Current Cancer Biomarkers

Electrochemical Biosensor for Cancer Biomarkers Detection

Author(s): Md Arifuzzaman, Mostafa Kamal Masud, Asif Ahmed, Md Morsaline Billah and Md Nazmul Islam *

Pp: 349-371 (23)

DOI: 10.2174/9789815079364123010017

* (Excluding Mailing and Handling)


Biosensors are common analytical devices, capable of sensing a myriad of biological analytes, including cancer biomarkers. Although biosensors have different transducer types, electrochemical biosensors provide fast analysis time, high sensitivity, and the ability to perform complex measurements such as multiplexed analysis or screening tests for early diagnosis and prognosis of cancer. This chapter describes the background and theory of electrochemical sensors and introduces the main readout techniques. Innovative electrochemical biosensing strategies for analysis and quantification of important early cancer biomarkers, which include circulating nucleic acids (e.g., circulating tumour DNA, gene mutations, and microRNA) proteins, circulating tumour cells, and extracellular vesicles are discussed with the recent developments to provide an overview of the possible academic and clinical approaches

Keywords: Biosensor, Early Detection, Electrochemistry, Voltammetry, Impedance, Biomarker, Exosomes, microRNA.

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