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CNS & Neurological Disorders - Drug Targets

Formerly: Current Drug Targets - CNS & Neurological Disorders

Volume 20, 10 Issues, 2021
ISSN: 1996-3181 (Online)
ISSN: 1871-5273 (Print)
This journal supports open access

Aims & Scope

CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes.

CNS & Neurological Disorders - Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

CNS & Neurological Disorders - Drug Targets

,

Volume 19

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Number 10



Biography   Open Access



Review Article

The Mechanism of Action of Salsolinol in Brain: Implications in Parkinson’s Disease

, 19(10): 725 - 740

Shee Man Voon, Khuen Yen Ng, Soi Moi Chye, Anna Pick Kiong Ling, Kenny Gah Leong Voon, Yiing Jye Yap and Rhun Yian Koh*


DOI: 10.2174/1871527319666200902134129










Acknowledgement   Open Access



Articles Ahead of Print

Cellular and Molecular Mechanisms of Dementia: Decoding the Causal link of Diabetes Mellitus in Alzheimer’s Disease


Mahmood Rasool*, Arif Malik, Sulayman Waquar, Ahmad Zaheer, Muhammad Asif, Zafar Iqbal, Kalamegam Gauthaman*, Mohammad Amjad Kamal and Peter Natesan Pushparaj*


DOI: 10.2174/1871527320666210212114116
View Abstract View on PubMed





Experimental Rodent Models of Vascular Dementia: A Systematic Review


Nidhi Tiwari, Jyoti Upadhyay, Mohd Nazam Ansari*, Syed Shadab Raza, Wasim Ahmad and Mohammad Azam Ansari


DOI: 10.2174/1871527319666210108123438
View Abstract View on PubMed


Deciphering the Role of Aberrant Protein Post-Translational Modification in the Pathology of Neurodegeneration


Sadat Shafi, Archu Singh, Paras Gupta, Pooja A. Chawla, Faizana Fayaz, Anjali Sharma and Faheem Hyder Pottoo*


DOI: 10.2174/1871527319666200903162200
View Abstract View on PubMed



Sleep Disorders Research From 1945 to 2020: A Bibliometric Analysis


Waseem Hassan*, Mehreen Zafar, Hamsa Noreen, Amina Ara, Antonia Eliene Duarte, Jean Paul Kamdem, Mohammad Amjad Kamal and Joao Batista Teixeira da Rocha


DOI: 10.2174/1871527320666210218085341
View Abstract View on PubMed




Abstracts Ahead of Print


Caracole as a Potential Neuroprotective Agent for Neurological Diseases: A Systematic


Mohammad Zamanian, Małgorzata Kujawska, Marjan Nikbakht Zadeh, Amin Hassanshahi, Soudeh Ramezanpour , Zahra Kamiab and Gholamreza Bazmandegan*


DOI: 10.2174/1871527320666210506185042
View Abstract








Modifiable Risk Factors Associated with Alzheimer’s Disease with Special Reference to Sleep Disturbance


Pallavi Singh Chauhan, Meerambika Mishra, Bhupendra Koul, Mayank Sharma and Dhananjay Yadav*


DOI: 10.2174/1871527320666210319111852
View Abstract


Beta-caryophyllene, a CB2R selective agonist, protects against cognitive impairment caused by neuro-inflammation and not in dementia due to ageing induced by mitochondrial dysfunction


Urja Kanojia, Shrikant Gyaneshwar Chaturbhuj, Runali Sankhe, Maushami Das, Raviteja Surubhotla, Nandakumar Krishnadas, Karthik Gourishetti, Pawan Ganesh Nayak and Anoop Kishore*


DOI: 10.2174/1871527320666210202121103
View Abstract


Published Contents

Editor's Choice

Nanoparticles Based Intranasal Delivery of Drug to Treat Alzheimer’s Disease: A Recent Update

, 2020; 19(9): 648 - 662

Manisha Pandey*, Hira Choudhury*, Rohit Kumar Verma, Viney Chawla, Subrat Kumar Bhattamisra, Bapi Gorain, Maria Abdul Ghafoor Raja and Muhammad Wahab Amjad


DOI: 10.2174/1871527319999200819095620





The MMP-2/TIMP-2 System in Alzheimer Disease

, 2020; 19(6): 402 - 416

Hongyue Wang, Longjian Huang, Lei Wu, Jiaqi Lan, Xinhong Feng, Pingping Li* and Ying Peng*


DOI: 10.2174/1871527319666200812223007



The locus of Action of CGRPergic Monoclonal Antibodies Against Migraine: Peripheral Over Central Mechanisms

