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CNS & Neurological Disorders - Drug Targets

Formerly: Current Drug Targets - CNS & Neurological Disorders

Volume 18, 10 Issues, 2019
ISSN: 1996-3181 (Online)
ISSN: 1871-5273 (Print)
This journal supports open access

Aims & Scope

CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes.

CNS & Neurological Disorders - Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

CNS & Neurological Disorders - Drug Targets

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Volume 18

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Number 2



Biography   Open Access



Review Article



Review Article



Research Article



Research Article



Research Article



Research Article

Cytarabine and Ferric Carboxymaltose (Fe+3) Increase Oxidative Damage and Alter Serotonergic Metabolism in Brain

, 18(2): 149 - 155

David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortíz Herrera, Hugo Juárez Olguín*, Armando Valenzuela Peraza, Ernestina Hernández García, Francisca Trujillo Jiménez and Gerardo Barragán Mejía


DOI: 10.2174/1871527318666181128144343


Research Article

Effects of Exercise and Ferulic Acid on Alpha Synuclein and Neuroprotective Heat Shock Protein 70 in An Experimental Model of Parkinsonism Disease

, 18(2): 156 - 169

Mona H. Askar, Abdelaziz M. Hussein*, Soheir F. Al-Basiony, Refka K. Meseha, Emile F. Metias, Mohamed M. Salama, Ashraf Antar and Aya El-Sayed


DOI: 10.2174/1871527317666180816095707


CNS & Neurological Disorders - Drug Targets , Volume 18 (2019) - Number 4


This issue is in progress but contains articles that are final and fully citable.

CNS & Neurological Disorders - Drug Targets , Volume 18 (2019) - Number 3


This issue is in progress but contains articles that are final and fully citable.

Abstracts Ahead of Print

Published Contents

Editor's Choice

Xuesaitong May Protect Against Ischemic Stroke by Modulating Microglial Phenotypes and Inhibiting Neuronal Cell Apoptosis via the STAT3 Signaling Pathway

, 2019; 18(2): 115 - 123

Fangfang Li, Haiping Zhao, Ziping Han, Rongliang Wang, Zhen Tao, Zhibin Fan, Sijia Zhang, Guangwen Li, Zhigang Chen* and Yumin Luo*


DOI: 10.2174/1871527317666181114140340



Motor Recovery after Chronic Spinal Cord Transection in Rats: A Proof-of-Concept Study Evaluating a Combined Strategy

, 2019; 18(1): 52 - 62

Antonio Ibarra*, Erika Mendieta-Arbesú, Paola Suarez-Meade, Elisa García-Vences, Susana Martiñón, Roxana Rodriguez-Barrera, Joel Lomelí, Adrian Flores-Romero, Raúl Silva-García, Vinnitsa Buzoianu-Anguiano, Cesar V. Borlongan and Tamara D. Frydman


DOI: 10.2174/1871527317666181105101756




Autophagy and Mitochondria: Targets in Neurodegenerative Disorders

, 2018; 17(9): 696 - 705

Ashutosh Kumar*, Amruta Dhawan, Alknanda Kadam and Akshada Shinde


DOI: 10.2174/1871527317666180816100203



Serum Tryptophan, Tryptophan Catabolites and Brain-derived Neurotrophic Factor in Subgroups of Youngsters with Autism Spectrum Disorders

, 2018; 17(8): 626 - 639

Heidi Ormstad*, Vesna Bryn, Robert Verkerk, Ola H. Skjeldal, Bente Halvorsen, Ola Didrik Saugstad, Jorn Isaksen and Michael Maes


DOI: 10.2174/1871527317666180720163221



Light-Emitting Diode (LED) Therapy Attenuates Neurotoxicity of Methanol-Induced Memory Impairment and Apoptosis in The Hippocampus

, 2018; 17(7): 528 - 538

Amir Ghanbari, Kazem Zibara, Sepideh Salari, Majid Ghareghani, Parastou Rad, Wael Mohamed, Elham Ebadi, Mohamad Malekzadeh and Hamdallah Delaviz*


DOI: 10.2174/1871527317666180703111643



Protective Effect of Kaempferol on the Transgenic Drosophila Model of Alzheimer’s Disease

