Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research
Volume 23, 10 Issues, 2020
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access
In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research
Aims & Scope
Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:
- Target identification and validation
- Assay design, development, miniaturization and comparison
- High throughput/high content/in silico screening and associated technologies
- Label-free detection technologies and applications
- Stem cell technologies
- Biomarkers
- ADMET/PK/PD methodologies and screening
- Probe discovery and development, hit to lead optimization
- Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
- Chemical library design and chemical diversity
- Chemo/bio-informatics, data mining
- Compound management
- Pharmacognosy
- Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products)
- Natural Product Analytical Studies
- Bipharmaceutical studies of Natural products
- Drug repurposing
- Data management and statistical analysis
- Laboratory automation, robotics, microfluidics, signal detection technologies
- Current & Future Institutional Research Profile
- Technology transfer, legal and licensing issues
- Patents
In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.
Combinatorial Chemistry & High Throughput Screening
,Volume 23
-Number 5
Biography Open Access
Meet Our Editorial Board Member
Research Article
Synthesis, Antitumor Activity and Molecular Docking Studies on Seven Novel Thiazacridine Derivatives
, 23(5): 359 - 368Marcel L. Almeida, Douglas C.F. Viana , Valécia C.M. da Costa, Flaviana A. dos Santos, Michelly C. Pereira, Maira G.R. Pitta , Moacyr J.B. de Melo Rêgo, Ivan R. Pitta and Marina G.R. Pitta*
DOI: 10.2174/1386207323666200319105239
Synthesis, Antitumor Activity and Molecular Docking Studies on Seven Novel Thiazacridine Derivatives
Research Article
Identification of Potential Biomarkers in Neonatal Sepsis by Establishing a Competitive Endogenous RNA Network
, 23(5): 369 - 380Ling Liu, Hong Wang, Xiaofei Zhang and Rui Chen*
DOI: 10.2174/1386207323666200401121204
Identification of Potential Biomarkers in Neonatal Sepsis by Establishing a Competitive Endogenous RNA Network
Research Article
Comprehensive Bioinformatics Analysis Identifies Tumor Microenvironment and Immune-related Genes in Small Cell Lung Cancer
, 23(5): 381 - 391Yongchun Song, Yanqin Sun, Tuanhe Sun and Ruixiang Tang*
DOI: 10.2174/1386207323666200407075004
Comprehensive Bioinformatics Analysis Identifies Tumor Microenvironment and Immune-related Genes in Small Cell Lung Cancer
Research Article
Synthesis, Spectroscopic, In-vitro and Computational Analysis of Hydrazones as Potential Antituberculosis Agents: (Part-I)
, 23(5): 392 - 401Bapu R. Thorat*, Deepa Rani, Ramesh S. Yamgar and Suraj N. Mali*
DOI: 10.2174/1386207323999200325125858
Synthesis, Spectroscopic, In-vitro and Computational Analysis of Hydrazones as Potential Antituberculosis Agents: (Part-I)
Research Article
Dendrobium officinalis Flower Improves Learning and Reduces Memory Impairment by Mediating Antioxidant Effect and Balancing the Release of Neurotransmitters in Senescent Rats
, 23(5): 402 - 410Lin-Zi Li, Shan-Shan Lei, Bo Li, Fu-Chen Zhou, Ye-Hui Chen, Jie Su, Gui-Yuan Lv* and Su-Hong Chen*
DOI: 10.2174/1386207323666200407080352
Dendrobium officinalis Flower Improves Learning and Reduces Memory Impairment by Mediating Antioxidant Effect and Balancing the Release of Neurotransmitters in Senescent Rats
Research Article
Screening and Interaction Analysis of Key Genes in miR-542-3p Over- Expressed Osteosarcoma Cells by Bioinformatics
, 23(5): 411 - 418Zhongqiu Li, Peng Zhang, Feifei Feng and Qiao Zhang*
DOI: 10.2174/1386207323666200401103353
Screening and Interaction Analysis of Key Genes in miR-542-3p Over- Expressed Osteosarcoma Cells by Bioinformatics
Research Article
A Study on the Mechanism of Lavender in the Treatment of Insomnia Based on Network Pharmacology
, 23(5): 419 - 432Yao Wang, Junbo Zou, Yanzhuo Jia, Yulin Liang, Xiaofei Zhang*, Chang-Li Wang, Xiao Wang*, Dongyan Guo, Yajun Shi and Ming Yang
DOI: 10.2174/1386207323666200401095008
A Study on the Mechanism of Lavender in the Treatment of Insomnia Based on Network Pharmacology
Combinatorial Chemistry & High Throughput Screening, Volume 23 (2020) - Number 7
This issue is in progress but contains articles that are final and fully citable.
