Frontiers in Cancer Immunology

Volume: 1

T Cell-Based Immunotherapy

Author(s): Tania G. Rodríguez-Cruz and Stephen Gottschalk

Pp: 25-46 (22)

DOI: 10.2174/9781681080482115010005

* (Excluding Mailing and Handling)


From its humble beginning in the 19th century, immunotherapy for cancer has emerged as a prospective curative approach in the last decade. Currently, different immunotherapies are being used in the clinic including monoclonal antibodies (MAbs), adoptively transferred T cells and cancer vaccines. Of these immunotherapies, MAbs are the most widely used, however their efficacy is restricted by their limited biodistribution, and reliance on antibody-dependent cell cytotoxicity and/or complement-mediated cell death, which can be impaired in cancer patients. In contrast, adoptively transferred T cells have the capacity to effectively traffic to tumor sites, recruit multiple cellular and humoral effector mechanisms, and persist for many years. In this chapter, we review T cell based immunotherapy for cancer, describe its current clinical impact, and discuss approaches that aim to combine T cells with other cancertargeted therapies.

Keywords: Cancer, chimeric antigen receptor, clinical trial, Epstein-Barr virus, gene therapy, T cell immunotherapy, T cell receptor, tumor antigen.

Related Journals
Related Books
© 2023 Bentham Science Publishers | Privacy Policy