Frontiers in Anti-Infective Drug Discovery

Volume: 3

In Silico Study Verifying Antiviral Activity of Proanthocyanidins with Special Reference to Dengue Virus

Author(s): Lakshmi Chandrasekaran, Koji Ichiyama, Vivian Feng Chen, Akiko Saito, Yoshiyuki Yoshinaka and Naoki Yamamoto

Pp: 317-338 (22)

DOI: 10.2174/9781608059126114030008


Proanthocyanidins exist as a part of a particular group of polyphenolic compounds known as flavanols. They are commonly occurring plant metabolites generally available in many sources such as fruits, bark, leaves and seeds of plants. They possess monomers, oligomers and polymers of varying molecular sizes composed of flavan-3-ols that serve as the building blocks. These compounds have been reported to have anti-carcinogenic, anti-inflammatory, anti-allergic, antioxidant, antibacterial and antiviral properties in human beings. This review will primarily focus on the in silico and in vitro analyses that verify antiviral activity of proanthocyanidins against several viruses, primarily the dengue virus.

Keywords: Antiviral activity, catechin, dengue virus, epicatechin, flavonoids, in silico, in vitro, proanthocyanidins.

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