Rab GTPases and Membrane Trafficking

Role of Rab4 in Transport through the Endosomal System

Author(s): Emma Martinez Sanchez, Ioana Popa, Magda Deneka and Peter van der Sluijs

Pp: 108-122 (15)

DOI: 10.2174/978160805365011201010108

* (Excluding Mailing and Handling)


The endosomal system is a mosaic of highly dynamic interconnected organelles that serve many physiological functions including nutrient uptake, regulation of cell polarity, migration and plasma membrane remodeling. These widely divergent processes rely on the flawless transfer of cargo molecules between the distinct endosomal subcompartments and is regulated by members of the rab family of small GTPases and their effector networks. Here we provide an overview of the function of rab4, and the machinery it deploys to regulating exocytic membrane trafficking from early endosomes.

Keywords: Rab4a, Rab4b, Endosomes, Recycling, Domain.

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