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"Combinatorial Chemistry & High Throughput Screening is a pivotal journal in the field of drug discovery."
Norman R. Farnsworth
University of Illinois at Chicago, USA
"Combinatorial Chemistry & High Throughput Screening is a pivotal journal in the field of drug discovery."
Norman R. Farnsworth
University of Illinois at Chicago, USA
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The Application of High-Throughput Technologies in Precision Diagnosis and Personalized TherapyGuest Editor(s): Tao Huang Download Description |
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Novel Bioinformatics and Systems Biology approaches and techniques in Pharmaceutical and Biochemical SciencesCombinatorial Chemistry & High Throughput Screening, Volume 21, Number 6 Guest Editor(s): Yudong Cai |
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I would like to greatly appreciate Bentham Science Publishers. They publish many good journals successfully. Bentham Science Publishers made our work easy and pleasant. They gave detailed information whenever required. It was a pleasure for me to work with Bentham Science Publishers. I would like to thank them for everything. Begum Evranos-Aksoz (Medicines and Medical Devices Agency, Analyses and Control Laboratories, Sıhhıye 06100, Ankara, Turkey) |
Combinatorial Chemistry & High Throughput Screening
,Volume 21
-Number 9
Biography Open Access
Meet Our Editorial Board Member
, 21(9): 615Juliano Smanioto Barin
DOI: 10.2174/138620732109190121154024
Meet Our Editorial Board Member
Review Article
Catalytic Conversion of Biorenewable Sugar Feedstocks into Market Chemicals
, 21(9): 616 - 630Gary Diamond, Alfred Hagemeyer*, Vince Murphy and Valery Sokolovskii
DOI: 10.2174/1386207322666181219155050
Catalytic Conversion of Biorenewable Sugar Feedstocks into Market Chemicals
Research Article
An Integrated Feature Selection Algorithm for Cancer Classification using Gene Expression Data
, 21(9): 631 - 645Saeed Ahmed*, Muhammad Kabir, Zakir Ali, Muhammad Arif, Farman Ali and Dong-Jun Yu
DOI: 10.2174/1386207322666181220124756
An Integrated Feature Selection Algorithm for Cancer Classification using Gene Expression Data
Research Article
A Novel, Fast and Efficient One-Pot Three-Component Procedure for the Preparation of New Imidazolidinone Derivatives from Isocyanide, Aldehyde and Urea
, 21(9): 646 - 651Hamidreza Safaei*, Neda Firoozi, Mahboobeh Zebarjadian, Seyed Ali Jehbez and Maryam Safaei
DOI: 10.2174/1386207322666181220123006
A Novel, Fast and Efficient One-Pot Three-Component Procedure for the Preparation of New Imidazolidinone Derivatives from Isocyanide, Aldehyde and Urea
Research Article
Prognostic Impact of Lymphadenectomy in Different Stages of Malignant Germ Cell Tumor of the Ovary Based on Propensity Score Matching
, 21(9): 652 - 661Ying Chen, Yang Ning, Qinghua Zhang and Ying Xie*
DOI: 10.2174/1386207322666181220121836
Prognostic Impact of Lymphadenectomy in Different Stages of Malignant Germ Cell Tumor of the Ovary Based on Propensity Score Matching
Research Article
In silico Prediction of Inhibitory Constant of Thrombin Inhibitors Using Machine Learning
, 21(9): 662 - 669Junnan Zhao, Lu Zhu, Weineng Zhou, Lingfeng Yin, Yuchen Wang, Yuanrong Fan, Yadong Chen* and Haichun Liu*
DOI: 10.2174/1386207322666181220130232
In silico Prediction of Inhibitory Constant of Thrombin Inhibitors Using Machine Learning
Research Article Open Access
A Network Integration Method for Deciphering the Types of Metabolic Pathway of Chemicals with Heterogeneous Information
