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Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 24, 10 Issues, 2021
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access

Aims & Scope

Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:

  • Target identification and validation
  • Assay design, development, miniaturization and comparison
  • High throughput/high content/in silico screening and associated technologies
  • Label-free detection technologies and applications
  • Stem cell technologies
  • Biomarkers
  • ADMET/PK/PD methodologies and screening
  • Probe discovery and development, hit to lead optimization
  • Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
  • Chemical library design and chemical diversity
  • Chemo/bio-informatics, data mining
  • Compound management
  • Pharmacognosy
  • Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products)
  • Natural Product Analytical Studies
  • Bipharmaceutical studies of Natural products
  • Drug repurposing
  • Data management and statistical analysis
  • Laboratory automation, robotics, microfluidics, signal detection technologies
  • Current & Future Institutional Research Profile
  • Technology transfer, legal and licensing issues
  • Patents

In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.

Combinatorial Chemistry & High Throughput Screening

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Volume 24

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Number 5



Review Article

Cervical Cancer Diagnosis: Insights into Biochemical Biomarkers and Imaging Techniques

, 24(5): 605 - 623

Fatemeh Tavakoli, Sara Sadat Khatami, Fatemeh Momeni, Javid Azadbakht* and Faezeh Ghasemi*


DOI: 10.2174/1386207323666200901101955


Review Article

Ethnomedicinal uses, Phytochemistry and Pharmacological Aspects of the Genus Berberis Linn: A Comprehensive Review

, 24(5): 624 - 644

Roohi Mohi-ud-din, Reyaz Hassan Mir, Prince Ahad Mir, Saeema Farooq, Syed Naiem Raza, Weekar Younis Raja, Mubashir Hussain Masoodi, Inder Pal Singh and Zulfiqar Ali Bhat*


DOI: 10.2174/1386207323999201102141206




Research Article

13-lncRNAs Signature to Improve Diagnostic and Prognostic Prediction of Hepatocellular Carcinoma

, 24(5): 656 - 667

Xinxin Zhang, Jia Yu, Juan Hu, Fang Tan, Juan Zhou, Xiaoyan Yang, Zhizhong Xie, Huifang Tang, Sen Dong and Xiaoyong Lei*


DOI: 10.2174/1386207323666200914095616








Research Article   Open Access



Combinatorial Chemistry & High Throughput Screening, Volume 24 (2021) - Number 7


This issue is in progress but contains articles that are final and fully citable.

Combinatorial Chemistry & High Throughput Screening, Volume 24 (2021) - Number 6


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Rapid Identification of Commercial Frankincense Products by MALDITOF Mass Spectrometry


Shang-Chih Lai, Ren-In You, Tz-Ting Chen, Yu Chang, Chao-Zong Liu, Hao-Ping Chen* and Chunhung Wu*


DOI: 10.2174/1386207324666210301092111
View Abstract View on PubMed




Water Mapping and Scoring Approaches to Predict the Role of Hydration Sites in the Binding Affinity of PAK1 Inhibitors


Jayashree Biswal, Prajisha Jayaprakash, Suresh Kumar Rayala, Ganesh Venkatraman, Raghu Rangasamy, Saritha Poopandi and Jeyaraman Jeyakanthan*


DOI: 10.2174/1386207324666210308110646
View Abstract View on PubMed





Pouteria sapota (Red Mamey Fruit): Chemistry and Biological Activity of Carotenoids


Johant Lakey-Beitia, Velmarini Vasquez, Randy Mojica-Flores, Arelys L. Fuentes C., Enrique Murillo, Muralidhar L. Hedge and K.S. Rao*


DOI: 10.2174/1386207324666210301093711
View Abstract View on PubMed


Predicting Drug-Target Affinity Based on Recurrent Neural Networks and Graph Convolutional Neural Networks


Qingyu Tian*, Mao Ding*, Hui Yang, Caibin Yue, Yue Zhong, Zhenzhen Du, Dayan Liu, Jiali Liu and Yufeng Deng


DOI: 10.2174/1386207324666210215101825
View Abstract View on PubMed



Abstracts Ahead of Print



Current Application of Chemometrics Analysis in Authentication of Natural Products: A Review


Abdelkrim Rebiai, Hadia Hemmami, Soumeia Zeghoud, Bachir Ben Seghir*, Imane Kouadri, Laouini Salah Eddine, Noureddine Elboughdiri, Saad Ghareba, Djamel Ghernaout and Nadir Abbas


DOI: 10.2174/1386207324666210309102239
View Abstract




FEN1 status and its correlation with clinicopathologic characteristic in colorectal cancer


Yundi Guo*, Zixuan Du *, Yuanshuai Zhou, Haijun Sun, Rui Liang, Min-Xuan Sun, Zaixiang Tang and Song-Bai Liu


DOI: 10.2174/1386207324666210401113351
View Abstract


Combinatorial Synthesis of Novel 3/5(3,5)-(Di)nitro/chloropaeonol Carbonyl Hydrazone Derivatives as Nematicidal Agents


Genqiang Chen, Lina Zhu, Yanfei Xia, Song Zhang, Yuanhao Li, Xiaolong Guo, Di Sun, Jiaxuan He, Yuee Tian, Shengming Liu, Jia Jiang and Zhiping Che*


DOI: 10.2174/1386207324666210324145627
View Abstract





Published Contents

Editor's Choice

Cervical Cancer Diagnosis: Insights into Biochemical Biomarkers and Imaging Techniques

, 2021; 24(5): 605 - 623

Fatemeh Tavakoli, Sara Sadat Khatami, Fatemeh Momeni, Javid Azadbakht* and Faezeh Ghasemi*


DOI: 10.2174/1386207323666200901101955








Rhodamine B - as New Chromophore for the Determination of Melatonin in Biological, Food, and Pharmaceutical Samples

