Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research
Volume 24, 10 Issues, 2021
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access
In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research
Aims & Scope
Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:
- Target identification and validation
- Assay design, development, miniaturization and comparison
- High throughput/high content/in silico screening and associated technologies
- Label-free detection technologies and applications
- Stem cell technologies
- Biomarkers
- ADMET/PK/PD methodologies and screening
- Probe discovery and development, hit to lead optimization
- Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
- Chemical library design and chemical diversity
- Chemo/bio-informatics, data mining
- Compound management
- Pharmacognosy
- Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products)
- Natural Product Analytical Studies
- Bipharmaceutical studies of Natural products
- Drug repurposing
- Data management and statistical analysis
- Laboratory automation, robotics, microfluidics, signal detection technologies
- Current & Future Institutional Research Profile
- Technology transfer, legal and licensing issues
- Patents
In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.
Combinatorial Chemistry & High Throughput Screening
,Volume 24
-Number 3
Editorial Open Access
Contemporary Issues on Pharmaceutical Researches (Part II)
, 24(3): 327Cem Erkmen, Bengi Uslu and Sevinc Kurbanoglu
DOI: 10.2174/138620732403210210103810
Contemporary Issues on Pharmaceutical Researches (Part II)
Research Article
Moxifloxacin Hydrochloride-Loaded Eudragit® RL 100 and Kollidon® SR Based Nanoparticles: Formulation, In vitro Characterization and Cytotoxicity
, 24(3): 328 - 341Gülsel Yurtdaş Kırımlıoğlu*, Sinan Özer, Gülay Büyükköroğlu and Yasemin Yazan
DOI: 10.2174/1386207323666200428091945
Moxifloxacin Hydrochloride-Loaded Eudragit® RL 100 and Kollidon® SR Based Nanoparticles: Formulation, In vitro Characterization and Cytotoxicity
Research Article
Simple and Fast Determination of Terbinafine in Human Urine by Dilute and Shoot HPLC-DAD Using a Core-Shell Column
, 24(3): 342 - 351Sercan Yıldırım*, Gökhan Demirdaş, Mert Fidan and Ahmet Yaşar
DOI: 10.2174/1386207323666200709171504
Simple and Fast Determination of Terbinafine in Human Urine by Dilute and Shoot HPLC-DAD Using a Core-Shell Column
Research Article
A Novel HPLC Method for Simultaneous Determination of Methyl, Ethyl, n-propyl, Isopropyl, n-butyl, Isobutyl and Benzyl Paraben in Pharmaceuticals and Cosmetics
, 24(3): 352 - 365Saniye Özcan, Serkan Levent, Nafiz Öncü Can* and Murat Kozanli
DOI: 10.2174/1386207323999200728121657
A Novel HPLC Method for Simultaneous Determination of Methyl, Ethyl, n-propyl, Isopropyl, n-butyl, Isobutyl and Benzyl Paraben in Pharmaceuticals and Cosmetics
Research Article
Voltammetric Analysis of Ephedrine in Pharmaceutical Dosage Forms and Urine Using poly(Nile Blue A) Modified Glassy Carbon Electrode
, 24(3): 366 - 375Fatma Ağın, Gökçe Öztürk and Dilek Kul*
DOI: 10.2174/1386207323666200727100231
Voltammetric Analysis of Ephedrine in Pharmaceutical Dosage Forms and Urine Using poly(Nile Blue A) Modified Glassy Carbon Electrode
Research Article
Electroanalytical Analysis of Guaifenesin on Poly(Acridine Orange) Modified Glassy Carbon Electrode and its Determination in Pharmaceuticals and Serum Samples
, 24(3): 376 - 385Hasan Işık, Gökçe Öztürk, Fatma Ağın* and Dilek Kul
DOI: 10.2174/1386207323666200709170450
Electroanalytical Analysis of Guaifenesin on Poly(Acridine Orange) Modified Glassy Carbon Electrode and its Determination in Pharmaceuticals and Serum Samples
Research Article
A Novel and Sensitive LC-MS/MS Method for the Quantitation of Ceftiofur in Pharmaceutical Preparations and Milk Samples
, 24(3): 386 - 399Serkan Levent, Saniye Özcan, Aysun Geven and Nafiz Öncü Can*
DOI: 10.2174/1386207323999201110192558
A Novel and Sensitive LC-MS/MS Method for the Quantitation of Ceftiofur in Pharmaceutical Preparations and Milk Samples
Research Article
Electrochemical Behavior and Square-Wave Stripping Voltammetric Determination of Roflumilast in Pharmaceutical Dosage Forms
, 24(3): 400 - 408Mustafa Çelebier, Aysegul Dogan, İncilay Süslü* and Sacide Altınöz
DOI: 10.2174/1386207323666200901102526
Electrochemical Behavior and Square-Wave Stripping Voltammetric Determination of Roflumilast in Pharmaceutical Dosage Forms
Combinatorial Chemistry & High Throughput Screening, Volume 24 (2021) - Number 5
This issue is in progress but contains articles that are final and fully citable.
