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Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 23, 10 Issues, 2020
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access

Ranking and Category

  • 67th of 79 in

    Biochemical Research Methods

  • 39th of 71 in

    Chemistry, Applied

  • 220th of 267 in

    Pharmacology & Pharmacy

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Aims & Scope

Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:

  • Target identification and validation
  • Assay design, development, miniaturization and comparison
  • High throughput/high content/in silico screening and associated technologies
  • Label-free detection technologies and applications
  • Stem cell technologies
  • Biomarkers
  • ADMET/PK/PD methodologies and screening
  • Probe discovery and development, hit to lead optimization
  • Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
  • Chemical library design and chemical diversity
  • Chemo/bio-informatics, data mining
  • Compound management
  • Pharmacognosy
  • Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products)
  • Natural Product Analytical Studies
  • Bipharmaceutical studies of Natural products
  • Drug repurposing
  • Data management and statistical analysis
  • Laboratory automation, robotics, microfluidics, signal detection technologies
  • Current & Future Institutional Research Profile
  • Technology transfer, legal and licensing issues
  • Patents

In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.

Combinatorial Chemistry & High Throughput Screening

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Volume 22

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Number 10



Biography   Open Access



Editorial   Open Access



Research Article



Research Article



Research Article



Research Article



Research Article



Research Article



Articles Ahead of Print


Green Route for the Removal of Pb from Aquatic Environment


Ahmed Refaat*, Hanan Elhaes, Nabila S. Ammar, Hanan S. Ibrahim and Medhat Ibrahim


DOI: 10.2174/1386207323666200127123349
View Abstract View on PubMed


Combinatorial Synthesis of A Series of Paeonol-based Phenylsulfonyl hydrazone Derivatives as Insecticidal Agents


Zhi-Ping Che*, Jin-Ming Yang, Di Sun, Yue-E Tian, Sheng-Ming Liu, Xiao-Min Lin, Jia Jiang and Gen-Qiang Chen


DOI: 10.2174/1386207323666200127121129
View Abstract View on PubMed









Abstracts Ahead of Print




An Efficient Procedure for Synthesis of 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione


Luu D. Huy*, Nguyen T. Diep, Tran K. Vu, Tatiana S. Savinova and Marina V. Donova


DOI: 10.2174/1386207323666200219122644
View Abstract



Favorable Effects of Astaxanthin on Brain Damage due to Ischemia-Reperfusion Injury


Esra Cakir*, Ufuk Cakir, Cuneyt Tayman, Tugba Taskin Turkmenoglu, Ataman Gonel and Isil Ozkocak Turan


DOI: 10.2174/1386207323666200219121600
View Abstract





Evaluation of thiol/disulfide homeostasis in pediatric patients with diabetic ketoacidosis


Mutlu Uysal Yazıcı*, Ganime Ayar, Semra Çetinkaya, Meliksah Keskin, Ebru Azapağası, Saim Neşelioğlu, Özcan Erel and Benan Bayrakçı


DOI: 10.2174/1386207323666200218114331
View Abstract


Published Contents

Editor's Choice

Synthesis of 2-Substituted 4-Arylidene-5(4H)-oxazolones as Potential Cytotoxic Agents in the Presence of Lemon Juice as a Biocatalyst

, 2019; 22(9): 625 - 634

Malavattu G. Prasad, Chapala V. Lakshmi, Naresh K. Katari*, Krishnan Anand, Manojit Pal* and Sreekantha B. Jonnalagadda


DOI: 10.2174/1386207322666191024105150




Screening GLP-1 Receptor Ligands from Natural Products in Herbs through High-Content Technique

, 2019; 22(7): 445 - 454

Kunhao Qin, Shengting Zhang, Jie Wang, Dongbo Liu, Yingying Xiang, Xiuling Ji and Yunlin Wei*


DOI: 10.2174/1386207322666190919143735





Recognition of Lung Adenocarcinoma-specific Gene Pairs Based on Genetic Algorithm and Establishment of a Deep Learning Prediction Model

, 2019; 22(4): 256 - 265

Zhongwei Zhao, Xiaoxi Fan, Lili Yang, Jingjing Song, Shiji Fang, Jianfei Tu, Minjiang Chen, Jie Li, Liyun Zheng, Fazong Wu, Dengke Zhang, Xihui Ying and Jiansong Ji*


DOI: 10.2174/1386207322666190530102245



Expression and Significance of LncRNA-MINCR and CDK2 mRNA in Primary Hepatocellular Carcinoma

, 2019; 22(3): 201 - 206

Jiangshan Lian, Xiaolin Zhang, Yingfeng Lu, Shaorui Hao, Zhe Zhang and Yida Yang*


DOI: 10.2174/1386207322666190404151020



Progress in Molecularly Imprinted Polymers for Biomedical Applications

, 2019; 22(2): 78 - 88

Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi and Alistair C. Cowie


DOI: 10.2174/1386207322666190325115526




Maxillary Metastasis of Esophageal Cancer: Report of the First Case and Literature Review

, 2018; 21(10): 801 - 805

Hong Hu, Jing Wang, Xiao-Yun Zhou, Meng-Ting Tong, Chong-Ya Zhai, Xin-Bing Sui, Yan-Hua Zhang, Xiao-Xi Xie, Hao Liu, Jian-Sheng Xie, Hong-Ming Pan* and Da Li*


