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Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 22, 10 Issues, 2019
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access

Ranking and Category

  • 67th of 79 in

    Biochemical Research Methods

  • 39th of 71 in

    Chemistry, Applied

  • 220th of 267 in

    Pharmacology & Pharmacy

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Aims & Scope

Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:

  • Target identification and validation
  • Assay design, development, miniaturization and comparison
  • High throughput/high content/in silico screening and associated technologies
  • Label-free detection technologies and applications
  • Stem cell technologies
  • Biomarkers
  • ADMET/PK/PD methodologies and screening
  • Probe discovery and development, hit to lead optimization
  • Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
  • Chemical library design and chemical diversity
  • Chemo/bio-informatics, data mining
  • Compound management
  • Pharmacognosy
  • Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products)
  • Natural Product Analytical Studies
  • Bipharmaceutical studies of Natural products
  • Drug repurposing
  • Data management and statistical analysis
  • Laboratory automation, robotics, microfluidics, signal detection technologies
  • Current & Future Institutional Research Profile
  • Technology transfer, legal and licensing issues
  • Patents

In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.

Combinatorial Chemistry & High Throughput Screening

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Volume 22

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Number 2



Biography   Open Access



Review Article



Research Article



Research Article



Research Article

Reynoutria Japonica from Traditional Chinese Medicine: A Source of Competitive Adenosine Deaminase Inhibitors for Anticancer

, 22(2): 113 - 122

Xin-guo Zhang*, Guo-Yan Ma, Fei Kou, Wen-Jie Liu, Qiao-Yun Sun, Guang-Jun Guo, Xiao-Di Ma, Si-Jia Guo and Zhu Jian-Ning


DOI: 10.2174/1386207322666190415100618


Research Article



Research Article



Research Article



Articles Ahead of Print



In Silico Molecular Docking, Synthesis of 4-(4-benzoylaminophenoxy) Phenol Derivatives as Androgen Receptor Antagonists


Ramakrishnan Elancheran*, Senthamaraikannan Kabilan*, Jibon Kotoky, Muthiah Ramanathan and Atanu Bhattacharjee


DOI: 10.2174/1386207322666190701124752
View Abstract




Relating Substructures and Side Effects of Drugs with Chemical-Chemical Interactions


Bo Zhou*, Xian Zhao, Jing Lu, Zuntao Sun, Min Liu, Yilu Zhou, Rongzhi Liu and Yihua Wang


DOI: 10.2174/1386207322666190702102752
View Abstract




Recognition of Lung Adenocarcinoma-specific Gene Pairs Based on Genetic Algorithm and Establishment of a Deep Learning Prediction Model


Zhongwei Zhao, Xiaoxi Fan, Lili Yang, Jingjing Song, Shiji Fang, Jianfei Tu, Minjiang Chen, Liyun Zheng, Fazong Wu, Dengke Zhang, Ying Xihui and Jiansong Ji*


DOI: 10.2174/1386207322666190530102245
View Abstract View on PubMed



Published Contents

Editor's Choice

Progress in Molecularly Imprinted Polymers for Biomedical Applications

, 2019; 22(2): 78 - 88

Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi and Alistair C. Cowie


DOI: 10.2174/1386207322666190325115526




Maxillary Metastasis of Esophageal Cancer: Report of the First Case and Literature Review

, 2018; 21(10): 801 - 805

Hong Hu, Jing Wang, Xiao-Yun Zhou, Meng-Ting Tong, Chong-Ya Zhai, Xin-Bing Sui, Yan-Hua Zhang, Xiao-Xi Xie, Hao Liu, Jian-Sheng Xie, Hong-Ming Pan* and Da Li*


DOI: 10.2174/1386207322666190103105938



Catalytic Conversion of Biorenewable Sugar Feedstocks into Market Chemicals

, 2018; 21(9): 616 - 630

Gary Diamond, Alfred Hagemeyer*, Vince Murphy and Valery Sokolovskii


DOI: 10.2174/1386207322666181219155050






A Six-Gene Signature Predicts Clinical Outcome of Gastric Adenocarcinoma

, 2018; 21(6): 444 - 452

YaQi Li, Qi Yu, Rui Zhu, Yi Wang, Jiarui Li, Qiang Wang, Wenna Guo, Shen Fu* and Liucun Zhu*


DOI: 10.2174/1871524918666180531085713




Phytochemical Screening, Antiproliferative and Antioxidant Properties of Various Extracts from Endemic Origanum acutidens

, 2018; 21(4): 281 - 291

Feyza Oke-Altuntas, Mehmet Ali Demirci, Ibrahim Demirtas*, Ayse Sahin Yaglioglu and Lutfi Behcet


DOI: 10.2174/1386207321666180416154404



Open Access Articles

Effect of the Phragmitis Rhizoma Aqueous Extract on the Pharmacokinetics of Docetaxel in Rats

, 2019; 22: 1 - 7 (E-Pub Ahead of Print)