, 21(9): 670 - 680Zi-Han Guo, Lei Chen* and Xian Zhao
DOI: 10.2174/1386207322666181206112641
A Network Integration Method for Deciphering the Types of Metabolic Pathway of Chemicals with Heterogeneous Information
Research Article
An Approach of Anomaly Detection and Neural Network Classifiers to Measure Cellulolytic Activity
, 21(9): 681 - 692Luis Francisco Barbosa-Santillán, María de los Angeles Calixto-Romo*, Juan Jaime Sánchez-Escobar and Liliana Ibeth Barbosa-Santillán
DOI: 10.2174/1386207322666181219160406
An Approach of Anomaly Detection and Neural Network Classifiers to Measure Cellulolytic Activity
Articles Ahead of Print
Computational Method for Identifying Malonylation Sites by Using Random Forest Algorithm
ShaoPeng Wang, JiaRui Li, Xijun Sun, Yu-Hang Zhang, Tao Huang* and Yudong Cai*
View Abstract View on PubMed
Prediction of Drug Combinations with a Network Embedding Method
Tianyun Wang, Lei Chen* and Xian Zhao
View Abstract
Computational Method for the Identification of Molecular Metabolites Involved in Cereal Hull Color Variations
Yunhua Zhang, Dong Dong, Dai Li, Lin Lu, JiaRui Li, YuHang Zhang and Lijuan Chen*
View Abstract View on PubMed
The Adverse Events Rate of Endothelial Progenitor Cell Capturing Stent in the Treatment of CAD Patients
Wei-Yuan Xu, Wei-Liang Tang, Min Yuan, Yong Sun, Feng Xu and Fang Peng*
View Abstract View on PubMed
Efficacy and Safety of Addition of Anti-PD1 to Chemotherapy in Treatment of Non-Small Cell Lung Cancer
Chu-Hui Ru and Yan-Bing Zhuang*
View Abstract View on PubMed
Using Naïve Bayes Algorithm to Estimate the Response to Drug in Lung Cancer Patients
Baoling Guo and Qiuxiang Zheng*
View Abstract View on PubMed
Integrative Analysis of Dysfunctional Modules Driven by Genomic Alterations at System Level Across 11 Cancer Types
Yin Wang, Zhenhao Liu, Baofeng Lian*, Lei Liu* and Lu Xie*
View Abstract View on PubMed
The Association of Vitamin D Receptor Gene Polymorphism with Lung Cancer Risk: An Update Meta-analysis
Zhi-Hong Yu, Miao Chen, Qing-Qian Zhang and Xun Hu*
View Abstract View on PubMed
Multiple-line Chemotherapy and Tyrosine Kinase Inhibitor Treatment in Patients with Advanced Lung Cancer
Hua Zhang, Jie Yang, Yan-ming Deng, Ning Zhao, Jian-miao Liang, Shuang Yang, Shun-da Zhang and Wei-neng Feng*
View Abstract View on PubMed
A Case Analysis on CT Guided Percutaneous Lung Puncture Biopsy of Lymphocyte Mesenchymal Pneumonia
Dan Zhu, Long Yu and Hui Chen*
View Abstract View on PubMed
Abstracts Ahead of Print
Network Pharmacology and Reverse Molecular Docking-Based Prediction of the Molecular Targets and Pathways for Avicularin against Cancer
Chaohui Duan, Yang Li , Xiaorui Dong, Weibin Xu and Yingli Ma *
View Abstract
Constructing Prediction Model of Lung Cancer Recurrence Risk Using Gene Function Clustering and Machine Learning
Jing Zhong, Jian-Ming Chen, Song-Lin Chen and Yun-Feng Yi*
View Abstract
Editor's Choice
Catalytic Conversion of Biorenewable Sugar Feedstocks into Market Chemicals
, 2018; 21(9): 616 - 630Gary Diamond, Alfred Hagemeyer*, Vince Murphy and Valery Sokolovskii
DOI: 10.2174/1386207322666181219155050
Prognostic Impact of Lymphadenectomy in Different Stages of Malignant Germ Cell Tumor of the Ovary Based on Propensity Score Matching
, 2018; 21(9): 652 - 661Ying Chen, Yang Ning, Qinghua Zhang and Ying Xie*
DOI: 10.2174/1386207322666181220121836
Synthesis of Novel α-amidino Carboxylic Acids and their Use as H-Bond Catalysts in Strecker Reaction
, 2018; 21(8): 609 - 614Zahra Zaghari and Javad Azizian*
DOI: 10.2174/1386207321666181114110039