, 2020; 23(10): 1080 - 1089

Alexandrina Lungu-Moscalu, Catalina C. Negut, Cristina Stefanov, Raluca-Ioana S. van Staden*, Andrei A. Bunaciu and Jacobus F. van Staden


DOI: 10.2174/1386207323666200628111958



Inhibition of Cyclooxygenase Enzyme by Bioflavonoids in Horsegram Seeds Alleviates Pain and Inflammation

, 2020; 23(9): 931 - 938

Malarvizhi Ramalingam, Veeresh K. Sali, Meenakshi Bhardwaj, Sugumar Mani and Hannah R. Vasanthi*


DOI: 10.2174/1386207323666200127114551





Open Access Articles





Exploring miRNA-related Molecular Targets of Erchen Decoction Against Lipid Metabolism Disorder using A Network Pharmacologic Approach

, 2021; 24: 1 - 12 (E-Pub Ahead of Print)

Shanshan Ding, Qiliang Chen, Yiqing Huang, Xiaomei Li, Yujuan Chai, Candong Li and Tetsuya Asakawa*





Network Pharmacology-based Investigation of the Underlying Mechanism of Panax notoginseng Treatment of Diabetic Retinopathy

, 2020; 23(4): 334 - 344

Chunli Piao*, Zheyu Sun, De Jin, Han Wang, Xuemin Wu, Naiwen Zhang, Fengmei Lian* and Xiaolin Tong*





Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development

, 2019; 22(6): 379 - 386

Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*




Effect of the Phragmitis Rhizoma Aqueous Extract on the Pharmacokinetics of Docetaxel in Rats

, 2019; 22(5): 326 - 332

Sarah Shin, No Soo Kim, Young Ah Kim, Hea Ry Oh and Ok-Sun Bang*







High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review

, 2016; 19(8): 605 - 615

Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*






Most Cited Articles


Research Article

Drug target group prediction with multiple drug networks

, 2020; 23(4): 274-284.

Jingang Che, Lei Chen*, Zi-Han Guo, Shuaiqun Wang and Aorigele


DOI: 10.2174/1386207322666190702103927



Research Article

Green route for the removal of pb from aquatic environment

, 2020; 23(7): 587-598.

Ahmed Refaat*, Hanan Elhaes, Nabila S. Ammar, Hanan S. Ibrahim and Medhat Ibrahim


DOI: 10.2174/1386207323666200127123349




Research Article

The use of texture features to extract and analyze useful information from retinal images

, 2020; 23(4): 313-318.

Xiaobo Zhang, Weiyang Chen*, Gang Li* and Weiwei Li


DOI: 10.2174/1386207322666191022123445



Research Article

Lignans and neolignans anti-tuberculosis identified by qsar and molecular modeling

, 2020; 23(6): 504-516.

Mayara S. Maia, Natália F. de Sousa, Gabriela C.S. Rodrigues, Alex F.M. Monteiro, Marcus T. Scotti and Luciana Scotti*


DOI: 10.2174/1386207323666200226094940





General Research Article

Discovery of potent sars-cov-2 inhibitors from approved antiviral drugs via docking and virtual screening

, 2021; 24(3): 441-454.

Samir Chtita *, Assia Belhassan, Adnane Aouidate, Salah Belaidi, Mohammed Bouachrine and Tahar Lakhlifi


DOI: 10.2174/1386207323999200730205447



Research Article

Inhibition of cyclooxygenase enzyme by bioflavonoids in horsegram seeds alleviates pain and inflammation

, 2020; 23(9): 931-938.

Malarvizhi Ramalingam, Veeresh K. Sali, Meenakshi Bhardwaj, Sugumar Mani and Hannah R. Vasanthi*


DOI: 10.2174/1386207323666200127114551



Most Accessed Articles

Computational Method for Identifying Malonylation Sites by Using Random Forest Algorithm

, 2020; 23(4): 304-312.

ShaoPeng Wang, JiaRui Li, Xijun Sun, Yu-Hang Zhang, Tao Huang* and Yudong Cai*


DOI: 10.2174/1386207322666181227144318


A Study on the Mechanism of Lavender in the Treatment of Insomnia Based on Network Pharmacology

, 2020; 23(5): 419-432.

Yao Wang, Junbo Zou, Yanzhuo Jia, Yulin Liang, Xiaofei Zhang*, Chang-Li Wang, Xiao Wang*, Dongyan Guo, Yajun Shi and Ming Yang


DOI: 10.2174/1386207323666200401095008




In vitro and in silico Xanthine Oxidase Inhibitory Activity of Selected Phytochemicals Widely Present in Various Edible Plants

, 2020; 23(9): 917-930.

Arshad Mehmood, Ashfaq Ur Rehman, Muhammad Ishaq, Liang Zhao, Jiayi Li, Muhammad Usman, Lei Zhao*, Abdur Rehman, Oumeddour D. Zad and Chengtao Wang*


DOI: 10.2174/1386207323666200428075224


Discovery of Potent SARS-CoV-2 Inhibitors from Approved Antiviral Drugs via Docking and Virtual Screening

, 2021; 24(3): 441-454.

Samir Chtita *, Assia Belhassan, Adnane Aouidate, Salah Belaidi, Mohammed Bouachrine and Tahar Lakhlifi


DOI: 10.2174/1386207323999200730205447













Editor-in-Chief

graphic
Gerald H. Lushington
LiS Consulting, Lawrence
KS
(USA)
Biography
View Full Editorial Board

COPE Compliant

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Journal History

Combinatorial Chemistry & High Throughput Screening Journal was launched in 1998. Dr. Gerald H. Lushington serves as the Editor-in-Chief of the journal.

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