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Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 23, 10 Issues, 2020
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access
Order Your Article Before PrintSubscribe to this Journal

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Aims & Scope

Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:

  • Target identification and validation
  • Assay design, development, miniaturization and comparison
  • High throughput/high content/in silico screening and associated technologies
  • Label-free detection technologies and applications
  • Stem cell technologies
  • Biomarkers
  • ADMET/PK/PD methodologies and screening
  • Probe discovery and development, hit to lead optimization
  • Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
  • Chemical library design and chemical diversity
  • Chemo/bio-informatics, data mining
  • Compound management
  • Pharmacognosy
  • Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products)
  • Natural Product Analytical Studies
  • Bipharmaceutical studies of Natural products
  • Drug repurposing
  • Data management and statistical analysis
  • Laboratory automation, robotics, microfluidics, signal detection technologies
  • Current & Future Institutional Research Profile
  • Technology transfer, legal and licensing issues
  • Patents

In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.

Combinatorial Chemistry & High Throughput Screening

,

Volume 23

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Number 5



Biography   Open Access



Research Article

Synthesis, Antitumor Activity and Molecular Docking Studies on Seven Novel Thiazacridine Derivatives

, 23(5): 359 - 368

Marcel L. Almeida, Douglas C.F. Viana , Valécia C.M. da Costa, Flaviana A. dos Santos, Michelly C. Pereira, Maira G.R. Pitta , Moacyr J.B. de Melo Rêgo, Ivan R. Pitta and Marina G.R. Pitta*


DOI: 10.2174/1386207323666200319105239


Research Article



Research Article



Research Article



Research Article



Research Article



Research Article

A Study on the Mechanism of Lavender in the Treatment of Insomnia Based on Network Pharmacology

, 23(5): 419 - 432

Yao Wang, Junbo Zou, Yanzhuo Jia, Yulin Liang, Xiaofei Zhang*, Chang-Li Wang, Xiao Wang*, Dongyan Guo, Yajun Shi and Ming Yang


DOI: 10.2174/1386207323666200401095008


Combinatorial Chemistry & High Throughput Screening, Volume 23 (2020) - Number 7


This issue is in progress but contains articles that are final and fully citable.

Combinatorial Chemistry & High Throughput Screening, Volume 23 (2020) - Number 6


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print







Effect of visnagin on altered steroidogenesis and spermatogenesis, and testicular injury induced by the heavy metal lead


Jamaan S. Ajarem, Ahmad K. Hegazy, Gamal A. Allam, Ahmed A. Allam, Saleh N. Maodaa and Ayman M. Mahmoud*


DOI: 10.2174/1386207323999200918124639
View Abstract


Anti-Respiratory Syncytial Virus Mechanism of Houttuynia cordata Thunb Exploration based on Network Pharmacology


Haitao Du, Jie Ding, Ping Wang, Guisheng Zhang, Dandan WANG*, Qingyun Ma*, Na Li and Tiefeng Sun*


DOI: 10.2174/1386207323999200918123631
View Abstract


Synthesis, characterization, antitubercular and anti-inflammatory activity of new pyrazolo[3,4-d]pyrimidines


Ravindra Kulkarni*, Krishna Kompalli, Naveen Gaddam, Chandrashekar V, Bikshupati Darna, Achaiah Garlapati, Dileep Kumar and Baswaraju Machha


DOI: 10.2174/1386207323999200918114905
View Abstract


Carbon Nano Tubes: Novel drug delivery system in amelioration of Alzheimer’s disease


Jayanti Mishra, Bhumika Kumar, Mukesh Pandey, Faheem Hyder Pottoo, Faizana Fayaz, Firdos Alam Khan and P.K. Sahoo*


DOI: 10.2174/1386207323999200918112538
View Abstract


Abstracts Ahead of Print

Acute inflammation and oxidative stress induced by lipopolysaccharide and the ameliorative effect of stingless bee honey


Yazan Ranneh*, Ayman M. Mahmoud*, Abdulmannan Fadel, Mohammed Albujja, Abdah Md Akim, Hasiah Ab. Hamid and Huzwah Khazaai


DOI: 10.2174/1386207323999200918152111
View Abstract


In-silico studies and Biological activity of potential BACE-1 Inhibitors


Richa Arya*, Sarvesh Paliwal, S.P Gupta, Swapnil Sharma, Kirtika Madan, Achal Mishra, Kanika Verma and Neha Chauhan