, 2020; 19(5): 344 - 359

Abimael González-Hernández, Bruno A. Marichal-Cancino, Enrique García-Boll and Carlos M. Villalón*


DOI: 10.2174/1871527319666200618144637




Interlink Between Insulin Resistance and Neurodegeneration with an Update on Current Therapeutic Approaches

, 2020; 19(3): 174 - 183

Subrat Kumar Bhattamisra*, Lee Yuen Shin, Hanis Izzati Binti Mohd Saad, Vikram Rao, Mayuren Candasamy, Manisha Pandey and Hira Choudhury


DOI: 10.2174/1871527319666200518102130





Pharmacotherapy of Down’s Syndrome: When and Which?

, 2019; 18(10): 750 - 757

Seyed K. Tayebati*, Alessandro Cecchi, Ilenia Martinelli, Elisa Carboni and Francesco Amenta


DOI: 10.2174/1871527318666191114092924



Open Access Articles

Restless Leg Syndrome in Patients with Liver Cirrhosis! Its Frequency, Severity, and Correlation

, 2021; 20: 1 - 8 (E-Pub Ahead of Print)

Iftikhar Haider Naqvi*, Jawad Ahmed, Maliha Salim, Muhammad Ubaid, Farheen Malik, Razna Afzal, Muhammad Moinuddin Ashrafi and Muhammad Arbaz Arshad Khan




Management of Impulse Control Disorders with Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease

, 2020; 19(8): 611 - 617

Deborah Amstutz, Steffen Paschen, Martin Lenard Lachenmayer, Marie Elise Maradan-Gachet, Günther Deuschl, Paul Krack and Ines Debove*




Low Serum Levels of Fibroblast Growth Factor 2 in Gunn Rats: A Hyperbilirubinemia Animal Model of Schizophrenic Symptoms

, 2020; 19(7): 503 - 508

Maiko Hayashida*, Sadayuki Hashioka*, Kenji Hayashida, Shoko Miura, Keiko Tsuchie, Tomoko Araki, Muneto Izuhara, Misako Kanayama, Koji Otsuki, Michiharu Nagahama, Muhammad Alim Jaya, Ryosuke Arauchi, Rei Wake, Arata Oh-Nishi, Jun Horiguchi, Tsuyoshi Miyaoka, Masatoshi Inagaki and Eishin Morita




When Sick Brain and Hopelessness Meet: Some Aspects of Suicidality in the Neurological Patient

, 2020; 19(4): 257 - 263

Alessandra Costanza*, Andrea Amerio, Andrea Aguglia, Andrea Escelsior, Gianluca Serafini, Isabella Berardelli, Maurizio Pompili and Mario Amore





Fire Needle Acupuncture Regulates Wnt/ERK Multiple Pathways to Promote Neural Stem Cells to Differentiate into Neurons in Rats with Spinal Cord Injury

, 2019; 18(3): 245 - 255

Jiachun Xu, Suli Cheng, Zhaohua Jiao, Zhiheng Zhao, Zhimin Cai, Nan Su, Baohong Liu, Zhen Zhou* and Yan Li*




Oleanolic Acid Ameliorates Aβ25-35 Injection-induced Memory Deficit in Alzheimer’s Disease Model Rats by Maintaining Synaptic Plasticity

, 2018; 17(5): 389 - 399

Kai Wang, Weiming Sun, Linlin Zhang, Wei Guo, Jiachun Xu, Shuang Liu, Zhen Zhou and Yulian Zhang*




Physiological and Morphological Principles Underpinning Recruitment of the Cerebellar Reserve

, 2018; 17(3): 184 - 192

Shinji Kakei*, Takahiro Ishikawa, Jongho Lee, Takeru Honda and Donna S. Hoffman




Demonstration of Biological and Immunological Equivalence of a Generic Glatiramer Acetate

, 2017; 16(6): 714 - 723

Josephine D`Alessandro, Kevin Garofalo, Ganlin Zhao, Christopher Honan, Jay Duffner, Ishan Capila, Ian Fier, Ganesh Kaundinya, Daniel Kantor and Tanmoy Ganguly*




Nanomaterials for Neurology: State-of-the-Art

, 2016; 15(10): 1306 - 1324

María Fernanda Veloz-Castillo, Rachel M. West, Jessica Cordero-Arreola, Oscar Arias-Carrión and Miguel A. Méndez-Rojas




The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders

, 2016; 15(5): 564 - 577

Yuko Okamoto, Makoto Ishitobi, Yuji Wada and Hirotaka Kosaka





The Effects of Testosterone Supplementation on Cognitive Functioning in Older Men.

