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CNS & Neurological Disorders - Drug Targets

Formerly: Current Drug Targets - CNS & Neurological Disorders

Volume 21, 10 Issues, 2022
ISSN: 1996-3181 (Online)
ISSN: 1871-5273 (Print)
This journal supports open access

Aims & Scope

CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes.

CNS & Neurological Disorders - Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

CNS & Neurological Disorders - Drug Targets

,

Volume 21

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Number 8




Review Article




Research Article

Lactose and Casein Cause Changes on Biomarkers of Oxidative Damage and Dysbiosis in an Experimental Model of Multiple Sclerosis

, 21(8): 680 - 692

Begoña M. Escribano*, Ana Muñoz-Jurado*, Evelio Luque, Cristina Conde*, Montse Feijóo, Manuel LaTorre, Manuel E. Valdelvira, Paula Buendía, Ana I. Giraldo, Javier Caballero-Villarraso, Abel Santamaría, Eduardo Agüera and Isaac Túnez*


DOI: 10.2174/1871527320666211207101113


Research Article

Dipsacoside B Exerts a Beneficial Effect on Brain Injury in the Ischemic Stroke Rat through Inhibition of Mitochondrial E3 Ubiquitin Ligase 1

, 21(8): 693 - 703

Kai-Di Ren, Zi-Mei Peng, Jing Tian, Ya-Wei Peng, Yi-Yue Zhang, Xiao-Jie Zhang, Zhong-Yang Hu, Xiu-Ju Luo and Jun Peng*


DOI: 10.2174/1871527320666211118143554




Clinical Trial

Comparing the Efficacy and Safety of Dexmedetomidine/Ketamine with Propofol/Fentanyl for Sedation in Colonoscopy Patients: A Doubleblinded Randomized Clinical Trial

, 21(8): 724 - 731

Reza Aminnejad, Ahmad Hormati*, Hamed Shafiee, Faezeh Alemi, Maryam Hormati, Mohammad Saeidi, Sajjad Ahmadpour*, Seyed Mahdi Sabouri and Mohammad Aghaali


DOI: 10.2174/1871527320666211006141406


CNS & Neurological Disorders - Drug Targets, Volume 21 (2022) - Number 9


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print



Elucidations of Molecular Mechanism and Mechanistic Effects of Environmental Toxicants in Neurological Disorders


Harsh Goel, Keshav Goyal, Avanish Kumar Pandey, Mercilena Benjamin, Fahad Khan, Pratibha Pandey, Sandeep Mittan, Danish Iqbal, Mohammed Alsaweed, Wael Alturaiki, Yahya Madkhali, Mohammad Amjad Kamal, Pranay Tanwar and Tarun Kumar Upadhyay*


DOI: 10.2174/1871527321666220329103610
View Abstract View on PubMed



Role of Brain-Gut-Microbiota Axis in Depression: Emerging Therapeutic Avenues


Shvetank Bhatt*, Jovita Kanoujia, S. Mohanalakshmi, CR. Patil, Gaurav Gupta, Dinesh Kumar Chellappan and Kamal Dua


DOI: 10.2174/1871527321666220329140804
View Abstract View on PubMed



Clozapine in a Young Female with Drug-Resistant Schizophrenia: A Case Report of Development of Serositis


Andrea Aguglia*, Valentina Maria Parisi, Gabriele Arduino, Andrea Amerio, Alessandra Costanza, Gianluca Serafini and Mario Amore


DOI: 10.2174/1871527321666220324121207
View Abstract View on PubMed



Hypomyelination with Atrophy of Basal Ganglia and Cerebellum (HABC) Due to UFM1 Mutation in Roma Patients - Severe Early Encephalopathy with Stridor and Severe Hearing and Visual Impairment. A Single Center Experience


Ivan Ivanov*, Iliyana Pacheva, Ralitsa Yordanova, Iglika Sotkova, Fani Galabova, Katerina Gaberova, Margarita Panova, Ina Gheneva, Tsvetelina Tsvetanova, Katerina Noneva, Diana Dimitrova, Stoyan Markov, Nikolay Sapundzhiev, Stoyan Bichev and Alexey Savov


DOI: 10.2174/1871527321666220221100704
View Abstract View on PubMed


Mini Review on Cariprazine: A Promising Antipsychotic Agent


Ashish Patel*, Arya Patel, Darshini Patel, Krina Patel and Tushar Bambharoliya


DOI: 10.2174/1871527321666220324121935
View Abstract View on PubMed


Abstracts Ahead of Print

The Effects of Vitamin Therapy on ASD and ADHD: A Narrative review


Mohadeseh Poudineh, Sadaf Parvin, Mehrnia Omidali, Farhad Nikzad, Fatemeh Mohammadyari, Fatemeh Sadeghi Poor Ranjbar, Fayaz Rasouli, Sepehr Nanbakhsh and Sepehr Olangian-Tehrani*


