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CNS & Neurological Disorders - Drug Targets

Formerly: Current Drug Targets - CNS & Neurological Disorders

Volume 18, 10 Issues, 2019
ISSN: 1996-3181 (Online)
ISSN: 1871-5273 (Print)
This journal supports open access

Ranking and Category

  • 150th of 267 in

    Neurosciences

  • 119th of 267 in

    Pharmacology & Pharmacy

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Aims & Scope

CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes.

CNS & Neurological Disorders - Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

CNS & Neurological Disorders - Drug Targets

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Volume 18

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Number 4



Review Article



Review Article



Review Article



Review Article



Review Article



Review Article



Systemic Review Article

Safety and Efficacy of Levetiracetam for the Management of Levodopa- Induced Dyskinesia in Patients with Parkinson’s Disease: A Systematic Review

, 18(4): 317 - 325

Mahmoud A. Ebada*, Souad Alkanj, Mohamed Ebada, Ahmed H. Abdelkarim, Ahmed Diab, Mohamed A.E. Aziz, Ahmed M. Soliman, Notila Fayed, Eshak I. Bahbah and Ahmed Negida


DOI: 10.2174/1871527318666190314101314


Clinical Trial

Ultramicronized Palmitoylethanolamide (um-PEA) as Add-on Treatment in Fibromyalgia Syndrome (FMS): Retrospective Observational Study on 407 Patients

, 18(4): 326 - 333

Vittorio Schweiger*, Alvise Martini, Paola Bellamoli, Katia Donadello, Carlo Schievano, Giovanna D. Balzo, Piercarlo Sarzi-Puttini, Massimo Parolini and Enrico Polati


DOI: 10.2174/1871527318666190227205359


CNS & Neurological Disorders - Drug Targets , Volume 18 (2019) - Number 6


This issue is in progress but contains articles that are final and fully citable.

CNS & Neurological Disorders - Drug Targets , Volume 18 (2019) - Number 5


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print







Co-ultraPEALut: Role in Preclinical and Clinical Delirium Manifestations


Maria Lia Lunardelli, Rosalia Crupi, Rosalba Siracusa, Giorgio Cocuzza, Marika Cordaro, Emilio Martini, Daniela Impellizzeri, Rosanna Di Paola and Salvatore Cuzzocrea*


DOI: 10.2174/1871527318666190617162041
View Abstract View on PubMed


Central Histamine, the H3-Receptor and Obesity Therapy


Néstor F. Díaz, Héctor Flores-Herrera, Guadalupe García-López and Anayansi Molina-Hernández*


DOI: 10.2174/1871527318666190703094846
View Abstract View on PubMed




Abstracts Ahead of Print


Ethyl acetohydroxamate containing chalcones: Unearthing of a novel class of multitarget MAO-B inhibitors against Alzheimer’s disease


Reeta, Seung Cheol Baek, Jae Pil Lee, T. M. Rangarajan*, Ayushee, Rishi Pal Singh, Manjula Singh, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Hoon Kim* and Bijo Mathew


DOI: 10.2174/1871527318666190906101326
View Abstract


Published Contents

Editor's Choice



Xuesaitong May Protect Against Ischemic Stroke by Modulating Microglial Phenotypes and Inhibiting Neuronal Cell Apoptosis via the STAT3 Signaling Pathway

, 2019; 18(2): 115 - 123

Fangfang Li, Haiping Zhao, Ziping Han, Rongliang Wang, Zhen Tao, Zhibin Fan, Sijia Zhang, Guangwen Li, Zhigang Chen* and Yumin Luo*


DOI: 10.2174/1871527317666181114140340



Motor Recovery after Chronic Spinal Cord Transection in Rats: A Proof-of-Concept Study Evaluating a Combined Strategy

, 2019; 18(1): 52 - 62

Antonio Ibarra*, Erika Mendieta-Arbesú, Paola Suarez-Meade, Elisa García-Vences, Susana Martiñón, Roxana Rodriguez-Barrera, Joel Lomelí, Adrian Flores-Romero, Raúl Silva-García, Vinnitsa Buzoianu-Anguiano, Cesar V. Borlongan and Tamara D. Frydman


