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Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 24, 10 Issues, 2021
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Aims & Scope

Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:

  • Target identification and validation
  • Assay design, development, miniaturization and comparison
  • High throughput/high content/in silico screening and associated technologies
  • Label-free detection technologies and applications
  • Stem cell technologies
  • Biomarkers
  • ADMET/PK/PD methodologies and screening
  • Probe discovery and development, hit to lead optimization
  • Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
  • Chemical library design and chemical diversity
  • Chemo/bio-informatics, data mining
  • Compound management
  • Pharmacognosy
  • Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products)
  • Natural Product Analytical Studies
  • Bipharmaceutical studies of Natural products
  • Drug repurposing
  • Data management and statistical analysis
  • Laboratory automation, robotics, microfluidics, signal detection technologies
  • Current & Future Institutional Research Profile
  • Technology transfer, legal and licensing issues
  • Patents

In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.

Combinatorial Chemistry & High Throughput Screening

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Volume 24

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Number 3



Editorial   Open Access

















Combinatorial Chemistry & High Throughput Screening, Volume 24 (2021) - Number 5


This issue is in progress but contains articles that are final and fully citable.

Combinatorial Chemistry & High Throughput Screening, Volume 24 (2021) - Number 4


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Nutraceuticals for Sleep Disorders


Ruhi Ali*, Sana Tariq, Ozaifa Kareem, Faizana Fayaz, Tahira Aziz, Meenu Dinesh, Faheem Hyder Pottoo and Nadeem Siddiqui


DOI: 10.2174/1386207324666210121111446
View Abstract View on PubMed








Herbal Medicine: Clinical Perspective & Regulatory Status


Md Abul Barkat*, Anjali Goyal, Harshita Abul Barkat, Mohammad Salauddin, Faheem Hyder Pottoo and Esra T. Anwer


DOI: 10.2174/1386207323999201110192942
View Abstract View on PubMed


Envisioning the Future of Nanomedicines in Management and Treatment of Neurological Disorders


Shobhit Kumar*, Priyanka Singh, Shrestha Sharma, Faheem Hyder Pottoo, Javed Ali and Sanjula Baboota


DOI: 10.2174/1386207323666201217151132
View Abstract View on PubMed


On m-polar Diophantine Fuzzy N-soft set with Applications


Jia-Bao Liu, Shahbaz Ali*, Muhammad Khalid Mahmood and Muhammad Haris Mateen


DOI: 10.2174/1386207323666201230092354
View Abstract View on PubMed


Abstracts Ahead of Print


DL-SMILES#: A Novel Encoding Scheme for Predicting Compound Protein Affinity by Deep Learning


Shudong Wang, Jiali Liu*, Mao Ding*, Yijun Gao*, Dayan Liu, Qingyu Tian and Jinfu Zhu


DOI: 10.2174/1386207324666210219102728
View Abstract


A Nanoinformatics Approach to Evaluate the Pharmacological Properties of Nanoparticles for the treatment of Alzheimer’s Disease


Muhammad Zohaib Nawaz*, Syed Awais Attique , Qurat-ul-Ain, Fahdah Ayed Alshammari , Heba Waheeb Alhamdi , Huda Ahmed Alghamdi * and Wei Yan*


DOI: 10.2174/1386207324666210217145733
View Abstract


The life cycle and in silico elucidation of non-structural replicating proteins of HCV through a pharmacoinformatics approach


Rana Adnan Tahir, Sumera Mughal, Amina Nazir, Asma Noureen, Ayesha Jawad, Muhammad Waqas and Sheikh Arslan Sehgal*


DOI: 10.2174/1386207324666210217144306
View Abstract


Graph Indices for Cartesian Product of F-sum of Connected Graphs


Jia-Bao Liu, Muhammad Imran*, Shakila Baby, Hafiz Muhammad Afzal Siddiqui and Muhammad Kashif Shafiq


DOI: 10.2174/1386207324666210217143114
View Abstract



Two Promising Anti-Cancer Compounds, 2-Hydroxycinnaldehyde and 2-Benzoyloxycinnamaldehyde: Where do we stand?