DOI: 10.2174/1871527321666220517205813
View Abstract



Mechanistic insight and possible mechanism of seizure in Covid-19: The nuances and focal points


Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Abdur Rauf, Fahad A. Alhumaydhi, Małgorzata Kujawska* and Gaber El-Saber Batiha*


DOI: 10.2174/1871527321666220517115227
View Abstract


Oxytocin effect in adult patients with autism: An updated systematic review and meta-analysis of randomized controlled trials


Zahra Kiani, Tahereh Farkhondeh, Hamed Aramjoo, Michael Aschner, Hossein Beydokhti, Aliakbar Esmaeili, Morteza Arab-Zozani* and Saeed Samarghandian*


DOI: 10.2174/1871527321666220517112612
View Abstract




Heavy and Chronic Cannabis Addiction does not Impact Motor Function: BOLD-fMRI Study


Saïd Boujraf*, Badreeddine Alami, Mohamed Chikri, Halima El Hamdaoui, Mustapha Maaroufi, Rachid Aalouane and Ismail Rammouz


DOI: 10.2174/1574886317666220516103501
View Abstract


Impact of dimethylfumarate on sleep in multiple sclerosis patients: an actigraphic study.


Chiara Rocchi*, Lucrezia Lombardi, Serena Broggi, Maura Chiara Danni, Simona Lattanzi, Giovanna Viticchi, Lorenzo Falsetti, Marco Bartolini, Mauro Silvestrini and Laura Buratti


DOI: 10.2174/1871527321666220513121138
View Abstract


Neurobiology of amphetamine use in stroke recovery combined with rehabilitative training and brain stimulation.


Mohammad Uzair, Muhammad Arshad, Turki Abualait, Zeyad T. Al-Harbi, Talal M. Al-Harbi, Reem Bunyan Fahad, Abida Arshad, Woo Kyoung Yoo and Shahid Bashir*


DOI: 10.2174/1871527321666220512155811
View Abstract



Published Contents

Editor's Choice


Cellular Senescence and ApoE4: Their Repercussions in Alzheimer’s Disease

, 2021; 20(9): 778 - 785

Angeles C. Tecalco-Cruz*, Jesús Zepeda-Cervantes, Lilia López-Canovas, Josué Oriando Ramírez-Jarquín, José Pedraza-Chaverrí and Alfredo Briones-Herrera


DOI: 10.2174/1871527320666210628102721




Cellular and Molecular Mechanisms of Dementia: Decoding the Causal link of Diabetes Mellitus in Alzheimer’s Disease

, 2021; 20(7): 602 - 612

Mahmood Rasool*, Arif Malik, Sulayman Waquar, Ahmad Zaheer, Muhammad Asif, Zafar Iqbal, Kalamegam Gauthaman*, Mohammad Amjad Kamal and Peter Natesan Pushparaj*


DOI: 10.2174/1871527320666210212114116




Neurological Manifestations of COVID-19 and the Importance of Magnetic Resonance Imaging

, 2021; 20(5): 390 - 391

Rubens J. Gagliardi*, Renan Domingues, Cristine Cukier, Maria F. Mendes, Vivian D.B. Gagliardi and Francisco T.M. de Oliveira


DOI: 10.2174/1871527320666210122093458




The Role of Statins in the Management of Delirium: Recent Advances

, 2021; 20(3): 203 - 215

Junhui Chen, Yuhai Wang, Ximin Hu, Mingchang Li, Kun Xiong, Zhaocai Zhang* and Qianxue Chen*


DOI: 10.2174/1871527319666200720111318




Nanoparticles Based Intranasal Delivery of Drug to Treat Alzheimer’s Disease: A Recent Update

, 2020; 19(9): 648 - 662

Manisha Pandey*, Hira Choudhury*, Rohit Kumar Verma, Viney Chawla, Subrat Kumar Bhattamisra, Bapi Gorain, Maria Abdul Ghafoor Raja and Muhammad Wahab Amjad


DOI: 10.2174/1871527319999200819095620



Open Access Articles

Molecular and Biochemical Pathways Encompassing Diabetes Mellitus and Dementia

, 2022; 21(7): 542 - 556

Tapan Behl*, Arpita Arora, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Ahmed Al-Harrasi, Simona Bungau and Ebrahim Mostafavi*




Effectiveness and Safety Profile of <i>Ginkgo biloba</i> Standardized Extract (EGb761®) in Patients with Amnestic Mild Cognitive Impairment