Sarah Shin, No Soo Kim, Young Ah Kim, Hea Ry Oh and Ok-Sun Bang*







High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review

, 2016; 19(8): 605 - 615

Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*





Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library

, 2016; 19(4): 262 - 274

Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh G. Santos, Marc A. Giulianotti and Robert J. Deschenes*




Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP

, 2015; 18(1): 3 - 17

Arjan J. van Adrichem, Annika Fagerholm, Laura Turunen, Anna Lehto, Jani Saarela, Ari Koskinen, Gretchen A. Repasky and Krister Wennerberg*




Digital Holographic Microscopy: A Quantitative Label-Free Microscopy Technique for Phenotypic Screening

, 2014; 17(1): 80 - 88

Benjamin Rappaz, Billy Breton, Etienne Shaffer and Gerardo Turcatti*




Chemical Informatics and the Drug Discovery Knowledge Pyramid

, 2013; 16(10): 764 - 776

Gerald H. Lushington*, Yinghua Dong and Bhargav Theertham







Alternative Medicine Safety: Agaricus blazei and Propolis

, 2011; 14(7): 616 - 621

Kenji Sorimachi* and Takaaki Nakamoto




The Design and Application of Target-Focused Compound Libraries

, 2011; 14(6): 521 - 531

C. John Harris, Richard D. Hill, David W. Sheppard*, Martin J. Slater and Pieter F.W. Stouten





Most Cited Articles

Research Article

Prediction of nitrated tyrosine residues in protein sequences by extreme learning machine and feature selection methods

, 2018; 21(6): 393-402.

Lei Chen*, ShaoPeng Wang, Yu-Hang Zhang , Lai Wei , XianLing Xu, Tao Huang * and Yu-Dong Cai *


DOI: 10.2174/1386207321666180531091619





Research Article

One-pot synthesis of novel 2-pyrazolo-3-phenyl-1,3-thiazolidine-4-ones using DSDABCOC as an effective media

, 1 January 2018; 21(1): 5-13.

Mostafa Fathollahi, Shahnaz Rostamizadeh* and Ali M. Amani


DOI: 10.2174/138620732166618012409405




Research Article

Prediction of drug combinations with a network embedding method

, 2018; 21(10): 789-797.

Tianyun Wang, Lei Chen* and Xian Zhao


DOI: 10.2174/1386207322666181226170140



Research Article

Hybrid feature selection algorithm mRMR-ICA for cancer classification from microarray gene expression data

, 2018; 21(6): 420-430.

Shuaiqun Wang*, Wei Kong, Aorigele, Jin Deng, Shangce Gao and Weiming Zeng


DOI: 10.2174/1386207321666180601074349


Research Article

Identification of human acetylcholinesterase inhibitors from the constituents of EGb761 by modeling docking and molecular dynamics simulations

, 1 January 2018; 21(1): 41-49.

Lihu Zhang, Dongdong Li, Fuliang Cao, Wei Xiao*, Linguo Zhao*, Gang Ding and Zhen zhong Wang


DOI: 10.2174/1386207320666171123201910


Research Article

Virtual screening of novel glucosamine-6-phosphate synthase inhibitors

, 2018; 21(3): 182-193.

Amit Lather, Sunil Sharma and Anurag Khatkar*


DOI: 10.2174/1386207321666180330114457




Case Report

Maxillary metastasis of esophageal cancer: Report of the first case and literature review

, 2018; 21(10): 801-805.

Hong Hu, Jing Wang, Xiao-Yun Zhou, Meng-Ting Tong, Chong-Ya Zhai, Xin-Bing Sui, Yan-Hua Zhang, Xiao-Xi Xie, Hao Liu, Jian-Sheng Xie, Hong-Ming Pan* and Da Li*


DOI: 10.2174/1386207322666190103105938



Most Accessed Articles



Clinical Characteristics and Antibiotic Resistance of Mycoplasma Pneumoniae Pneumonia in Hospitalized Chinese Children

, 2018; 21(10): 749-754.

Chen Yuan, Fang-Mei Min, Yin-Jie Ling, Gang Li, Hong-Zhou Ye, Jia-Hui Pan, Ling Wang and Yan-Ping Xie*


DOI: 10.2174/1386207322666190111112946




Ultrastructural Analysis of Human Gallstones using Synchrotron Radiation µCT

, 2019; 22(1): 13-17.

Weixin Chen, Riming Liu, Suo Tao, Weixing Shen, Weihong Zhou, Chao Song, Huanhua Lu and Chungen Xing*


DOI: 10.2174/1386207322666190222122007








Editor-in-Chief

Gerald H. Lushington
LiS Consulting, Lawrence
KS
USA

Biography View Full Editorial Board

Journal History

Combinatorial Chemistry & High Throughput Screening Journal was launched in 1998. Dr. Gerald H. Lushington serves as the Editor-in-Chief of the journal.
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