DOI: 10.2174/1386207323999200918151331
View Abstract


Published Contents

Editor's Choice

Synthesis, Antitumor Activity and Molecular Docking Studies on Seven Novel Thiazacridine Derivatives

, 2020; 23(5): 359 - 368

Marcel L. Almeida, Douglas C.F. Viana , Valécia C.M. da Costa, Flaviana A. dos Santos, Michelly C. Pereira, Maira G.R. Pitta , Moacyr J.B. de Melo Rêgo, Ivan R. Pitta and Marina G.R. Pitta*


DOI: 10.2174/1386207323666200319105239



Drug Target Group Prediction with Multiple Drug Networks

, 2020; 23(4): 274 - 284

Jingang Che, Lei Chen*, Zi-Han Guo, Shuaiqun Wang and Aorigele


DOI: 10.2174/1386207322666190702103927





Synthesis of 2-Substituted 4-Arylidene-5(4H)-oxazolones as Potential Cytotoxic Agents in the Presence of Lemon Juice as a Biocatalyst

, 2019; 22(9): 625 - 634

Malavattu G. Prasad, Chapala V. Lakshmi, Naresh K. Katari*, Krishnan Anand, Manojit Pal* and Sreekantha B. Jonnalagadda


DOI: 10.2174/1386207322666191024105150




Screening GLP-1 Receptor Ligands from Natural Products in Herbs through High-Content Technique

, 2019; 22(7): 445 - 454

Kunhao Qin, Shengting Zhang, Jie Wang, Dongbo Liu, Yingying Xiang, Xiuling Ji and Yunlin Wei*


DOI: 10.2174/1386207322666190919143735





Recognition of Lung Adenocarcinoma-specific Gene Pairs Based on Genetic Algorithm and Establishment of a Deep Learning Prediction Model

, 2019; 22(4): 256 - 265

Zhongwei Zhao, Xiaoxi Fan, Lili Yang, Jingjing Song, Shiji Fang, Jianfei Tu, Minjiang Chen, Jie Li, Liyun Zheng, Fazong Wu, Dengke Zhang, Xihui Ying and Jiansong Ji*


DOI: 10.2174/1386207322666190530102245



Open Access Articles

Network Pharmacology-based Investigation of the Underlying Mechanism of Panax notoginseng Treatment of Diabetic Retinopathy

, 2020; 23(4): 334 - 344

Chunli Piao*, Zheyu Sun, De Jin, Han Wang, Xuemin Wu, Naiwen Zhang, Fengmei Lian* and Xiaolin Tong*






Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development

, 2019; 22(6): 379 - 386

Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*




Effect of the Phragmitis Rhizoma Aqueous Extract on the Pharmacokinetics of Docetaxel in Rats

, 2019; 22(5): 326 - 332

Sarah Shin, No Soo Kim, Young Ah Kim, Hea Ry Oh and Ok-Sun Bang*







High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review

, 2016; 19(8): 605 - 615

Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*





Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library

, 2016; 19(4): 262 - 274

Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh G. Santos, Marc A. Giulianotti and Robert J. Deschenes*




Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP

, 2015; 18(1): 3 - 17

Arjan J. van Adrichem, Annika Fagerholm, Laura Turunen, Anna Lehto, Jani Saarela, Ari Koskinen, Gretchen A. Repasky and Krister Wennerberg*




Digital Holographic Microscopy: A Quantitative Label-Free Microscopy Technique for Phenotypic Screening

, 2014; 17(1): 80 - 88

Benjamin Rappaz, Billy Breton, Etienne Shaffer and Gerardo Turcatti*




Chemical Informatics and the Drug Discovery Knowledge Pyramid

, 2013; 16(10): 764 - 776

Gerald H. Lushington*, Yinghua Dong and Bhargav Theertham






Most Cited Articles

Research Article

Drug target group prediction with multiple drug networks

, 2020; 23(4): 274-284.

Jingang Che, Lei Chen*, Zi-Han Guo, Shuaiqun Wang and Aorigele


DOI: 10.2174/1386207322666190702103927


Review Article

Progress in molecularly imprinted polymers for biomedical applications

, 2019; 22(2): 78-88.

Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi and Alistair C. Cowie


DOI: 10.2174/1386207322666190325115526




Research Article

Green route for the removal of pb from aquatic environment

, 2020; 23(7): 587-598.