Review Article
Cervical Cancer Diagnosis: Insights into Biochemical Biomarkers and Imaging Techniques
, 24(5): 605 - 623Fatemeh Tavakoli, Sara Sadat Khatami, Fatemeh Momeni, Javid Azadbakht* and Faezeh Ghasemi*
DOI: 10.2174/1386207323666200901101955
Cervical Cancer Diagnosis: Insights into Biochemical Biomarkers and Imaging Techniques
Review Article
Ethnomedicinal uses, Phytochemistry and Pharmacological Aspects of the Genus Berberis Linn: A Comprehensive Review
, 24(5): 624 - 644Roohi Mohi-ud-din, Reyaz Hassan Mir, Prince Ahad Mir, Saeema Farooq, Syed Naiem Raza, Weekar Younis Raja, Mubashir Hussain Masoodi, Inder Pal Singh and Zulfiqar Ali Bhat*
DOI: 10.2174/1386207323999201102141206
Ethnomedicinal uses, Phytochemistry and Pharmacological Aspects of the Genus Berberis Linn: A Comprehensive Review
Research Article
Screening and Identification of Differentially Expressed Genes Between Diabetic Nephropathy Glomerular and Normal Glomerular via Bioinformatics Technology
, 24(5): 645 - 655Junjie Du, Jihong Yang* and Lingbing Meng
DOI: 10.2174/1386207323999200821163314
Screening and Identification of Differentially Expressed Genes Between Diabetic Nephropathy Glomerular and Normal Glomerular via Bioinformatics Technology
Research Article
13-lncRNAs Signature to Improve Diagnostic and Prognostic Prediction of Hepatocellular Carcinoma
, 24(5): 656 - 667Xinxin Zhang, Jia Yu, Juan Hu, Fang Tan, Juan Zhou, Xiaoyan Yang, Zhizhong Xie, Huifang Tang, Sen Dong and Xiaoyong Lei*
DOI: 10.2174/1386207323666200914095616
13-lncRNAs Signature to Improve Diagnostic and Prognostic Prediction of Hepatocellular Carcinoma
Research Article
Systematic Evaluation of the Mechanisms of Mulberry Leaf (Morus alba Linne) Acting on Diabetes Based on Network Pharmacology and Molecular Docking
Research Article
Activated Carbon/MoO3: Efficient Catalyst for Green Synthesis of Chromeno[d]pyrimidinediones and Xanthenones
, 24(5): 683 - 694Niloofar Sabet Mehr, Shahrzad Abdolmohammadi* and Maryam Afsharpour
DOI: 10.2174/1386207323666200924111602
Activated Carbon/MoO3: Efficient Catalyst for Green Synthesis of Chromeno[d]pyrimidinediones and Xanthenones
Research Article
Microwave-assisted Synthesis of Novel Pyrazole Derivatives and their Biological Evaluation as Anti-Bacterial Agents
, 24(5): 695 - 700Hadis Khodadad, Farhad Hatamjafari*, Khalil Pourshamsian* and Babak Sadeghi
DOI: 10.2174/1386207323666201019152206
Microwave-assisted Synthesis of Novel Pyrazole Derivatives and their Biological Evaluation as Anti-Bacterial Agents
Research Article Open Access
Elucidation of the Mechanisms and Molecular Targets of Qishen Yiqi Formula for the Treatment of Pulmonary Arterial Hypertension using a Bioinformatics/Network Topology-based Strategy
, 24(5): 701 - 715Peiliang Wu, Xiaona Xie, Mayun Chen, Junwei Sun, Luqiong Cai, Jinqiu Wei, Lin Yang, Xiaoying Huang* and Liangxing Wang*
DOI: 10.2174/1386207323666201019145354
Elucidation of the Mechanisms and Molecular Targets of Qishen Yiqi Formula for the Treatment of Pulmonary Arterial Hypertension using a Bioinformatics/Network Topology-based Strategy
Combinatorial Chemistry & High Throughput Screening, Volume 24 (2021) - Number 4
This issue is in progress but contains articles that are final and fully citable.