Biography Open Access
Meet Our Editorial Board Member
Editorial Open Access
Doctoral Degree Surplus and Dwindling Quality: A Perilous Blend for Young Scientists in Tackling COVID-19 Like Pandemics
, 23(7): 564 - 565Deepak Sharma
DOI: 10.2174/138620732307200713115636
Doctoral Degree Surplus and Dwindling Quality: A Perilous Blend for Young Scientists in Tackling COVID-19 Like Pandemics
Editorial Open Access
Raman, Infrared and NMR Spectroscopy: Advances in Structural, Conformational and Environmental Analysis
, 23(7): 566 - 567Tarek A. Mohamed
DOI: 10.2174/138620732307200713120351
Raman, Infrared and NMR Spectroscopy: Advances in Structural, Conformational and Environmental Analysis
Research Article
Synthesis, Conformational Analysis, Infrared, Raman and UV-Visible Spectra of Novel Schiff Bases compiled with DFT Calculations
, 23(7): 568 - 586Samy M. Ahmed, Ibrahim A. Shaaban, Elsayed H. El-Mossalamy and Tarek A. Mohamed*
DOI: 10.2174/1386207323666200127161207
Synthesis, Conformational Analysis, Infrared, Raman and UV-Visible Spectra of Novel Schiff Bases compiled with DFT Calculations
Research Article
Green Route for the Removal of Pb from Aquatic Environment
, 23(7): 587 - 598Ahmed Refaat*, Hanan Elhaes, Nabila S. Ammar, Hanan S. Ibrahim and Medhat Ibrahim
DOI: 10.2174/1386207323666200127123349
Green Route for the Removal of Pb from Aquatic Environment
Research Article
The Significance of Buffer Solutions on Corrosion Processes of Cobalt Ferrite CoFe2O4 Thin Film on Different Substrates
, 23(7): 599 - 610Elsayed M. Elsayed, Hazem F. Khalil*, Ibrahim A. Ibrahim, Mostafa R. Hussein and Mohamed M.B. El-Sabbah
DOI: 10.2174/1386207323666191217130209
The Significance of Buffer Solutions on Corrosion Processes of Cobalt Ferrite CoFe2O4 Thin Film on Different Substrates
Research Article
New Platinum (II) Ternary Complexes of Formamidine and Pyrophosphate: Synthesis, Characterization and DFT Calculations and In vitro Cytotoxicity
, 23(7): 611 - 623Ahmed A. Soliman*, Fawzy A. Attaby, Othman I. Alajrawy, Azza A. A. Abou-hussein and Wolfgang Linert
DOI: 10.2174/1386207323666200218115700
New Platinum (II) Ternary Complexes of Formamidine and Pyrophosphate: Synthesis, Characterization and DFT Calculations and In vitro Cytotoxicity
General Review Article
Genus Arisaema: A Review of Traditional Importance, Chemistry and Biological Activities
, 23(7): 624 - 648Kamal Kant*, Uma Ranjan Lal, Ravi Rawat, Anoop Kumar and Manik Ghosh*
DOI: 10.2174/1386207323666200416150754
Genus Arisaema: A Review of Traditional Importance, Chemistry and Biological Activities
Combinatorial Chemistry & High Throughput Screening, Volume 23 (2020) - Number 6
This issue is in progress but contains articles that are final and fully citable.
