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CNS & Neurological Disorders - Drug Targets

Formerly: Current Drug Targets - CNS & Neurological Disorders

Volume 20, 10 Issues, 2021
ISSN: 1996-3181 (Online)
ISSN: 1871-5273 (Print)
This journal supports open access

Aims & Scope

CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes.

CNS & Neurological Disorders - Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

CNS & Neurological Disorders - Drug Targets

,

Volume 20

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Number 2



Biography   Open Access







Review Article (Mini-Review)

Sepsis-Associated Encephalopathy: Insight into Injury and Pathogenesis

, 20(2): 112 - 124

Lina Zhao, Yanxia Gao, Shigong Guo, Xin Lu, Shiyuan Yu, Zeng Zheng Ge, Hua Dong Zhu and Yi Li*


DOI: 10.2174/1871527319999201117122158


Review Article

Nanomedicinal Strategies as Emerging Therapeutic Avenues to Treat and Manage Cerebral Ischemia

, 20(2): 125 - 144

Saman Fatima, Syed Naved Quadri, Shaheda Parveen, Sarwar Beg*, Md Abul Barkat, Mohamed Samim, M.Z. Abdin and Farhan Jalees Ahmad


DOI: 10.2174/1871527319666201102100330


Review Article

Importance of Zebrafish as an Efficient Research Model for the Screening of Novel Therapeutics in Neurological Disorders

, 20(2): 145 - 157

Diksha Saluja, Rishabh Jhanji, Swati Kaushal, Bharti Verma, Neelam Sharma, Rima Singh, Shelly Agrawal, Meena Yadav, Anoop Kumar, Charan Singh and Arti Singh*


DOI: 10.2174/1871527319666201207211927




Systematic Review Article



Articles Ahead of Print

Conifer Essential Oils Reversed Amyloid Beta1-42 Action by Modulating BDNF and ARC Expression in The Rat Hippocampus


Paula Alexandra Postu, Adrian Tiron, Crina Elena Tiron, Dragoș Lucian Gorgan, Marius Mihasan and Lucian Hritcu*


DOI: 10.2174/1871527320666210303111537
View Abstract View on PubMed




Effectiveness and Safety Profile of Ginkgo Biloba Standardized Extract (EGb761®) in Patients with Amnestic Mild Cognitive Impairment


Ovidiu Băjenaru*, Gabriel Prada, Florina Antochi, Cătălin Jianu, Cătălina Tudose, Adina Cuciureanu, Any Axelerad Docu, Valérie Perrot, Madalina Avram and Cristina Tiu


DOI: 10.2174/1871527320666210208125524
View Abstract View on PubMed








Abstracts Ahead of Print



GluN2B/N-methyl-D-aspartate receptor antagonists: Advances in design, synthesis, and pharmacological evaluation studies


Vinod Ugale*, Ashish Dhote, Rushikesh Narwade, Saurabh Khadse, P. Narayana Reddy and Atul Shirkhedkar


DOI: 10.2174/1871527320666210309141627
View Abstract


The Link between Exercise and Homocysteine in the Alzheimer’s disease: A Bioinformatic Network Model


Luana Leão, Laís Felício, Knut Engedal, Gro Tangen, Kari Kristiansen, Sérgio Henrique S. Santos, Alfredo Paula and Renato Sobral Monteiro-Junior*


DOI: 10.2174/1871527320666210706122618
View Abstract


Lipid nanocarriers for neurotherapeuticals: Introduction, challenges, blood-brain barrier and promises of delivery approaches


Mohammed Aslam, Md. Noushad Javed*, Hala Hasan Deeb, Michel Kaisar Nicola, Aamir Mirza, Md. Sabir Alam, Habban Akhtar and Aafrin Waziri


DOI: 10.2174/1871527320666210706104240
View Abstract



Cellular senescence and ApoE4: their repercussions in Alzheimer’s disease


Angeles Tecalco–Cruz*, Jesús Zepeda–Cervantes, Lilia López-Canovas, Josué O. Ramírez–Jarquín, José Pedraza-Chaverrí and Alfredo Briones-Herera


DOI: 10.2174/1871527320666210628102721
View Abstract



Benzodiazepines and Sleep Architecture: a Systematic Review.