DOI: 10.2174/1871527317666181105101756




Autophagy and Mitochondria: Targets in Neurodegenerative Disorders

, 2018; 17(9): 696 - 705

Ashutosh Kumar*, Amruta Dhawan, Alknanda Kadam and Akshada Shinde


DOI: 10.2174/1871527317666180816100203



Serum Tryptophan, Tryptophan Catabolites and Brain-derived Neurotrophic Factor in Subgroups of Youngsters with Autism Spectrum Disorders

, 2018; 17(8): 626 - 639

Heidi Ormstad*, Vesna Bryn, Robert Verkerk, Ola H. Skjeldal, Bente Halvorsen, Ola Didrik Saugstad, Jorn Isaksen and Michael Maes


DOI: 10.2174/1871527317666180720163221



Light-Emitting Diode (LED) Therapy Attenuates Neurotoxicity of Methanol-Induced Memory Impairment and Apoptosis in The Hippocampus

, 2018; 17(7): 528 - 538

Amir Ghanbari, Kazem Zibara, Sepideh Salari, Majid Ghareghani, Parastou Rad, Wael Mohamed, Elham Ebadi, Mohamad Malekzadeh and Hamdallah Delaviz*


DOI: 10.2174/1871527317666180703111643



Protective Effect of Kaempferol on the Transgenic Drosophila Model of Alzheimer’s Disease

, 2018; 17(6): 421 - 429

Tanveer Beg, Smita Jyoti, Falaq Naz, Rahul, Fahad Ali, Syed Kashif Ali, Ahmed Mohamed Reyad and Yasir Hasan Siddique*


DOI: 10.2174/1871527317666180508123050



Pain-Related Behavior and Brain Activation in a Cynomolgus Macaque Model of Postoperative Pain

, 2018; 17(5): 348 - 360

Aldric Hama*, Takahiro Natsume, Shin`ya Ogawa, Yuji Awaga, Ikuo Hayashi, Akihisa Matsuda and Hiroyuki Takamatsu


DOI: 10.2174/1871527317666180515121350



Open Access Articles


Oleanolic Acid Ameliorates Aβ25-35 Injection-induced Memory Deficit in Alzheimer’s Disease Model Rats by Maintaining Synaptic Plasticity

, 2018; 17(5): 389 - 399

Kai Wang, Weiming Sun, Linlin Zhang, Wei Guo, Jiachun Xu, Shuang Liu, Zhen Zhou and Yulian Zhang*




Physiological and Morphological Principles Underpinning Recruitment of the Cerebellar Reserve

, 2018; 17(3): 184 - 192

Shinji Kakei*, Takahiro Ishikawa, Jongho Lee, Takeru Honda and Donna S. Hoffman




Demonstration of Biological and Immunological Equivalence of a Generic Glatiramer Acetate

, 2017; 16(6): 714 - 723

Josephine D`Alessandro, Kevin Garofalo, Ganlin Zhao, Christopher Honan, Jay Duffner, Ishan Capila, Ian Fier, Ganesh Kaundinya, Daniel Kantor and Tanmoy Ganguly*




Nanomaterials for Neurology: State-of-the-Art

, 2016; 15(10): 1306 - 1324

María Fernanda Veloz-Castillo, Rachel M. West, Jessica Cordero-Arreola, Oscar Arias-Carrión and Miguel A. Méndez-Rojas




The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders

, 2016; 15(5): 564 - 577

Yuko Okamoto, Makoto Ishitobi, Yuji Wada and Hirotaka Kosaka





The Effects of Testosterone Supplementation on Cognitive Functioning in Older Men.