, 2018; 17(6): 421 - 429

Tanveer Beg, Smita Jyoti, Falaq Naz, Rahul, Fahad Ali, Syed Kashif Ali, Ahmed Mohamed Reyad and Yasir Hasan Siddique*


DOI: 10.2174/1871527317666180508123050



Pain-Related Behavior and Brain Activation in a Cynomolgus Macaque Model of Postoperative Pain

, 2018; 17(5): 348 - 360

Aldric Hama*, Takahiro Natsume, Shin`ya Ogawa, Yuji Awaga, Ikuo Hayashi, Akihisa Matsuda and Hiroyuki Takamatsu


DOI: 10.2174/1871527317666180515121350



Cerebrolysin and Aquaporin 4 Inhibition Improve Pathological and Motor Recovery after Ischemic Stroke

, 2018; 17(4): 299 - 308

Bogdan Catalin, Otilia-Constantina Rogoveanu, Ionica Pirici, Tudor Adrian Balseanu, Adina Stan, Valerica Tudorica, Maria Balea, Ion Mindrila, Carmen Valeria Albu, Guleed Mohamed, Daniel Pirici* and Dafin Fior Muresanu


DOI: 10.2174/1871527317666180425124340




Open Access Articles

Oleanolic Acid Ameliorates Aβ25-35 Injection-induced Memory Deficit in Alzheimer’s Disease Model Rats by Maintaining Synaptic Plasticity

, 2018; 17(5): 389 - 399

Kai Wang, Weiming Sun, Linlin Zhang, Wei Guo, Jiachun Xu, Shuang Liu, Zhen Zhou and Yulian Zhang*




Physiological and Morphological Principles Underpinning Recruitment of the Cerebellar Reserve

, 2018; 17(3): 184 - 192

Shinji Kakei*, Takahiro Ishikawa, Jongho Lee, Takeru Honda and Donna S. Hoffman




Demonstration of Biological and Immunological Equivalence of a Generic Glatiramer Acetate

, 2017; 16(6): 714 - 723

Josephine D`Alessandro, Kevin Garofalo, Ganlin Zhao, Christopher Honan, Jay Duffner, Ishan Capila, Ian Fier, Ganesh Kaundinya, Daniel Kantor and Tanmoy Ganguly*




Nanomaterials for Neurology: State-of-the-Art

, 2016; 15(10): 1306 - 1324

María Fernanda Veloz-Castillo, Rachel M. West, Jessica Cordero-Arreola, Oscar Arias-Carrión and Miguel A. Méndez-Rojas




The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders

, 2016; 15(5): 564 - 577

Yuko Okamoto, Makoto Ishitobi, Yuji Wada and Hirotaka Kosaka





The Effects of Testosterone Supplementation on Cognitive Functioning in Older Men.

, 2016; 15(3): 337 - 343

Eka J. Wahjoepramono, Prita R. Asih, Vilia Aniwiyanti, Kevin Taddei, Satvinder S. Dhaliwal, Stephanie J. Fuller, Jonathan Foster, Malcolm Carruthers, Giuseppe Verdile, Hamid R Sohrabi and Ralph N. Martins




Ouabain-Induced Signaling and Cell Survival in SK-N-SH Neuroblastoma Cells Differentiated by Retinoic Acid

, 2015; 14(10): 1343 - 1349

Evgeny E. Akkuratov, Jian Wu, David Sowa, Zahoor A. Shah and Lijun Liu






The Role of Neuroimaging in Our Understanding of the Suicidal Brain

, 2013; 12(7): 921 - 929

Stefanie Desmyter, Stijn Bijttebier and Kees van Heeringen






Glutamate Receptors in Microglia

, 2013; 12(6): 773 - 784

Madhuvika Murugan, Eng-Ang Ling and Charanjit Kaur






Most Cited Articles

Inflammatory Mechanisms and Oxidative Stress as Key Factors Responsible for Progression of Neurodegeneration: Role of Brain Innate Immune System

, 2016; 15(3): 329-336.

Jerzy Leszek, George E. Barreto, Kazimierz Gąsiorowski, Euphrosyni Koutsouraki, Marco Ávila-Rodrigues and Gjumrakch Aliev


DOI: 10.2174/1871527315666160202125914


Recent updates on the dynamic association between oxidative stress and neurodegenerative disorders

, 2016; 15(3): 310-320.

