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"Combinatorial Chemistry & High Throughput Screening is a pivotal journal in the field of drug discovery."
Norman R. Farnsworth
University of Illinois at Chicago, USA
"Combinatorial Chemistry & High Throughput Screening is a pivotal journal in the field of drug discovery."
Norman R. Farnsworth
University of Illinois at Chicago, USA
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The Application of High-Throughput Technologies in Precision Diagnosis and Personalized TherapyGuest Editor(s): Tao Huang Download Description |
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Novel Bioinformatics and Systems Biology approaches and techniques in Pharmaceutical and Biochemical SciencesCombinatorial Chemistry & High Throughput Screening, Volume 21, Number 6 Guest Editor(s): Yudong Cai |
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I would like to greatly appreciate Bentham Science Publishers. They publish many good journals successfully. Bentham Science Publishers made our work easy and pleasant. They gave detailed information whenever required. It was a pleasure for me to work with Bentham Science Publishers. I would like to thank them for everything. Begum Evranos-Aksoz (Medicines and Medical Devices Agency, Analyses and Control Laboratories, Sıhhıye 06100, Ankara, Turkey) |
Combinatorial Chemistry & High Throughput Screening
,Volume 21
-Number 6
Biography Open Access
Meet Our Editorial Board Member
Editorial Open Access
Novel Bioinformatics and Systems Biology approaches and techniques in Pharmaceutical and Biochemical Sciences
, 21(6): 391 - 392Yudong Cai*
DOI: 10.2174/138620732106180730112445
Novel Bioinformatics and Systems Biology approaches and techniques in Pharmaceutical and Biochemical Sciences
Research Article
Prediction of Nitrated Tyrosine Residues in Protein Sequences by Extreme Learning Machine and Feature Selection Methods
, 21(6): 393 - 402Lei Chen*, ShaoPeng Wang, Yu-Hang Zhang , Lai Wei , XianLing Xu, Tao Huang * and Yu-Dong Cai *
DOI: 10.2174/1386207321666180531091619
Prediction of Nitrated Tyrosine Residues in Protein Sequences by Extreme Learning Machine and Feature Selection Methods
Research Article
An Integrated Multi-Label Classifier with Chemical-Chemical Interactions for Prediction of Chemical Toxicity Effects
, 21(6): 403 - 410Tao Liu , Lei Chen* and Xiaoyong Pan
DOI: 10.2174/1386207321666180601075428
An Integrated Multi-Label Classifier with Chemical-Chemical Interactions for Prediction of Chemical Toxicity Effects
Research Article
Oscillatory Dynamics of P53 Network With Time Delays
, 21(6): 411 - 419Conghua Wang, Fang Yan, Yuan Zhang, Haihong Liu* and Linghai Zhang
DOI: 10.2174/1386207321666180601080026
Oscillatory Dynamics of P53 Network With Time Delays
Research Article
Hybrid Feature Selection Algorithm mRMR-ICA for Cancer Classification from Microarray Gene Expression Data
, 21(6): 420 - 430Shuaiqun Wang*, Wei Kong, Aorigele, Jin Deng, Shangce Gao and Weiming Zeng
DOI: 10.2174/1386207321666180601074349
Hybrid Feature Selection Algorithm mRMR-ICA for Cancer Classification from Microarray Gene Expression Data
Research Article
Dynamic Effects of Two-Time Delays on a Model for Tumor Growth
, 21(6): 431 - 443Haihong Liu, Lina Guo, Fang Yan* and Linghai Zhang
DOI: 10.2174/1386207321666180619122913
Dynamic Effects of Two-Time Delays on a Model for Tumor Growth
Research Article
