摘要
背景:肿瘤的免疫治疗包括嵌合抗原受体(CAR)-T细胞、CAR-自然杀伤细胞(NK)、PD1和PD-L1抑制剂。然而,对癌症免疫治疗有反应的患者比例并不令人满意。与此同时,纳米技术在癌症诊断和治疗方面也经历了一场革命。虽然许多治疗性纳米载体已被批准用于临床应用,但很少有临床批准的纳米颗粒能够选择性地结合和靶向癌细胞并结合分子。目前还没有关于纳米医学和免疫疗法如何联合应用于治疗癌症的系统综述。 目的:这篇综述旨在说明纳米医学和免疫疗法如何能够用于癌症治疗,以克服对癌症免疫治疗有反应的患者比例低和临床使用纳米材料稀少的局限性。 方法:对MEDLINE、PubMed / PubMed Central和谷歌学术进行了文献综述。我们对有关纳米颗粒药物给药系统的文献进行了结构化检索,包括光动力疗法、光热疗法、光声疗法和免疫疗法。此外,我们详细介绍了各种纳米粒子与分子结合的优缺点,以讨论与癌症治疗相关的挑战和解决方案。 结论:本综述确定了与改善卫生保健和结果相关的优势和劣势。这篇综述的发现证实了纳米药物联合免疫疗法对提高癌症治疗效果的重要性。利用纳米材料实现协同抗肿瘤免疫可能成为开发新型癌症治疗方法的新途径。
关键词: 肿瘤免疫治疗,CAR- NK细胞,药物传递,纳米药物,协同效应,CAR-T细胞
[http://dx.doi.org/10.3322/caac.21551] [PMID: 30620402]
[http://dx.doi.org/10.3892/ol.2014.2820] [PMID: 25663890]
[http://dx.doi.org/10.1039/C9CC02567G] [PMID: 31073580]
[http://dx.doi.org/10.7150/ijbs.28608] [PMID: 30585269]
[http://dx.doi.org/10.1016/S0140-6736(16)31679-8] [PMID: 27733284]
[http://dx.doi.org/10.1074/jbc.M115.679852] [PMID: 26487718]
[http://dx.doi.org/10.7150/ijbs.25928] [PMID: 29910690]
[http://dx.doi.org/10.1016/j.yexmp.2014.09.007] [PMID: 25220345]
[http://dx.doi.org/10.1128/JVI.05312-11] [PMID: 21880764]
[http://dx.doi.org/10.1074/jbc.M115.650903] [PMID: 25851904]
[http://dx.doi.org/10.1128/JVI.05119-11] [PMID: 21715496]
[http://dx.doi.org/10.1158/1535-7163.MCT-12-0172] [PMID: 22553356]
[http://dx.doi.org/10.1158/1535-7163.MCT-11-0281] [PMID: 21750218]
[http://dx.doi.org/10.1002/ijc.29588] [PMID: 25924852]
[http://dx.doi.org/10.2217/imt.14.90] [PMID: 25524384]
[http://dx.doi.org/10.1038/nrc3153] [PMID: 22020206]
[http://dx.doi.org/10.2147/BCTT.S175360] [PMID: 30697064]
[http://dx.doi.org/10.1159/000495558] [PMID: 30695783]
[http://dx.doi.org/10.1016/S0007-4551(19)30052-9] [PMID: 30686360]
[http://dx.doi.org/10.1097/PPO.0000000000000356] [PMID: 30694858]
[http://dx.doi.org/10.1016/j.tibtech.2016.07.006] [PMID: 27492049]
[http://dx.doi.org/10.1038/s41422-018-0091-x] [PMID: 30254335]
[http://dx.doi.org/10.1016/j.addr.2017.07.003] [PMID: 28694026]
[http://dx.doi.org/10.1016/j.bioorg.2019.01.019] [PMID: 30658232]
[http://dx.doi.org/10.1038/s41467-018-08165-y] [PMID: 30659197]
[http://dx.doi.org/10.1016/j.gene.2019.01.002] [PMID: 30658857]
[http://dx.doi.org/10.1186/s12951-019-0445-7] [PMID: 30660179]
[http://dx.doi.org/10.1039/C8BM00693H] [PMID: 30633255]
[http://dx.doi.org/10.3390/pharmaceutics11010016] [PMID: 30621174]
[http://dx.doi.org/10.1002/adma.201806095]
[http://dx.doi.org/10.3390/molecules24010195] [PMID: 30621054]
[http://dx.doi.org/10.1002/smll.201804671]
[http://dx.doi.org/10.1186/s12903-018-0694-0] [PMID: 30634966]
[http://dx.doi.org/10.1002/smll.201804111]]
[http://dx.doi.org/10.1007/s10237-018-01116-y] [PMID: 30617526]
[http://dx.doi.org/10.1007/s00281-016-0583-z] [PMID: 27456849]
[http://dx.doi.org/10.3389/fimmu.2013.00438] [PMID: 24376443]
[http://dx.doi.org/10.3389/fchem.2014.00105] [PMID: 25505783]
[http://dx.doi.org/10.1097/MD.0000000000000340] [PMID: 25526496]
[http://dx.doi.org/10.1146/annurev-med-062315-120245] [PMID: 27860544]
[http://dx.doi.org/10.3389/fimmu.2019.00456] [PMID: 30941126]
[http://dx.doi.org/10.1089/hgtb.2016.153] [PMID: 28330372]
[http://dx.doi.org/10.1158/2159-8290.CD-NB2017-126] [PMID: 28887358]
