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CNS & Neurological Disorders - Drug Targets

Formerly: Current Drug Targets - CNS & Neurological Disorders

Volume 19, 10 Issues, 2020
ISSN: 1996-3181 (Online)
ISSN: 1871-5273 (Print)
This journal supports open access
Order Your Article Before Print

Ranking and Category

  • 150th of 267 in

    Neurosciences

  • 119th of 267 in

    Pharmacology & Pharmacy

In the current Pandemic scenario, all articles related to Coronavirus will be processed on a free, quick track basis, to ensure timely review and publication of much needed research

Aims & Scope

CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes.

CNS & Neurological Disorders - Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

CNS & Neurological Disorders - Drug Targets

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Volume 19

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Number 1



Biography   Open Access



Review Article



Research Article



Research Article

The Role of Annexin A1 and Formyl Peptide Receptor 2/3 Signaling in Chronic Corticosterone-Induced Depression-Like behaviors and Impairment in Hippocampal-Dependent Memory

, 19(1): 27 - 43

Alessio Filippo Peritore, Rosalia Crupi, Maria Scuto, Enrico Gugliandolo, Rosalba Siracusa, Daniela Impellizzeri, Marika Cordaro, Ramona D’amico, Roberta Fusco, Rosanna Di Paola and Salvatore Cuzzocrea*


DOI: 10.2174/1871527319666200107094732


Research Article



Research Article



Research Article

BDNF-TrkB and proBDNF-p75NTR/Sortilin Signaling Pathways are Involved in Mitochondria-Mediated Neuronal Apoptosis in Dorsal Root Ganglia after Sciatic Nerve Transection

, 19(1): 66 - 82

Xianbin Wang, Wei Ma, Tongtong Wang, Jinwei Yang, Zhen Wu, Kuangpin Liu, Yunfei Dai, Chenghao Zang, Wei Liu, Jie Liu, Yu Liang, Jianhui Guo* and Liyan Li*


DOI: 10.2174/1871527319666200117110056


CNS & Neurological Disorders - Drug Targets , Volume 19 (2020) - Number 2


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

The β-secretase enzyme BACE1: A biochemical enigma for Alzheimer’s disease


Hirak Shah, Ashish Patel*, Vruti Parikh, Afzal Nagani, Bhargav Bhimani, Umang Shah and Tushar Bambharoliya


DOI: 10.2174/1871527319666200526144141
View Abstract



The Combination of rTMS and Pharmacotherapy on in vitro Models: A Mini-Review


Chryssa Pourzitaki*, Ioannis Dardalas, Frideriki Poutoglidou, Dimitrios Kouvelas and Vasilios K. Kimiskidis


DOI: 10.2174/1871527319666200518100716
View Abstract View on PubMed



Interlink between insulin resistance and neurodegeneration with an update on current therapeutic approaches


Subrat Kumar Bhattamisra*, Lee Yuen Shin, Hanis Izzati Binti Mohd Saad, Vikram Rao, Mayuren Candasamy, Manisha Pandey and Hira Choudhury


DOI: 10.2174/1871527319666200518102130
View Abstract




Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Published Contents

Editor's Choice


Pharmacotherapy of Down’s Syndrome: When and Which?

, 2019; 18(10): 750 - 757

Seyed K. Tayebati*, Alessandro Cecchi, Ilenia Martinelli, Elisa Carboni and Francesco Amenta


DOI: 10.2174/1871527318666191114092924




Cordycepin Exerts Neuroprotective Effects via an Anti-Apoptotic Mechanism based on the Mitochondrial Pathway in a Rotenone-Induced Parkinsonism Rat Model

, 2019; 18(8): 609 - 620

Xin Jiang, Pei-Chen Tang, Qin Chen, Xin Zhang, Yi-Yun Fan, Bo-Cheng Yu, Xin-Xia Gu, Ying Sun, Xiao-Qun Ge* and Xiao-Ling Zhang*


DOI: 10.2174/1871527318666190905152138



Co-ultraPEALut: Role in Preclinical and Clinical Delirium Manifestations

, 2019; 18(7): 530 - 554

Maria Lia Lunardelli, Rosalia Crupi, Rosalba Siracusa, Giorgio Cocuzza, Marika Cordaro, Emilio Martini, Daniela Impellizzeri, Rosanna Di Paola and Salvatore Cuzzocrea*


DOI: 10.2174/1871527318666190617162041



The Effect of Vitamin D3 Supplementation on Serum BDNF, Dopamine, and Serotonin in Children with Attention-Deficit/Hyperactivity Disorder