, 2016; 15(3): 337 - 343

Eka J. Wahjoepramono, Prita R. Asih, Vilia Aniwiyanti, Kevin Taddei, Satvinder S. Dhaliwal, Stephanie J. Fuller, Jonathan Foster, Malcolm Carruthers, Giuseppe Verdile, Hamid R Sohrabi and Ralph N. Martins




Ouabain-Induced Signaling and Cell Survival in SK-N-SH Neuroblastoma Cells Differentiated by Retinoic Acid

, 2015; 14(10): 1343 - 1349

Evgeny E. Akkuratov, Jian Wu, David Sowa, Zahoor A. Shah and Lijun Liu






The Role of Neuroimaging in Our Understanding of the Suicidal Brain

, 2013; 12(7): 921 - 929

Stefanie Desmyter, Stijn Bijttebier and Kees van Heeringen






Glutamate Receptors in Microglia

, 2013; 12(6): 773 - 784

Madhuvika Murugan, Eng-Ang Ling and Charanjit Kaur





Most Cited Articles

Review Article

Oxidative stress: Major threat in traumatic brain injury

, 2018; 17(9): 689-695.

Nidhi Khatri, Manisha Thakur, Vikas Pareek, Sandeep Kumar, Sunil Sharma and Ashok Kumar Datusalia*


DOI: 10.2174/1871527317666180627120501


Review Article

Dl-3-n-butylphthalide (NBP): A promising therapeutic agent for ischemic stroke

, 2018; 17(5): 338-347.

Shan Wang, Fei Ma, Longjian Huang, Yong Zhang, Yuchen Peng, Changhong Xing, Yipu Feng, Xiaoliang Wang* and Ying Peng*


DOI: 10.2174/1871527317666180612125843


Research Article

Protective effect of kaempferol on the transgenic drosophila model of Alzheimer’s disease

, 2018; 17(6): 421-429.

Tanveer Beg, Smita Jyoti, Falaq Naz, Rahul, Fahad Ali, Syed Kashif Ali, Ahmed Mohamed Reyad and Yasir Hasan Siddique*


DOI: 10.2174/1871527317666180508123050



General Review Article

The underlying role of oxidative stress in neurodegeneration: A mechanistic review

, 2018; 17(3): 207-215.

Habib Yaribeygi, Yunes Panahi*, Behjat Javadi and Amirhossein Sahebkar*


DOI: 10.2174/1871527317666180425122557


Review Article

Neurotransplantation therapy and cerebellar reserve

, 2018; 17(3): 172-183.

Jan Cendelin, Hiroshi Mitoma* and Mario Manto


DOI: 10.2174/1871527316666170810114559



Review Article

Autophagy and mitochondria: Targets in neurodegenerative disorders

, 2018; 17(9): 696-705.

Ashutosh Kumar*, Amruta Dhawan, Alknanda Kadam and Akshada Shinde


DOI: 10.2174/1871527317666180816100203


Research Article

Development of a nasal donepezil-loaded microemulsion for the treatment of Alzheimer’s disease: In vitro and Ex vivo characterization

, 2018; 17(1): 43-53.

Lupe C. Espinoza, Marisol Vacacela, Beatriz Clares*, Maria Luisa Garcia, Maria-Jose Fabrega and Ana C. Calpena


DOI: 10.2174/1871527317666180104122347


Review Article

Nf-κb as a key mediator of brain inflammation in Alzheimer’s disease

, 2019; 18(1): 3-10.

Chul Ju Hwang, Dong-Young Choi, Mi Hee Park and Jin Tae Hong*


DOI: 10.2174/1871527316666170807130011


Review Article

C-Abl inhibition; A novel therapeutic target for Parkinson’s disease

, 2018; 17(1): 14-21.

Abdelrahman Ibrahim Abushouk, Ahmed Negida*, Rasha Abdelsalam Elshenawy, Hossam Zein, Ali M. Hammad, Ahmed Menshawy and Wael M.Y. Mohamed


DOI: 10.2174/1871527316666170602101538


Research Article

A novel combination of ω-3 fatty acids and nano-curcumin modulates interleukin-6 gene expression and high sensitivity C-reactive protein serum levels in patients with migraine: A randomized clinical trial study

, 2018; 17(6): 430-438.