Haroon Iqbal, Farid Menaa*, Naveed Ullah Khan, Anam Razzaq, Zaheer Ullah Khan, Kifayat Ullah, Robia Kamal, Muhammad Sohail, Gobika Thiripuranathar, Bushra Uzair, Nosheen Fatima Rana, Barkat Ali Khan and Bouzid Menaa


DOI: 10.2174/1386207324666210216094428
View Abstract



Predicting drug-target affinity based on recurrent neural networks and graph convolutional neural networks


Qingyu Tian*, Mao Ding*, Hui Yang, Caibin Yue, Yue Zhong, Zhenzhen Du, Dayan Liu, Jiali Liu and Yufeng Deng


DOI: 10.2174/1386207324666210215101825
View Abstract


Anti-mycobacterial activity of 22 Iranian endemic or rare plant extracts against multi-drug and extensively drug resistant Mycobacterium tuberculosis


Sina Dehestani, Javid Davoodi, Seyed Ahmad Emami, Fereshteh Sadat Seddighinia, Amirhossein Sahebkar* and Saman Soleimanpour*


DOI: 10.2174/1386207324666210215100931
View Abstract


Published Contents

Editor's Choice





Rhodamine B - as New Chromophore for the Determination of Melatonin in Biological, Food, and Pharmaceutical Samples

, 2020; 23(10): 1080 - 1089

Alexandrina Lungu-Moscalu, Catalina C. Negut, Cristina Stefanov, Raluca-Ioana S. van Staden*, Andrei A. Bunaciu and Jacobus F. van Staden


DOI: 10.2174/1386207323666200628111958



Inhibition of Cyclooxygenase Enzyme by Bioflavonoids in Horsegram Seeds Alleviates Pain and Inflammation

, 2020; 23(9): 931 - 938

Malarvizhi Ramalingam, Veeresh K. Sali, Meenakshi Bhardwaj, Sugumar Mani and Hannah R. Vasanthi*


DOI: 10.2174/1386207323666200127114551





iSP-RAAC: Identify Secretory Proteins of Malaria Parasite Using Reduced Amino Acid Composition

, 2020; 23(6): 536 - 545

Haoyue Zhang, Qilemuge Xi, Shenghui Huang, Lei Zheng, Wuritu Yang* and Yongchun Zuo*


DOI: 10.2174/1386207323666200402084518



Synthesis, Antitumor Activity and Molecular Docking Studies on Seven Novel Thiazacridine Derivatives

, 2020; 23(5): 359 - 368

Marcel L. Almeida, Douglas C.F. Viana , Valécia C.M. da Costa, Flaviana A. dos Santos, Michelly C. Pereira, Maira G.R. Pitta , Moacyr J.B. de Melo Rêgo, Ivan R. Pitta and Marina G.R. Pitta*


DOI: 10.2174/1386207323666200319105239



Open Access Articles



Network Pharmacology-based Investigation of the Underlying Mechanism of Panax notoginseng Treatment of Diabetic Retinopathy

, 2020; 23(4): 334 - 344

Chunli Piao*, Zheyu Sun, De Jin, Han Wang, Xuemin Wu, Naiwen Zhang, Fengmei Lian* and Xiaolin Tong*





Analysis of Chinese Herbal Formulae Recommended for COVID-19 in Dif- ferent Schemes in China: A Data Mining Approach

, 2020; 23: 1 - 11 (E-Pub Ahead of Print)

LiWei Yin, YaCen Gao, ZiPing Li*, MengYu Wang and KaiXin Chen




Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development

, 2019; 22(6): 379 - 386

Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*




Effect of the Phragmitis Rhizoma Aqueous Extract on the Pharmacokinetics of Docetaxel in Rats

, 2019; 22(5): 326 - 332

Sarah Shin, No Soo Kim, Young Ah Kim, Hea Ry Oh and Ok-Sun Bang*







High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review

, 2016; 19(8): 605 - 615

Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*





Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library

, 2016; 19(4): 262 - 274

Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh G. Santos, Marc A. Giulianotti and Robert J. Deschenes*




Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP

, 2015; 18(1): 3 - 17

Arjan J. van Adrichem, Annika Fagerholm, Laura Turunen, Anna Lehto, Jani Saarela, Ari Koskinen, Gretchen A. Repasky and Krister Wennerberg*




Digital Holographic Microscopy: A Quantitative Label-Free Microscopy Technique for Phenotypic Screening

, 2014; 17(1): 80 - 88

Benjamin Rappaz, Billy Breton, Etienne Shaffer and Gerardo Turcatti*





Most Cited Articles


Research Article

Drug target group prediction with multiple drug networks

, 2020; 23(4): 274-284.

