Genetic Similarity between Type 2 Diabetes and Breast Cancer: A Brief Report

Recent progress in genetics research has accelerated our comprehension of complex disorders such as type 2 Diabetes Mellitus and breast cancer. Genome-wide association studies on a large scale have facilitated our exploration of the underlying pathology. Individuals with type 2 diabetes are at a higher risk of developing several types of cancer as a result of common risk factors, such as obesity, poor diet, aging, and low levels of physical activity. While several susceptibility genes have been identified, we must consider tissue specificity and direction of effect when investigating the shared genetic aetiology. Techniques such as Mendelian randomisation allow us to unravel the link between the two diseases and answer critical questions. By deconstructing the type 2 Diabetes GRS and studying genetic variants in relation to their biological function, we may be able to evaluate the causal association between different groups and various cancer types. Genetic research also has the potential to investigate epigenetic modifications that contribute to the development of cancer. This work explores the association between the genetic similarity between type 2 diabetes and breast cancer.

Keywords: Breast cancer, Gene disease association, Type 2 Diabetes, cosignalling mechanism.