Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research
Volume 22, 10 Issues, 2019
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access
Aims & Scope
Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:
- Target identification and validation
- Assay design, development, miniaturization and comparison
- High throughput/high content/in silico screening and associated technologies
- Label-free detection technologies and applications
- Stem cell technologies
- Biomarkers
- ADMET/PK/PD methodologies and screening
- Probe discovery and development, hit to lead optimization
- Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
- Chemical library design and chemical diversity
- Chemo/bio-informatics, data mining
- Compound management
- Pharmacognosy
- Drug repurposing
- Data management and statistical analysis
- Laboratory automation, robotics, microfluidics, signal detection technologies
- Current & Future Institutional Research Profile
- Technology transfer, legal and licensing issues
- Patents
In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.
Combinatorial Chemistry & High Throughput Screening
,Volume 21
-Number 10
Biography Open Access
Meet Our Editorial Board Member
Editorial Open Access
The Application of High-Throughput Technologies in Precision Diagnosis and Personalized Therapy
, 21(10): 702 - 703Tao Huang
DOI: 10.2174/138620732110190226170226
The Application of High-Throughput Technologies in Precision Diagnosis and Personalized Therapy
Review Article
The Association of Vitamin D Receptor Gene Polymorphism with Lung Cancer Risk: An Update Meta-analysis
, 21(10): 704 - 710Zhi-Hong Yu, Miao Chen, Qing-Qian Zhang and Xun Hu*
DOI: 10.2174/1386207322666190125150557
The Association of Vitamin D Receptor Gene Polymorphism with Lung Cancer Risk: An Update Meta-analysis
Review Article
Efficacy and Safety of Addition of Anti-PD1 to Chemotherapy in Treatment of Non-Small Cell Lung Cancer
, 21(10): 711 - 717Chu-Hui Ru and Yan-Bing Zhuang*
DOI: 10.2174/1386207322666190125150921
Efficacy and Safety of Addition of Anti-PD1 to Chemotherapy in Treatment of Non-Small Cell Lung Cancer
Review Article
Efficacy and Toxicity of Addition of Bevacizumab to Chemotherapy in Patients with Metastatic Colorectal Cancer
, 21(10): 718 - 724Wen-Cong Ruan, Yue-Ping Che, Li Ding and Hai-Feng Li*
DOI: 10.2174/1386207322666190119162352
Efficacy and Toxicity of Addition of Bevacizumab to Chemotherapy in Patients with Metastatic Colorectal Cancer
Research Article
The Adverse Events Rate of Endothelial Progenitor Cell Capturing Stent in the Treatment of CAD Patients
, 21(10): 725 - 733Wei-Yuan Xu, Wei-Liang Tang, Min Yuan, Yong Sun, Feng Xu and Fang Peng*
DOI: 10.2174/1386207322666190129113448
The Adverse Events Rate of Endothelial Progenitor Cell Capturing Stent in the Treatment of CAD Patients
Research Article
Using Naïve Bayes Algorithm to Estimate the Response to Drug in Lung Cancer Patients
, 21(10): 734 - 748Baoling Guo and Qiuxiang Zheng*
DOI: 10.2174/1386207322666190125151624
Using Naïve Bayes Algorithm to Estimate the Response to Drug in Lung Cancer Patients
Research Article
Clinical Characteristics and Antibiotic Resistance of Mycoplasma Pneumoniae Pneumonia in Hospitalized Chinese Children
, 21(10): 749 - 754Chen Yuan, Fang-Mei Min, Yin-Jie Ling, Gang Li, Hong-Zhou Ye, Jia-Hui Pan, Ling Wang and Yan-Ping Xie*
DOI: 10.2174/1386207322666190111112946
Clinical Characteristics and Antibiotic Resistance of Mycoplasma Pneumoniae Pneumonia in Hospitalized Chinese Children
