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Current Medicinal Chemistry

Volume 28, 42 Issues, 2021
ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)
This journal supports open access

Aims & Scope

Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth/mini reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

Current Medicinal Chemistry

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Volume 28

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Number 12



Biography   Open Access









Review Article



Review Article

Drug Repurposing: Promises of Edaravone Target Drug in Traumatic Brain Injury

, 28(12): 2369 - 2391

Zaynab Shakkour, Hawraa Issa, Helene Ismail, Ohanes Ashekyan, Karl John Habashy, Leila Nasrallah, Hussam Jourdi, Eva Hamade, Stefania Mondello, Mirna Sabra*, Kazem Zibara* and Firas Kobeissy*


DOI: 10.2174/0929867327666200812221022


Review Article

Targeting COVID-19 in Parkinson’s Patients: Drugs Repurposed

, 28(12): 2392 - 2408

Firoz Anwar*, Salma Naqvi, Fahad A. Al-Abbasi, Nauroz Neelofar, Vikas Kumar, Ankit Sahoo and Mohammad Amjad Kamal*


DOI: 10.2174/0929867327666200903115138


Review Article

Repurposing Cilostazol for Raynaud's Phenomenon

, 28(12): 2409 - 2417

Nehme El-Hachem, Manal M. Fardoun, Hasan Slika, Elias Baydoun and Ali H. Eid*


DOI: 10.2174/0929867327666200903114154


Current Medicinal Chemistry, Volume 28 (2021) - Number 15


This issue is in progress but contains articles that are final and fully citable.

Current Medicinal Chemistry, Volume 28 (2021) - Number 14


This issue is in progress but contains articles that are final and fully citable.

Current Medicinal Chemistry, Volume 28 (2021) - Number 13


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Na, K-ATPase as a Biological Target for Gold(III) Complexes: A Theoretical and Experimental Approach


Aleksandra M. Bondžić, Dragana D. Vasić Anićijević, Goran V. Janjić, Ivana Zeković, Tatjana Momić, Ana Vujačić Nikezić and Vesna M. Vasić*


DOI: 10.2174/0929867328999210101233801
View Abstract View on PubMed


Advances of Inorganic Materials in the Detection and Therapeutic Uses Against Coronaviruses


Sathish Veerasamy*, Manivannan Chandrakumar, Malathi Balasubramaniyan, Ramesh Kumar Arumugam and Thanasekaran Pounraj*


DOI: 10.2174/0929867328666210219142208
View Abstract View on PubMed



Conventional and Non-Conventional Targets of Natural Products in the Management of Diabetes Mellitus and Associated Complications


Mohamad Fawzi Mahomoodally, Devina Lobine, Marie Carene Nancy Picot-Allain, Nabeelah Sadeer, Sharmeen Jugreet and Gokhan Zengin*


DOI: 10.2174/0929867327666201102120120
View Abstract View on PubMed







Engineered Polymer Nanoplatforms for Targeted Tumor Cells and Controlled Release Cargos to Enhance Cancer Treatment


Zhenjie Wang, Longguang Tang, Qingchun Mu, Siyao Che*, Yongbing Sun*, Lei Bai, Yan Luo, Yeguo Yang, Meng Yu and Zhiqiang Yu*


DOI: 10.2174/0929867328666210226143148
View Abstract View on PubMed


Abstracts Ahead of Print



Mediterranean Diet, Brain and Muscle: Olive Polyphenols and Resveratrol Protection in Neurodegenerative and Neuromuscular Disorders


Carla Petrella*, Maria Grazia Di Certo, Francesca Gabanella, Christian Barbato, Flavio Maria Ceci, Antonio Greco, Massimo Ralli, Antonella Polimeni, Antonio Angeloni, Cinzia Severini1, Mario Vitali, Giampiero Ferraguti, Mauro Ceccanti, Marco Lucarelli, Carola Severi and Marco Fiore*


DOI: 10.2174/0929867328666210504113445
View Abstract



Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2): A Review on Pathophysiology, Diagnosis and Investigational Therapeutics


Rahul Sharma, Dharmendra Khokhar, Bhanushree Gupta*, Purnendu Saxena, Kallol Kumar Ghosh, Arvind Kumar Geda and Kamil Kuca


DOI: 10.2174/0929867328666210504110520
View Abstract




Protein-ligand Docking Simulations with AutoDock4 Focused on the Main Protease of SARS-CoV-2


Walter Filgueira de Azevedo Junior*, Gabriela Bitencourt-Ferreira, Joana Retzke Godoy, Hilda Mayela Aran Adriano, Wallyson André dos Santos Bezerra and Alexandra Martins dos Santos Soares


DOI: 10.2174/0929867328666210329094111
View Abstract


Overview of PCTK3/CDK18: A Cyclin-Dependent Kinase Involved in Specific Functions in Post-Mitotic Cells


