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Central Nervous System Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Central Nervous System Agents

Volume 21, 3 Issues, 2021
ISSN: 1875-6166 (Online)
ISSN: 1871-5249 (Print)
This journal supports open access

Aims & Scope

Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents.

Containing a series of in-depth/mini reviews, original research articles, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.

Central Nervous System Agents in Medicinal Chemistry

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Volume 20

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Number 3



Biography   Open Access



Review Article

Old Drugs with New Tricks: Paradigm in Drug Development Pipeline for Alzheimer’s Disease

, 20(3): 157 - 176

Tanay Dalvi, Bhaskar Dewangan, Rudradip Das, Jyoti Rani, Suchita D. Shinde, Nazmina Vhora, Alok Jain and Bichismita Sahu*


DOI: 10.2174/1871524920666201021164805




Research Article

Extraction, GC-MS Evaluation and Anti-epileptic Potential of Seeds Ethanolic Extract of Putranjiva roxburghii Wall

, 20(3): 186 - 193

Chandra Kala*, Syed S. Imam, Mohamad Taleuzzaman, Sadaf J. Gilani, Syed S. Ali, Iqra Rahat, Adil Ahmad and Najam A. Khan


DOI: 10.2174/1871524920999201027125743


Research Article

Anti-nociceptive Effect of Euphorbia hirta Leaf Extract: Involvement of Adenosine, Cholinergic, and Opioid Receptors

, 20(3): 194 - 205

Temitope Janet Olatoyan-Layonu, Olayemi Kamoru Wakeel*, Abraham Ifedayo Abe, Olusola Ojurongbe and Oluwaseyi Adegboyega Adeyeba


DOI: 10.2174/1871524920666200705221956




Case Report

The Efficacy of Melanin Precursor QIAPI 1© Against Age-related Macular Degeneration (AMD): A Case Report

, 20(3): 218 - 225

Arturo S. Herrera, Narasimha M. Beeraka, Luis Fernando T. Solis, Liudmila M. Mikhaleva, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*


DOI: 10.2174/1871524920666201109152951




Articles Ahead of Print


Withdrawal Notice: Applying Peer Mentoring to Improve Learning Human Anatomy


Vladimir N. Nikolenko, Negoriya A. Rizaeva, Marine V. Oganesyan, Valentina A. Kudryashova, Polina I. Dubrovina, Alexandra A. Dubovets, Anastasia A. Bolotskaya, Kirill V. Bulygin, Cristian Muresanu, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*


DOI: 10.2174/1871524921666210212110151
View Abstract




The Neuroprotective Properties, Functions, and Roles of Cannabis sativa in Selected Diseases Related to the Nervous System


Onesimus Mahdi, Mohamad Taufik Hidayat Baharuldin, Nurul Huda Mohd Nor, Samaila Musa Chiroma, Saravanan Jagadeesan and Mohamad Aris Mohd Moklas*


DOI: 10.2174/1871524921666210127110028
View Abstract View on PubMed





Abstracts Ahead of Print

Statistical Review of the Suicide Attempts Rates Committed on Polish Railway Tracks between the years 2013-2016


Marta Makara-Studzinska, Adam Czabański, Katarzyna Gronowska, Jerzy Leszek, Elizaveta V. Mikhaylenko, Marco F. Avila-Rodriguez, Cristian Muresanu, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*


DOI: 10.2174/1871524921666210204220621
View Abstract


Published Contents

Editor's Choice



Antioxidant Effect of Flavonoids Present in Euterpe oleracea Martius and Neurodegenerative Diseases: A Literature Review

, 2019; 19(2): 75 - 99

Nayana Keyla Seabra de Oliveira*, Marcos Rafael Silva Almeida, Franco Márcio Maciel Pontes, Mariana Pegrucci Barcelos, Carlos Henrique Tomich de Paula da Silva, Joaquín María Campos Rosa, Rodrigo Alves Soares Cruz and Lorane Izabel da Silva Hage-Melim*


DOI: 10.2174/1871524919666190502105855



A Novel Non-invasive Effective Method for Potential Treatment of Degenerative Disc Disease: A Hypothesis

, 2019; 19(1): 8 - 14

Siva G. Somasundaram, Cristian Muresanu, Pamela Schield, Alfiya Makhmutovа, Elena V. Bovina, Vladimir P. Fisenko, Nusrat F. Hasanov and Gjumrakch Aliev*


DOI: 10.2174/1871524918666181017152053



Classification (Agonist/Antagonist) and Regression “Structure-Activity” Models of Drug Interaction with 5-HT6

, 2018; 18(3): 213 - 221

Oleg A. Raevsky, Veniamin Y. Grigorev, Alexander V. Yarkov, Daniel E. Polianczyk, Vadim V. Tarasov, Elena V. Bovina, Elena N. Bryzhakina, John C. Dearden, Marco Avila-Rodriguez and Gjumrakch Aliev*