, 2019; 18(6): 496 - 501

Marzieh Seyedi, Fatemeh Gholami, Mahsa Samadi, Mahmoud Djalali, Mohammad Effatpanah*, Mir Saeed Yekaninejad, Rezvan Hashemi, Mina Abdolahi, Maryam Chamari and Niyaz Mohammadzadeh Honarvar


DOI: 10.2174/1871527318666190703103709






Xuesaitong May Protect Against Ischemic Stroke by Modulating Microglial Phenotypes and Inhibiting Neuronal Cell Apoptosis via the STAT3 Signaling Pathway

, 2019; 18(2): 115 - 123

Fangfang Li, Haiping Zhao, Ziping Han, Rongliang Wang, Zhen Tao, Zhibin Fan, Sijia Zhang, Guangwen Li, Zhigang Chen* and Yumin Luo*


DOI: 10.2174/1871527317666181114140340



Open Access Articles


Fire Needle Acupuncture Regulates Wnt/ERK Multiple Pathways to Promote Neural Stem Cells to Differentiate into Neurons in Rats with Spinal Cord Injury

, 2019; 18(3): 245 - 255

Jiachun Xu, Suli Cheng, Zhaohua Jiao, Zhiheng Zhao, Zhimin Cai, Nan Su, Baohong Liu, Zhen Zhou* and Yan Li*




Oleanolic Acid Ameliorates Aβ25-35 Injection-induced Memory Deficit in Alzheimer’s Disease Model Rats by Maintaining Synaptic Plasticity

, 2018; 17(5): 389 - 399

Kai Wang, Weiming Sun, Linlin Zhang, Wei Guo, Jiachun Xu, Shuang Liu, Zhen Zhou and Yulian Zhang*




Physiological and Morphological Principles Underpinning Recruitment of the Cerebellar Reserve

, 2018; 17(3): 184 - 192

Shinji Kakei*, Takahiro Ishikawa, Jongho Lee, Takeru Honda and Donna S. Hoffman




Demonstration of Biological and Immunological Equivalence of a Generic Glatiramer Acetate

, 2017; 16(6): 714 - 723

Josephine D`Alessandro, Kevin Garofalo, Ganlin Zhao, Christopher Honan, Jay Duffner, Ishan Capila, Ian Fier, Ganesh Kaundinya, Daniel Kantor and Tanmoy Ganguly*




Nanomaterials for Neurology: State-of-the-Art

, 2016; 15(10): 1306 - 1324

María Fernanda Veloz-Castillo, Rachel M. West, Jessica Cordero-Arreola, Oscar Arias-Carrión and Miguel A. Méndez-Rojas




The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders

, 2016; 15(5): 564 - 577

Yuko Okamoto, Makoto Ishitobi, Yuji Wada and Hirotaka Kosaka





The Effects of Testosterone Supplementation on Cognitive Functioning in Older Men.

, 2016; 15(3): 337 - 343

Eka J. Wahjoepramono, Prita R. Asih, Vilia Aniwiyanti, Kevin Taddei, Satvinder S. Dhaliwal, Stephanie J. Fuller, Jonathan Foster, Malcolm Carruthers, Giuseppe Verdile, Hamid R Sohrabi and Ralph N. Martins




Ouabain-Induced Signaling and Cell Survival in SK-N-SH Neuroblastoma Cells Differentiated by Retinoic Acid

, 2015; 14(10): 1343 - 1349

Evgeny E. Akkuratov, Jian Wu, David Sowa, Zahoor A. Shah and Lijun Liu






The Role of Neuroimaging in Our Understanding of the Suicidal Brain

, 2013; 12(7): 921 - 929

Stefanie Desmyter, Stijn Bijttebier and Kees van Heeringen







Most Cited Articles

Review Article

Nf-κb as a key mediator of brain inflammation in Alzheimer’s disease

, 2019; 18(1): 3-10.

Chul Ju Hwang, Dong-Young Choi, Mi Hee Park and Jin Tae Hong*


DOI: 10.2174/1871527316666170807130011



Review Article

Epigenetics in neurodegenerative diseases: The role of histone deacetylases

, 2019; 18(1): 11-18.

Sorabh Sharma, K.C. Sarathlal and Rajeev Taliyan*


DOI: 10.2174/1871527317666181004155136


Research Article

Exosomal miR-214-5p released from glioblastoma cells modulates inflammatory response of microglia after lipopolysaccharide stimulation through targeting CXCR5

, 2019; 18(1): 78-87.

Jian-kai Yang*, Hong-jiang Liu, Yuanyu Wang, Chen Li, Ji-peng Yang, Liang Yang, Xue-jiao Qi, Yin-long Zhao, Xue-fang Shi, Jing-chen Li, Guo-zhu Sun and Bao-hua Jiao


DOI: 10.2174/1871527317666181105112009


Review Article

Noncoding RNAs and intracerebral hemorrhage

, 2019; 18(3): 205-211.