Rebeka de Oliveir Pepino, Fernanda Coelho, Tatiane Aparecida Buzanello Janku, Diandra Pinheiro Alencar, Walter Figueira de Azevedo Jr* and Fernanda Canduri*


DOI: 10.2174/0929867328666210329122147
View Abstract


Targeting Never-In-Mitosis-A Related Kinase 5 in Cancer: A Review


Margarite D. Matossian*, Carrow I. Wells, William J. Zuercher, Bridgette M. Collins-Burow, David H. Drewry* and Matthew E. Burow*


DOI: 10.2174/0929867328666210322101749
View Abstract


Published Contents

Open Access Articles

Role of Alpha-Fetoprotein in Hepatocellular Carcinoma Drug Resistance

, 2021; 28(6): 1126 - 1142

Wei Li, Kun Liu, Yi Chen, Mingyue Zhu* and Mengsen Li*




Deep Learning in the Quest for Compound Nomination for Fighting COVID-19

, 2021; 28: 1 - 32 (E-Pub Ahead of Print)

Maria Mernea, Eliza. C. Martin, Andrei-José Petrescu* and Speranta Avram*




Tumor in 3D: In Vitro Complex Cellular Models to Improve Nanodrugs Cancer Therapy

, 2020; 27(42): 7234 - 7255

Soraia Fernandes*, Marco Cassani, Stefania Pagliari, Petr Filipensky, Francesca Cavalieri and Giancarlo Forte*





Osteoporosis: Current and Emerging Therapies Targeted to Immunological Checkpoints

, 2020; 27(37): 6356 - 6372

Massimo De Martinis, Maria Maddalena Sirufo and Lia Ginaldi*











Complex Signaling Networks Controlling Dynamic Molecular Changes in Pseudomonas aeruginosa Biofilm

, 2019; 26(11): 1979 - 1993

Grzegorz Guła, Agata Dorotkiewicz-Jach, Kamila Korzekwa, Miguel A. Valvano and Zuzanna Drulis-Kawa*





Fighting Type-2 Diabetes: Present and Future Perspectives

, 2019; 26(10): 1891 - 1907

Cai-Guo Yu, Ying Fu, Yuan Fang, Ning Zhang, Rong-Xin Sun, Dong Zhao, Ying-Mei Feng* and Bao-Yu Zhang*





Most Cited Articles


Review Article

Osteoporosis: Current and emerging therapies targeted to immunological checkpoints

, 2020; 27(37): 6356-6372.

Massimo De Martinis, Maria Maddalena Sirufo and Lia Ginaldi*


DOI: 10.2174/0929867326666190730113123


General Review Article

Aptamer-based targeted drug delivery systems: Current potential and challenges

, 2020; 27(13): 2189-2219.

Fen He, Nachuan Wen, Daipeng Xiao, Jianhua Yan, Hongjie Xiong, Shundong Cai, Zhenbao Liu* and Yanfei Liu*


DOI: 10.2174/0929867325666181008142831


Review Article

Antimicrobial capacity of plant polyphenols against gram-positive bacteria: A comprehensive review

, 2020; 27(15): 2576-2606.

Francisco Javier Álvarez-Martínez, Enrique Barrajón-Catalán*, José Antonio Encinar, Juan Carlos Rodríguez-Díaz and Vicente Micol


DOI: 10.2174/0929867325666181008115650


Review Article

Antiviral activities of human host defense peptides

, 2020; 27(9): 1420-1443.

David C. Brice and Gill Diamond*


DOI: 10.2174/0929867326666190805151654


Review Article

Targeting N-3 polyunsaturated fatty acids in non-alcoholic fatty liver disease

, 2020; 27(31): 5250-5272.

Rodrigo Valenzuela*, Macarena Ortiz, María Catalina Hernández-Rodas, Francisca Echeverría and Luis Alberto Videla


DOI: 10.2174/0929867326666190410121716


Review Article

Recent progress in histone deacetylase inhibitors as anticancer agents

, 2020; 27(15): 2449-2493.

Loredana Cappellacci*, Diego R. Perinelli, Filippo Maggi, Mario Grifantini and Riccardo Petrelli*


DOI: 10.2174/0929867325666181016163110


Review Article

The role of diet related short-chain fatty acids in colorectal cancer metabolism and survival: Prevention and therapeutic implications

, 2020; 27(24): 4087-4108.

Sara Daniela Gomes, Cláudia Suellen Oliveira, João Azevedo-Silva, Marta R. Casanova, Judite Barreto, Helena Pereira, Susana R. Chaves, Lígia R. Rodrigues, Margarida Casal, Manuela Côrte-Real, Fatima Baltazar and Ana Preto*


DOI: 10.2174/0929867325666180530102050


General Review Article

The role of matrix gla protein (MGP) in vascular calcification

, 2020; 27(10): 1647-1660.

