Frontiers in Natural Product Chemistry

Volume: 1

Nature as Source and Inspiration for the Synthesis of New Anticancer Drugs

Author(s): Daniele Passarella, Alessandra Giardini, Giordano Lesma, Alessandra Silvani and Bruno Danieli

Pp: 51-54 (4)

DOI: 10.2174/978160805212710501010051

* (Excluding Mailing and Handling)


The bifunctional taxoid-colchicinoid hybrids were synthesised and evaluated in assays of cytotoxicity and tubulin assembly/disassembly. All compounds showed a high degree of cytotoxicity.

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