DOI: 10.2174/1871524918666180827100437




Astrocyte`s RAGE: More Than Just a Question of Mood

, 2018; 18(1): 39 - 48

Rodrigo E. Gonzalez-Reyes* and Maria G. Rubiano


DOI: 10.2174/1871524916999160505105121





Psychomotor Seizure Screening and in vitro Neuroprotection Assay of Hydrazones Derived from 2-Acetyl Thiophene

, 2017; 17(1): 51 - 57

Bijo Mathew, Githa E. Mathew, Jerad Suresh, Mohammed Jaseel, D. Usman, P. N. Shiva Subramanyan, Kallivalappil F. Safna and Jobin K. Vilapurathu


DOI: 10.2174/1871524915999151028111728



Open Access Articles




The Role of Melanin to Dissociate Oxygen from Water to Treat Retinopathy of Prematurity

, 2019; 19(3): 215 - 222

Arturo S. Herrera, María del Carmen A. Esparza, Paola E.S. Arias, Ghulam M. Ashraf, Osama F. Mosa, Vladimir P. Fisenko, Susanna S. Sologova, Samira A. Dostdar, Alexander V. Sokolov, Elena V. Bovina, Vladimir N. Chubarev, Vadim V. Tarasov, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*




A Novel Highly Selective Cannabinoid CB2 Agonist Reduces in vitro Growth and TGF-beta Release of Human Glial Cell Tumors

, 2019; 19(3): 206 - 214

Chiara Cioni, Maristella Tassi, Giuseppe Marotta, Claudia Mugnaini, Federico Corelli* and Pasquale Annunziata*





Noradrenergic Regulation of Hippocampus-Dependent Memory

, 2019; 19(3): 187 - 196

Peter V. Nguyen and Steven A. Connor*




Berberine: A Plant-derived Alkaloid with Therapeutic Potential to Combat Alzheimer’s disease

, 2019; 19(3): 154 - 170

Anurag K. Singh, Santosh K. Singh, Manmath K. Nandi, Gaurav Mishra, Anand Maurya, Arati Rai, Gopal K. Rai, Rajendra Awasthi*, Bhupesh Sharma and Giriraj T. Kulkarni




Antioxidant Effect of Flavonoids Present in Euterpe oleracea Martius and Neurodegenerative Diseases: A Literature Review

, 2019; 19(2): 75 - 99

Nayana Keyla Seabra de Oliveira*, Marcos Rafael Silva Almeida, Franco Márcio Maciel Pontes, Mariana Pegrucci Barcelos, Carlos Henrique Tomich de Paula da Silva, Joaquín María Campos Rosa, Rodrigo Alves Soares Cruz and Lorane Izabel da Silva Hage-Melim*








Opening New Scenarios for Human MAO Inhibitors

, 2016; 16(2): 98 - 104

Celeste De Monte, Melissa D'Ascenzio, Paolo Guglielmi, Veronica Mancini and Simone Carradori






Most Cited Articles


Review Article (Mini-Review)

Understanding the pathogenesis involved in parkinson’s disease and potential therapeutic treatment strategies

, 2020; 20(2): 88-102.

Meenakshi Dhanawat, Dinesh K. Mehta, Sumeet Gupta and Rina Das*


DOI: 10.2174/1871524920666200705222842





Research Article

Anti-nociceptive effect of Euphorbia hirta leaf extract: Involvement of adenosine, cholinergic, and opioid receptors

, 2020; 20(3): 194-205.

Temitope Janet Olatoyan-Layonu, Olayemi Kamoru Wakeel*, Abraham Ifedayo Abe, Olusola Ojurongbe and Oluwaseyi Adegboyega Adeyeba


DOI: 10.2174/1871524920666200705221956


Research Article

Extraction, GC-MS evaluation and anti-epileptic potential of seeds etha-nolic extract of Putranjiva roxburghii wall

, 2020; 20(3): 186-193.

Chandra Kala*, Syed S. Imam, Mohamad Taleuzzaman, Sadaf J. Gilani, Syed S. Ali, Iqra Rahat, Adil Ahmad and Najam A. Khan


DOI: 10.2174/1871524920999201027125743


Review Article

Old drugs with new tricks: Paradigm in drug development pipeline for Alzheimer’s disease

, 2020; 20(3): 157-176.

Tanay Dalvi, Bhaskar Dewangan, Rudradip Das, Jyoti Rani, Suchita D. Shinde, Nazmina Vhora, Alok Jain and Bichismita Sahu*


DOI: 10.2174/1871524920666201021164805



Case Report

The efficacy of melanin precursor QIAPI 1<sup>©</sup> against age-related macular degeneration (AMD): A case report

, 2020; 20(3): 218-225.