Geir Bjørklund*, Erik Svanberg, Maryam Dadar, David J. Card, Salvatore Chirumbolo, Dominic J. Harrington and Jan Aaseth


DOI: 10.2174/0929867325666180716104159


Review Article

Structural basis for inhibition of enoyl-[acyl carrier protein] reductase (Inha) from mycobacterium tuberculosis

, 2020; 27(5): 745-759.

Maurício Boff de Ávila, Gabriela Bitencourt-Ferreira and Walter Filgueira de Azevedo*


DOI: 10.2174/0929867326666181203125229



Review Article

Obesity and body composition in man and woman: Associated diseases and the new role of gut microbiota

, 2020; 27(2): 216-229.

Ennio Avolio*, Paola Gualtieri , Lorenzo Romano, Claudio Pecorella, Simona Ferraro, Giuseppe Palma, Laura Di Renzo and Antonino De Lorenzo


DOI: 10.2174/0929867326666190326113607


Review Article

Polyoxometalates in biomedicine: Update and overview

, 2020; 27(3): 362-379.

Mirjana B. Čolović, Milan Lacković, Jovana Lalatović, Ali S. Mougharbel, Ulrich Kortz* and Danijela Z. Krstić*


DOI: 10.2174/0929867326666190827153532


General Review Article

Role of microRNAs in chronic lymphocytic leukemia pathogenesis

, 2020; 27(2): 282-297.

Ehsan Javandoost, Ehsan Firoozi-Majd, Hosein Rostamian, Mohammad Khakpoor- Koosheh and Hamid Reza Mirzaei*


DOI: 10.2174/0929867326666190911114842


Review Article

Role of resveratrol in modulating microRNAs in human diseases: From cancer to inflammatory disorder

, 2021; 28(2): 360-376.

Atefeh Amiri, Maryam Mahjoubin-Tehran, Zatollah Asemi, Alimohammad Shafiee, Sarah Hajighadimi, Sanaz Moradizarmehri, Hamid Reza Mirzaei* and Hamed Mirzaei*


DOI: 10.2174/0929867326666191212102407



Most Accessed Articles

Drug Repurposing: Promises of Edaravone Target Drug in Traumatic Brain Injury

, 2021; 28(12): 2369-2391.

Zaynab Shakkour, Hawraa Issa, Helene Ismail, Ohanes Ashekyan, Karl John Habashy, Leila Nasrallah, Hussam Jourdi, Eva Hamade, Stefania Mondello, Mirna Sabra*, Kazem Zibara* and Firas Kobeissy*


DOI: 10.2174/0929867327666200812221022


Machine Learning-Based Scoring Functions, Development and Applications with SAnDReS

, 2021; 28(9): 1746-1756.

Gabriela Bitencourt-Ferreira, Camila Rizzotto and Walter Filgueira de Azevedo Junior*


DOI: 10.2174/0929867327666200515101820



Targeting COVID-19 in Parkinson’s Patients: Drugs Repurposed

, 2021; 28(12): 2392-2408.

Firoz Anwar*, Salma Naqvi, Fahad A. Al-Abbasi, Nauroz Neelofar, Vikas Kumar, Ankit Sahoo and Mohammad Amjad Kamal*


DOI: 10.2174/0929867327666200903115138




Monoclonal Antibodies: A Prospective and Retrospective View

, 2021; 28(3): 435-471.

Jwala Sivaccumar*, Annamaria Sandomenico*, Luigi Vitagliano and Menotti Ruvo*


DOI: 10.2174/0929867327666200219142231



Dual-target Inhibitors Based on BRD4: Novel Therapeutic Approaches for Cancer

, 2021; 28(9): 1775-1795.

Sitao Zhang, Yanzhao Chen, Chengsen Tian, Yujing He, Zeru Tian, Yichao Wan and Tingting Liu*


DOI: 10.2174/0929867327666200610174453





Insights into RNA-dependent RNA Polymerase Inhibitors as Antiinfluenza Virus Agents

, 2021; 28(6): 1068-1090.

Ilaria Giacchello, Francesca Musumeci*, Ilaria D’Agostino, Chiara Greco, Giancarlo Grossi and Silvia Schenone


DOI: 10.2174/0929867327666200114115632


Recent Advances in c-Jun N-Terminal Kinase (JNK) Inhibitors

, 2021; 28(3): 607-627.

Gang Li, Wenqing Qi, Xiaoxun Li, Jinwu Zhao, Meihua Luo and Jianjun Chen*


DOI: 10.2174/0929867327666200210144114





Editor-in-Chief

graphic
Atta-ur-Rahman, FRS
(32052 citations)
Kings College
University of Cambridge
Cambridge
(UK)
Biography
View Full Editorial Board

Nobel Laureates on Editorial Board

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Prof. John Gurdon
(UK)

graphic
Prof. Jean-Marie Lehn
(France)

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Prof. Ferid Murad
(USA)

COPE Compliant

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Journal History

Current Medicinal Chemistry was introduced in 1994 with the assistance of Dr. Atta-ur-Rahman, who is the current Editor-in-Chief serving since 1994.

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