Felipe Maraucci Ribeiro de Mendonça, Giulia Paulo Rossi Ribeiro de Mendonça, Laura Costa Souza, Lucas Pequeno Galvão, Henrique Soares Paiva, Cintia de Azevedo Marques Périco, Julio Torales, Antonio Ventriglio, João Maurício Castaldelli-Maia and Anderson Sousa Martins Silva*


DOI: 10.2174/1871527320666210618103344
View Abstract


Recent Advancement of Pyrazole Scaffold Based Neuroprotective Agents: A Review


Subham Das, Saleem Akbar, Bahar Ahmed, Rikeshwar Prasad Dewangan, Mohammad Kashif Iqubal, Ashif Iqubal, Pooja Chawla, Faheem Hyder Pottoo* and Alex Joseph*


DOI: 10.2174/1871527320666210602152308
View Abstract


Published Contents

Editor's Choice


Nanoparticles Based Intranasal Delivery of Drug to Treat Alzheimer’s Disease: A Recent Update

, 2020; 19(9): 648 - 662

Manisha Pandey*, Hira Choudhury*, Rohit Kumar Verma, Viney Chawla, Subrat Kumar Bhattamisra, Bapi Gorain, Maria Abdul Ghafoor Raja and Muhammad Wahab Amjad


DOI: 10.2174/1871527319999200819095620





The MMP-2/TIMP-2 System in Alzheimer Disease

, 2020; 19(6): 402 - 416

Hongyue Wang, Longjian Huang, Lei Wu, Jiaqi Lan, Xinhong Feng, Pingping Li* and Ying Peng*


DOI: 10.2174/1871527319666200812223007



The locus of Action of CGRPergic Monoclonal Antibodies Against Migraine: Peripheral Over Central Mechanisms

, 2020; 19(5): 344 - 359

Abimael González-Hernández, Bruno A. Marichal-Cancino, Enrique García-Boll and Carlos M. Villalón*


DOI: 10.2174/1871527319666200618144637




Interlink Between Insulin Resistance and Neurodegeneration with an Update on Current Therapeutic Approaches

, 2020; 19(3): 174 - 183

Subrat Kumar Bhattamisra*, Lee Yuen Shin, Hanis Izzati Binti Mohd Saad, Vikram Rao, Mayuren Candasamy, Manisha Pandey and Hira Choudhury


DOI: 10.2174/1871527319666200518102130





Open Access Articles

Restless Leg Syndrome in Patients with Liver Cirrhosis! Its Frequency, Severity, and Correlation

, 2021; 20: 1 - 8 (E-Pub Ahead of Print)

Iftikhar Haider Naqvi*, Jawad Ahmed, Maliha Salim, Muhammad Ubaid, Farheen Malik, Razna Afzal, Muhammad Moinuddin Ashrafi and Muhammad Arbaz Arshad Khan




Effectiveness and Safety Profile of Ginkgo Biloba Standardized Extract (EGb761®) in Patients with Amnestic Mild Cognitive Impairment

, 2021; 20: 1 - 7 (E-Pub Ahead of Print)

Ovidiu Băjenaru*, Gabriel Prada, Florina Antochi, Cătălin Jianu, Cătălina Tudose, Adina Cuciureanu, Any Axelerad Docu, Valérie Perrot, Madalina Avram and Cristina Tiu




Management of Impulse Control Disorders with Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease

, 2020; 19(8): 611 - 617

Deborah Amstutz, Steffen Paschen, Martin Lenard Lachenmayer, Marie Elise Maradan-Gachet, Günther Deuschl, Paul Krack and Ines Debove*




Low Serum Levels of Fibroblast Growth Factor 2 in Gunn Rats: A Hyperbilirubinemia Animal Model of Schizophrenic Symptoms

