Biological Models Volume Title: From Knowledge Networks to Biological Models

Mechanism of Synergistic Carcinogenesis from Hypergastrinemia and Helicobacter Infection

Author(s): Anton Yuryev

Pp: 131-150 (20)

DOI: 10.2174/978160805437411201010131

* (Excluding Mailing and Handling)

Abstract

We have built a model for gastric cancer predisposition caused by hypergastrenimia during Helicobacter infection. The model was built using publically available data form hypergastrenimic transgenic mice infected with Helicobacter. We used the model to identify potential drug targets for gastric cancer, annexin II and TRAF6, and to find prognostic biomarkers for gastric cancer predisposition due to hypergastrenimia.


Keywords: Bioinformatics, pathway analysis, biomarkers, mechanistic model, gastric cancer, stomach cancer, Helicobacter, gene expression microarray, subnetwork enrichment analysis, NF-kappaB, annexin, gastrin, Pathway Studio.

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