Taqi A. Khan, Iftekhar Hassan, Ausaf Ahmad, Asma Perveen, Shazia Aman, Saima Quddusi, Ibrahim M. Alhazza, Ghulam M. Ashraf and Gjumrakch Aliev


DOI: 10.2174/1871527315666160202124518



Novel Therapeutic Strategies for Dementia

, 2016; 15(2): 141-241.

Ramón Cacabelos, Clara Torrellas, Iván Carrera, Pablo Cacabelos, Lola Corzo, Lucía Fernández-Novoa, Iván Tellado, Juan C. Carril and Gjumrakch Aliev


DOI: 10.2174/1871527315666160202121548


Implication of Green Tea as a Possible Therapeutic Approach for Parkinson Disease

, 2016; 15(3): 292-300.

Juan C. Jurado-Coronel, Marco Ávila-Rodriguez, Valentina Echeverria, Oscar Alejandro Hidalgo, Janneth Gonzalez, Gjumrakch Aliev and George E. Barreto


DOI: 10.2174/1871527315666160202125519



Nanowired Drug Delivery Across the Blood-Brain Barrier in Central Nervous System Injury and Repair

, 2016; 15(9): 1092-1117.

Aruna Sharma, Preeti Menon, Dafin F. Muresanu, Asya Ozkizilcik, Z. Ryan Tian, José V. Lafuente and Hari S. Sharma


DOI: 10.2174/1871527315666160819123059


Coenzyme Q10 for Patients with Parkinson's Disease: A Systematic Review and Meta-Analysis

, 2016; 15(1): 45-53.

Ahmed Negida, Ahmed Menshawy, Gehad El Ashal, Yasmin Elfouly, Yasmein Hani, Yasmin Hegazy, Samar El ghonimy, Samar Fouda and Yomna Rashad


DOI: 10.2174/1871527314666150821103306


A comprehensive review on the efficacy of S-Adenosyl-L-methionine in Major Depressive Disorder.

, 2016; 15(1): 35-44.

Domenico De Berardis, Laura Orsolini, Nicola Serroni, Gabriella Girinelli, Felice Iasevoli, Carmine Tomasetti, Andrea de Bartolomeis, Monica Mazza, Alessandro Valchera, Michele Fornaro, Giampaolo Perna, Monica Piersanti, Marco Di Nicola, Marilde Cavuto, Giovanni Martinotti and Massimo Di Giannantonio


DOI: 10.2174/1871527314666150821103825


Alzheimer’s Disease Detection by Pseudo Zernike Moment and Linear Regression Classification

, 2017; 16(1): 11-15.

Shui-Hua Wang, Sidan Du, Yin Zhang, Preetha Phillips, Le-Nan Wu, Xian-Qing Chen and Yu-Dong Zhang


DOI: 10.2174/1871527315666161111123024



Most Accessed Articles

Autophagy and Mitochondria: Targets in Neurodegenerative Disorders

, 2018; 17(9): 696-705.

Ashutosh Kumar*, Amruta Dhawan, Alknanda Kadam and Akshada Shinde


DOI: 10.2174/1871527317666180816100203


Cariprazine in Bipolar Depression and Mania: State of the Art

, 2018; 17(10): 723-727.

Marianna Mazza*, Giuseppe Marano, Gianandrea Traversi, Valentina Carocci, Benedetta Romano and Luigi Janiri


DOI: 10.2174/1871527317666180828120256








Effects of Exercise on Anxiety and Depression Disorders: Review of Meta- Analyses and Neurobiological Mechanisms

, 2014; 13(6): 1002-1014.

Mirko Wegner, Ingo Helmich, Sergio Machado, Antonio E. Nardi, Oscar Arias-Carrion and Henning Budde


DOI: 10.2174/1871527313666140612102841


The Efficacy and Safety of Pharmacological Treatments for Post-stroke Aphasia

, 2018; 17(7): 509-521.

Xiaoyan Zhang, Bohui Shu, Dongdong Zhang, Lina Huang, Qizhi Fu and Ganqin Du*


DOI: 10.2174/1871527317666180706143051



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