Letter Article
Positive Role of Synthesis Method and Hard Template on the Catalytic Performance of SAPO-34 in Methanol to Olefin Reaction
Research Article
Structural/Texture Evolution During Facile Substitution of Ni into ZSM-5 Nanostructure vs. its Impregnation Dispersion Used in Selective Transformation of Methanol to Ethylene and Propylene
, 24(4): 488 - 506Parisa Sadeghpour, Mohammad Haghighi* and Mehrdad Esmaeili
DOI: 10.2174/1386207323666200825144543
Structural/Texture Evolution During Facile Substitution of Ni into ZSM-5 Nanostructure vs. its Impregnation Dispersion Used in Selective Transformation of Methanol to Ethylene and Propylene
Research Article
Comparative Synthesis and Characterization of Nanostructured SAPO-34 Using TEA and Morpholine: Effect of Mono vs. Dual Template on Catalytic Properties and Performance toward Methanol to Light Olefins
, 24(4): 507 - 518Sogand Aghamohammadi, Mohammad Haghighi*, Parisa Sadeghpour and Tayebeh Souri
DOI: 10.2174/1386207323666200914104904
Comparative Synthesis and Characterization of Nanostructured SAPO-34 Using TEA and Morpholine: Effect of Mono vs. Dual Template on Catalytic Properties and Performance toward Methanol to Light Olefins
Research Article
Catalytic Longevity of Hierarchical SAPO-34/AlMCM-41 Nanocomposite Molecular Sieve In Methanol-to-Olefins Process
, 24(4): 519 - 531Hossein Roohollahi, Rouein Halladj* and Sima Askari
DOI: 10.2174/1386207323666200428092404
Catalytic Longevity of Hierarchical SAPO-34/AlMCM-41 Nanocomposite Molecular Sieve In Methanol-to-Olefins Process
Research Article
Life Time Improvement of Hierarchically Structured SAPO-34 Nanocatalyst in MTO Reaction via Applying Clinoptilolite: Investigating of Composite Design via RSM
, 24(4): 532 - 543Reza Yazdanpanah, Eshagh Moradiyan, Rouein Halladj* and Sima Askari
DOI: 10.2174/1386207323666200428093154
Life Time Improvement of Hierarchically Structured SAPO-34 Nanocatalyst in MTO Reaction via Applying Clinoptilolite: Investigating of Composite Design via RSM
Research Article
Effects of Desilication in NaOH/Piperidine Medium and Phosphorus Modification on the Catalytic Activity of HZSM-5 Catalyst in Methanol to Propylene Conversion
, 24(4): 544 - 557Ebrahim Safaei and Majid Taghizadeh*
DOI: 10.2174/1386207323666200714002844
Effects of Desilication in NaOH/Piperidine Medium and Phosphorus Modification on the Catalytic Activity of HZSM-5 Catalyst in Methanol to Propylene Conversion
Research Article
CFD Modeling of Methanol to Light Olefins in a Sodalite Membrane Reactor using SAPO-34 Catalyst with In Situ Steam Removal
, 24(4): 558 - 568Abbas Aghaeinejad-Meybodi*, Seyed Mahdi Mousavi, Ali Asghar Shahabi and Mohammad Rostampour Kakroudi
DOI: 10.2174/1386207323999200818171101
CFD Modeling of Methanol to Light Olefins in a Sodalite Membrane Reactor using SAPO-34 Catalyst with In Situ Steam Removal
Research Article
Presenting a Four-Lump Dynamic Kinetic Model for Methanol to Light Olefins Process Over the Hierarchical SAPO-34 Catalyst Using Power Law Models
, 24(4): 569 - 579Mohammad Javad Azarhoosh* and Alireza Azarhoosh
DOI: 10.2174/1386207323666200915092724
Presenting a Four-Lump Dynamic Kinetic Model for Methanol to Light Olefins Process Over the Hierarchical SAPO-34 Catalyst Using Power Law Models
Articles Ahead of Print
Nutraceuticals for Sleep Disorders
Ruhi Ali*, Sana Tariq, Ozaifa Kareem, Faizana Fayaz, Tahira Aziz, Meenu Dinesh, Faheem Hyder Pottoo and Nadeem Siddiqui
DOI: 10.2174/1386207324666210121111446
View Abstract View on PubMed
Validation of an UPLC-DAD Method for the Quantification of Phenolic Acids, Verbascoside and 6-epi-aucubin in Crescentia cujete Fruit
Andrés Rivera-Mondragón*, Catherina Caballero-George, Luc Pieters and Kenn Foubert
DOI: 10.2174/1386207323666201207114302
View Abstract View on PubMed
On Extremal Graphs of Degree Distance Index by Using Edge-Grafting Transformations Method
Muhammad Imran*, Shehnaz Akhtar, Uzma Ahmad, Sarfraz Ahmad and Ahsan Bilal
DOI: 10.2174/1386207323666201224123643
View Abstract View on PubMed
Prognostic Hub Genes in the Immune Microenvironment of Lung Adenocarcinoma by Estimation
