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Review Article

作为抗癌药物的小分子CSF1R抑制剂

卷 27, 期 23, 2020

页: [3944 - 3966] 页: 23

弟呕挨: 10.2174/1573394715666190618121649

价格: $65

摘要

有说服力的证据表明肿瘤相关巨噬细胞(TAMs)的浸润与肿瘤发生的驱动力以及抗肿瘤免疫的抑制有关。在这种情况下，CSF1R作为集落刺激因子-1 (CSF1)和白介素34 (IL-34)的细胞受体，在控制TAMs的行为中起着核心作用，CSF1R信号的失调与许多特定癌症的癌症进展和免疫抑制有关。因此，CSF1R激酶已经成为癌症治疗中一个很有兴趣的目标，大量的研究都集中在开发小分子CSF1R抑制剂上。在这篇综述中，我们重点介绍了这些小分子CSF1R抑制剂作为抗癌药物的研究进展。特别注意可用于先进临床试验的化合物。

关键词: 肿瘤相关巨噬细胞(TAMs)

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