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Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 22, 10 Issues, 2019
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access

Aims & Scope

Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:

  • Target identification and validation
  • Assay design, development, miniaturization and comparison
  • High throughput/high content/in silico screening and associated technologies
  • Label-free detection technologies and applications
  • Stem cell technologies
  • Biomarkers
  • ADMET/PK/PD methodologies and screening
  • Probe discovery and development, hit to lead optimization
  • Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
  • Chemical library design and chemical diversity
  • Chemo/bio-informatics, data mining
  • Compound management
  • Pharmacognosy
  • Drug repurposing
  • Data management and statistical analysis
  • Laboratory automation, robotics, microfluidics, signal detection technologies
  • Current & Future Institutional Research Profile
  • Technology transfer, legal and licensing issues
  • Patents

In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.

Combinatorial Chemistry & High Throughput Screening

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Volume 21

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Number 10



Biography   Open Access



Editorial   Open Access



Review Article



Review Article



Review Article



Research Article



Research Article



Research Article

Clinical Characteristics and Antibiotic Resistance of Mycoplasma Pneumoniae Pneumonia in Hospitalized Chinese Children

, 21(10): 749 - 754

Chen Yuan, Fang-Mei Min, Yin-Jie Ling, Gang Li, Hong-Zhou Ye, Jia-Hui Pan, Ling Wang and Yan-Ping Xie*


DOI: 10.2174/1386207322666190111112946


Articles Ahead of Print


Reynoutria Japonica from Traditional Chinese Medicine: A Source of Competitive Adenosine Deaminase Inhibitors for Anticancer


Xin-guo Zhang*, Guo-Yan Ma, Fei Kou, Wen-Jie Liu, Qiao-Yun Sun, Guang-Jun Guo, Xiao-Di Ma, Si-Jia Guo and Zhu Jian-Ning


View Abstract View on PubMed








Expression and Significance of LncRNA-MINCR and CDK2 mRNA in Primary Hepatocellular Carcinoma


Jiangshan Lian, Xiaolin Zhang, Yingfeng Lu, Shaorui Hao, Zhe Zhang and Yida Yang*


View Abstract View on PubMed



Abstracts Ahead of Print




Identification of N-Substituted Triazolo-azetidines as Novel Antibacterials using pDualrep2 HTS Platform


Yan A. Ivanenkov*, Renat S. Yamidanov, Ilya A. Osterman, Petr V. Sergiev, Vladimir A. Aladinskiy, Anastasia V. Aladinskaya, Victor A. Terentiev, Mark S. Veselov, Andrey A. Ayginin, Dmitry A. Skvortsov, Katerina S. Komarova, Alexey V. Chemeris, Alexey Kh. Baimiev, Alina A. Sofronova, Alexander S. Malyshev, Alexey E. Machulkin, Rostislav A. Petrov, Dmitry S. Bezrukov, Gleb I. Filkov, Maria M. Puchinina, Liana F. Zainullina, Marina A. Maximova, Zulfiya R. Zileeva, Yulia V. Vakhitova and Olga A. Dontsova


View Abstract




Editor's Choice

Maxillary Metastasis of Esophageal Cancer: Report of the First Case and Literature Review

, 2018; 21(10): 801 - 805

Hong Hu, Jing Wang, Xiao-Yun Zhou, Meng-Ting Tong, Chong-Ya Zhai, Xin-Bing Sui, Yan-Hua Zhang, Xiao-Xi Xie, Hao Liu, Jian-Sheng Xie, Hong-Ming Pan* and Da Li*


DOI: 10.2174/1386207322666190103105938



Catalytic Conversion of Biorenewable Sugar Feedstocks into Market Chemicals

, 2018; 21(9): 616 - 630

Gary Diamond, Alfred Hagemeyer*, Vince Murphy and Valery Sokolovskii


DOI: 10.2174/1386207322666181219155050






A Six-Gene Signature Predicts Clinical Outcome of Gastric Adenocarcinoma

, 2018; 21(6): 444 - 452

YaQi Li, Qi Yu, Rui Zhu, Yi Wang, Jiarui Li, Qiang Wang, Wenna Guo, Shen Fu* and Liucun Zhu*


DOI: 10.2174/1871524918666180531085713




Phytochemical Screening, Antiproliferative and Antioxidant Properties of Various Extracts from Endemic Origanum acutidens

, 2018; 21(4): 281 - 291

Feyza Oke-Altuntas, Mehmet Ali Demirci, Ibrahim Demirtas*, Ayse Sahin Yaglioglu and Lutfi Behcet


DOI: 10.2174/1386207321666180416154404



Extraction, Identification and Biological Activities of Saponins in Sea Cucumber Pearsonothuria graeffei

, 2018; 21(3): 222 - 231

Rafat Afifi Khattab, Mohamed Elbandy, Andrew Lawrence, Tim Paget, Jung Rae-Rho, Yaser S. Binnaser and Imran Ali*


DOI: 10.2174/1386207321666180212165448




Open Access Articles




High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review

, 2016; 19(8): 605 - 615

Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*





Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library

, 2016; 19(4): 262 - 274

Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh G. Santos, Marc A. Giulianotti and Robert J. Deschenes*




Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP

, 2015; 18(1): 3 - 17

Arjan J. van Adrichem, Annika Fagerholm, Laura Turunen, Anna Lehto, Jani Saarela, Ari Koskinen, Gretchen A. Repasky and Krister Wennerberg*




Digital Holographic Microscopy: A Quantitative Label-Free Microscopy Technique for Phenotypic Screening

, 2014; 17(1): 80 - 88

Benjamin Rappaz, Billy Breton, Etienne Shaffer and Gerardo Turcatti*




Chemical Informatics and the Drug Discovery Knowledge Pyramid

, 2013; 16(10): 764 - 776

Gerald H. Lushington*, Yinghua Dong and Bhargav Theertham







Alternative Medicine Safety: Agaricus blazei and Propolis

, 2011; 14(7): 616 - 621

Kenji Sorimachi* and Takaaki Nakamoto




The Design and Application of Target-Focused Compound Libraries

, 2011; 14(6): 521 - 531

C. John Harris, Richard D. Hill, David W. Sheppard*, Martin J. Slater and Pieter F.W. Stouten






Most Cited Articles



SAnDReS a Computational Tool for Statistical Analysis of Docking Results and Development of Scoring Functions

, 2016; 19(10): 801-812.

Mariana Morrone Xavier, Gabriela Sehnem Heck, Mauricio Boff de Avila, Nayara Maria Bernhardt Levin, Val Oliveira Pintro, Nathalia Lemes Carvalho and Walter Filgueira de Azevedo


DOI: 10.2174/1386207319666160927111347










Most Accessed Articles


A High-throughput Screening of a Chemical Compound Library in Ovarian Cancer Stem Cells

, 2018; 21(1): 50-56.

F. Ricci*, L. Carrassa, M. S. Christodoulou, D. Passarella, B. Michel, R. Benhida, N. Martinet, A. Hunyadi, E. Ioannou, V. Roussis, L. Musso, S. Dallavalle, R. Silvestri, N. Westwood, M. Mori, C. Ingallina, B. Botta, E. Kavetsou, A. Detsi, Z. Majer, F. Hudecz, S. Bosze, B. Kaminska, T.V. Hansen, P. Bertrand, C. M. Athanassopoulos and G. Damia*


DOI: 10.2174/1386207321666180124093406











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