Shanshan Liu, Wenjuan Tian and Burong Li*
DOI: 10.2174/1386207323666201211090604
View Abstract View on PubMed
MicroRNA and Exosome in Retinal-related Diseases: Their Roles in the Pathogenesis and Diagnosis
Arash Salmaninejad*, Ghazaleh Pourali, Ali Shahini, Hassan Darabi and Sara Azhdari
DOI: 10.2174/1386207323999201230205435
View Abstract View on PubMed
The Cosmetic Potential of The Medicinal Halophyte Tamarix Gallica L. (Tamaricaceae) Growing in The Eastern Part of Algeria: Photoprotective and Antioxidant Activities
Mostefa Lefahal, El-Hani Makhloufi, Warda Trifa, Radia Ayad, Mohamed El Hattab, Merzoug Benahmed, Merve Keskin* and Salah Akkal
DOI: 10.2174/1386207323666201204141541
View Abstract View on PubMed
Herbal Medicine: Clinical Perspective & Regulatory Status
Md Abul Barkat*, Anjali Goyal, Harshita Abul Barkat, Mohammad Salauddin, Faheem Hyder Pottoo and Esra T. Anwer
DOI: 10.2174/1386207323999201110192942
View Abstract View on PubMed
Envisioning the Future of Nanomedicines in Management and Treatment of Neurological Disorders
Shobhit Kumar*, Priyanka Singh, Shrestha Sharma, Faheem Hyder Pottoo, Javed Ali and Sanjula Baboota
DOI: 10.2174/1386207323666201217151132
View Abstract View on PubMed
On m-polar Diophantine Fuzzy N-soft set with Applications
Jia-Bao Liu, Shahbaz Ali*, Muhammad Khalid Mahmood and Muhammad Haris Mateen
DOI: 10.2174/1386207323666201230092354
View Abstract View on PubMed
Abstracts Ahead of Print
Status analysis of herbal drug therapies in epilepsy: advancements in the use of medicinal plants with anti-inflammatory properties
Monika Pahuja *, Jogender Mehla and Yogendra Kumar Gupta
DOI: 10.2174/1386207324666210219103430
View Abstract
DL-SMILES#: A Novel Encoding Scheme for Predicting Compound Protein Affinity by Deep Learning
Shudong Wang, Jiali Liu*, Mao Ding*, Yijun Gao*, Dayan Liu, Qingyu Tian and Jinfu Zhu
DOI: 10.2174/1386207324666210219102728
View Abstract
A Nanoinformatics Approach to Evaluate the Pharmacological Properties of Nanoparticles for the treatment of Alzheimer’s Disease
Muhammad Zohaib Nawaz*, Syed Awais Attique , Qurat-ul-Ain, Fahdah Ayed Alshammari , Heba Waheeb Alhamdi , Huda Ahmed Alghamdi * and Wei Yan*
DOI: 10.2174/1386207324666210217145733
View Abstract
The life cycle and in silico elucidation of non-structural replicating proteins of HCV through a pharmacoinformatics approach
Rana Adnan Tahir, Sumera Mughal, Amina Nazir, Asma Noureen, Ayesha Jawad, Muhammad Waqas and Sheikh Arslan Sehgal*
DOI: 10.2174/1386207324666210217144306
View Abstract
Graph Indices for Cartesian Product of F-sum of Connected Graphs
Jia-Bao Liu, Muhammad Imran*, Shakila Baby, Hafiz Muhammad Afzal Siddiqui and Muhammad Kashif Shafiq
DOI: 10.2174/1386207324666210217143114
View Abstract
A Label-Free Fluorescent AND Logic Gate Aptasensor for Carbohydrate Antigen 15-3 Detection Based on Graphene Oxide
Wenxiao Hu, Yafei Dong*, Luhui Wang, Yue Wang, Mengyao Qian and Sunfan Xi
DOI: 10.2174/1386207324666210216095053
View Abstract
Two Promising Anti-Cancer Compounds, 2-Hydroxycinnaldehyde and 2-Benzoyloxycinnamaldehyde: Where do we stand?
Haroon Iqbal, Farid Menaa*, Naveed Ullah Khan, Anam Razzaq, Zaheer Ullah Khan, Kifayat Ullah, Robia Kamal, Muhammad Sohail, Gobika Thiripuranathar, Bushra Uzair, Nosheen Fatima Rana, Barkat Ali Khan and Bouzid Menaa
DOI: 10.2174/1386207324666210216094428
View Abstract
Extracellular vesicle-derived miR-26b-5p is up-regulated in the serum of patients with diabetic retinopathy
Yuru Zhang, Jun Wei, Le Zhang, Guangwei Jiang, Bing Wang and Liping Jiang*
DOI: 10.2174/1386207324666210216092917
View Abstract
Predicting drug-target affinity based on recurrent neural networks and graph convolutional neural networks
Qingyu Tian*, Mao Ding*, Hui Yang, Caibin Yue, Yue Zhong, Zhenzhen Du, Dayan Liu, Jiali Liu and Yufeng Deng
DOI: 10.2174/1386207324666210215101825
View Abstract
Anti-mycobacterial activity of 22 Iranian endemic or rare plant extracts against multi-drug and extensively drug resistant Mycobacterium tuberculosis