Biography Open Access
Meet Our Editorial Board Member
Editorial Open Access
In Silico Methodologies Applied to Anti-infections Drug Discovery
, 23(6): 456 - 457Luciana Scotti and Marcus T. Scotti
DOI: 10.2174/138620732306200612101828
In Silico Methodologies Applied to Anti-infections Drug Discovery
Review Article
Recent Breakthroughs in Various Antimicrobial Resistance Induced Quorum Sensing Biosynthetic Pathway Mediated Targets and Design of their Inhibitors
, 23(6): 458 - 476Mohit Kumar, Mridula Saxena, Anil Kumar Saxena* and Sisir Nandi*
DOI: 10.2174/1386207323666200425205808
Recent Breakthroughs in Various Antimicrobial Resistance Induced Quorum Sensing Biosynthetic Pathway Mediated Targets and Design of their Inhibitors
Research Article
Macromolecular Targets of Antiparasitic Germacranolide Sesquiterpenoids: An In-Silico Investigation
, 23(6): 477 - 503Phillip M. Arnston and William N. Setzer*
DOI: 10.2174/1386207323666200218114759
Macromolecular Targets of Antiparasitic Germacranolide Sesquiterpenoids: An In-Silico Investigation
Research Article
Lignans and Neolignans Anti-tuberculosis Identified by QSAR and Molecular Modeling
, 23(6): 504 - 516Mayara S. Maia, Natália F. de Sousa, Gabriela C.S. Rodrigues, Alex F.M. Monteiro, Marcus T. Scotti and Luciana Scotti*
DOI: 10.2174/1386207323666200226094940
Lignans and Neolignans Anti-tuberculosis Identified by QSAR and Molecular Modeling
Research Article
Association of Virulence Genes with Antibiotic Resistance in Pakistani Uropathogenic E. coli Isolates
, 23(6): 517 - 524Khayam Ul Haq, Shazia Noreen, Sheikh A. Sehgal, Rana A. Tahir, Amjad Essa, Awais Ihsan, Mahreen ul Hassan, Waheed Iqbal, Masroor Hussain, Hamid Hussain and Sami Siraj*
DOI: 10.2174/1386207323666200402083234
Association of Virulence Genes with Antibiotic Resistance in Pakistani Uropathogenic E. coli Isolates
Editorial Open Access
Development and Application of Computational Methods in Biological and Medical Data
, 23(6): 525 - 526Hui Ding
DOI: 10.2174/138620732306200612105300
Development and Application of Computational Methods in Biological and Medical Data
Research Article
Identification of 2’-O-methylation site by Investigating Multi-feature Extracting Techniques
, 23(6): 527 - 535Qin-Lai Huang, Lida Wang, Shu-Guang Han* and Hua Tang*
DOI: 10.2174/1386207323666200425210609
Identification of 2’-O-methylation site by Investigating Multi-feature Extracting Techniques
Articles Ahead of Print
In silico modeling of small molecule carboxamides as inhibitors of SARS-CoV 3CL protease: An approach towards combating COVID-19
Pathan Mohsin Khan, Vinay Kumar and Kunal Roy*
DOI: 10.2174/1386207323666200914094712
View Abstract
G-Lymphatic, Vascular and Immune Pathways for Aβ Clearance Cascade and Therapeutic Targets For Alzheimer’s Disease
Saurav Chakraborty, Jyothsna ThimmaReddygari and Divakar Selvaraj*
DOI: 10.2174/1386207323666200901095003
View Abstract View on PubMed
Electrochemical Behavior and Square-Wave Stripping Voltammetric Determination of Roflumilast in Pharmaceutical Dosage Forms
Mustafa Celebier, Aysegul Dogan, İncilay Süslü* and Sacide Altınöz
DOI: 10.2174/1386207323666200901102526
View Abstract View on PubMed
Activated Carbon/MoO3: Efficient Catalyst for Green Synthesis of Chromeno[d]pyrimidinediones and Xanthenones
Niloofar Sabet Mehr, Shahrzad Abdolmohammadi* and Maryam Afsharpour
DOI: 10.2174/1386207323666200924111602
View Abstract
Moringa oleifera leaf extract attenuates Pb acetate-induced testicular damage in rats
Gadah Albasher*, Rola Alrajhi, Entesar Alshammry and Rafa Almeer
DOI: 10.2174/1386207323666200923142831
View Abstract