, 2021; 20(4): 378 - 384

Ovidiu Băjenaru, Gabriel Prada, Florina Antochi, Cătălin Jianu, Cătălina Tudose, Adina Cuciureanu, Any A. Docu, Valérie Perrot, Madalina Avram and Cristina Tiu*




Management of Impulse Control Disorders with Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease

, 2020; 19(8): 611 - 617

Deborah Amstutz, Steffen Paschen, Martin Lenard Lachenmayer, Marie Elise Maradan-Gachet, Günther Deuschl, Paul Krack and Ines Debove*




When Sick Brain and Hopelessness Meet: Some Aspects of Suicidality in the Neurological Patient

, 2020; 19(4): 257 - 263

Alessandra Costanza*, Andrea Amerio, Andrea Aguglia, Andrea Escelsior, Gianluca Serafini, Isabella Berardelli, Maurizio Pompili and Mario Amore





Fire Needle Acupuncture Regulates Wnt/ERK Multiple Pathways to Promote Neural Stem Cells to Differentiate into Neurons in Rats with Spinal Cord Injury

, 2019; 18(3): 245 - 255

Jiachun Xu, Suli Cheng, Zhaohua Jiao, Zhiheng Zhao, Zhimin Cai, Nan Su, Baohong Liu, Zhen Zhou* and Yan Li*




Oleanolic Acid Ameliorates A&#946;25-35 Injection-induced Memory Deficit in Alzheimer’s Disease Model Rats by Maintaining Synaptic Plasticity

, 2018; 17(5): 389 - 399

Kai Wang, Weiming Sun, Linlin Zhang, Wei Guo, Jiachun Xu, Shuang Liu, Zhen Zhou and Yulian Zhang*




Physiological and Morphological Principles Underpinning Recruitment of the Cerebellar Reserve

, 2018; 17(3): 184 - 192

Shinji Kakei*, Takahiro Ishikawa, Jongho Lee, Takeru Honda and Donna S. Hoffman




Demonstration of Biological and Immunological Equivalence of a Generic Glatiramer Acetate

, 2017; 16(6): 714 - 723

Josephine D`Alessandro, Kevin Garofalo, Ganlin Zhao, Christopher Honan, Jay Duffner, Ishan Capila, Ian Fier, Ganesh Kaundinya, Daniel Kantor and Tanmoy Ganguly*




Nanomaterials for Neurology: State-of-the-Art

, 2016; 15(10): 1306 - 1324

María Fernanda Veloz-Castillo, Rachel M. West, Jessica Cordero-Arreola, Oscar Arias-Carrión and Miguel A. Méndez-Rojas




The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders

, 2016; 15(5): 564 - 577

Yuko Okamoto, Makoto Ishitobi, Yuji Wada and Hirotaka Kosaka





The Effects of Testosterone Supplementation on Cognitive Functioning in Older Men.

, 2016; 15(3): 337 - 343

Eka J. Wahjoepramono, Prita R. Asih, Vilia Aniwiyanti, Kevin Taddei, Satvinder S. Dhaliwal, Stephanie J. Fuller, Jonathan Foster, Malcolm Carruthers, Giuseppe Verdile, Hamid R Sohrabi and Ralph N. Martins





Most Cited Articles

Review Article

Nf-κb as a key mediator of brain inflammation in Alzheimer’s disease

, 2019; 18(1): 3-10.

Chul Ju Hwang, Dong-Young Choi, Mi Hee Park and Jin Tae Hong*


DOI: 10.2174/1871527316666170807130011


Research Article

Ethyl acetohydroxamate incorporated chalcones: Unveiling a novel class of chalcones for multitarget monoamine oxidase-b inhibitors against alzheimer’s disease

, 2019; 18(8): 643-654.

Reeta, Seung Cheol Baek, Jae Pil Lee, T.M. Rangarajan*, Ayushee, Rishi Pal Singh, Manjula Singh, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Hoon Kim* and Bijo Mathew*


DOI: 10.2174/1871527318666190906101326



Review Article

Epigenetics in neurodegenerative diseases: The role of histone deacetylases

, 2019; 18(1): 11-18.

Sorabh Sharma, K.C. Sarathlal and Rajeev Taliyan*


DOI: 10.2174/1871527317666181004155136


Letter Article

When sick brain and hopelessness meet: Some aspects of suicidality in the neurological patient

, 2020; 19(4): 257-263.

Alessandra Costanza*, Andrea Amerio, Andrea Aguglia, Andrea Escelsior, Gianluca Serafini, Isabella Berardelli, Maurizio Pompili and Mario Amore


DOI: 10.2174/1871527319666200611130804


Review Article

Perspective design of chalcones for the management of cns disorders: A mini-review

, 2019; 18(6): 432-445.

