Abstract
Nucleic acids have been extensively modified by replacing the phosphodiester group or the whole sugar-phosphodiester backbone with alternative anionic, neutral and cationic structures. Several of these modified oligonucleotides exhibit improved properties including enhanced recognition and binding to RNA, duplex DNA and proteins. This has resulted in the development of new and more potent antisense and antigene agents, as well as aptamers. Furthermore, backbone modified oligonucleotides have also been used in the development of several alternative strategies, which rely on altogether different mechanisms of action and show significant promise for therapeutic intervention. In this review the latest advances in the synthesis and evaluation of the most promising backbone modified oligos will be discussed, with a view to their future as novel pharmaceuticals.
Keywords: Nucleic Acids Synthesis, potent antisense, antigene agents, aptamers, Therapeutic Targets, Phosphoramidate Modification, Boranophosphate Oligos, Methylphosophonates, Deoxyribonucleic Guanidine (DNG) Oligos, Morpholino Oligos
Current Medicinal Chemistry
Title: Backbone Modification of Nucleic Acids: Synthesis, Structure and Therapeutic Applications
Volume: 8 Issue: 10
Author(s): Jason Micklefield
Affiliation:
Keywords: Nucleic Acids Synthesis, potent antisense, antigene agents, aptamers, Therapeutic Targets, Phosphoramidate Modification, Boranophosphate Oligos, Methylphosophonates, Deoxyribonucleic Guanidine (DNG) Oligos, Morpholino Oligos
Abstract: Nucleic acids have been extensively modified by replacing the phosphodiester group or the whole sugar-phosphodiester backbone with alternative anionic, neutral and cationic structures. Several of these modified oligonucleotides exhibit improved properties including enhanced recognition and binding to RNA, duplex DNA and proteins. This has resulted in the development of new and more potent antisense and antigene agents, as well as aptamers. Furthermore, backbone modified oligonucleotides have also been used in the development of several alternative strategies, which rely on altogether different mechanisms of action and show significant promise for therapeutic intervention. In this review the latest advances in the synthesis and evaluation of the most promising backbone modified oligos will be discussed, with a view to their future as novel pharmaceuticals.
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Cite this article as:
Micklefield Jason, Backbone Modification of Nucleic Acids: Synthesis, Structure and Therapeutic Applications, Current Medicinal Chemistry 2001; 8 (10) . https://dx.doi.org/10.2174/0929867013372391
DOI https://dx.doi.org/10.2174/0929867013372391 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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