[http://dx.doi.org/10.1186/s40425-018-0343-9] [PMID: 29907163]
[http://dx.doi.org/10.1182/blood-2013-02-485623] [PMID: 23678006]
[http://dx.doi.org/10.3390/ijms20020317] [PMID: 30646574]
[http://dx.doi.org/10.1038/aps.2017.125] [PMID: 28880014]
[http://dx.doi.org/10.3389/fimmu.2018.00283] [PMID: 29497427]
[http://dx.doi.org/10.1016/j.stem.2018.07.007] [PMID: 30075127]
[PMID: 30034945]
[http://dx.doi.org/10.4049/jimmunol.1003933] [PMID: 21321107]
[http://dx.doi.org/10.1155/2010/683875] [PMID: 21127709]
[http://dx.doi.org/10.3389/fimmu.2017.01597] [PMID: 29255458]
[http://dx.doi.org/10.1186/s13045-016-0277-y] [PMID: 27234522]
[http://dx.doi.org/10.1084/jem.179.2.523] [PMID: 7507508]
[http://dx.doi.org/10.1007/978-981-10-6020-5_18] [PMID: 29282694]
[http://dx.doi.org/10.1016/0167-5699(93)90262-J] [PMID: 7506034]
[http://dx.doi.org/10.1111/imm.13008] [PMID: 30320408]
[http://dx.doi.org/10.1021/ja311090e] [PMID: 23379863]
[http://dx.doi.org/10.1039/C8CC02791A] [PMID: 29744485]
[http://dx.doi.org/10.1016/j.jcis.2017.09.007] [PMID: 28923749]
[http://dx.doi.org/10.1002/bit.26566] [PMID: 29457630]
[http://dx.doi.org/10.1038/sj.mt.6300323] [PMID: 17923843]
[http://dx.doi.org/10.1016/j.jconrel.2007.11.002] [PMID: 18083264]
[http://dx.doi.org/10.1021/mp060039w] [PMID: 17009857]
[http://dx.doi.org/10.1016/j.bbamem.2009.06.022] [PMID: 19595666]
[http://dx.doi.org/10.1080/10408444.2016.1181047] [PMID: 27195425]
[http://dx.doi.org/10.3109/17435390.2014.980759] [PMID: 25405262]
[http://dx.doi.org/10.1080/10937400902902062] [PMID: 19466673]
[http://dx.doi.org/10.1016/j.jconrel.2016.05.044] [PMID: 27208862]
[http://dx.doi.org/10.1016/j.addr.2012.08.009] [PMID: 22964425]
[http://dx.doi.org/10.2174/157016311798109335] [PMID: 21726187]
[http://dx.doi.org/10.1021/ja804561g]]
[http://dx.doi.org/10.1007/s00262-006-0216-9] [PMID: 16937115]
[http://dx.doi.org/10.1038/nbt.4181] [PMID: 29985479]
[http://dx.doi.org/10.1126/scitranslmed.aaa4963] [PMID: 25696001]
[http://dx.doi.org/10.1073/pnas.0307298101] [PMID: 14762166]
[http://dx.doi.org/10.1126/science.aaa4967] [PMID: 25838374]
[http://dx.doi.org/10.1038/ncomms13193] [PMID: 27767031]
[http://dx.doi.org/10.1007/s10856-018-6160-3] [PMID: 30276528]
[http://dx.doi.org/10.1038/nature18300] [PMID: 27281205]
[http://dx.doi.org/10.1016/j.biomaterials.2013.10.003] [PMID: 24144906]
[http://dx.doi.org/10.1021/acsnano.7b05465] [PMID: 28858473]
[http://dx.doi.org/10.1021/acs.bioconjchem.7b00238] [PMID: 28520406]
[http://dx.doi.org/10.1142/S1793545819410025]
[http://dx.doi.org/10.2147/IJN.S146192] [PMID: 30271144]
[http://dx.doi.org/10.1016/j.biomaterials.2005.05.044] [PMID: 16023200]
[http://dx.doi.org/10.1038/nmat4822] [PMID: 28024156]
[http://dx.doi.org/10.1016/j.biomaterials.2018.08.016] [PMID: 30121425]
[http://dx.doi.org/10.1021/acs.nanolett.5b05030] [PMID: 26999507]
[http://dx.doi.org/10.1016/j.bbrc.2007.12.112] [PMID: 18158918]
[http://dx.doi.org/10.1371/journal.pone.0101854] [PMID: 25013909]
[http://dx.doi.org/10.1016/j.biomaterials.2014.05.077] [PMID: 24969637]
[http://dx.doi.org/10.1038/ncomms12499] [PMID: 27530650]
[http://dx.doi.org/10.1038/s41467-017-01830-8] [PMID: 29170511]
[http://dx.doi.org/10.1039/C8BM00588E] [PMID: 30151523]