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Review Article

简述可注射的热响应性水凝胶及其生物医学应用进展

卷 27, 期 34, 2020

页: [5773 - 5789] 页: 17

弟呕挨: 10.2174/0929867325666190603110045

价格: $65

摘要

背景：可注射水凝胶是一种基于生物材料的热响应系统。可注射水凝胶主要作为包括药物、蛋白质、细胞和生物活性分子在内的治疗药物的载体或支架被广泛研究，用于治疗癌症等疾病以及组织的修复和再生。 结果：有几项研究描述了水凝胶的多种特征。然而，在水凝胶的应用中打破常规的主要方面是它们的热响应性，即它们的性质会因温度的微小变化而发生突变。因此，具有溶胶-凝胶转变特性的热响应型水凝胶在过去几十年中受到了特别的关注。这些水凝胶在接近人体生理温度时出现相变。这一特性是将其应用于与人类健康相关的研究领域的关键。 结论：本研究的目的是概述可注射水凝胶及其在医学应用方面的最新进展，包括生物活性化合物给药、组织工程和再生医学。

关键词: 热响应水凝胶，可注射水凝胶，生物材料，溶胶-凝胶转变，药物传递，组织工程，再生医学

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