Sina Dehestani, Javid Davoodi, Seyed Ahmad Emami, Fereshteh Sadat Seddighinia, Amirhossein Sahebkar* and Saman Soleimanpour*
DOI: 10.2174/1386207324666210215100931
View Abstract
Published Contents
- Combinatorial Chemistry & High Throughput Screening, Volume 24, 2021
- Combinatorial Chemistry & High Throughput Screening, Volume 23, 2020
- Combinatorial Chemistry & High Throughput Screening, Volume 22, 2019
- Combinatorial Chemistry & High Throughput Screening, Volume 21, 2018
- Combinatorial Chemistry & High Throughput Screening, Volume 20, 2017
- Combinatorial Chemistry & High Throughput Screening, Volume 19, 2016
- Combinatorial Chemistry & High Throughput Screening, Volume 18, 2015
- Combinatorial Chemistry & High Throughput Screening, Volume 17, 2014
- Combinatorial Chemistry & High Throughput Screening, Volume 16, 2013
- Combinatorial Chemistry & High Throughput Screening, Volume 15, 2012
- Combinatorial Chemistry & High Throughput Screening, Volume 14, 2011
- Combinatorial Chemistry & High Throughput Screening, Volume 13, 2010
- Combinatorial Chemistry & High Throughput Screening, Volume 12, 2009
- Combinatorial Chemistry & High Throughput Screening, Volume 11, 2008
- Combinatorial Chemistry & High Throughput Screening, Volume 10, 2007
- Combinatorial Chemistry & High Throughput Screening, Volume 9, 2006
- Combinatorial Chemistry & High Throughput Screening, Volume 8, 2005
- Combinatorial Chemistry & High Throughput Screening, Volume 7, 2004
- Combinatorial Chemistry & High Throughput Screening, Volume 6, 2003
- Combinatorial Chemistry & High Throughput Screening, Volume 5, 2002
- Combinatorial Chemistry & High Throughput Screening, Volume 4, 2001
- Combinatorial Chemistry & High Throughput Screening, Volume 3, 2000
Editor's Choice
Electrochemical Behavior and Square-Wave Stripping Voltammetric Determination of Roflumilast in Pharmaceutical Dosage Forms
, 2021; 24(3): 400 - 408Mustafa Çelebier, Aysegul Dogan, İncilay Süslü* and Sacide Altınöz
DOI: 10.2174/1386207323666200901102526
An Insight into Unani Hypoglycemic Drugs and Their Mechanism of Action
, 2021; 24(2): 165 - 176Mohammad Fazil, Sadia Nikhat and Imran Ali*
DOI: 10.2174/1386207323666200717143540
Potential of MurA Enzyme and GBAP in Fsr Quorum Sensing System as Antibacterial Drugs Target: In vitro and In silico Study of Antibacterial Compounds from Myrmecodia pendans
, 2021; 24(1): 109 - 118Eti Apriyanti, Mieke H. Satari and Dikdik Kurnia*
DOI: 10.2174/1386207323666200628111348
Host-directed Therapy: A New Arsenal to Come
, 2021; 24(1): 59 - 70Mradul Mohan* and Debapriya Bhattacharya*
DOI: 10.2174/1386207323999200728115857
Rhodamine B - as New Chromophore for the Determination of Melatonin in Biological, Food, and Pharmaceutical Samples
, 2020; 23(10): 1080 - 1089Alexandrina Lungu-Moscalu, Catalina C. Negut, Cristina Stefanov, Raluca-Ioana S. van Staden*, Andrei A. Bunaciu and Jacobus F. van Staden
DOI: 10.2174/1386207323666200628111958
Inhibition of Cyclooxygenase Enzyme by Bioflavonoids in Horsegram Seeds Alleviates Pain and Inflammation
, 2020; 23(9): 931 - 938Malarvizhi Ramalingam, Veeresh K. Sali, Meenakshi Bhardwaj, Sugumar Mani and Hannah R. Vasanthi*
DOI: 10.2174/1386207323666200127114551
Synthesis of New 3-Arylaminophthalides and 3-Indolyl-phthalides using Ammonium Chloride, Evaluation of their Anti-Mycobacterial Potential and Docking Study
, 2020; 23(8): 723 - 739Avinash Patil, Harleen Duggal, Kamini T. Bagul, Sonali Kamble, Pradeep Lokhande*, Rajesh Gacche* and Rohan Meshram*
DOI: 10.2174/1386207323666200422082754
Synthesis, Conformational Analysis, Infrared, Raman and UV-Visible Spectra of Novel Schiff Bases compiled with DFT Calculations
, 2020; 23(7): 568 - 586Samy M. Ahmed, Ibrahim A. Shaaban, Elsayed H. El-Mossalamy and Tarek A. Mohamed*
DOI: 10.2174/1386207323666200127161207
iSP-RAAC: Identify Secretory Proteins of Malaria Parasite Using Reduced Amino Acid Composition
, 2020; 23(6): 536 - 545Haoyue Zhang, Qilemuge Xi, Shenghui Huang, Lei Zheng, Wuritu Yang* and Yongchun Zuo*
DOI: 10.2174/1386207323666200402084518
Synthesis, Antitumor Activity and Molecular Docking Studies on Seven Novel Thiazacridine Derivatives