Ahmed Refaat*, Hanan Elhaes, Nabila S. Ammar, Hanan S. Ibrahim and Medhat Ibrahim


DOI: 10.2174/1386207323666200127123349




Research Article

Lignans and neolignans anti-tuberculosis identified by qsar and molecular modeling

, 2020; 23(6): 504-516.

Mayara S. Maia, Natália F. de Sousa, Gabriela C.S. Rodrigues, Alex F.M. Monteiro, Marcus T. Scotti and Luciana Scotti*


DOI: 10.2174/1386207323666200226094940



Research Article

New computational tool based on machine-learning algorithms for the identification of rhinovirus infection-related genes

, 2019; 22(10): 665-674.

Yan Xu, Yu-Hang Zhang, JiaRui Li, Xiao Y. Pan, Tao Huang* and Yu-Dong Cai*


DOI: 10.2174/1386207322666191129114741


Research Article

Identification of the active constituents and significant pathways of guizhi-shaoyao-zhimu decoction for the treatment of diabetes mellitus based on molecular docking and network pharmacology

, 2019; 22(9): 584-598.

Qing Zhang, Ruolan Li, Wei Peng, Mengmeng Zhang, Jia Liu, Shujun Wei, Jiaolong Wang, Chunjie Wu, Yongxiang Gao* and Xufeng Pu*


DOI: 10.2174/1386207322666191022101613




Research Article

Clustering and sampling of the c-met conformational space: a computational drug discovery study

, 2019; 22(9): 635-648.

Korosh Mashayekh, Shahrzad Sharifi, Tahereh Damghani, Maryam Elyasi, Mohammad S. Avestan and Somayeh Pirhadi*


DOI: 10.2174/1386207322666191024103902


Research Article

Same target, different therapeutic outcomes: The case of CAY10471 and fevipiprant on CRTh2 receptor in treatment of allergic rhinitis and asthma

, 2019; 22(8): 521-533.

Abdul R. Issahaku, Clement Agoni, Opeyemi S. Soremekun, Patrick A. Kubi, Ransford O. Kumi, Fisayo A. Olotu and Mahmoud E.S. Soliman*


DOI: 10.2174/1386207322666190919113006



Most Accessed Articles


Network Pharmacology-based Investigation of the Underlying Mechanism of Panax notoginseng Treatment of Diabetic Retinopathy

, 2020; 23(4): 334-344.

Chunli Piao*, Zheyu Sun, De Jin, Han Wang, Xuemin Wu, Naiwen Zhang, Fengmei Lian* and Xiaolin Tong*


DOI: 10.2174/1386207323666200305093709



Relating Substructures and Side Effects of Drugs with Chemical-chemical Interactions

, 2020; 23(4): 285-294.

Bo Zhou*, Xian Zhao, Jing Lu, Zuntao Sun, Min Liu, Yilu Zhou, Rongzhi Liu and Yihua Wang


DOI: 10.2174/1386207322666190702102752



A Systematic SAR Study of C10 Modified Paclitaxel Analogues Using a Combinatorial Approach

, 2002; 5(1): 39-48.

Yanbin Liu, Syed M. Ali, Thomas C. Boge, Gunda I. Georg, Samuel Victory, Jan Zygmunt, Rebecca T. Marquez and Richard H. Himes


DOI: 10.2174/1386207023330615


Effectiveness of Tolvaptan in the Treatment for Patients with Autosomal Dominant Polycystic Kidney Disease: A Meta-analysis

, 2020; 23(1): 6-16.

Xuan Xie, Qian Cai, Xiao-Yuan Guo, Dong-Hai Bai, Hai-Zhong Sheng, Bao-Kui Wang*, Kai Yan, An-Ming Lu and Xin-Ran Wang


DOI: 10.2174/1386207322666191203092715



Evaluation of Micro-RNA Levels, Apoptosis and Oxidative Stress Markers in Patients Recieving Chemotherapy

, 2020; 23(1): 17-27.

Idris Kirhan*, Fehmi Kas, Hüseyin Taskiran, Hakan Buyukhatipoglu, Ataman Gönel and Ismail Koyuncu


DOI: 10.2174/1386207323666191224111348



Editor-in-Chief

Gerald H. Lushington
LiS Consulting, Lawrence
KS
(USA)
Biography
View Full Editorial Board

Journal History

Combinatorial Chemistry & High Throughput Screening Journal was launched in 1998. Dr. Gerald H. Lushington serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 1.33

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