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当代阿耳茨海默病研究

Editor-in-Chief

ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Research Article

轻度和中度阿尔茨海默病疫苗接种成本效益分析的异质性

卷 16, 期 6, 2019

页: [495 - 504] 页: 10

弟呕挨: 10.2174/1567205016666190612162121

Open Access Journals Promotions 2
摘要

背景:近年来阿尔茨海默病(AD)的免疫治疗获得了动力。其应用的一个问题涉及人口平均和特定亚组差异的成本效益分析(CEA),因为这种治疗对于卫生决策者分配有限资源是必不可少的。然而,这种考虑异质人口和风险因素调整的CEA模型很少得到解决。 方法:我们的目的是显示CEA在AD免疫治疗中的异质性,与没有干预的比较物相比较。经质量调整生命年(QALY),通过增量成本效益比(ICER)和成本效益可接受性曲线(CEAC)进行经济评估。首先,人口平均CEA是在有和没有年龄和性别调整的情况下进行的。其次,根据马尔可夫过程,对性别和年龄的分层进行了分组CEA。 结果:鉴于支付意愿的门槛为20,000美元,ICER的年龄和性别调整结果显示出相似的结果(14,691美元/ QALY和17,604美元/ QALY)。不同年龄组和性别的子组ICER结果显示出显着差异。 CEAC显示,在人口水平的QALY方面,成本效益的概率仅为48.8%-53.3%,而在50-64岁的女性中为85.5%,65-74岁的女性为0.2%,降至0.2%在男性≥75岁。 结论:在接种疫苗的CEA中观察到相当大的异质性。与个性化医疗的发展一样,健康决策者评估的CEA结果不仅应考虑人口平均水平,还应考虑特定的亚群水平。

关键词: 阿尔茨海默病,免疫疗法,疫苗接种,成本效益分析,异质性,个性化医疗。

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