Articles Ahead of Print
Invasive-noninvasive Sequential Ventilation for the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Jian-Da Huang, Tong-Jie Gu, Zhi-Lin Hu, Dan-Fei Zhou and Jun Ying*
View Abstract View on PubMed
Reynoutria Japonica from Traditional Chinese Medicine: A Source of Competitive Adenosine Deaminase Inhibitors for Anticancer
Xin-guo Zhang*, Guo-Yan Ma, Fei Kou, Wen-Jie Liu, Qiao-Yun Sun, Guang-Jun Guo, Xiao-Di Ma, Si-Jia Guo and Zhu Jian-Ning
View Abstract View on PubMed
Comparison of Clinical Efficacy and Complications Between Laparoscopic Versus Open Surgery for Low Rectal Cancer
Jian Dai* and Zhou Yu
View Abstract View on PubMed
Closed Loop Duodenal Obstruction Secondary to Pancreatic Carcinoma: A Case Report
Zhihong Shen, Jianhua Yu, Haijun Tang and Baochun Lu*
View Abstract View on PubMed
Video-assisted Thoracoscopic Surgery versus Thoracotomy for Non-Small Cell Lung Cancer: A Meta-Analysis
Bo Ye and Ming Wang*
View Abstract View on PubMed
The Effectiveness and Safety of Open Versus laparoscopic Surgery for Rectal Cancer after Preoperative Chemo-radiotherapy: A Meta-Analysis
Jun-Jie Zhang, Bao-Ling Guo, Qiu-Xiang Zheng and Zhi-Yong Chen*
View Abstract View on PubMed
The Key microRNAs Regulated the Development of Non-small Cell Lung Cancer by Targeting TGF-β-induced epithelial–mesenchymal Transition
Gang Chen and Bo Ye*
View Abstract View on PubMed
Contribution of Resveratrol in the Development of Novel Urease Inhibitors: Synthesis, Biological Evaluation and Molecular Docking Studies
Ritu Kataria and Anurag Khatkar*
View Abstract View on PubMed
Expression and Significance of LncRNA-MINCR and CDK2 mRNA in Primary Hepatocellular Carcinoma
Jiangshan Lian, Xiaolin Zhang, Yingfeng Lu, Shaorui Hao, Zhe Zhang and Yida Yang*
View Abstract View on PubMed
Expression and Significance of Th17 Cells and Related Factors in Patients with Autoimmune Hepatitis
Jihong An*
View Abstract View on PubMed
Abstracts Ahead of Print
Quantitative Structure-Activity Relationship Analysis for Predicting Lipophilicity of Aniline Derivatives (Including some Pharmaceutical Compounds)
Morteza Rezaei, Esmat Mohammadinasab* and Tahere Momeni Esfahani
View Abstract
Effect of the Phragmitis Rhizoma Aqueous Extract on the Pharmacokinetics of Docetaxel in Rats
Sarah Shin, No Soo Kim, Young Ah Kim, Hea Ry Oh and Ok-Sun Bang*
View Abstract
False Immunosuppressant Measurement by LC-MS/MS Method Due to Radiopaque Agents
Ataman Gönel* and Ismail Koyuncu
View Abstract
Identification of N-Substituted Triazolo-azetidines as Novel Antibacterials using pDualrep2 HTS Platform
Yan A. Ivanenkov*, Renat S. Yamidanov, Ilya A. Osterman, Petr V. Sergiev, Vladimir A. Aladinskiy, Anastasia V. Aladinskaya, Victor A. Terentiev, Mark S. Veselov, Andrey A. Ayginin, Dmitry A. Skvortsov, Katerina S. Komarova, Alexey V. Chemeris, Alexey Kh. Baimiev, Alina A. Sofronova, Alexander S. Malyshev, Alexey E. Machulkin, Rostislav A. Petrov, Dmitry S. Bezrukov, Gleb I. Filkov, Maria M. Puchinina, Liana F. Zainullina, Marina A. Maximova, Zulfiya R. Zileeva, Yulia V. Vakhitova and Olga A. Dontsova
View Abstract
Efficacy and safety of robot-assisted thoracic surgery (RATS) compare with video-assisted thoracoscopic surgery (VATS) for lung lobectomy in patients with non-small cell lung cancer
Xun Hu and Ming Wang*
View Abstract
Effect of Chinese herbal monomer hairy Calycosin on nonalcoholic fatty liver rats and its mechanism
Xiang Liu, Zhi-Hong Xie, Chen-Yuan Liu and Ying Zhang*
View Abstract
Editor's Choice