, 2020; 23(5): 359 - 368Marcel L. Almeida, Douglas C.F. Viana , Valécia C.M. da Costa, Flaviana A. dos Santos, Michelly C. Pereira, Maira G.R. Pitta , Moacyr J.B. de Melo Rêgo, Ivan R. Pitta and Marina G.R. Pitta*
DOI: 10.2174/1386207323666200319105239
Open Access Articles
Elucidation of the Mechanisms and Molecular Targets of Qishen Yiqi Formula for the Treatment of Pulmonary Arterial Hypertension using a Bioinformatics/Network Topology-based Strategy
, 2021; 24(5): 701 - 715Peiliang Wu, Xiaona Xie, Mayun Chen, Junwei Sun, Luqiong Cai, Jinqiu Wei, Lin Yang, Xiaoying Huang* and Liangxing Wang*
Potential of MurA Enzyme and GBAP in Fsr Quorum Sensing System as Antibacterial Drugs Target: In vitro and In silico Study of Antibacterial Compounds from Myrmecodia pendans
, 2021; 24(1): 109 - 118Eti Apriyanti, Mieke H. Satari and Dikdik Kurnia*
Network Pharmacology-based Investigation of the Underlying Mechanism of Panax notoginseng Treatment of Diabetic Retinopathy
, 2020; 23(4): 334 - 344Chunli Piao*, Zheyu Sun, De Jin, Han Wang, Xuemin Wu, Naiwen Zhang, Fengmei Lian* and Xiaolin Tong*
An Investigation of the Mechanism of Rapid Relief of Ulcerative Colitis Induced by Five-flavor Sophora Flavescens Enteric-coated Capsules Based on Network Pharmacology
, 2020; 23(3): 239 - 252Sizhen Gu, Yan Xue, Yuli Zhang, Kanjun Chen, Shigui Xue, Ji Pan, Yini Tang, Hui Zhu, Huan Wu and Danbo Dou*
Analysis of Chinese Herbal Formulae Recommended for COVID-19 in Dif- ferent Schemes in China: A Data Mining Approach
, 2020; 23: 1 - 11 (E-Pub Ahead of Print)LiWei Yin, YaCen Gao, ZiPing Li*, MengYu Wang and KaiXin Chen
Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development
, 2019; 22(6): 379 - 386Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*
Effect of the Phragmitis Rhizoma Aqueous Extract on the Pharmacokinetics of Docetaxel in Rats
, 2019; 22(5): 326 - 332Sarah Shin, No Soo Kim, Young Ah Kim, Hea Ry Oh and Ok-Sun Bang*
Integrative Analysis of Dysfunctional Modules Driven by Genomic Alterations at System Level Across 11 Cancer Types
, 2018; 21(10): 771 - 783Yin Wang, Zhenhao Liu, Baofeng Lian*, Lei Liu* and Lu Xie*
A Network Integration Method for Deciphering the Types of Metabolic Pathway of Chemicals with Heterogeneous Information
, 2018; 21(9): 670 - 680Zi-Han Guo, Lei Chen* and Xian Zhao
Protein Sequence Comparison and DNA-binding Protein Identification with Generalized PseAAC and Graphical Representation
, 2018; 21(2): 100 - 110Chun Li*, Jialing Zhao, Changzhong Wang and Yuhua Yao
High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review
, 2016; 19(8): 605 - 615Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*
An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever
, 2016; 19(7): 516 - 536Chelsea N. Powers and William N. Setzer*
Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library
, 2016; 19(4): 262 - 274Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh G. Santos, Marc A. Giulianotti and Robert J. Deschenes*
Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP
, 2015; 18(1): 3 - 17Arjan J. van Adrichem, Annika Fagerholm, Laura Turunen, Anna Lehto, Jani Saarela, Ari Koskinen, Gretchen A. Repasky and Krister Wennerberg*
Digital Holographic Microscopy: A Quantitative Label-Free Microscopy Technique for Phenotypic Screening
, 2014; 17(1): 80 - 88Benjamin Rappaz, Billy Breton, Etienne Shaffer and Gerardo Turcatti*
Most Cited Articles
Perspective
Kds2010: A potent highly selective and reversible mao-b inhibitor for alzheimer’s disease
, 2020; 23(9): 836-841.Abdullah Al Mamun and Md. Sahab Uddin*
DOI: 10.2174/1386207323666200117103144
Research Article
Drug target group prediction with multiple drug networks
, 2020; 23(4): 274-284.Jingang Che, Lei Chen*, Zi-Han Guo, Shuaiqun Wang and Aorigele
DOI: 10.2174/1386207322666190702103927
Research Article
Design and fabrication of a magnetite-based polymer-supported hybrid nanocomposite: A promising heterogeneous catalytic system utilized in known palladium-assisted coupling reactions
, 2020; 23(2): 119-125.Ali Maleki*, Reza Taheri-Ledari and Reza Ghalavand
DOI: 10.2174/1386207323666200128152136