Application of QSAR Analysis and Different Quantum Chemical Calculation Methods in Activity Evaluation of Selected Fluoroquinolones
, 2018; 21(7): 468 - 475Piotr Kawczak*, Leszek Bober and Tomasz Bączek
DOI: 10.2174/1386207321666180827105856
A Six-Gene Signature Predicts Clinical Outcome of Gastric Adenocarcinoma
, 2018; 21(6): 444 - 452YaQi Li, Qi Yu, Rui Zhu, Yi Wang, Jiarui Li, Qiang Wang, Wenna Guo, Shen Fu* and Liucun Zhu*
DOI: 10.2174/1871524918666180531085713
Assessing and Grouping Chemicals Applying Partial Ordering Alkyl Anilines as an Illustrative Example
, 2018; 21(5): 349 - 357Lars Carlsen* and Rainer Bruggemann
DOI: 10.2174/1386207321666180604103942
Phytochemical Screening, Antiproliferative and Antioxidant Properties of Various Extracts from Endemic Origanum acutidens
, 2018; 21(4): 281 - 291Feyza Oke-Altuntas, Mehmet Ali Demirci, Ibrahim Demirtas*, Ayse Sahin Yaglioglu and Lutfi Behcet
DOI: 10.2174/1386207321666180416154404
Extraction, Identification and Biological Activities of Saponins in Sea Cucumber Pearsonothuria graeffei
, 2018; 21(3): 222 - 231Rafat Afifi Khattab, Mohamed Elbandy, Andrew Lawrence, Tim Paget, Jung Rae-Rho, Yaser S. Binnaser and Imran Ali*
DOI: 10.2174/1386207321666180212165448
Chemometric Analysis for the Classification of some Groups of Drugs with Divergent Pharmacological Activity on the Basis of some Chromatographic and Molecular Modeling Parameters
, 2018; 21(2): 125 - 137Jolanta Stasiak, Marcin Koba*, Marcin Gackowski and Tomasz Baczek
DOI: 10.2174/1386207321666180129102149
A High-throughput Screening of a Chemical Compound Library in Ovarian Cancer Stem Cells
, 2018; 21(1): 50 - 56F. Ricci*, L. Carrassa, M. S. Christodoulou, D. Passarella, B. Michel, R. Benhida, N. Martinet, A. Hunyadi, E. Ioannou, V. Roussis, L. Musso, S. Dallavalle, R. Silvestri, N. Westwood, M. Mori, C. Ingallina, B. Botta, E. Kavetsou, A. Detsi, Z. Majer, F. Hudecz, S. Bosze, B. Kaminska, T.V. Hansen, P. Bertrand, C. M. Athanassopoulos and G. Damia*
DOI: 10.2174/1386207321666180124093406
Open Access Articles
A Network Integration Method for Deciphering the Types of Metabolic Pathway of Chemicals with Heterogeneous Information
, 2018; 21(9): 670 - 680Zi-Han Guo, Lei Chen* and Xian Zhao
Protein Sequence Comparison and DNA-binding Protein Identification with Generalized PseAAC and Graphical Representation
, 2018; 21(2): 100 - 110Chun Li*, Jialing Zhao, Changzhong Wang and Yuhua Yao
High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review
, 2016; 19(8): 605 - 615Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*
An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever
, 2016; 19(7): 516 - 536Chelsea N. Powers and William N. Setzer*
Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library
, 2016; 19(4): 262 - 274Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh G. Santos, Marc A. Giulianotti and Robert J. Deschenes*
Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP
, 2015; 18(1): 3 - 17Arjan J. van Adrichem, Annika Fagerholm, Laura Turunen, Anna Lehto, Jani Saarela, Ari Koskinen, Gretchen A. Repasky and Krister Wennerberg*
Digital Holographic Microscopy: A Quantitative Label-Free Microscopy Technique for Phenotypic Screening
, 2014; 17(1): 80 - 88Benjamin Rappaz, Billy Breton, Etienne Shaffer and Gerardo Turcatti*
Chemical Informatics and the Drug Discovery Knowledge Pyramid
, 2013; 16(10): 764 - 776Gerald H. Lushington*, Yinghua Dong and Bhargav Theertham
A Generalized Model and High Throughput Data Analysis System for Functional Modulation of Receptor-Agonist Systems Suitable for use in Drug Discovery
, 2013; 16(3): 199 - 209Aaron C. Pawlyk*, R. Kyle Palmer, Dennis Sprous and Chip Allee