A Six-Gene Signature Predicts Clinical Outcome of Gastric Adenocarcinoma
, 21(6): 444 - 452YaQi Li, Qi Yu, Rui Zhu, Yi Wang, Jiarui Li, Qiang Wang, Wenna Guo, Shen Fu* and Liucun Zhu*
DOI: 10.2174/1871524918666180531085713
A Six-Gene Signature Predicts Clinical Outcome of Gastric Adenocarcinoma
Articles Ahead of Print
Quantitative Structure- Property Relationship (QSPR) Investigation of Camptothecin Drugs Derivatives
Neda Ahmadinejad, Fatemeh Shafiei* and Tahereh Momeni Isfahani
View Abstract View on PubMed
Synthesis and Antifungal Activities of Drimane-Amide Derivatives from Sclareol
Miaofeng Ma, Jili Feng, Dezhi Wang, Shu-Wei Chen and Hui Xu*
View Abstract View on PubMed
Simultaneous Electrochemical Evaluation of Ascorbic Acid, Epinephrine and Uric Acid at Disposable Pencil Graphite Electrode: Highly Sensitive Determination in Pharmaceuticals and Biological Liquids by Differential Pulse Voltammetry
Abdulkadir Levent* and Gunay Onal
View Abstract View on PubMed
Synthesis and Characterization of a Novel Ionic Liquid Based on N,N,N,Ntetra Methyl Ethylene Diamine and its Application in the Synthesis of 1,8- dioxo-octahydro Xanthenes
Zahra Abdi Piralghar, Mohammad Mahmoodi Hashemi* and Ali Ezabadi
View Abstract View on PubMed
Structural Characterization of Gallbladder Stones Using Energy Dispersive X-ray Spectroscopy and X-ray Diffraction
Hassan A. Almarshad, Sayed M. Badawy* and Abdalkarem F. Alsharari
View Abstract View on PubMed
Serum Interleukin-33 as a Biomarker in Predicting Neonatal Sepsis in Premature Infants
Halit Halil*, Cuneyt Tayman, Mehmet Buyuktiryaki, Nilufer Okur, Ufuk Cakir and Utku Serkant
View Abstract View on PubMed
A Simple and One-pot Synthesis of Tetrahydrobenzo[b]pyrans and Spirooxindoles Catalyzed by H-Fe3O4@DA-SO3H as an Efficient, Light and Reusable Nanocatalyst
Marziye Sadat Mirhosseyni, Firouzeh Nemati* and Ali Elhampour
View Abstract View on PubMed
Application of QSAR Analysis and Different Quantum Chemical Calculation Methods in Activity Evaluation of Selected Fluoroquinolones
Piotr Kawczak*, Leszek Bober and Tomasz Baczek
View Abstract View on PubMed
Identification of Xanthine Derivatives as Inhibitors of Phosphodiesterase 9A Through In silico and Biological Studies
Nivedita Singh, Swagata Patra and Sanjukta Patra*
View Abstract View on PubMed
Controlled Growth and Characterization Ag/ZnO Nanotetrapods for Humidity Sensing
Babak Sadeghi*
View Abstract View on PubMed
Abstracts Ahead of Print
Synthesis of functionalized magnetite titanium dioxide nanocomposite for removal of Acid Fuchsine dye
Sara Rahnama, Shahab Shariati* and Fatan Divsar
View Abstract
Ischemia Modified Albumin: A Novel Systemic Indicator of Periodontal Tissue Damage
M. Ayse Tayman*, Canan Onder, Sivge Kurgan, Muhittin A. Serdar and Meral Gunhan
View Abstract
TiO2 NPs-Coated Carbone Nanotubes as a Green and Efficient Catalyst for the Synthesis of [1]Benzopyrano[b][1]benzopyranones and Xanthenols in Water
Shahrzad Abdolmohammadi*
View Abstract
Inexpensive Weight-Reducing Aid (L-Carnitine) as An Efficient Catalyst for Synthesis of Benzimidazoles
Min Zhang, Guoling Huang, Xuefang Zhang, Zhenyuan Lin, Yibiao Li, Bin Li and Lu Chen*
View Abstract
Development of an Information System of Structures and Force Field Parameters of Chemical Compounds from Sri Lankan Flora
Samith Rathnayake and Samantha Weerasinghe*
View Abstract
Neuroprotective effects of extracts from the radix Curcuma aromatic on H2O2-induced damage in PC12 cells