, 2020; 19(7): 503 - 508

Maiko Hayashida*, Sadayuki Hashioka*, Kenji Hayashida, Shoko Miura, Keiko Tsuchie, Tomoko Araki, Muneto Izuhara, Misako Kanayama, Koji Otsuki, Michiharu Nagahama, Muhammad Alim Jaya, Ryosuke Arauchi, Rei Wake, Arata Oh-Nishi, Jun Horiguchi, Tsuyoshi Miyaoka, Masatoshi Inagaki and Eishin Morita




When Sick Brain and Hopelessness Meet: Some Aspects of Suicidality in the Neurological Patient

, 2020; 19(4): 257 - 263

Alessandra Costanza*, Andrea Amerio, Andrea Aguglia, Andrea Escelsior, Gianluca Serafini, Isabella Berardelli, Maurizio Pompili and Mario Amore





Fire Needle Acupuncture Regulates Wnt/ERK Multiple Pathways to Promote Neural Stem Cells to Differentiate into Neurons in Rats with Spinal Cord Injury

, 2019; 18(3): 245 - 255

Jiachun Xu, Suli Cheng, Zhaohua Jiao, Zhiheng Zhao, Zhimin Cai, Nan Su, Baohong Liu, Zhen Zhou* and Yan Li*




Oleanolic Acid Ameliorates Aβ25-35 Injection-induced Memory Deficit in Alzheimer’s Disease Model Rats by Maintaining Synaptic Plasticity

, 2018; 17(5): 389 - 399

Kai Wang, Weiming Sun, Linlin Zhang, Wei Guo, Jiachun Xu, Shuang Liu, Zhen Zhou and Yulian Zhang*




Physiological and Morphological Principles Underpinning Recruitment of the Cerebellar Reserve

, 2018; 17(3): 184 - 192

Shinji Kakei*, Takahiro Ishikawa, Jongho Lee, Takeru Honda and Donna S. Hoffman





Demonstration of Biological and Immunological Equivalence of a Generic Glatiramer Acetate

, 2017; 16(6): 714 - 723

Josephine D`Alessandro, Kevin Garofalo, Ganlin Zhao, Christopher Honan, Jay Duffner, Ishan Capila, Ian Fier, Ganesh Kaundinya, Daniel Kantor and Tanmoy Ganguly*




Nanomaterials for Neurology: State-of-the-Art

, 2016; 15(10): 1306 - 1324

María Fernanda Veloz-Castillo, Rachel M. West, Jessica Cordero-Arreola, Oscar Arias-Carrión and Miguel A. Méndez-Rojas




The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders

, 2016; 15(5): 564 - 577

Yuko Okamoto, Makoto Ishitobi, Yuji Wada and Hirotaka Kosaka





The Effects of Testosterone Supplementation on Cognitive Functioning in Older Men.

, 2016; 15(3): 337 - 343

Eka J. Wahjoepramono, Prita R. Asih, Vilia Aniwiyanti, Kevin Taddei, Satvinder S. Dhaliwal, Stephanie J. Fuller, Jonathan Foster, Malcolm Carruthers, Giuseppe Verdile, Hamid R Sohrabi and Ralph N. Martins





Most Cited Articles

Review Article

Nf-κb as a key mediator of brain inflammation in Alzheimer’s disease

, 2019; 18(1): 3-10.

Chul Ju Hwang, Dong-Young Choi, Mi Hee Park and Jin Tae Hong*


DOI: 10.2174/1871527316666170807130011



Research Article

Ethyl acetohydroxamate incorporated chalcones: Unveiling a novel class of chalcones for multitarget monoamine oxidase-b inhibitors against alzheimer’s disease

, 2019; 18(8): 643-654.

Reeta, Seung Cheol Baek, Jae Pil Lee, T.M. Rangarajan*, Ayushee, Rishi Pal Singh, Manjula Singh, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Hoon Kim* and Bijo Mathew*


DOI: 10.2174/1871527318666190906101326


Review Article

Epigenetics in neurodegenerative diseases: The role of histone deacetylases

, 2019; 18(1): 11-18.

Sorabh Sharma, K.C. Sarathlal and Rajeev Taliyan*


DOI: 10.2174/1871527317666181004155136


Review Article

Perspective design of chalcones for the management of cns disorders: A mini-review

, 2019; 18(6): 432-445.