, 2016; 15(3): 337 - 343

Eka J. Wahjoepramono, Prita R. Asih, Vilia Aniwiyanti, Kevin Taddei, Satvinder S. Dhaliwal, Stephanie J. Fuller, Jonathan Foster, Malcolm Carruthers, Giuseppe Verdile, Hamid R Sohrabi and Ralph N. Martins




Ouabain-Induced Signaling and Cell Survival in SK-N-SH Neuroblastoma Cells Differentiated by Retinoic Acid

, 2015; 14(10): 1343 - 1349

Evgeny E. Akkuratov, Jian Wu, David Sowa, Zahoor A. Shah and Lijun Liu






Most Cited Articles

Letter Article

When sick brain and hopelessness meet: Some aspects of suicidality in the neurological patient

, 2020; 19(4): 257-263.

Alessandra Costanza*, Andrea Amerio, Andrea Aguglia, Andrea Escelsior, Gianluca Serafini, Isabella Berardelli, Maurizio Pompili and Mario Amore


DOI: 10.2174/1871527319666200611130804


Research Article

The role of annexin A1 and formyl peptide receptor 2/3 signaling in chronic corticosterone-induced depression-like behaviors and impairment in hippocampal-dependent memory

, 2020; 19(1): 27-43.

Alessio Filippo Peritore, Rosalia Crupi, Maria Scuto, Enrico Gugliandolo, Rosalba Siracusa, Daniela Impellizzeri, Marika Cordaro, Ramona D’amico, Roberta Fusco, Rosanna Di Paola and Salvatore Cuzzocrea*


DOI: 10.2174/1871527319666200107094732


Review Article (Mini-Review)

Inflammation and mitochondrial dysfunction in autism spectrum disorder

, 2020; 19(5): 320-333.

Maria Gevezova, Victoria Sarafian*, George Anderson and Michael Maes


DOI: 10.2174/1871527319666200628015039


Research Article

Stingless bee honey reduces anxiety and improves memory of the metabolic disease-induced rats

, 2020; 19(2): 115-126.

Nurul ‘Ain Arshad, Teoh Seong Lin and Mohamad Fairuz Yahaya*


DOI: 10.2174/1871527319666200117105133


Research Article

Quantitative characterization of phenotypical markers after differentiation of SH-SY5Y cells

, 2020; 19(8): 618-629.

Angélique D. Ducray, Linda Wiedmer, Fabienne Herren, Hans Rudolf Widmer and Meike Mevissen*


DOI: 10.2174/1871527319666200708132716


Review Article

A pivotal role of the nrf2 signaling pathway in spinal cord injury: A prospective therapeutics study

, 2020; 19(3): 207-219.

Saeed Samarghandian, Ali Mohammad Pourbagher-Shahri, Milad Ashrafizadeh, Haroon Khan, Fatemeh Forouzanfar, Hamed Aramjoo and Tahereh Farkhondeh*


DOI: 10.2174/1871527319666200604175118



Review Article

Transdermal drug delivery systems and their potential in alzheimer’s disease management

, 2020; 19(5): 360-373.

Panoraia I. Siafaka, Ece Ö. Bülbül, Gökce Mutlu, Mehmet E. Okur, Ioannis D. Karantas and Neslihan Ü. Okur*


DOI: 10.2174/1871527319666200618150046


Review Article

Nanoparticles based intranasal delivery of drug to treat Alzheimer’s disease: A recent update

, 2020; 19(9): 648-662.

Manisha Pandey*, Hira Choudhury*, Rohit Kumar Verma, Viney Chawla, Subrat Kumar Bhattamisra, Bapi Gorain, Maria Abdul Ghafoor Raja and Muhammad Wahab Amjad


DOI: 10.2174/1871527319999200819095620


Review Article

Road from nose to brain for treatment of alzheimer: The bumps and humps

, 2020; 19(9): 663-675.

Rajesh Kumar, Monica Gulati*, Sachin Kumar Singh, Deepika Sharma and Omji Porwal*


DOI: 10.2174/1871527319666200708124726


Review Article

Autoimmune encephalitis: Current knowledge on subtypes, disease mechanisms and treatment

, 2020; 19(8): 584-598.

Mette Scheller Nissen, Matias Ryding, Morten Meyer and Morten Blaabjerg*


DOI: 10.2174/1871527319666200708133103


Review Article

Levodopa therapy for parkinson's disease: History, current status and perspectives

, 2020; 19(8): 572-583.

