This reference presents basic concepts relevant to respiratory function in normal and diseased states.The volume stresses a quantitative approach to physical parameters used as indicators of normal and diseased physiological respiratory function. The contents of this reference allow medical students and physiology researchers to become “clinical detectives” - by presenting information that can be useful for enhancing their understanding of the major abnormalities in terms of ventilation, pulmonary blood perfusion, venous admixture, wasted alveolar ventilation, tissue oxygenation, acid-base balance, respiratory mechanics, control of breathing, etc. This book is intended for first and second year medical students as well as for residents and fellows, especially in disciplines such as anesthesiology and pulmonary medicine. In addition, the unique mechanistic approach of this book also provides a useful reference for teachers of respiratory physiology who are not involved in respiratory research or those who have not been specifically trained in organ-system physiology. This book thus fills this gap by providing a modern physiology faculty some tools for learning the “nuts-and-bolts” of lung physiology and associated respiratory care.

Frontiers in Clinical Drug Research - Alzheimer Disorders is an e-Book series concerned with Alzheimer's disease (AD) that causes dementia, or loss of brain function. The disease affects the parts of the brain that deal with memory, thought, and language. Chapters in each volume focus on (Alzheimer Disorders) drug research with special emphasis on clinical trials, research on drugs in advanced stages of development and cure for Alzheimer’s disease and related disorders. Frontiers in Clinical Drug Research - Alzheimer Disorders will be of particular interest to readers interested in drug therapy of this specific neurodegenerative condition and related brain disorders as the series provides relevant reviews written by experts in field of Alzheimer’s Disease research.

“Frontiers in Anti-Infective Drug Discovery” is an Ebook series devoted to publishing the latest and the most important advances in Anti-Infective drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The Ebook series should prove to be of interest to all pharmaceutical scientists involved in research in Anti-Infective drug design and discovery. Each volume is devoted to the major advances in Anti-Infective drug design and discovery. The Ebook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

This e-book covers Helicobacter pylori research as it looks in 2014. The discovery of the bacterium in 1982 by B.J. Marshall and R. I. Warren had a tremendous impact on basic research and clinical medicine, resulting, in the past 3 decades, in more than 34,000 published articles. The editor of this volume and the contributing authors have compiled a unique collection of chapters dealing the with the microbiology, epidemiology, clinical diagnosis and treatment of H. pylori infections in a country-specific manner, with contributors having the opportunity to present the peculiarities and specifics of Helicobacter research in their area or country without overlapping any other previously published e-book. This e-book is a useful reference for gastrointestinal physicians and medical researchers seeking the latest information related to H. pylori.

Cancer is a disease responsible for several million annual deaths among humans, worldwide. However, advances in healthcare - which include breakthroughs in science and medicine as well as access to medical treatment - have improved the survival rate of cancer patients over the last few decades.

Therapeutic Revolution relates the story of one of the great scientific tales of the twentieth century: how the field of medical oncology was created and its subsequent development owing to medical and scientific breakthroughs. The book unfolds the pre-clinical and clinical concepts and innovations that led to the creation of the medical subspecialty now known as oncology.

Therapeutic Revolution is the first book ever written on the events that led to this subspecialty of internal medicine. It relates the recollection of key events obtained from interviews of the pioneers who laid the foundations of medical oncology, as well as the author’s own experience of the pre-specialty era of medical practice.

The eBook is essential reading for all readers interested in the history of cancer treatment and also serves as a historical primer for medical students learning oncology.

Cancer is a broad group of diseases involving unregulated cell growth with elevated death rates as more people live in old age with mass lifestyle changes occurring in the world. The causes of cancer are diverse, complex, and still only partially understood. The chances of surviving the disease vary remarkably by the type and location of the malignancy and the extent of disease at the start of treatment. Early cancer detection is proving to be a valid approach. Cancer can be detected in a number of ways, including the presence of certain signs and symptoms, screening tests, or medical imaging. Cancer therapy is dynamically changing and revision and change in patient management is constant as our knowledge increases. Cancer is routinely treated with chemotherapy, radiation therapy and surgery. Tailored cancer targeted therapy is becoming an emerging objective of today. In this book, a constructive group of cancer research experts bring the reader their shared vision, to give an extensive and realistic view of individual tumors such as breast, oral, prostate, gastric, and neuroendocrine tumors. New and contemporary terms and concepts in genetics and epigenetics, diet, anticancer treatments, and anticancer drug delivery systems are introduced in this volume. This reference highlights present experimental strategies and key findings that enhance our understanding of cancer and of future therapies. This eBook is aimed at a broad audience of undergraduates, medical students, PhDs, cancer researchers, and also cancer patient families with the goal to conceive a curiosity about the subjects presented that will hopefully lead to further studies.

Frontiers in Clinical Drug Research – Diabetes and Obesity is an eBook series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of two metabolic diseases – diabetes and obesity. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs affecting endocrine and metabolic processes linked with diabetes and obesity. Reviews in this series also include research on specific receptor targets and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Diabetes and Obesity is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of diabetes and obesity research. The first volume of this series features 6 chapters that cover a variety of topics including: -Angiotensin blockers -Agents targeting advanced glycation end products -Drugs and the peroxisome proliferator activated receptors -Topical Drugs for diabetic complications -Research on Liraglutide -Research on MicroRNAs as agents for diabetes treatment

Following the post 9/11 distribution of anthrax spores through the U.S. mail, and the resulting deaths of five individuals - primarily due to initial misdiagnosis - there has been a renewed interest in anthrax among clinicians and intelligence agencies, particularly as a biological warfare agent. This monograph brings forth essential knowledge about anthrax. Included in this volume, are, the early history, non-natural outbreaks of anthrax, characteristics of the causative organism Bacillus anthracis and its relationship to other members of the B. cereus family. Also included are reports on extensive clinical findings, mechanisms of anthrax virulence and the genetics responsible for these virulence factors. The extensive studies over the years regarding the development of veterinary and human vaccines, and molecular studies, including conventional PCR and real-time PCR are explained in comprehensive detail, with the help of tables, figures and extensive references. This eBook serves as an advanced presentation and reference work for individuals seeking detailed information regarding anthrax and as a primary guide for individuals pursuing studies on anthrax.

Frontiers in Clinical Drug Research – HIV is an eBook series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of acquired immune deficiency syndrome (AIDS) and other disorders associated with human immunodeficiency virus (HIV) infection. The scope of the eBook series covers a range of topics including the medicinal chemistry and pharmacology of natural and synthetic drugs employed in the treatment of AIDS (including HAART) and resulting complications, and the virology and immunological study of HIV and related viruses. Frontiers in Clinical Drug Research – HIV is a valuable resource for pharmaceutical scientists, clinicians and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in HIV/AIDS research. The first volume of this series features 7 chapters that cover a variety of topics including: -Antiretroviral drug development -HIV-1 genomics -HIV drug targets such as ribosomes and HIV Integrase -HAART associated nephrotoxicity

This ebook series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the ebook series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field. The third volume of this series features 6 chapters that cover a variety of topics including: - Drug Discovery for TB - Therapeutic Limitations due to Antibiotic Drug Resistance - Applications for Virus Vaccine Vectors in Infectious Disease Research - NewCastle Disease Virus - Anti-Infective Therapy Against Leishmaniasis - Anti-Viral Activity of Proanthocyanidins