Bijo Mathew*, Della Grace Thomas Parambi, Vishnu Sankar Sivasankarapillai, Md. Sahab Uddin, Jerad Suresh, Githa Elizabeth Mathew, Monu Joy, Akash Marathakam and Sheeba Varghese Gupta


DOI: 10.2174/1871527318666190610111246



Letter Article

When sick brain and hopelessness meet: Some aspects of suicidality in the neurological patient

, 2020; 19(4): 257-263.

Alessandra Costanza*, Andrea Amerio, Andrea Aguglia, Andrea Escelsior, Gianluca Serafini, Isabella Berardelli, Maurizio Pompili and Mario Amore


DOI: 10.2174/1871527319666200611130804


Research Article

Xuesaitong may protect against ischemic stroke by modulating microglial phenotypes and inhibiting neuronal cell apoptosis via the STAT3 signaling pathway

, 2019; 18(2): 115-123.

Fangfang Li , Haiping Zhao, Ziping Han, Rongliang Wang, Zhen Tao, Zhibin Fan, Sijia Zhang, Guangwen Li, Zhigang Chen* and Yumin Luo*


DOI: 10.2174/1871527317666181114140340


Clinical Trial

Ultramicronized palmitoylethanolamide (Um-PEA) as add-on treatment in fibromyalgia syndrome (FMS): Retrospective observational study on 407 patients

, 2019; 18(4): 326-333.

Vittorio Schweiger*, Alvise Martini, Paola Bellamoli, Katia Donadello, Carlo Schievano, Giovanna D. Balzo, Piercarlo Sarzi-Puttini, Massimo Parolini and Enrico Polati


DOI: 10.2174/1871527318666190227205359


Research Article

The role of annexin A1 and formyl peptide receptor 2/3 signaling in chronic corticosterone-induced depression-like behaviors and impairment in hippocampal-dependent memory

, 2020; 19(1): 27-43.

Alessio Filippo Peritore, Rosalia Crupi, Maria Scuto, Enrico Gugliandolo, Rosalba Siracusa, Daniela Impellizzeri, Marika Cordaro, Ramona D’amico, Roberta Fusco, Rosanna Di Paola and Salvatore Cuzzocrea*


DOI: 10.2174/1871527319666200107094732


Research Article

Cordycepin exerts neuroprotective effects via an anti-apoptotic mechanism based on the mitochondrial pathway in a rotenone-induced parkinsonism rat model

, 2019; 18(8): 609-620.

Xin Jiang, Pei-Chen Tang, Qin Chen, Xin Zhang, Yi-Yun Fan, Bo-Cheng Yu, Xin-Xia Gu, Ying Sun, Xiao-Qun Ge* and Xiao-Ling Zhang*


DOI: 10.2174/1871527318666190905152138


Review Article

Neuro-psychiatric alterations in patients with diabetic foot syndrome

, 2019; 18(8): 598-608.

Emmanuel Navarro-Flores, Pilar Pérez-Ros, Francisco Miguel Martínez-Arnau, Iván Julían-Rochina and Omar Cauli*


DOI: 10.2174/1871527318666191002094406


Systemic Review Article

Efficacy of celecoxib adjunct treatment on bipolar disorder: Systematic review and meta-analysis

, 2019; 18(1): 19-28.

Daniela V. Bavaresco, Tamy Colonetti, Antônio J. Grande, Francesc Colom, Samira S. Valvassori, João Quevedo and Maria I. da Rosa*


DOI: 10.2174/1871527317666181105162347


Research Article

Formononetin ameliorates cognitive disorder via PGC-1α pathway in neuroinflammation conditions in high-fat diet-induced mice

, 2019; 18(7): 566-577.

Xinxin Fu, Tingting Qin, Jiayu Yu, Jie Jiao, Zhanqiang Ma, Qiang Fu, Xueyang Deng and Shiping Ma*


DOI: 10.2174/1871527318666190807160137


Systemic Review Article

Suicide in parkinson’s disease: A systematic review

, 2019; 18(6): 466-477.