A Simple Method for Analyzing Actives in Random RNAi Screens: Introducing the “H Score” for Hit Nomination & Gene Prioritization
, 2012; 15(9): 686 - 704Bhavneet Bhinder and Hakim Djaballah*
Application of NMR Metabolomics to Search for Human Disease Biomarkers
, 2012; 15(8): 595 - 610Teklab Gebregiworgis and Robert Powers*
Alternative Medicine Safety: Agaricus blazei and Propolis
, 2011; 14(7): 616 - 621Kenji Sorimachi* and Takaaki Nakamoto
The Design and Application of Target-Focused Compound Libraries
, 2011; 14(6): 521 - 531C. John Harris, Richard D. Hill, David W. Sheppard*, Martin J. Slater and Pieter F.W. Stouten
Two Panels of Steroid Receptor Luciferase Reporter Cell Lines for Compound Profiling
, 2011; 14(4): 248 - 266David Sedlak, Aileen Paguio and Petr Bartunek*
Building a Tiered Approach to In Vitro Predictive Toxicity Screening: A Focus on Assays with In Vivo Relevance
, 2010; 13(2): 188 - 206James M. McKim Jr.*
Most Cited Articles
Predicting the types of metabolic pathway of compounds using molecular fragments and sequential minimal optimization
, 2016; 19(2): 136-143.Lei Chen, Chen Chu and Kaiyan Feng
DOI: 10.2174/1386207319666151110122453
A novel machine learning method for cytokine-receptor interaction prediction
, 2016; 19(2): 144-152.Leyi Wei, Quan Zou, Minghong Liao, Huijuan Lu and Yuming Zhao
DOI: 10.2174/1386207319666151110122621
SAnDReS a Computational Tool for Statistical Analysis of Docking Results and Development of Scoring Functions
, 2016; 19(10): 801-812.Mariana Morrone Xavier, Gabriela Sehnem Heck, Mauricio Boff de Avila, Nayara Maria Bernhardt Levin, Val Oliveira Pintro, Nathalia Lemes Carvalho and Walter Filgueira de Azevedo
DOI: 10.2174/1386207319666160927111347
A Theoretical Study on Stepwise- and Concertedness of the Mechanism of 1,3-Dipolar Cycloaddition Reaction Between Tetra Amino Ethylene and Trifluoro Methyl Azide
, 2016; 19(2): 170-175.Seyyed Amir Siadati
DOI: 10.2174/1386207319666151216145408
Molecular Modeling and Virtual Screening Approach to Discover Potential Antileishmanial Inhibitors Against Ornithine Decarboxylase
, 2016; 19(10): 813-823.Rajan Kumar Pandey, Priyanka Prajapati, Sukriti Goyal, Abhinav Grover and Vijay Kumar Prajapati
DOI: 10.2174/1386207319666160907100134
δ-Cadinene,Calarene and δ-4-Carene from Kadsura heteroclita Essential Oil as Novel Larvicides Against Malaria, Dengue and Filariasis Mosquitoes
, 2016; 19(7): 565-571.Marimuthu Govindarajan, Mohan Rajeswary and Giovanni Benelli
DOI: 10.2174/1386207319666160506123520
Analysis of the relationship between PM2.5 and lung cancer based on protein-protein interactions
, 2016; 19(2): 100-108.Yang Shu, Liucun Zhu, Fei Yuan, Xiangyin Kong, Tao Huang and Yu-Dong Cai
DOI: 10.2174/1386207319666151110123345
Determining Partition Coefficient (Log P), Distribution Coefficient (Log D) and Ionization Constant (pKa) in Early Drug Discovery
, 2016; 19(6): 461-469.Sonali S. Bharate, Vikas Kumar and Ram A. Vishwakarma
DOI: 10.2174/1386207319666160502123917
An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever
, 2016; 19(7): 516-536.Chelsea N. Powers and William N. Setzer*
DOI: 10.2174/1386207319666160506123715
Analysis and Prediction of Myristoylation Sites Using the mRMR Method, the IFS Method and an Extreme Learning Machine Algorithm
, 2017; 20(2): 96-106.ShaoPeng Wang, Yu-Hang Zhang, GuoHua Huang, Lei Chen* and Yu-Dong Cai*
DOI: 10.2174/1386207319666161220114424
Most Accessed Articles
Synergistic Interplay of The Co-administration of Rifampin And Newly Developed Anti-TB Drug: Could It Be a Promising New Line of TB Therapy?