Screening and Identification of Differentially Expressed Genes Between Diabetic Nephropathy Glomerular and Normal Glomerular via Bioinformatics Technology
Junjie Du, Jihong Yang* and Lingbing Meng
DOI: 10.2174/1386207323999200821163314
View Abstract View on PubMed
Effect of visnagin on altered steroidogenesis and spermatogenesis, and testicular injury induced by the heavy metal lead
Jamaan S. Ajarem, Ahmad K. Hegazy, Gamal A. Allam, Ahmed A. Allam, Saleh N. Maodaa and Ayman M. Mahmoud*
DOI: 10.2174/1386207323999200918124639
View Abstract
Anti-Respiratory Syncytial Virus Mechanism of Houttuynia cordata Thunb Exploration based on Network Pharmacology
Haitao Du, Jie Ding, Ping Wang, Guisheng Zhang, Dandan WANG*, Qingyun Ma*, Na Li and Tiefeng Sun*
DOI: 10.2174/1386207323999200918123631
View Abstract
Synthesis, characterization, antitubercular and anti-inflammatory activity of new pyrazolo[3,4-d]pyrimidines
Ravindra Kulkarni*, Krishna Kompalli, Naveen Gaddam, Chandrashekar V, Bikshupati Darna, Achaiah Garlapati, Dileep Kumar and Baswaraju Machha
DOI: 10.2174/1386207323999200918114905
View Abstract
Carbon Nano Tubes: Novel drug delivery system in amelioration of Alzheimer’s disease
Jayanti Mishra, Bhumika Kumar, Mukesh Pandey, Faheem Hyder Pottoo, Faizana Fayaz, Firdos Alam Khan and P.K. Sahoo*
DOI: 10.2174/1386207323999200918112538
View Abstract
Abstracts Ahead of Print
Acute inflammation and oxidative stress induced by lipopolysaccharide and the ameliorative effect of stingless bee honey
Yazan Ranneh*, Ayman M. Mahmoud*, Abdulmannan Fadel, Mohammed Albujja, Abdah Md Akim, Hasiah Ab. Hamid and Huzwah Khazaai
DOI: 10.2174/1386207323999200918152111
View Abstract
In-silico studies and Biological activity of potential BACE-1 Inhibitors
Richa Arya*, Sarvesh Paliwal, S.P Gupta, Swapnil Sharma, Kirtika Madan, Achal Mishra, Kanika Verma and Neha Chauhan
DOI: 10.2174/1386207323999200918151331
View Abstract
Published Contents
- Combinatorial Chemistry & High Throughput Screening, Volume 23, 2020
- Combinatorial Chemistry & High Throughput Screening, Volume 22, 2019
- Combinatorial Chemistry & High Throughput Screening, Volume 21, 2018
- Combinatorial Chemistry & High Throughput Screening, Volume 20, 2017
- Combinatorial Chemistry & High Throughput Screening, Volume 19, 2016
- Combinatorial Chemistry & High Throughput Screening, Volume 18, 2015
- Combinatorial Chemistry & High Throughput Screening, Volume 17, 2014
- Combinatorial Chemistry & High Throughput Screening, Volume 16, 2013
- Combinatorial Chemistry & High Throughput Screening, Volume 15, 2012
- Combinatorial Chemistry & High Throughput Screening, Volume 14, 2011
- Combinatorial Chemistry & High Throughput Screening, Volume 13, 2010
- Combinatorial Chemistry & High Throughput Screening, Volume 12, 2009
- Combinatorial Chemistry & High Throughput Screening, Volume 11, 2008
- Combinatorial Chemistry & High Throughput Screening, Volume 10, 2007
- Combinatorial Chemistry & High Throughput Screening, Volume 9, 2006
- Combinatorial Chemistry & High Throughput Screening, Volume 8, 2005
- Combinatorial Chemistry & High Throughput Screening, Volume 7, 2004
- Combinatorial Chemistry & High Throughput Screening, Volume 6, 2003
- Combinatorial Chemistry & High Throughput Screening, Volume 5, 2002
- Combinatorial Chemistry & High Throughput Screening, Volume 4, 2001
- Combinatorial Chemistry & High Throughput Screening, Volume 3, 2000
Editor's Choice
Synthesis, Antitumor Activity and Molecular Docking Studies on Seven Novel Thiazacridine Derivatives
, 2020; 23(5): 359 - 368Marcel L. Almeida, Douglas C.F. Viana , Valécia C.M. da Costa, Flaviana A. dos Santos, Michelly C. Pereira, Maira G.R. Pitta , Moacyr J.B. de Melo Rêgo, Ivan R. Pitta and Marina G.R. Pitta*