Juxiang Liu, Lianli Zhang, Dan Liu, Baocai Li and Mi Zhang *
View Abstract
Editor's Choice
A Six-Gene Signature Predicts Clinical Outcome of Gastric Adenocarcinoma
, 2018; 21(6): 444 - 452YaQi Li, Qi Yu, Rui Zhu, Yi Wang, Jiarui Li, Qiang Wang, Wenna Guo, Shen Fu* and Liucun Zhu*
DOI: 10.2174/1871524918666180531085713
Assessing and Grouping Chemicals Applying Partial Ordering Alkyl Anilines as an Illustrative Example
, 2018; 21(5): 349 - 357Lars Carlsen* and Rainer Bruggemann
DOI: 10.2174/1386207321666180604103942
Phytochemical Screening, Antiproliferative and Antioxidant Properties of Various Extracts from Endemic Origanum acutidens
, 2018; 21(4): 281 - 291Feyza Oke-Altuntas, Mehmet Ali Demirci, Ibrahim Demirtas*, Ayse Sahin Yaglioglu and Lutfi Behcet
DOI: 10.2174/1386207321666180416154404
Extraction, Identification and Biological Activities of Saponins in Sea Cucumber Pearsonothuria graeffei
, 2018; 21(3): 222 - 231Rafat Afifi Khattab, Mohamed Elbandy, Andrew Lawrence, Tim Paget, Jung Rae-Rho, Yaser S. Binnaser and Imran Ali*
DOI: 10.2174/1386207321666180212165448
Chemometric Analysis for the Classification of some Groups of Drugs with Divergent Pharmacological Activity on the Basis of some Chromatographic and Molecular Modeling Parameters
, 2018; 21(2): 125 - 137Jolanta Stasiak, Marcin Koba*, Marcin Gackowski and Tomasz Baczek
DOI: 10.2174/1386207321666180129102149
A High-throughput Screening of a Chemical Compound Library in Ovarian Cancer Stem Cells
, 2018; 21(1): 50 - 56F. Ricci*, L. Carrassa, M. S. Christodoulou, D. Passarella, B. Michel, R. Benhida, N. Martinet, A. Hunyadi, E. Ioannou, V. Roussis, L. Musso, S. Dallavalle, R. Silvestri, N. Westwood, M. Mori, C. Ingallina, B. Botta, E. Kavetsou, A. Detsi, Z. Majer, F. Hudecz, S. Bosze, B. Kaminska, T.V. Hansen, P. Bertrand, C. M. Athanassopoulos and G. Damia*
DOI: 10.2174/1386207321666180124093406
A Review of Computational Drug Repositioning Approaches
, 2017; 20(10): 831 - 838Guohua Huang*, Jincheng Li, Peng Wang and Weibiao Li
DOI: 10.2174/1386207321666171221112835
High Throughput Screening Assay to Identify Modulators of IL-17 Expression
, 2017; 20(9): 804 - 819Mohamed Boudjelal*, Ana Maria Ruiz-Avendano, Gonzalo Colmenarejo, Sergio A. Senar-Sancho, Ashley Barnes and Stephen A. Harrison*
DOI: 10.2174/1386207320666170602091308
Synthesis and Anticancer Evaluation of Thiazacridine Derivatives Reveals New Selective Molecules to Hematopoietic Neoplastic Cells
, 2017; 20(8): 713 - 718Moacyr J.B. de Melo Rego*, Wanessa l.b. de Sena, Ricardo O. de Moura, Iris T.T. Jacob, Thiago U. Lins e Lins, Michelly C. Pereira, Maria do Carmo A. Lima, Marina R. Galdino-Pitta, Ivan da R. Pitta and Maira G. da Rocha Pitta
DOI: 10.2174/1386207320666170724114802
The Safety of Ovarian Preservation in Stage I Endometrial Endometrioid Adenocarcinoma Based on Propensity Score Matching
, 2017; 20(7): 647 - 655Ting Hou, Yidi Sun, Junyi Li, Chenglin Liu, Zhen Wang, Yixue Li* and Yuan Lu*
DOI: 10.2174/1386207320666170417145856
Open Access Articles
Protein Sequence Comparison and DNA-binding Protein Identification with Generalized PseAAC and Graphical Representation
, 2018; 21(2): 100 - 110Chun Li*, Jialing Zhao, Changzhong Wang and Yuhua Yao
High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review
, 2016; 19(8): 605 - 615Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*
