quantum Mechanics and Quantitative Structure- Activity Relationships Approach
, 2019; 22(2): 97-112.Piotr Kawczak*, Leszek Bober and Tomasz Bączek
DOI: 10.2174/1386207322666190425144209
Management and Treatment of Dengue and Chikungunya - Natural Products to the Rescue
, 2016; 19(7): 554-564.Shanoo Suroowan, Fawzi Mahomoodally and Luxcha Ragoo
DOI: 10.2174/1386207319666160506123401
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Editor-in-Chief
Gerald H. Lushington
LiS Consulting, Lawrence
KS
USA
Biography
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LiS Consulting, Lawrence
KS
USA
Biography
Biography of Gerald H. Lushington
Dr. Gerald Lushington received his Ph.D. in Chemistry from the University of New Brunswick. The author of 181 journal articles, nine book chapters and four patents, Lushington is currently Principal Consultant at LiS Consulting, and serves as Adjunct Professor of Food Nutrition Dietetic Health at Kansas State University. With more than 25 years experience in the application of molecular modeling, simulation and informatics to a diverse range of scientific applications, Lushington's primary areas of focus are in drug discovery and pharmacology.
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Combinatorial Chemistry & High Throughput Screening Journal was launched in 1998. Dr. Gerald H. Lushington serves as the Editor-in-Chief of the journal.
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