DOI: 10.2174/1386207323666200319105239
Drug Target Group Prediction with Multiple Drug Networks
, 2020; 23(4): 274 - 284Jingang Che, Lei Chen*, Zi-Han Guo, Shuaiqun Wang and Aorigele
DOI: 10.2174/1386207322666190702103927
Design and Fabrication of a Magnetite-based Polymer-supported Hybrid Nanocomposite: A Promising Heterogeneous Catalytic System Utilized in Known Palladium-assisted Coupling Reactions
, 2020; 23(2): 119 - 125Ali Maleki*, Reza Taheri-Ledari and Reza Ghalavand
DOI: 10.2174/1386207323666200128152136
Network Pharmacology Analysis on Zhichan Powder in the Treatment of Parkinson's Disease
, 2020; 23(1): 28 - 40Jia Li, Xinchang Qi, Yajuan Sun, Yingyu Zhang and Jiajun Chen*
DOI: 10.2174/1386207323666200102124302
Synthesis of 2-Substituted 4-Arylidene-5(4H)-oxazolones as Potential Cytotoxic Agents in the Presence of Lemon Juice as a Biocatalyst
, 2019; 22(9): 625 - 634Malavattu G. Prasad, Chapala V. Lakshmi, Naresh K. Katari*, Krishnan Anand, Manojit Pal* and Sreekantha B. Jonnalagadda
DOI: 10.2174/1386207322666191024105150
New Amine and Aromatic Substituted Analogues of Phencyclidine: Synthesis and Determination of Acute and Chronic Pain Activities
, 2019; 22(8): 570 - 576Maryam Shokrollahi, Marjaneh Samadizadeh, Mohsen Khalili, Seyed A. Sobhanian and Abbas Ahmadi*
DOI: 10.2174/1386207322666191016152157
Screening GLP-1 Receptor Ligands from Natural Products in Herbs through High-Content Technique
, 2019; 22(7): 445 - 454Kunhao Qin, Shengting Zhang, Jie Wang, Dongbo Liu, Yingying Xiang, Xiuling Ji and Yunlin Wei*
DOI: 10.2174/1386207322666190919143735
Systematic Investigation of Quercetin for Treating Cardiovascular Disease Based on Network Pharmacology
, 2019; 22(6): 411 - 420Xian-Jun Wu, Xin-Bin Zhou, Chen Chen and Wei Mao *
DOI: 10.2174/1386207322666190717124507
Biochemometrics and Required Tools in Botanical Natural Products Research: A Review
, 2019; 22(5): 290 - 306Kevin M. Wyss, Graham C. Llivina and Angela I. Calderón*
DOI: 10.2174/1386207322666190704094003
Recognition of Lung Adenocarcinoma-specific Gene Pairs Based on Genetic Algorithm and Establishment of a Deep Learning Prediction Model
, 2019; 22(4): 256 - 265Zhongwei Zhao, Xiaoxi Fan, Lili Yang, Jingjing Song, Shiji Fang, Jianfei Tu, Minjiang Chen, Jie Li, Liyun Zheng, Fazong Wu, Dengke Zhang, Xihui Ying and Jiansong Ji*
DOI: 10.2174/1386207322666190530102245
Open Access Articles
Network Pharmacology-based Investigation of the Underlying Mechanism of Panax notoginseng Treatment of Diabetic Retinopathy
, 2020; 23(4): 334 - 344Chunli Piao*, Zheyu Sun, De Jin, Han Wang, Xuemin Wu, Naiwen Zhang, Fengmei Lian* and Xiaolin Tong*
An Investigation of the Mechanism of Rapid Relief of Ulcerative Colitis Induced by Five-flavor Sophora Flavescens Enteric-coated Capsules Based on Network Pharmacology
, 2020; 23(3): 239 - 252Sizhen Gu, Yan Xue, Yuli Zhang, Kanjun Chen, Shigui Xue, Ji Pan, Yini Tang, Hui Zhu, Huan Wu and Danbo Dou*
Potential of MurA Enzyme and GBAP in Fsr Quorum Sensing System as Antibacterial Drugs Target: In vitro and In silico Study of Antibacterial Compounds from Myrmecodia pendans
, 2020; 23: 1 - 10 (E-Pub Ahead of Print)Eti Apriyanti, Mieke H. Satari and Dikdik Kurnia*
Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development
, 2019; 22(6): 379 - 386Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*
Effect of the Phragmitis Rhizoma Aqueous Extract on the Pharmacokinetics of Docetaxel in Rats
, 2019; 22(5): 326 - 332Sarah Shin, No Soo Kim, Young Ah Kim, Hea Ry Oh and Ok-Sun Bang*
Integrative Analysis of Dysfunctional Modules Driven by Genomic Alterations at System Level Across 11 Cancer Types