Research Article
Green route for the removal of pb from aquatic environment
, 2020; 23(7): 587-598.Ahmed Refaat*, Hanan Elhaes, Nabila S. Ammar, Hanan S. Ibrahim and Medhat Ibrahim
DOI: 10.2174/1386207323666200127123349
Research Article
Three major phosphoacceptor sites in HIV-1 capsid protein enhances its structural stability and resistance against the inhibitor: Explication through molecular dynamics simulation, molecular docking and DFT analysis
, 2020; 23(1): 41-54.Nouman Rasool* and Waqar Hussain
DOI: 10.2174/1386207323666191213142223
Editorial
Nanoinformatics: Artificial intelligence and nanotechnology in the new decade
, 2020; 23(1): 4-5.Antreas Afantitis
DOI: 10.2174/138620732301200316112000
Research Article
Lignans and neolignans anti-tuberculosis identified by qsar and molecular modeling
, 2020; 23(6): 504-516.Mayara S. Maia, Natália F. de Sousa, Gabriela C.S. Rodrigues, Alex F.M. Monteiro, Marcus T. Scotti and Luciana Scotti*
DOI: 10.2174/1386207323666200226094940
Research Article
Inhibition of cyclooxygenase enzyme by bioflavonoids in horsegram seeds alleviates pain and inflammation
, 2020; 23(9): 931-938.Malarvizhi Ramalingam, Veeresh K. Sali, Meenakshi Bhardwaj, Sugumar Mani and Hannah R. Vasanthi*
DOI: 10.2174/1386207323666200127114551
Research Article
ISP-RAAC: Identify secretory proteins of malaria parasite using reduced amino acid composition
, 2020; 23(6): 536-545.Haoyue Zhang, Qilemuge Xi, Shenghui Huang, Lei Zheng, Wuritu Yang* and Yongchun Zuo*
DOI: 10.2174/1386207323666200402084518
Research Article
Comprehensive bioinformatics analysis identifies tumor microenvironment and immune-related genes in small cell lung cancer
, 2020; 23(5): 381-391.Yongchun Song, Yanqin Sun, Tuanhe Sun and Ruixiang Tang*
DOI: 10.2174/1386207323666200407075004
Research Article
Synthesis, spectroscopic, in-vitro and computational analysis of hydrazones as potential antituberculosis agents: (part-I)
, 2020; 23(5): 392-401.Bapu R. Thorat*, Deepa Rani, Ramesh S. Yamgar and Suraj N. Mali*
DOI: 10.2174/1386207323999200325125858
Review Article
A comprehensive review of monoamine oxidase-a inhibitors in their syntheses and potencies
, 2020; 23(9): 898-914.Nisha A. Rehuman, Bijo Mathew*, Rakesh K. Jat, Orazio Nicolotti and Hoon Kim*
DOI: 10.2174/1386207323666200428091306
Research Article
In vitro and in silico xanthine oxidase inhibitory activity of selected phytochemicals widely present in various edible plants
, 2020; 23(9): 917-930.Arshad Mehmood, Ashfaq Ur Rehman, Muhammad Ishaq, Liang Zhao, Jiayi Li, Muhammad Usman, Lei Zhao*, Abdur Rehman, Oumeddour D. Zad and Chengtao Wang*
DOI: 10.2174/1386207323666200428075224
Research Article
Preparation of a magnetic nanosensor based on cobalt ferrite nanoparticles for the electrochemical determination of methyldopa in the presence of uric acid
, 2020; 23(10): 1023-1031.Khadijeh Najafi, Karim Asadpour-Zeynali* and Fariba Mollarasouli*
DOI: 10.2174/1386207323666200521123657
Perspective
Privileged pharmacophore of FDA approved drugs in combination with chalcone framework: A new hope for Alzheimer’s treatment
, 2020; 23(9): 842-846.Bijo Mathew*
DOI: 10.2174/1386207323999200728122627
Most Accessed Articles
Computational Method for Identifying Malonylation Sites by Using Random Forest Algorithm
, 2020; 23(4): 304-312.ShaoPeng Wang, JiaRui Li, Xijun Sun, Yu-Hang Zhang, Tao Huang* and Yudong Cai*
DOI: 10.2174/1386207322666181227144318
The Identification of Three Key Genes Related to Stemness in Thyroid Carcinoma through Comprehensive Analysis
, 2021; 24(3): 423-432.Tonglong Zhang, Chunhong Yan, Zhengdu Ye, Xingling Yin and Tian-an Jiang*
DOI: 10.2174/1386207323666200806164003
A Study on the Mechanism of Lavender in the Treatment of Insomnia Based on Network Pharmacology
, 2020; 23(5): 419-432.Yao Wang, Junbo Zou, Yanzhuo Jia, Yulin Liang, Xiaofei Zhang*, Chang-Li Wang, Xiao Wang*, Dongyan Guo, Yajun Shi and Ming Yang
DOI: 10.2174/1386207323666200401095008
Virtual Screening of the Multi-pathway and Multi-gene Regulatory Molecular Mechanism of Dachengqi Decoction in the Treatment of Stroke Based on Network Pharmacology
