Abstract
Cancer and diabetes are two of the most prevalent and complicated diseases.
Several epidemiological studies have found a link between type 2 diabetes and an
increased risk of breast cancer. This chapter aims to highlight the advances in
understanding the mechanisms that connect diabetes and breast cancer. Alterations in
glucose metabolism, hyperinsulinemia, insulin resistance, changes in the hormonal
environment, and substrate availability create a metabolic environment that is
particularly favourable for the growth of tumours. Therefore, it is vital to understand
the correlation between diabetes mellitus and breast cancer. A precise analysis of these
relationships could help in finding biomarkers that can predict disease risk and
prognosis, and aid in selecting appropriate, evidence-based diagnostic and therapeutic
approaches
Keywords: Breast cancer, Hyperlipidemia, Insulin resistance, Inflammatory cytokines, RAGEs, Signalling pathway, Type 2 diabetes.
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