, 2018; 21(10): 771 - 783Yin Wang, Zhenhao Liu, Baofeng Lian*, Lei Liu* and Lu Xie*
A Network Integration Method for Deciphering the Types of Metabolic Pathway of Chemicals with Heterogeneous Information
, 2018; 21(9): 670 - 680Zi-Han Guo, Lei Chen* and Xian Zhao
Protein Sequence Comparison and DNA-binding Protein Identification with Generalized PseAAC and Graphical Representation
, 2018; 21(2): 100 - 110Chun Li*, Jialing Zhao, Changzhong Wang and Yuhua Yao
High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review
, 2016; 19(8): 605 - 615Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*
An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever
, 2016; 19(7): 516 - 536Chelsea N. Powers and William N. Setzer*
Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library
, 2016; 19(4): 262 - 274Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh G. Santos, Marc A. Giulianotti and Robert J. Deschenes*
Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP
, 2015; 18(1): 3 - 17Arjan J. van Adrichem, Annika Fagerholm, Laura Turunen, Anna Lehto, Jani Saarela, Ari Koskinen, Gretchen A. Repasky and Krister Wennerberg*
Digital Holographic Microscopy: A Quantitative Label-Free Microscopy Technique for Phenotypic Screening
, 2014; 17(1): 80 - 88Benjamin Rappaz, Billy Breton, Etienne Shaffer and Gerardo Turcatti*
Chemical Informatics and the Drug Discovery Knowledge Pyramid
, 2013; 16(10): 764 - 776Gerald H. Lushington*, Yinghua Dong and Bhargav Theertham
A Generalized Model and High Throughput Data Analysis System for Functional Modulation of Receptor-Agonist Systems Suitable for use in Drug Discovery
, 2013; 16(3): 199 - 209Aaron C. Pawlyk*, R. Kyle Palmer, Dennis Sprous and Chip Allee
Most Cited Articles
Research Article
Drug target group prediction with multiple drug networks
, 2020; 23(4): 274-284.Jingang Che, Lei Chen*, Zi-Han Guo, Shuaiqun Wang and Aorigele
DOI: 10.2174/1386207322666190702103927
Review Article
Progress in molecularly imprinted polymers for biomedical applications
, 2019; 22(2): 78-88.Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi and Alistair C. Cowie
DOI: 10.2174/1386207322666190325115526
Research Article
Design and fabrication of a magnetite-based polymer-supported hybrid nanocomposite: A promising heterogeneous catalytic system utilized in known palladium-assisted coupling reactions
, 2020; 23(2): 119-125.Ali Maleki*, Reza Taheri-Ledari and Reza Ghalavand
DOI: 10.2174/1386207323666200128152136
Research Article
Systematic investigation of quercetin for treating cardiovascular disease based on network pharmacology
, 2019; 22(6): 411-420.Xian-Jun Wu, Xin-Bin Zhou, Chen Chen and Wei Mao *
DOI: 10.2174/1386207322666190717124507
Research Article
Green route for the removal of pb from aquatic environment
, 2020; 23(7): 587-598.Ahmed Refaat*, Hanan Elhaes, Nabila S. Ammar, Hanan S. Ibrahim and Medhat Ibrahim
DOI: 10.2174/1386207323666200127123349
Research Article
Expression and significance of Th17 cells and related factors in patients with autoimmune hepatitis
, 2019; 22(4): 232-237.Jihong An*
DOI: 10.2174/1386207322666190402160455
Research Article
The key microRNAs regulated the development of non-small cell lung cancer by targeting TGF-β-induced epithelial–mesenchymal transition
, 2019; 22(4): 238-244.Gang Chen and Bo Ye*
DOI: 10.2174/1386207322666190410151945
Research Article
Lignans and neolignans anti-tuberculosis identified by qsar and molecular modeling
, 2020; 23(6): 504-516.Mayara S. Maia, Natália F. de Sousa, Gabriela C.S. Rodrigues, Alex F.M. Monteiro, Marcus T. Scotti and Luciana Scotti*
DOI: 10.2174/1386207323666200226094940
Research Article