DOI: 10.2174/1386207322666190103105938



Open Access Articles

Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development

, 2019; 22(6): 379 - 386

Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*




Effect of the Phragmitis Rhizoma Aqueous Extract on the Pharmacokinetics of Docetaxel in Rats

, 2019; 22(5): 326 - 332

Sarah Shin, No Soo Kim, Young Ah Kim, Hea Ry Oh and Ok-Sun Bang*







High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review

, 2016; 19(8): 605 - 615

Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*





Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library

, 2016; 19(4): 262 - 274

Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh G. Santos, Marc A. Giulianotti and Robert J. Deschenes*




Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP

, 2015; 18(1): 3 - 17

Arjan J. van Adrichem, Annika Fagerholm, Laura Turunen, Anna Lehto, Jani Saarela, Ari Koskinen, Gretchen A. Repasky and Krister Wennerberg*




Digital Holographic Microscopy: A Quantitative Label-Free Microscopy Technique for Phenotypic Screening

, 2014; 17(1): 80 - 88

Benjamin Rappaz, Billy Breton, Etienne Shaffer and Gerardo Turcatti*




Chemical Informatics and the Drug Discovery Knowledge Pyramid

, 2013; 16(10): 764 - 776

Gerald H. Lushington*, Yinghua Dong and Bhargav Theertham







Alternative Medicine Safety: Agaricus blazei and Propolis

, 2011; 14(7): 616 - 621

Kenji Sorimachi* and Takaaki Nakamoto





Most Cited Articles







Review Article

Progress in molecularly imprinted polymers for biomedical applications

, 2019; 22(2): 78-88.

Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi and Alistair C. Cowie


DOI: 10.2174/1386207322666190325115526



Research Article

Identification of anti-cancer peptides based on multi-classifier system

, 2019; 22(10): 694-704.

Wanben Zhong, Bineng Zhong*, Hongbo Zhang, Ziyi Chen and Yan Chen


DOI: 10.2174/1386207322666191203141102


Research Article

New computational tool based on machine-learning algorithms for the identification of rhinovirus infection-related genes

, 2019; 22(10): 665-674.

Yan Xu, Yu-Hang Zhang, JiaRui Li, Xiao Y. Pan, Tao Huang* and Yu-Dong Cai*


DOI: 10.2174/1386207322666191129114741


Research Article

Rare germline GLMN variants identified from blue rubber bleb nevus syndrome might impact mTOR signaling

, 2019; 22(10): 665-674.

Yan Xu, Yu-Hang Zhang, JiaRui Li, Xiao Y. Pan, Tao Huang* and Yu-Dong Cai*


DOI: 10.2174/1386207322666191203110042



Research Article

Statistical modelling outcome of in vitro fertilization and intracytoplasmic sperm injection: A single centre study

, 2019; 22(4): 225-231.

Boyun Xu, Chang Liu, Lianfen Qian, Yue Qu, Weijue Su, Jialing Xu and Junzhao Zhao*


DOI: 10.2174/1386207322666190404145448





Most Accessed Articles


Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development

, 2019; 22(6): 379-386.

Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*


DOI: 10.2174/1386207322666190704095602





Molecular Docking Supplements an In vitro Determination of the Leading CYP Isoform for Arylpiperazine Derivatives

, 2019; 22(6): 370-378.

Szymon Ulenberg, Tomasz Bączek*, Joanna Zieliñska, Mariusz Belka, Marek Król and Franciszek Herold


DOI: 10.2174/1386207322666190705143322


Substituted Furanocoumarins as Novel Class of Antibacterial Translation Inhibitors

, 2019; 22(6): 400-410.

Yan A. Ivanenkov, Renat S. Yamidanov, Ilya A. Osterman, Petr V. Sergiev, Andrey A. Ayginin*, Vladimir A. Aladinskiy, Anastasia V. Aladinskaya, Victor A. Terentiev, Mark S. Veselov, Dmitry A. Skvortsov, Katerina S. Komarova, Alexey V. Chemeris, Liana F. Zainullina, Marina A. Maximova, Zulfiya R. Zileeva, Yulia V. Vakhitova, Alexey Kh. Baymiev, Andrey Kh. Baymiev, Alina A. Sofronova, Alexey E. Machulkin, Rostislav A. Petrov, Dmitry S. Bezrukov, Maria M. Puchinina, Dmitrii A. Lukianov and Olga A. Dontsova


DOI: 10.2174/1386207322666190723110539



Same Target, Different Therapeutic Outcomes: The Case of CAY10471 and Fevipiprant on CRTh2 Receptor in Treatment of Allergic Rhinitis and Asthma

, 2019; 22(8): 521-533.

Abdul R. Issahaku, Clement Agoni, Opeyemi S. Soremekun, Patrick A. Kubi, Ransford O. Kumi, Fisayo A. Olotu and Mahmoud E.S. Soliman*


DOI: 10.2174/1386207322666190919113006





Editor-in-Chief

Gerald H. Lushington
LiS Consulting, Lawrence
KS
USA

Biography View Full Editorial Board

Journal History

Combinatorial Chemistry & High Throughput Screening Journal was launched in 1998. Dr. Gerald H. Lushington serves as the Editor-in-Chief of the journal.
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