, 2020; 23(8): 775-787.Lishan Pei, Xia Shen, Yonggang Yan*, Conge Tan*, Kai Qu, Junbo Zou, Yanxia Wang and Fan Ping
DOI: 10.2174/1386207323666200311113747
In vitro and in silico Xanthine Oxidase Inhibitory Activity of Selected Phytochemicals Widely Present in Various Edible Plants
, 2020; 23(9): 917-930.Arshad Mehmood, Ashfaq Ur Rehman, Muhammad Ishaq, Liang Zhao, Jiayi Li, Muhammad Usman, Lei Zhao*, Abdur Rehman, Oumeddour D. Zad and Chengtao Wang*
DOI: 10.2174/1386207323666200428075224
New Platinum (II) Ternary Complexes of Formamidine and Pyrophosphate: Synthesis, Characterization and DFT Calculations and In vitro Cytotoxicity
, 2020; 23(7): 611-623.Ahmed A. Soliman*, Fawzy A. Attaby, Othman I. Alajrawy, Azza A.A. Abou-hussein and Wolfgang Linert
DOI: 10.2174/1386207323666200218115700
Lignans and Neolignans Anti-tuberculosis Identified by QSAR and Molecular Modeling
, 2020; 23(6): 504-516.Mayara S. Maia, Natália F. de Sousa, Gabriela C.S. Rodrigues, Alex F.M. Monteiro, Marcus T. Scotti and Luciana Scotti*
DOI: 10.2174/1386207323666200226094940
Potential of MurA Enzyme and GBAP in Fsr Quorum Sensing System as Antibacterial Drugs Target: In vitro and In silico Study of Antibacterial Compounds from Myrmecodia pendans
, 2021; 24(1): 109-118.Eti Apriyanti, Mieke H. Satari and Dikdik Kurnia*
DOI: 10.2174/1386207323666200628111348
Macromolecular Targets of Antiparasitic Germacranolide Sesquiterpenoids: An In Silico Investigation
, 2020; 23(6): 477-503.Phillip M. Arnston and William N. Setzer*
DOI: 10.2174/1386207323666200218114759
KDS2010: A Potent Highly Selective and Reversible MAO-B Inhibitor for Alzheimer’s Disease
, 2020; 23(9): 836-841.Abdullah Al Mamun and Md. Sahab Uddin*
DOI: 10.2174/1386207323666200117103144
In vitro α-amylase and α-glucosidase Inhibition, Antioxidant, Anti- Inflammatory Activity and GC-MS Profiling of Avicennia alba Blume
, 2020; 23(9): 945-954.Swagat K. Das*, Sagarika Dash, Hrudayanath Thatoi and Jayanta K. Patra*
DOI: 10.2174/1386207323666200428081748
Comprehensive Bioinformatics Analysis Identifies Tumor Microenvironment and Immune-related Genes in Small Cell Lung Cancer
, 2020; 23(5): 381-391.Yongchun Song, Yanqin Sun, Tuanhe Sun and Ruixiang Tang*
DOI: 10.2174/1386207323666200407075004
The Development of Spectrophotometric and Validated Stability- Indicating RP-HPLC Methods for Simultaneous Determination of Ephedrine HCL, Naphazoline HCL, Antazoline HCL, and Chlorobutanol in Pharmaceutical Pomade Form
, 2020; 23(10): 1090-1099.Çiğdem K. Dindar, Cem Erkmen, Bengi Uslu* and Nilgün G. Göğer*
DOI: 10.2174/1386207323666200720101835
A Recent Look into Natural Products that have Potential to Inhibit Cholinesterases and Monoamine Oxidase B: Update for 2010-2019
, 2020; 23(9): 862-876.Hayrettin O. Gulcan and Ilkay E. Orhan*
DOI: 10.2174/1386207323666200127145246
Design of Lamivudine Loaded Nanoparticles for Oral Application by Nano Spray Drying Method: A New Approach to use an Antiretroviral Drug for Lung Cancer Treatment
, 2020; 23(10): 1064-1079.Ahmet Alper Öztürk*, İrem Namlı, Kadri Güleç and Şennur Görgülü
DOI: 10.2174/1386207323666200325155020
Editor-in-Chief
Gerald H. Lushington
LiS Consulting, Lawrence
KS
(USA)
Biography
LiS Consulting, Lawrence
KS
Biography
Biography of Gerald H. Lushington
Dr. Gerald Lushington received his Ph.D. in Chemistry from the University of New Brunswick. The author of 181 journal articles, nine book chapters and four patents, Lushington is currently Principal Consultant at LiS Consulting, and serves as Adjunct Professor of Food Nutrition Dietetic Health at Kansas State University. With more than 25 years experience in the application of molecular modeling, simulation and informatics to a diverse range of scientific applications, Lushington's primary areas of focus are in drug discovery and pharmacology.
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Combinatorial Chemistry & High Throughput Screening Journal was launched in 1998. Dr. Gerald H. Lushington serves as the Editor-in-Chief of the journal.
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