Isabella Berardelli, Daniele Belvisi, Adele Nardella, Giulia Falcone, Dorian A. Lamis, Giovanni Fabbrini, Alfredo Berardelli, Paolo Girardi and Maurizio Pompili*


DOI: 10.2174/1871527318666190703093345



Most Accessed Articles

Sepsis-Associated Encephalopathy: Insight into Injury and Pathogenesis

, 2021; 20(2): 112-124.

Lina Zhao, Yanxia Gao, Shigong Guo, Xin Lu, Shiyuan Yu, Zeng Zheng Ge, Hua Dong Zhu and Yi Li*


DOI: 10.2174/1871527319999201117122158


Acute Phenobarbital Poisoning for the Management of Seizures in Newborns and Children; A Systematic Literature Review

, 2021; 20(2): 174-180.

Adel Ghorani-Azam, Mahdi Balali-Mood, Bamdad Riahi-Zanjani, Emadodin Darchini-Maragheh and Mahmood Sadeghi*


DOI: 10.2174/1871527319666201207205916


Novel Targets Explored in the Treatment of Alcohol Withdrawal Syndrome

, 2021; 20(2): 158-173.

Antra Gupta, Heena Khan, Amarjot Kaur and Thakur Gurjeet Singh*


DOI: 10.2174/1871527319999201118155721


Importance of Zebrafish as an Efficient Research Model for the Screening of Novel Therapeutics in Neurological Disorders

, 2021; 20(2): 145-157.

Diksha Saluja, Rishabh Jhanji, Swati Kaushal, Bharti Verma, Neelam Sharma, Rima Singh, Shelly Agrawal, Meena Yadav, Anoop Kumar, Charan Singh and Arti Singh*


DOI: 10.2174/1871527319666201207211927




Nanomedicinal Strategies as Emerging Therapeutic Avenues to Treat and Manage Cerebral Ischemia

, 2021; 20(2): 125-144.

Saman Fatima, Syed Naved Quadri, Shaheda Parveen, Sarwar Beg*, Md Abul Barkat, Mohamed Samim, M.Z. Abdin and Farhan Jalees Ahmad


DOI: 10.2174/1871527319666201102100330


Histone Deacetylase Inhibitors Prevented the Development of Morphine Tolerance by Decreasing IL6 Production and Upregulating μ-Opioid Receptors

, 2021; 20(2): 190-198.

Sahil Jindal*, Nitesh Kumar*, Aarti Abhishek Shah, Abhishek Shah, Karthik Gourishetti and Mallikarjuna R. Chamallamudi


DOI: 10.2174/1871527319999201113102852





Current Strategies and Novel Drug Approaches for Alzheimer Disease

, 2020; 19(9): 676-690.

Roma Ghai*, Kandasamy Nagarajan, Meenakshi Arora, Parul Grover, Nazakat Ali and Garima Kapoor


DOI: 10.2174/1871527319666200717091513


The Mechanism of Action of Salsolinol in Brain: Implications in Parkinson’s Disease

, 2020; 19(10): 725-740.

Shee Man Voon, Khuen Yen Ng, Soi Moi Chye, Anna Pick Kiong Ling, Kenny Gah Leong Voon, Yiing Jye Yap and Rhun Yian Koh*


DOI: 10.2174/1871527319666200902134129



Quantitative Characterization of Phenotypical Markers After Differentiation of SH-SY5Y Cells

, 2020; 19(8): 618-629.

Angélique D. Ducray, Linda Wiedmer, Fabienne Herren, Hans Rudolf Widmer and Meike Mevissen*


DOI: 10.2174/1871527319666200708132716




Editor-in-Chief

graphic
Edoardo Spina
Department of Clinical and Experimental Medicine
University of Messina
Policlinico Universitario
Via Consolare Valeria
Messina
(Italy)
Biography
View Full Editorial Board

COPE Compliant

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Journal History

Current Drug Targets - CNS & Neurological Disorders was launched in 2002 and later renamed in 2006 as CNS & Neurological Disorders - Drug Targets.

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