An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever
, 2016; 19(7): 516 - 536Chelsea N. Powers and William N. Setzer*
Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library
, 2016; 19(4): 262 - 274Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh G. Santos, Marc A. Giulianotti and Robert J. Deschenes*
Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP
, 2015; 18(1): 3 - 17Arjan J. van Adrichem, Annika Fagerholm, Laura Turunen, Anna Lehto, Jani Saarela, Ari Koskinen, Gretchen A. Repasky and Krister Wennerberg*
Digital Holographic Microscopy: A Quantitative Label-Free Microscopy Technique for Phenotypic Screening
, 2014; 17(1): 80 - 88Benjamin Rappaz, Billy Breton, Etienne Shaffer and Gerardo Turcatti*
Chemical Informatics and the Drug Discovery Knowledge Pyramid
, 2013; 16(10): 764 - 776Gerald H. Lushington*, Yinghua Dong and Bhargav Theertham
A Generalized Model and High Throughput Data Analysis System for Functional Modulation of Receptor-Agonist Systems Suitable for use in Drug Discovery
, 2013; 16(3): 199 - 209Aaron C. Pawlyk*, R. Kyle Palmer, Dennis Sprous and Chip Allee
A Simple Method for Analyzing Actives in Random RNAi Screens: Introducing the “H Score” for Hit Nomination & Gene Prioritization
, 2012; 15(9): 686 - 704Bhavneet Bhinder and Hakim Djaballah*
Application of NMR Metabolomics to Search for Human Disease Biomarkers
, 2012; 15(8): 595 - 610Teklab Gebregiworgis and Robert Powers*
Alternative Medicine Safety: Agaricus blazei and Propolis
, 2011; 14(7): 616 - 621Kenji Sorimachi* and Takaaki Nakamoto
The Design and Application of Target-Focused Compound Libraries
, 2011; 14(6): 521 - 531C. John Harris, Richard D. Hill, David W. Sheppard*, Martin J. Slater and Pieter F.W. Stouten
Two Panels of Steroid Receptor Luciferase Reporter Cell Lines for Compound Profiling
, 2011; 14(4): 248 - 266David Sedlak, Aileen Paguio and Petr Bartunek*
Building a Tiered Approach to In Vitro Predictive Toxicity Screening: A Focus on Assays with In Vivo Relevance
, 2010; 13(2): 188 - 206James M. McKim Jr.*
Generating ‘Omic Knowledge’: The Role of Informatics in High Content Screening
, 2009; 12(9): 917 - 925Mark A. Collins*
Most Cited Articles
Predicting the types of metabolic pathway of compounds using molecular fragments and sequential minimal optimization
, 2016; 19(2): 136-143.Lei Chen, Chen Chu and Kaiyan Feng
DOI: 10.2174/1386207319666151110122453
A novel machine learning method for cytokine-receptor interaction prediction
, 2016; 19(2): 144-152.Leyi Wei, Quan Zou, Minghong Liao, Huijuan Lu and Yuming Zhao
DOI: 10.2174/1386207319666151110122621
SAnDReS a Computational Tool for Statistical Analysis of Docking Results and Development of Scoring Functions
, 2016; 19(10): 801-812.Mariana Morrone Xavier, Gabriela Sehnem Heck, Mauricio Boff de Avila, Nayara Maria Bernhardt Levin, Val Oliveira Pintro, Nathalia Lemes Carvalho and Walter Filgueira de Azevedo
DOI: 10.2174/1386207319666160927111347
A Theoretical Study on Stepwise- and Concertedness of the Mechanism of 1,3-Dipolar Cycloaddition Reaction Between Tetra Amino Ethylene and Trifluoro Methyl Azide
, 2016; 19(2): 170-175.Seyyed Amir Siadati
DOI: 10.2174/1386207319666151216145408
Molecular Modeling and Virtual Screening Approach to Discover Potential Antileishmanial Inhibitors Against Ornithine Decarboxylase
, 2016; 19(10): 813-823.Rajan Kumar Pandey, Priyanka Prajapati, Sukriti Goyal, Abhinav Grover and Vijay Kumar Prajapati
