Rab GTPases and Membrane Trafficking

Transport from Late Endosomes to the Golgi: Rab9 GTPase

Author(s): Eric J. Espinosa and Suzanne R. Pfeffer

Pp: 144-154 (11)

DOI: 10.2174/978160805365011201010144

* (Excluding Mailing and Handling)


Rab9 functions in the retrieval of mannose 6-phosphate receptors (MPRs) from late endosomes and their subsequent delivery to the trans Golgi network (TGN). In this chapter, we will discuss how Rab9 is recruited onto membranes, how Rab9 functions to select and segregate MPRs into a specific microdomain depleted of Rab7, and ultimately, how Rab9-containing transport vesicles dock and fuse at the TGN.

Keywords: Rab9, Late Endosomes, Mannose 6-phosphate receptor, Lysosome, Retrograde Transport.

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