Helle Bogetofte, Arezo Alamyar, Morten Blaabjerg and Morten Meyer*


DOI: 10.2174/1871527319666200722153156



General Research Article

Neuroprotection of rotenone-induced parkinsonism by ursolic acid in pd mouse model

, 2020; 19(7): 527-540.

Walia Zahra, Sachchida Nand Rai, Hareram Birla, Saumitra Sen Singh, Aaina Singh Rathore, Hagera Dilnashin, Richa Singh, Chetan Keswani, Rakesh K. Singh and Surya Pratap Singh*


DOI: 10.2174/1871527319666200812224457




Most Accessed Articles

Current Strategies and Novel Drug Approaches for Alzheimer Disease

, 2020; 19(9): 676-690.

Roma Ghai*, Kandasamy Nagarajan, Meenakshi Arora, Parul Grover, Nazakat Ali and Garima Kapoor


DOI: 10.2174/1871527319666200717091513




Transdermal Drug Delivery Systems and their Potential in Alzheimer’s Disease Management

, 2020; 19(5): 360-373.

Panoraia I. Siafaka, Ece Ö. Bülbül, Gökce Mutlu, Mehmet E. Okur, Ioannis D. Karantas and Neslihan Ü. Okur*


DOI: 10.2174/1871527319666200618150046


The Mechanism of Action of Salsolinol in Brain: Implications in Parkinson’s Disease

, 2020; 19(10): 725-740.

Shee Man Voon, Khuen Yen Ng, Soi Moi Chye, Anna Pick Kiong Ling, Kenny Gah Leong Voon, Yiing Jye Yap and Rhun Yian Koh*


DOI: 10.2174/1871527319666200902134129




Nanoparticles Based Intranasal Delivery of Drug to Treat Alzheimer’s Disease: A Recent Update

, 2020; 19(9): 648-662.

Manisha Pandey*, Hira Choudhury*, Rohit Kumar Verma, Viney Chawla, Subrat Kumar Bhattamisra, Bapi Gorain, Maria Abdul Ghafoor Raja and Muhammad Wahab Amjad


DOI: 10.2174/1871527319999200819095620


Role of Forkhead Transcription Factors of the O Class (FoxO) in Development and Progression of Alzheimer’s Disease

, 2020; 19(9): 709-721.

Shikha Goswami, Ozaifa Kareem, Ramesh K. Goyal, Sayed M. Mumtaz, Rajiv K. Tonk, Rahul Gupta and Faheem H. Pottoo*


DOI: 10.2174/1871527319666201001105553



Beyond the Obvious: Smoking and Respiratory Infection Implications on Alzheimer's Disease

, 2020; 19(9): 698-708.

Ridhima Wadhwa, Keshav Raj Paudel, Meenu Mehta , Shakti D. Shukla, Krishna Sunkara, Parteek Prasher, Nisha Panth, Rohit Goyal, Dinesh Kumar Chellappan, Gaurav Gupta, Philip M. Hansbro, Alaa A.A. Aljabali, Murtaza M. Tambuwala and Kamal Dua*


DOI: 10.2174/1871527319999200817112427


Road From Nose to Brain for Treatment of Alzheimer: The Bumps and Humps

, 2020; 19(9): 663-675.

Rajesh Kumar, Monica Gulati*, Sachin Kumar Singh, Deepika Sharma and Omji Porwal*


DOI: 10.2174/1871527319666200708124726


Quantitative Characterization of Phenotypical Markers After Differentiation of SH-SY5Y Cells

, 2020; 19(8): 618-629.

Angélique D. Ducray, Linda Wiedmer, Fabienne Herren, Hans Rudolf Widmer and Meike Mevissen*


DOI: 10.2174/1871527319666200708132716


Design and Microwave-Assisted Synthesis of Aza-Resveratrol Analogs with Potent Cholinesterase Inhibition

, 2020; 19(8): 630-641.

Brunella Biscussi, Victoria Richmond, Carlos Javier Baier, Pau Arroyo Mañez and Ana Paula Murray*


DOI: 10.2174/1871527319666200905121536





Editor-in-Chief

graphic
Edoardo Spina
Department of Clinical and Experimental Medicine
University of Messina
Policlinico Universitario
Via Consolare Valeria
Messina
(Italy)
Biography
View Full Editorial Board

COPE Compliant

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Journal History

Current Drug Targets - CNS & Neurological Disorders was launched in 2002 and later renamed in 2006 as CNS & Neurological Disorders - Drug Targets.

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