This volume is a complete review of the cutting-edge scientific evidence about the isolation, identification, bioactivity and molecular analysis of the biologically active peptides (BAPs) obtained from several underutilized grains. It provides a general review of current and new technologies in isolating and bioprospecting BAPs before going into the details of 11 grains. Amaranth, quinoa, millet, buckwheat, sorghum, lupin, mung bean, chickpea, broad bean, cocoa bean and chia are extensively discussed in dedicated chapters. Additionally, these chapters provide information about the characteristics of the crop, its main varieties, traditional uses, economic importance, nutritional aspects, structure and chemical composition of the grains, as well as the classification and distribution of the grain protein fractions. Moreover, the advances in the analytical techniques used for the concentration, purification and molecular characterization of BAPs are described. The impact of BAPs in the promotion of health is highlighted, as well as their potential incorporation as promising ingredients in the development of functional foods, nutraceuticals and cosmeceuticals. Finally, the main findings related to the potential antiviral and anti-COVID-19 activities of BAPs derived from underutilized grains are described. This reference will be of interest for academics, professionals and researchers focused in food science, biotechnology, pharmacology and agriculture, and to professionals involved in the research and development of natural products, pharmaceuticals and cosmeceuticals.

Cerium is the most abundant metal of rare-earth elements. It can be used to make materials such as phosphors and alloys, that have applications in various applied fields (like electronics, magnetics and heterogeneous catalysis) and devices (like catalytic converters and gas mantles). Cerium-Based Materials: Synthesis, Properties and Applications presents detailed knowledge about cerium materials. Starting with the history of cerium-based materials, it gives an introduction to the synthesis of chemicals like cerium oxides and composites. This is followed by information about characterization of cerium nanoparticles and industrial applications of cerium-based materials, with a focus on catalysis, biomedical engineering and pharmaceutical chemistry. This book is an essential reference for researchers and chemical engineers who want a summary of cerium materials and its applications.

A biosensor is an integrated receptor-transducer device that converts a biological response into an electrical signal. The design and development of biosensors have taken center stage for researchers or scientists in the recent decade owing to the wide range of biosensor applications in healthcare and disease diagnosis, environmental monitoring, water and food quality, and drug delivery. Due to their adaptability, ease of use in relatively complex samples, and portability, the significance of electrochemical biosensors in analytical chemistry has increased manifold. Electrochemistry has been pivotal in developing transduction methods for biological processes and biosensors. In parallel, the explosion of activity in nanoscience and nanotechnology and their huge success have profoundly affected biosensor technology, opening new avenues of research for electrode materials and transduction. Electrochemical Biosensors in Practice: Material and Methods particularly explores the use of silver and gold nanoparticles for signal amplification, photocurrent transduction, and aptamer design. Therefore, the book serves as an introductory text for those specializing in biosensors and bioelectronics and their practical applications. Key features - Includes structured information for easy understanding of the subject - Provides an introduction to biosensors and electrochemical biosensor classification - Explains fundamental concepts and practical electrochemistry techniques for research - Provides notes on essential electrochemical sensor materials such as graphene, carbon nanotubes, conductive polymers, and other advanced materials - Provides information about electrochemical biosensor development - Informs readers about recent applications and research findings - Includes references for further reading

Rare-earth hexaborides are a group of materials composed of octahedral boron units. They are useful for making advanced ceramics that have a wide range of industrial applications due to their low electronic work functions, hardness, refractory properties, low electrical resistances and specific thermal expansion coefficients. Rare-Earth Metal Hexaborides: Synthesis, Properties, and Applications provides a quick reference on rare-earth metal hexaborides and their engineering applications. It provides a primer on rare earth elements followed by details of rare-earth hexaboride structures, synthetic methods, and information about their alloys and ceramic composites. References to scholarly research are also provided for assisting advanced readers. This reference is a handy source of information for chemical engineering and materials science scholars, and anyone interested in the applied chemistry of rare-earth metals and borides.

Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases. This book set explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice. Volume 2 gives (1) a detailed overview of the sesquiterpenes polypharmacology, (2) an interesting journey around the world of cannabinoids that reveals the development of new synthetic Δ9-THC derivatives, (3) the design of specific formulations to overcome the volatility of small sized terpenes-based essential oils, (4) an update on the latest generations of endoperoxides endowed with antimalarial activity and finally (5) a summary of MedChem strategies to fix the most common issues in formulating terpene derivatives (like low potency and poor solubility). The objective of this book set is to fulfill gaps in currently acquired knowledge with information from the recent years. It serves as a guide for academic and professional researchers and clinicians.