Maxillary Metastasis of Esophageal Cancer: Report of the First Case and Literature Review
, 2018; 21(10): 801 - 805Hong Hu, Jing Wang, Xiao-Yun Zhou, Meng-Ting Tong, Chong-Ya Zhai, Xin-Bing Sui, Yan-Hua Zhang, Xiao-Xi Xie, Hao Liu, Jian-Sheng Xie, Hong-Ming Pan* and Da Li*
DOI: 10.2174/1386207322666190103105938
Catalytic Conversion of Biorenewable Sugar Feedstocks into Market Chemicals
, 2018; 21(9): 616 - 630Gary Diamond, Alfred Hagemeyer*, Vince Murphy and Valery Sokolovskii
DOI: 10.2174/1386207322666181219155050
Prognostic Impact of Lymphadenectomy in Different Stages of Malignant Germ Cell Tumor of the Ovary Based on Propensity Score Matching
, 2018; 21(9): 652 - 661Ying Chen, Yang Ning, Qinghua Zhang and Ying Xie*
DOI: 10.2174/1386207322666181220121836
Synthesis of Novel α-amidino Carboxylic Acids and their Use as H-Bond Catalysts in Strecker Reaction
, 2018; 21(8): 609 - 614Zahra Zaghari and Javad Azizian*
DOI: 10.2174/1386207321666181114110039
Application of QSAR Analysis and Different Quantum Chemical Calculation Methods in Activity Evaluation of Selected Fluoroquinolones
, 2018; 21(7): 468 - 475Piotr Kawczak*, Leszek Bober and Tomasz Bączek
DOI: 10.2174/1386207321666180827105856
A Six-Gene Signature Predicts Clinical Outcome of Gastric Adenocarcinoma
, 2018; 21(6): 444 - 452YaQi Li, Qi Yu, Rui Zhu, Yi Wang, Jiarui Li, Qiang Wang, Wenna Guo, Shen Fu* and Liucun Zhu*
DOI: 10.2174/1871524918666180531085713
Assessing and Grouping Chemicals Applying Partial Ordering Alkyl Anilines as an Illustrative Example
, 2018; 21(5): 349 - 357Lars Carlsen* and Rainer Bruggemann
DOI: 10.2174/1386207321666180604103942
Phytochemical Screening, Antiproliferative and Antioxidant Properties of Various Extracts from Endemic Origanum acutidens
, 2018; 21(4): 281 - 291Feyza Oke-Altuntas, Mehmet Ali Demirci, Ibrahim Demirtas*, Ayse Sahin Yaglioglu and Lutfi Behcet
DOI: 10.2174/1386207321666180416154404
Extraction, Identification and Biological Activities of Saponins in Sea Cucumber Pearsonothuria graeffei
, 2018; 21(3): 222 - 231Rafat Afifi Khattab, Mohamed Elbandy, Andrew Lawrence, Tim Paget, Jung Rae-Rho, Yaser S. Binnaser and Imran Ali*
DOI: 10.2174/1386207321666180212165448
Chemometric Analysis for the Classification of some Groups of Drugs with Divergent Pharmacological Activity on the Basis of some Chromatographic and Molecular Modeling Parameters
, 2018; 21(2): 125 - 137Jolanta Stasiak, Marcin Koba*, Marcin Gackowski and Tomasz Baczek
DOI: 10.2174/1386207321666180129102149
Open Access Articles
Integrative Analysis of Dysfunctional Modules Driven by Genomic Alterations at System Level Across 11 Cancer Types
, 2018; 21(10): 771 - 783Yin Wang, Zhenhao Liu, Baofeng Lian*, Lei Liu* and Lu Xie*
A Network Integration Method for Deciphering the Types of Metabolic Pathway of Chemicals with Heterogeneous Information
, 2018; 21(9): 670 - 680Zi-Han Guo, Lei Chen* and Xian Zhao
Protein Sequence Comparison and DNA-binding Protein Identification with Generalized PseAAC and Graphical Representation
, 2018; 21(2): 100 - 110Chun Li*, Jialing Zhao, Changzhong Wang and Yuhua Yao
High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review
, 2016; 19(8): 605 - 615Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*
An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever
, 2016; 19(7): 516 - 536Chelsea N. Powers and William N. Setzer*
Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library
, 2016; 19(4): 262 - 274Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh G. Santos, Marc A. Giulianotti and Robert J. Deschenes*
Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP
, 2015; 18(1): 3 - 17Arjan J. van Adrichem, Annika Fagerholm, Laura Turunen, Anna Lehto, Jani Saarela, Ari Koskinen, Gretchen A. Repasky and Krister Wennerberg*
Digital Holographic Microscopy: A Quantitative Label-Free Microscopy Technique for Phenotypic Screening
, 2014; 17(1): 80 - 88Benjamin Rappaz, Billy Breton, Etienne Shaffer and Gerardo Turcatti*
Chemical Informatics and the Drug Discovery Knowledge Pyramid
, 2013; 16(10): 764 - 776Gerald H. Lushington*, Yinghua Dong and Bhargav Theertham
A Generalized Model and High Throughput Data Analysis System for Functional Modulation of Receptor-Agonist Systems Suitable for use in Drug Discovery
, 2013; 16(3): 199 - 209Aaron C. Pawlyk*, R. Kyle Palmer, Dennis Sprous and Chip Allee
A Simple Method for Analyzing Actives in Random RNAi Screens: Introducing the “H Score” for Hit Nomination & Gene Prioritization
, 2012; 15(9): 686 - 704Bhavneet Bhinder and Hakim Djaballah*
Application of NMR Metabolomics to Search for Human Disease Biomarkers
, 2012; 15(8): 595 - 610Teklab Gebregiworgis and Robert Powers*
Alternative Medicine Safety: Agaricus blazei and Propolis
, 2011; 14(7): 616 - 621Kenji Sorimachi* and Takaaki Nakamoto
The Design and Application of Target-Focused Compound Libraries
, 2011; 14(6): 521 - 531C. John Harris, Richard D. Hill, David W. Sheppard*, Martin J. Slater and Pieter F.W. Stouten
Two Panels of Steroid Receptor Luciferase Reporter Cell Lines for Compound Profiling
, 2011; 14(4): 248 - 266David Sedlak, Aileen Paguio and Petr Bartunek*
Most Cited Articles
Predicting the types of metabolic pathway of compounds using molecular fragments and sequential minimal optimization
, 2016; 19(2): 136-143.Lei Chen, Chen Chu and Kaiyan Feng
DOI: 10.2174/1386207319666151110122453
A novel machine learning method for cytokine-receptor interaction prediction
, 2016; 19(2): 144-152.Leyi Wei, Quan Zou, Minghong Liao, Huijuan Lu and Yuming Zhao
DOI: 10.2174/1386207319666151110122621
SAnDReS a Computational Tool for Statistical Analysis of Docking Results and Development of Scoring Functions
, 2016; 19(10): 801-812.Mariana Morrone Xavier, Gabriela Sehnem Heck, Mauricio Boff de Avila, Nayara Maria Bernhardt Levin, Val Oliveira Pintro, Nathalia Lemes Carvalho and Walter Filgueira de Azevedo
DOI: 10.2174/1386207319666160927111347
A Theoretical Study on Stepwise- and Concertedness of the Mechanism of 1,3-Dipolar Cycloaddition Reaction Between Tetra Amino Ethylene and Trifluoro Methyl Azide
, 2016; 19(2): 170-175.Seyyed Amir Siadati
DOI: 10.2174/1386207319666151216145408
Molecular Modeling and Virtual Screening Approach to Discover Potential Antileishmanial Inhibitors Against Ornithine Decarboxylase
, 2016; 19(10): 813-823.Rajan Kumar Pandey, Priyanka Prajapati, Sukriti Goyal, Abhinav Grover and Vijay Kumar Prajapati
DOI: 10.2174/1386207319666160907100134
δ-Cadinene,Calarene and δ-4-Carene from Kadsura heteroclita Essential Oil as Novel Larvicides Against Malaria, Dengue and Filariasis Mosquitoes
, 2016; 19(7): 565-571.Marimuthu Govindarajan, Mohan Rajeswary and Giovanni Benelli
DOI: 10.2174/1386207319666160506123520
Analysis of the relationship between PM2.5 and lung cancer based on protein-protein interactions
, 2016; 19(2): 100-108.Yang Shu, Liucun Zhu, Fei Yuan, Xiangyin Kong, Tao Huang and Yu-Dong Cai
DOI: 10.2174/1386207319666151110123345
Determining Partition Coefficient (Log P), Distribution Coefficient (Log D) and Ionization Constant (pKa) in Early Drug Discovery