DOI: 10.2174/1386207319666160907100134
δ-Cadinene,Calarene and δ-4-Carene from Kadsura heteroclita Essential Oil as Novel Larvicides Against Malaria, Dengue and Filariasis Mosquitoes
, 2016; 19(7): 565-571.Marimuthu Govindarajan, Mohan Rajeswary and Giovanni Benelli
DOI: 10.2174/1386207319666160506123520
Analysis of the relationship between PM2.5 and lung cancer based on protein-protein interactions
, 2016; 19(2): 100-108.Yang Shu, Liucun Zhu, Fei Yuan, Xiangyin Kong, Tao Huang and Yu-Dong Cai
DOI: 10.2174/1386207319666151110123345
Determining Partition Coefficient (Log P), Distribution Coefficient (Log D) and Ionization Constant (pKa) in Early Drug Discovery
, 2016; 19(6): 461-469.Sonali S. Bharate, Vikas Kumar and Ram A. Vishwakarma
DOI: 10.2174/1386207319666160502123917
An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever
, 2016; 19(7): 516-536.Chelsea N. Powers and William N. Setzer*
DOI: 10.2174/1386207319666160506123715
Analysis and Prediction of Myristoylation Sites Using the mRMR Method, the IFS Method and an Extreme Learning Machine Algorithm
, 2017; 20(2): 96-106.ShaoPeng Wang, Yu-Hang Zhang, GuoHua Huang, Lei Chen* and Yu-Dong Cai*
DOI: 10.2174/1386207319666161220114424
Most Accessed Articles
Molecular Docking for Prediction and Interpretation of Adverse Drug Reactions
, 2018; 21(5): 314-322.Heng Luo, Achille Fokoue-Nkoutche, Nalini Singh, Lun Yang, Jianying Hu and Ping Zhang*
DOI: 10.2174/1386207321666180524110013
A High-throughput Screening of a Chemical Compound Library in Ovarian Cancer Stem Cells
, 2018; 21(1): 50-56.F. Ricci*, L. Carrassa, M. S. Christodoulou, D. Passarella, B. Michel, R. Benhida, N. Martinet, A. Hunyadi, E. Ioannou, V. Roussis, L. Musso, S. Dallavalle, R. Silvestri, N. Westwood, M. Mori, C. Ingallina, B. Botta, E. Kavetsou, A. Detsi, Z. Majer, F. Hudecz, S. Bosze, B. Kaminska, T.V. Hansen, P. Bertrand, C. M. Athanassopoulos and G. Damia*
DOI: 10.2174/1386207321666180124093406
Efficient Isothermal Titration Calorimetry Technique Identifies Direct Interaction of Small Molecule Inhibitors with the Target Protein
, 2016; 19(1): 4-13.Maayan Gal, Itai Bloch, Nelia Shechter, Olga Romanenko and Ofer M. Shir
DOI: 10.2174/1386207319666151203001529
Prediction of Nitrated Tyrosine Residues in Protein Sequences by Extreme Learning Machine and Feature Selection Methods
, 2018; 21(6): 393-402.Lei Chen*, ShaoPeng Wang, Yu-Hang Zhang, Lai Wei, XianLing Xu, Tao Huang* and Yu-Dong Cai*
DOI: 10.2174/1386207321666180531091619
A Rapid Python-Based Methodology for Target-Focused Combinatorial Library Design
, 2016; 19(1): 25-35.Shiliang Li, Yuwei Song, Xiaofeng Liu and Honglin Li
DOI: 10.2174/1386207318666151102094055
Predictive and Descriptive CoMFA Models: The Effect of Variable Selection
, 2018; 21(2): 117-124.Bakhtyar Sepehri, Nematollah Omidikia, Mohsen Kompany-Zareh and Raouf Ghavami*
DOI: 10.2174/1386207321666180212162028
Phytochemical Screening, Antiproliferative and Antioxidant Properties of Various Extracts from Endemic Origanum acutidens
, 2018; 21(4): 281-291.Feyza Oke-Altuntas, Mehmet Ali Demirci, Ibrahim Demirtas*, Ayse Sahin Yaglioglu and Lutfi Behcet
DOI: 10.2174/1386207321666180416154404
Atom-based and Pharmacophore-based 3D – QSAR Studies on Vitamin D Receptor (VDR)
, 2018; 21(5): 329-343.Selvaraman Nagamani, Chandrasekhar Kesavan and Karthikeyan Muthusamy*
DOI: 10.2174/1386207321666180607101720
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