Experimental Stroke

Erythropoietin and Ischemic Brain Remodeling

Author(s): Zheng Gang Zhang and Michael Chopp

Pp: 90-93 (4)

Doi: 10.2174/978160805001710901010090

* (Excluding Mailing and Handling)

Abstract

Erythropoietin (EPO) is a hematopoietic cytokine and has the neuroprotective effect for treatment of acute ischemic stroke. Emerging data indicate that EPO also plays an important role in brain remodeling after stroke. This chapter reviews the effect of EPO on neurogenesis and angiogenesis and signaling pathways that mediate EPO-enhanced coupling of neurovascular niche in the ischemic brain.

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