Three major phosphoacceptor sites in HIV-1 capsid protein enhances its structural stability and resistance against the inhibitor: Explication through molecular dynamics simulation, molecular docking and DFT analysis
, 2020; 23(1): 41-54.Nouman Rasool* and Waqar Hussain
DOI: 10.2174/1386207323666191213142223
Research Article
New computational tool based on machine-learning algorithms for the identification of rhinovirus infection-related genes
, 2019; 22(10): 665-674.Yan Xu, Yu-Hang Zhang, JiaRui Li, Xiao Y. Pan, Tao Huang* and Yu-Dong Cai*
DOI: 10.2174/1386207322666191129114741
Research Article
Identification of the active constituents and significant pathways of guizhi-shaoyao-zhimu decoction for the treatment of diabetes mellitus based on molecular docking and network pharmacology
, 2019; 22(9): 584-598.Qing Zhang, Ruolan Li, Wei Peng, Mengmeng Zhang, Jia Liu, Shujun Wei, Jiaolong Wang, Chunjie Wu, Yongxiang Gao* and Xufeng Pu*
DOI: 10.2174/1386207322666191022101613
Research Article
Effect of chinese herbal monomer hairy calycosin on nonalcoholic fatty liver rats and its mechanism
, 2019; 22(3): 194-200.Xiang Liu, Zhi-Hong Xie, Chen-Yuan Liu and Ying Zhang*
DOI: 10.2174/1386207322666190411112814
Meta-Analysis
Video-assisted thoracoscopic surgery versus thoracotomy for non-small cell lung cancer: A meta-analysis
, 2019; 22(3): 187-193.Bo Ye and Ming Wang*
DOI: 10.2174/1386207322666190415103030
Research Article
Clustering and sampling of the c-met conformational space: a computational drug discovery study
, 2019; 22(9): 635-648.Korosh Mashayekh, Shahrzad Sharifi, Tahereh Damghani, Maryam Elyasi, Mohammad S. Avestan and Somayeh Pirhadi*
DOI: 10.2174/1386207322666191024103902
Research Article
Same target, different therapeutic outcomes: The case of CAY10471 and fevipiprant on CRTh2 receptor in treatment of allergic rhinitis and asthma
, 2019; 22(8): 521-533.Abdul R. Issahaku, Clement Agoni, Opeyemi S. Soremekun, Patrick A. Kubi, Ransford O. Kumi, Fisayo A. Olotu and Mahmoud E.S. Soliman*
DOI: 10.2174/1386207322666190919113006
Most Accessed Articles
The Multicomponent Reactions and their Libraries for Natural and Preparative Chemistry
, 2001; 4(1): 1-34.I. Ugi and S. Heck
DOI: 10.2174/1386207013331291
Network Pharmacology-based Investigation of the Underlying Mechanism of Panax notoginseng Treatment of Diabetic Retinopathy
, 2020; 23(4): 334-344.Chunli Piao*, Zheyu Sun, De Jin, Han Wang, Xuemin Wu, Naiwen Zhang, Fengmei Lian* and Xiaolin Tong*
DOI: 10.2174/1386207323666200305093709
An Investigation of the Mechanism of Rapid Relief of Ulcerative Colitis Induced by Five-flavor Sophora Flavescens Enteric-coated Capsules Based on Network Pharmacology
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Editor-in-Chief
Gerald H. Lushington
LiS Consulting, Lawrence
KS
(USA)
Biography
LiS Consulting, Lawrence
KS
Biography
Biography of Gerald H. Lushington
Dr. Gerald Lushington received his Ph.D. in Chemistry from the University of New Brunswick. The author of 181 journal articles, nine book chapters and four patents, Lushington is currently Principal Consultant at LiS Consulting, and serves as Adjunct Professor of Food Nutrition Dietetic Health at Kansas State University. With more than 25 years experience in the application of molecular modeling, simulation and informatics to a diverse range of scientific applications, Lushington's primary areas of focus are in drug discovery and pharmacology.
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Journal History
Combinatorial Chemistry & High Throughput Screening Journal was launched in 1998. Dr. Gerald H. Lushington serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 1.33
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