Lingzhi Li, Pingping Wang, Haiping Zhao* and Yumin Luo*


DOI: 10.2174/1871527318666190204102604


Review Article

A pharmacological appraisal of neuroprotective and neurorestorative flavonoids against neurodegenerative diseases

, 2019; 18(2): 103-114.

Jia Zhao*, Mengxia Zhu, Mukesh Kumar, Fung Yin Ngo, Yinghui Li, Lixing Lao and Jianhui Rong


DOI: 10.2174/1871527317666181105093834


Review Article

New drug discovery from medicinal plants and phytoconstituents for depressive disorders

, 2019; 18(2): 92-102.

Fatma Tuğçe Gürağaç Dereli, Mert Ilhan and Esra Küpeli Akkol*


DOI: 10.2174/1871527317666181114141129


Research Article

Ethyl acetohydroxamate incorporated chalcones: Unveiling a novel class of chalcones for multitarget monoamine oxidase-b inhibitors against alzheimer’s disease

, 2019; 18(8): 643-654.

Reeta, Seung Cheol Baek, Jae Pil Lee, T.M. Rangarajan*, Ayushee, Rishi Pal Singh, Manjula Singh, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Hoon Kim* and Bijo Mathew*


DOI: 10.2174/1871527318666190906101326



Review Article

Perspective design of chalcones for the management of cns disorders: A mini-review

, 2019; 18(6): 432-445.

Bijo Mathew*, Della Grace Thomas Parambi, Vishnu Sankar Sivasankarapillai, Md. Sahab Uddin, Jerad Suresh, Githa Elizabeth Mathew, Monu Joy, Akash Marathakam and Sheeba Varghese Gupta


DOI: 10.2174/1871527318666190610111246


Review Article

The role of traditional chinese herbal medicines and bioactive ingredients on ion channels: A brief review and prospect

, 2019; 18(4): 257-265.

Yian Huang, Shumei Ma, Yan Wang, Renjie Yan, Sheng Wang, Nan Liu, Ben Chen, Jia Chen and Li Liu*


DOI: 10.2174/1871527317666181026165400


Clinical Trial

Ultramicronized palmitoylethanolamide (Um-PEA) as add-on treatment in fibromyalgia syndrome (FMS): Retrospective observational study on 407 patients

, 2019; 18(4): 326-333.

Vittorio Schweiger*, Alvise Martini, Paola Bellamoli, Katia Donadello, Carlo Schievano, Giovanna D. Balzo, Piercarlo Sarzi-Puttini, Massimo Parolini and Enrico Polati


DOI: 10.2174/1871527318666190227205359



Systemic Review Article

Efficacy of celecoxib adjunct treatment on bipolar disorder: Systematic review and meta-analysis

, 2019; 18(1): 19-28.

Daniela V. Bavaresco, Tamy Colonetti, Antônio J. Grande, Francesc Colom, Samira S. Valvassori, João Quevedo and Maria I. da Rosa*


DOI: 10.2174/1871527317666181105162347


Research Article

Xuesaitong may protect against ischemic stroke by modulating microglial phenotypes and inhibiting neuronal cell apoptosis via the STAT3 signaling pathway

, 2019; 18(2): 115-123.

Fangfang Li , Haiping Zhao, Ziping Han, Rongliang Wang, Zhen Tao, Zhibin Fan, Sijia Zhang, Guangwen Li, Zhigang Chen* and Yumin Luo*


DOI: 10.2174/1871527317666181114140340



Most Accessed Articles



A Review for Lithium: Pharmacokinetics, Drug Design, and Toxicity

, 2019; 18(10): 769-778.

Jinhua Wen*, Darrell Sawmiller*, Brendan Wheeldon and Jun Tan


DOI: 10.2174/1871527318666191114095249






Pharmacotherapy of Down’s Syndrome: When and Which?

, 2019; 18(10): 750-757.

Seyed K. Tayebati*, Alessandro Cecchi, Ilenia Martinelli, Elisa Carboni and Francesco Amenta


DOI: 10.2174/1871527318666191114092924





Editor-in-Chief

Edoardo Spina
Department of Clinical and Experimental Medicine
University of Messina
Policlinico Universitario
Via Consolare Valeria
Messina
(Italy)
Biography View Full Editorial Board

Journal History

Current Drug Targets - CNS & Neurological Disorders was launched in 2002 and later renamed in 2006 as CNS & Neurological Disorders - Drug Targets.
Scopus CiteScore Metrics: 2.72

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