Advanced Catalysts Based on Metal-organic Frameworks is a comprehensive introduction to advanced catalysts based on MOFs. It covers basic information about MOF catalysts with industrial and environmental applications. The detailed chapters update readers on current applications and strategies to apply MOF-based catalysts in industrial processes geared for sustainability initiatives such as renewable energy, pollution control and combating carbon emissions. Key Features - 13 structured, easy to read chapters that comprehensively cover MOF catalysts - An introduction to basic information about MOF catalysts - In-depth coverage of advanced applications of MOF catalysts - Explanation of MOF modifications and applications of derivative compounds - In-depth coverage of MOF catalysts used for electrocatalysis and photocatalysis - Detailed explanation of environmental-friendly and sustainable technologies (biomass upgrading, water purification, CO2 capture) - Updated references for advanced readers The is an essential reference for chemical engineers, scientists in the manufacturing and sustainability industry and post-graduate scholars working on MOFs and chemical catalysis.

This book introduces readers to the fundamentals of oxygen atom transfer reactions. It also gives mechanistic insights into the redox processes occurring through the oxygen atom transfer reactions. It also includes information about catalytic activation of oxygen through enzymes and oxo-metallic complexes. All topics are explored in separate chapters. Key features: - reviews the basic mechanisms in redox processes involving oxo-atom transfer reactions. - presents progress in the biomimetic activation of dioxygen related to the catalytic oxidations by synthetic metal organic complexes. - covers an important class of metal-organic compounds - nickel-oxygen species - generated in catalytic oxidation processes as oxygen atom transfer agents. - explains the mechanistic aspects of the heterogeneous photochemical redox processes via oxo-atom transfer reactions - provides references for further reading It is a reference for both professional scientists in the fields of chemistry, biology and applied sciences, and for graduate and undergraduate students interested in understanding reaction mechanisms involving oxygen.

Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases. This book explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice. Each chapter follows a specific format for a phytochemical agent with common chemical features: - General background on the (phyto)chemistry of the scaffold - General background on the pharmacological profile of the scaffold - A Description of the proposed derivatives and their advantages with respect to the parent compounds (emphasizing the synthetic approaches and structure-activity relationships) - In silico analysis of the crucial interactions with the biological target - Clinical studies and patent survey (if available) on the new and proposed structures The objective of this book set is to fulfil gaps in currently acquired knowledge with information from the recent years. It serves as a guide for academic and professional researchers and clinicians.

The book is an evidence-based reference about biochemical mechanisms of action of plant secondary metabolites. It conveys an understanding about how plant-based therapies work, and explains their role in the treatment of complementary and alternative medicine for in the treatment of diabetes, cancer, neurodegenerative disorders, microbial infections, etc., The 15 chapters are written by eminent scholars, lecturers, and experts in indigenous knowledge systems (IKS), industrial and medicinal plants, phytotherapeutics, and phytoinformatics. Reports on health benefits of specific phytochemicals are also highlighted. In addition to basic concepts in medicinal chemistry and ethnopharmacology, the book covers the role of modern computer techniques in developing new pharmaceuticals from plat sources. Therapeutic Uses of Plant Secondary Metabolites is timely and valuable reference for both undergraduate and postgraduate students in medicinal chemistry, as well as researchers and professionals in IKS, phytomedicine, ethnopharmacology, phytopharmacology, plant biotechnology, drug discovery and development, and phytotherapeutics.

Frontiers in Computational Chemistry presents contemporary research on molecular modeling techniques used in drug discovery and the drug development process: computer aided molecular design, drug discovery and development, lead generation, lead optimization, database management, computer and molecular graphics, and the development of new computational methods or efficient algorithms for the simulation of chemical phenomena including analyses of biological activity. The sixth volume of this series features these six different perspectives on the application of computational chemistry in rational drug design: - Computer-aided molecular design in computational chemistry - The role of ensemble conformational sampling using molecular docking and dynamics in drug discovery - Molecular dynamics applied to discover antiviral agents - Pharmacophore modeling approach in drug discovery against the tropical infectious disease malaria - Advances in computational network pharmacology for Traditional Chinese Medicine (TCM) research - Progress in electronic-structure based computational methods: from small molecules to large molecular systems of biological significance