Mina Abdolahi, Payam Sarraf, Mohammad Hassan Javanbakht, Niyaz Mohammadzadeh Honarvar, Mahsa Hatami, Neda Soveyd, Abbas Tafakhori, Mohsen Sedighiyan, Mona Djalali, Arash Jafarieh, Yousef Masoudian and Mahmoud Djalali*


DOI: 10.2174/1871527317666180625101643



Review Article

Cognitive impact of cerebellar damage: Is there a future for cognitive rehabilitation?

, 2018; 17(3): 199-206.

Kim van Dun, Frank V. Overwalle, Mario Manto* and Peter Marien


DOI: 10.2174/1871527317666180110125043


Review Article

Non-invasive cerebellar stimulation in cerebellar disorders

, 2018; 17(3): 193-198.

Chiara Di Nuzzo, Fabiana Ruggiero, Francesca Cortese, Ilaria Cova, Alberto Priori and Roberta Ferrucci*


DOI: 10.2174/1871527317666180404113444



Most Accessed Articles

Ultramicronized Palmitoylethanolamide (um-PEA) as Add-on Treatment in Fibromyalgia Syndrome (FMS): Retrospective Observational Study on 407 Patients

, 2019; 18(4): 326-333.

Vittorio Schweiger*, Alvise Martini, Paola Bellamoli, Katia Donadello, Carlo Schievano, Giovanna D. Balzo, Piercarlo Sarzi-Puttini, Massimo Parolini and Enrico Polati


DOI: 10.2174/1871527318666190227205359



Noncoding RNAs and Intracerebral Hemorrhage

, 2019; 18(3): 205-211.

Lingzhi Li, Pingping Wang, Haiping Zhao* and Yumin Luo*


DOI: 10.2174/1871527318666190204102604


The Role of Traditional Chinese Herbal Medicines and Bioactive Ingredients on Ion Channels: A Brief Review and Prospect

, 2019; 18(4): 257-265.

Yian Huang, Shumei Ma, Yan Wang, Renjie Yan, Sheng Wang, Nan Liu, Ben Chen, Jia Chen and Li Liu*


DOI: 10.2174/1871527317666181026165400


The Associations between Central Nervous System Diseases and Haemostatic Disorders

, 2019; 18(4): 307-316.

Maria Podsiedlik*, Magdalena Markowicz-Piasecka, Elżbieta Mikiciuk-Olasik and Joanna Sikora


DOI: 10.2174/1871527318666190314101946


Understanding Genotypes and Phenotypes of the Mutations in Voltage- Gated Sodium Channel α Subunits in Epilepsy

, 2019; 18(4): 266-272.

Yijun Feng, Shuzhang Zhang, Zhiping Zhang, Jingkang Guo, Zhiyong Tan, Yudan Zhu*, Jie Tao* and Yong-Hua Ji*


DOI: 10.2174/1871527317666181026164825





Xuesaitong May Protect Against Ischemic Stroke by Modulating Microglial Phenotypes and Inhibiting Neuronal Cell Apoptosis via the STAT3 Signaling Pathway

, 2019; 18(2): 115-123.

Fangfang Li, Haiping Zhao, Ziping Han, Rongliang Wang, Zhen Tao, Zhibin Fan, Sijia Zhang, Guangwen Li, Zhigang Chen* and Yumin Luo*


DOI: 10.2174/1871527317666181114140340




Editor-in-Chief

Cesar V. Borlongan
Department of Neurosurgery and Brain Repair
University of South Florida Morsani College of Medicine
Tampa, FL
USA

Biography View Full Editorial Board

Journal History

Current Drug Targets - CNS & Neurological Disorders was launched in 2002 and later renamed in 2006 as CNS & Neurological Disorders - Drug Targets.
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Scopus CiteScore Metrics: 1.13

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