Bijo Mathew*, Della Grace Thomas Parambi, Vishnu Sankar Sivasankarapillai, Md. Sahab Uddin, Jerad Suresh, Githa Elizabeth Mathew, Monu Joy, Akash Marathakam and Sheeba Varghese Gupta


DOI: 10.2174/1871527318666190610111246



Research Article

The role of annexin A1 and formyl peptide receptor 2/3 signaling in chronic corticosterone-induced depression-like behaviors and impairment in hippocampal-dependent memory

, 2020; 19(1): 27-43.

Alessio Filippo Peritore, Rosalia Crupi, Maria Scuto, Enrico Gugliandolo, Rosalba Siracusa, Daniela Impellizzeri, Marika Cordaro, Ramona D’amico, Roberta Fusco, Rosanna Di Paola and Salvatore Cuzzocrea*


DOI: 10.2174/1871527319666200107094732


Research Article

Xuesaitong may protect against ischemic stroke by modulating microglial phenotypes and inhibiting neuronal cell apoptosis via the STAT3 signaling pathway

, 2019; 18(2): 115-123.

Fangfang Li , Haiping Zhao, Ziping Han, Rongliang Wang, Zhen Tao, Zhibin Fan, Sijia Zhang, Guangwen Li, Zhigang Chen* and Yumin Luo*


DOI: 10.2174/1871527317666181114140340


Review Article

Neuro-psychiatric alterations in patients with diabetic foot syndrome

, 2019; 18(8): 598-608.

Emmanuel Navarro-Flores, Pilar Pérez-Ros, Francisco Miguel Martínez-Arnau, Iván Julían-Rochina and Omar Cauli*


DOI: 10.2174/1871527318666191002094406


Research Article

Cordycepin exerts neuroprotective effects via an anti-apoptotic mechanism based on the mitochondrial pathway in a rotenone-induced parkinsonism rat model

, 2019; 18(8): 609-620.

Xin Jiang, Pei-Chen Tang, Qin Chen, Xin Zhang, Yi-Yun Fan, Bo-Cheng Yu, Xin-Xia Gu, Ying Sun, Xiao-Qun Ge* and Xiao-Ling Zhang*


DOI: 10.2174/1871527318666190905152138


General Research Article

Neuroprotection of rotenone-induced parkinsonism by ursolic acid in pd mouse model

, 2020; 19(7): 527-540.

Walia Zahra, Sachchida Nand Rai, Hareram Birla, Saumitra Sen Singh, Aaina Singh Rathore, Hagera Dilnashin, Richa Singh, Chetan Keswani, Rakesh K. Singh and Surya Pratap Singh*


DOI: 10.2174/1871527319666200812224457



Clinical Trial

Ultramicronized palmitoylethanolamide (Um-PEA) as add-on treatment in fibromyalgia syndrome (FMS): Retrospective observational study on 407 patients

, 2019; 18(4): 326-333.

Vittorio Schweiger*, Alvise Martini, Paola Bellamoli, Katia Donadello, Carlo Schievano, Giovanna D. Balzo, Piercarlo Sarzi-Puttini, Massimo Parolini and Enrico Polati


DOI: 10.2174/1871527318666190227205359




Most Accessed Articles

Therapeutic Potential of Biochanin-A Against Isoproterenol-Induced Myocardial Infarction in Rats

, 2020; 18(1): 31-36.

Govindasami, Sangeethadevi; Uddandrao, Veera Venkata Sathibabu; Raveendran, Nivedha; Sasikumar, Vadivukkarasi


DOI: 10.2174/1871525718666200206114304


Antiobesity Effect of Biochanin-A: Effect on Trace Element Metabolism in High Fat Diet-Induced Obesity in Rats

, 2020; 18(1): 21-30.

Rathinasamy, Jansy Isabella Rani Antony; Uddandrao, Veera Venkata Sathibabu; Raveendran, Nivedha; Sasikumar, Vadivukkarasi


DOI: 10.2174/1871524920666200207101920


Stevia as a Natural Sweetener: A Review

, 2020; 18(2): 94-103.

Arumugam, Balakrishnan; Subramaniam, Arunambiga; Alagaraj, Praveena


DOI: 10.2174/1871525718666200207105436




Editor-in-Chief

graphic
Edoardo Spina
Department of Clinical and Experimental Medicine
University of Messina
Policlinico Universitario
Via Consolare Valeria
Messina
(Italy)
Biography
View Full Editorial Board

COPE Compliant

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Journal History

Current Drug Targets - CNS & Neurological Disorders was launched in 2002 and later renamed in 2006 as CNS & Neurological Disorders - Drug Targets.

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