, 2016; 19(6): 461-469.Sonali S. Bharate, Vikas Kumar and Ram A. Vishwakarma
DOI: 10.2174/1386207319666160502123917
An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever
, 2016; 19(7): 516-536.Chelsea N. Powers and William N. Setzer*
DOI: 10.2174/1386207319666160506123715
Analysis and Prediction of Myristoylation Sites Using the mRMR Method, the IFS Method and an Extreme Learning Machine Algorithm
, 2017; 20(2): 96-106.ShaoPeng Wang, Yu-Hang Zhang, GuoHua Huang, Lei Chen* and Yu-Dong Cai*
DOI: 10.2174/1386207319666161220114424
Most Accessed Articles
Integrative Analysis of Dysfunctional Modules Driven by Genomic Alterations at System Level Across 11 Cancer Types
, 2018; 21(10): 771-783.Yin Wang, Zhenhao Liu, Baofeng Lian*, Lei Liu* and Lu Xie*
DOI: 10.2174/1386207322666190122110726
A High-throughput Screening of a Chemical Compound Library in Ovarian Cancer Stem Cells
, 2018; 21(1): 50-56.F. Ricci*, L. Carrassa, M. S. Christodoulou, D. Passarella, B. Michel, R. Benhida, N. Martinet, A. Hunyadi, E. Ioannou, V. Roussis, L. Musso, S. Dallavalle, R. Silvestri, N. Westwood, M. Mori, C. Ingallina, B. Botta, E. Kavetsou, A. Detsi, Z. Majer, F. Hudecz, S. Bosze, B. Kaminska, T.V. Hansen, P. Bertrand, C. M. Athanassopoulos and G. Damia*
DOI: 10.2174/1386207321666180124093406
Determining Partition Coefficient (Log P), Distribution Coefficient (Log D) and Ionization Constant (pKa) in Early Drug Discovery
, 2016; 19(6): 461-469.Sonali S. Bharate, Vikas Kumar and Ram A. Vishwakarma
DOI: 10.2174/1386207319666160502123917
Efficacy and Toxicity of Addition of Bevacizumab to Chemotherapy in Patients with Metastatic Colorectal Cancer
, 2018; 21(10): 718-724.Wen-Cong Ruan, Yue-Ping Che, Li Ding and Hai-Feng Li*
DOI: 10.2174/1386207322666190119162352
Efficacy and Safety of Addition of Anti-PD1 to Chemotherapy in Treatment of Non-Small Cell Lung Cancer
, 2018; 21(10): 711-717.Chu-Hui Ru and Yan-Bing Zhuang*
DOI: 10.2174/1386207322666190125150921
A Network Integration Method for Deciphering the Types of Metabolic Pathway of Chemicals with Heterogeneous Information
, 2018; 21(9): 670-680.Zi-Han Guo, Lei Chen* and Xian Zhao
DOI: 10.2174/1386207322666181206112641
A Universal, Fully Automated High Throughput Screening Assay for Pyrophosphate and Phosphate Release from Enzymatic Reactions
, 2010; 13(1): 27-38.Scott D. Pegan, Yang Tian, Valerie Sershon and Andrew D. Mesecar
DOI: 10.2174/138620710790218203
Prediction of Drug Combinations with a Network Embedding Method
, 2018; 21(10): 789-797.Tianyun Wang, Lei Chen* and Xian Zhao
DOI: 10.2174/1386207322666181226170140
Serum α-1 Acid Glycoprotein is a Biomarker for the Prediction of Targeted Therapy Resistance in Advanced EGFR-positive Lung Adenocarcinoma
, 2018; 21(10): 755-759.Yu-Fen Xu, Yao Xu, Xia Li and Xin-Mei Yang*
DOI: 10.2174/1386207322666190119163024
Computational Method for the Identification of Molecular Metabolites Involved in Cereal Hull Color Variations
, 2018; 21(10): 760-770.Yunhua Zhang, Dong Dong, Dai Li, Lin Lu, JiaRui Li, YuHang Zhang and Lijuan Chen*
DOI: 10.2174/1386207322666190129105441
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Editor-in-Chief
Gerald H. Lushington
LiS Consulting, Lawrence
KS
USA
LiS Consulting, Lawrence
KS
USA
About the Journal
For Authors
For Librarians & Readers
Journal History
Combinatorial Chemistry & High Throughput Screening Journal was launched in 2000. Dr. Gerald H. Lushington serves as the Editor-in-Chief of the journal.
Webmaster Contact: info@benthamscience.net