, 2018; 21(6): 453-460.Clement Agoni, Pritika Ramharack and Mahmoud E.S. Soliman*
DOI: 10.2174/1386207321666180716093617
Molecular Docking for Prediction and Interpretation of Adverse Drug Reactions
, 2018; 21(5): 314-322.Heng Luo, Achille Fokoue-Nkoutche, Nalini Singh, Lun Yang, Jianying Hu and Ping Zhang*
DOI: 10.2174/1386207321666180524110013
Prediction of Nitrated Tyrosine Residues in Protein Sequences by Extreme Learning Machine and Feature Selection Methods
, 2018; 21(6): 393-402.Lei Chen*, ShaoPeng Wang, Yu-Hang Zhang, Lai Wei, XianLing Xu, Tao Huang* and Yu-Dong Cai*
DOI: 10.2174/1386207321666180531091619
An Integrated Multi-Label Classifier with Chemical-Chemical Interactions for Prediction of Chemical Toxicity Effects
, 2018; 21(6): 403-410.Tao Liu , Lei Chen* and Xiaoyong Pan
DOI: 10.2174/1386207321666180601075428
Atom-based and Pharmacophore-based 3D – QSAR Studies on Vitamin D Receptor (VDR)
, 2018; 21(5): 329-343.Selvaraman Nagamani, Chandrasekhar Kesavan and Karthikeyan Muthusamy*
DOI: 10.2174/1386207321666180607101720
Determining Partition Coefficient (Log P), Distribution Coefficient (Log D) and Ionization Constant (pKa) in Early Drug Discovery
, 2016; 19(6): 461-469.Sonali S. Bharate, Vikas Kumar and Ram A. Vishwakarma
DOI: 10.2174/1386207319666160502123917
Dynamic Effects of Two-Time Delays on a Model for Tumor Growth
, 2018; 21(6): 431-443.Haihong Liu, Lina Guo, Fang Yan* and Linghai Zhang
DOI: 10.2174/1386207321666180619122913
Oscillatory Dynamics of P53 Network With Time Delays
, 2018; 21(6): 411-419.Conghua Wang, Fang Yan, Yuan Zhang, Haihong Liu* and Linghai Zhang
DOI: 10.2174/1386207321666180601080026
A Six-Gene Signature Predicts Clinical Outcome of Gastric Adenocarcinoma
, 2018; 21(6): 444-452.YaQi Li, Qi Yu, Rui Zhu, Yi Wang, Jiarui Li, Qiang Wang, Wenna Guo, Shen Fu* and Liucun Zhu*
DOI: 10.2174/1871524918666180531085713
A Simple and One-pot Synthesis of Tetrahydrobenzo[b]pyrans and Spirooxindoles Catalyzed by H-Fe3O4@DA-SO3H as an Efficient, Light and Reusable Nanocatalyst
, 2018; 21(7): 487-494.Marzie Sadat Mirhosseyni, Firouzeh Nemati* and Ali Elhampour
DOI: 10.2174/1386207321666180817142658
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