Jingang Che, Lei Chen*, Zi-Han Guo, Shuaiqun Wang and Aorigele


DOI: 10.2174/1386207322666190702103927



Research Article

Green route for the removal of pb from aquatic environment

, 2020; 23(7): 587-598.

Ahmed Refaat*, Hanan Elhaes, Nabila S. Ammar, Hanan S. Ibrahim and Medhat Ibrahim


DOI: 10.2174/1386207323666200127123349




Research Article

Lignans and neolignans anti-tuberculosis identified by qsar and molecular modeling

, 2020; 23(6): 504-516.

Mayara S. Maia, Natália F. de Sousa, Gabriela C.S. Rodrigues, Alex F.M. Monteiro, Marcus T. Scotti and Luciana Scotti*


DOI: 10.2174/1386207323666200226094940


Research Article

Inhibition of cyclooxygenase enzyme by bioflavonoids in horsegram seeds alleviates pain and inflammation

, 2020; 23(9): 931-938.

Malarvizhi Ramalingam, Veeresh K. Sali, Meenakshi Bhardwaj, Sugumar Mani and Hannah R. Vasanthi*


DOI: 10.2174/1386207323666200127114551


Research Article

ISP-RAAC: Identify secretory proteins of malaria parasite using reduced amino acid composition

, 2020; 23(6): 536-545.

Haoyue Zhang, Qilemuge Xi, Shenghui Huang, Lei Zheng, Wuritu Yang* and Yongchun Zuo*


DOI: 10.2174/1386207323666200402084518




Review Article

A comprehensive review of monoamine oxidase-a inhibitors in their syntheses and potencies

, 2020; 23(9): 898-914.

Nisha A. Rehuman, Bijo Mathew*, Rakesh K. Jat, Orazio Nicolotti and Hoon Kim*


DOI: 10.2174/1386207323666200428091306


Research Article

In vitro and in silico xanthine oxidase inhibitory activity of selected phytochemicals widely present in various edible plants

, 2020; 23(9): 917-930.

Arshad Mehmood, Ashfaq Ur Rehman, Muhammad Ishaq, Liang Zhao, Jiayi Li, Muhammad Usman, Lei Zhao*, Abdur Rehman, Oumeddour D. Zad and Chengtao Wang*


DOI: 10.2174/1386207323666200428075224





Most Accessed Articles

Computational Method for Identifying Malonylation Sites by Using Random Forest Algorithm

, 2020; 23(4): 304-312.

ShaoPeng Wang, JiaRui Li, Xijun Sun, Yu-Hang Zhang, Tao Huang* and Yudong Cai*


DOI: 10.2174/1386207322666181227144318



A Study on the Mechanism of Lavender in the Treatment of Insomnia Based on Network Pharmacology

, 2020; 23(5): 419-432.

Yao Wang, Junbo Zou, Yanzhuo Jia, Yulin Liang, Xiaofei Zhang*, Chang-Li Wang, Xiao Wang*, Dongyan Guo, Yajun Shi and Ming Yang


DOI: 10.2174/1386207323666200401095008



In vitro and in silico Xanthine Oxidase Inhibitory Activity of Selected Phytochemicals Widely Present in Various Edible Plants

, 2020; 23(9): 917-930.

Arshad Mehmood, Ashfaq Ur Rehman, Muhammad Ishaq, Liang Zhao, Jiayi Li, Muhammad Usman, Lei Zhao*, Abdur Rehman, Oumeddour D. Zad and Chengtao Wang*


DOI: 10.2174/1386207323666200428075224



Lignans and Neolignans Anti-tuberculosis Identified by QSAR and Molecular Modeling

, 2020; 23(6): 504-516.

Mayara S. Maia, Natália F. de Sousa, Gabriela C.S. Rodrigues, Alex F.M. Monteiro, Marcus T. Scotti and Luciana Scotti*


DOI: 10.2174/1386207323666200226094940











Editor-in-Chief

graphic
Gerald H. Lushington
LiS Consulting, Lawrence
KS
(USA)
Biography
View Full Editorial Board

COPE Compliant

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Journal History

Combinatorial Chemistry & High Throughput Screening Journal was launched in 1998. Dr. Gerald H. Lushington serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 1.33

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