Arturo S. Herrera, Narasimha M. Beeraka, Luis Fernando T. Solis, Liudmila M. Mikhaleva, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*


DOI: 10.2174/1871524920666201109152951




Research Article

Drug repositioning: Antimalarial activities of gaba analogs in mice infected with plasmodium berghei

, 2020; 20(2): 110-121.

Akeem A. Ayankunle*, Olayemi K. Wakeel, Oyetunji T. Kolawole, Adesola O. Oyekale, Olusola Ojurongbe and Oluwaseyi A. Adeyeba


DOI: 10.2174/1871524920666200604151907


Research Article

Theoretical study of monoamine oxidase b inhibitors as drug candidates for treatment of parkinson’s disease

, 2020; 20(2): 128-143.

Lucilene R. Souza, Leide C.S. Picanço, Maiara F.B. Brito, Marcos R.S. Almeida, Bianca L.B. Marino, Kessia P.A. Sousa, Jaderson V. Ferreira, Cleydson B.R. dos Santos, Guilherme M. Silva, Carlos H.T.P. Silva, Carlton A. Taft and Lorane I.S. Hage-Melim*


DOI: 10.2174/1871524920666200217110211


Research Article

Potential mechanisms involved in the anticonvulsant effect of methanol extract of pyrenancantha staudtii in mice

, 2020; 20(2): 144-154.

Olayemi K. Wakeel*, Oluropo B. Awosan, Oyetunji T. Kolawole, Akeem A. Ayankunle, Olukunle J. Onaolapo and Oluwaseyi A. Adeyeba


DOI: 10.2174/1871524920666200211113633



Most Accessed Articles

Old Drugs with New Tricks: Paradigm in Drug Development Pipeline for Alzheimer’s Disease

, 2020; 20(3): 157-176.

Tanay Dalvi, Bhaskar Dewangan, Rudradip Das, Jyoti Rani, Suchita D. Shinde, Nazmina Vhora, Alok Jain and Bichismita Sahu*


DOI: 10.2174/1871524920666201021164805





Anti-nociceptive Effect of Euphorbia hirta Leaf Extract: Involvement of Adenosine, Cholinergic, and Opioid Receptors

, 2020; 20(3): 194-205.

Temitope Janet Olatoyan-Layonu, Olayemi Kamoru Wakeel*, Abraham Ifedayo Abe, Olusola Ojurongbe and Oluwaseyi Adegboyega Adeyeba


DOI: 10.2174/1871524920666200705221956



The Efficacy of Melanin Precursor QIAPI 1© Against Age-related Macular Degeneration (AMD): A Case Report

, 2020; 20(3): 218-225.

Arturo S. Herrera, Narasimha M. Beeraka, Luis Fernando T. Solis, Liudmila M. Mikhaleva, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*


DOI: 10.2174/1871524920666201109152951


Extraction, GC-MS Evaluation and Anti-epileptic Potential of Seeds Ethanolic Extract of Putranjiva roxburghii Wall

, 2020; 20(3): 186-193.

Chandra Kala*, Syed S. Imam, Mohamad Taleuzzaman, Sadaf J. Gilani, Syed S. Ali, Iqra Rahat, Adil Ahmad and Najam A. Khan


DOI: 10.2174/1871524920999201027125743


Drug Repositioning: Antimalarial Activities of GABA Analogs in Mice Infected with Plasmodium berghei

, 2020; 20(2): 110-121.

Akeem A. Ayankunle*, Olayemi K. Wakeel, Oyetunji T. Kolawole, Adesola O. Oyekale, Olusola Ojurongbe and Oluwaseyi A. Adeyeba


DOI: 10.2174/1871524920666200604151907




Theoretical Study of Monoamine Oxidase B Inhibitors as Drug Candidates for Treatment of Parkinson’s Disease

, 2020; 20(2): 128-143.

Lucilene R. Souza, Leide C.S. Picanço, Maiara F.B. Brito, Marcos R.S. Almeida, Bianca L.B. Marino, Kessia P.A. Sousa, Jaderson V. Ferreira, Cleydson B.R. dos Santos, Guilherme M. Silva, Carlos H.T.P. Silva, Carlton A. Taft and Lorane I.S. Hage-Melim*


DOI: 10.2174/1871524920666200217110211


Potential Mechanisms Involved in the Anticonvulsant Effect of Methanol Extract of Pyrenancantha staudtii in Mice

, 2020; 20(2): 144-154.

Olayemi K. Wakeel*, Oluropo B. Awosan, Oyetunji T. Kolawole, Akeem A. Ayankunle, Olukunle J. Onaolapo and Oluwaseyi A. Adeyeba


DOI: 10.2174/1871524920666200211113633





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