Pd-Catalyzed Carbonylation-cyclization of N′-(2-bromophenyl)benzamidines by Chloroform as a CO Precursor for the Synthesis of Quinazolin- 4(3H)-ones

Abbasian       Sepideh; Kabirifard       Hassan; Mahdavi       Mohammad

doi:10.2174/1570178616666190514085642

Abstract

We present an efficient method for the synthesis of quinazolin-4(3H)-ones via Pdcatalyzed carbonylation-cyclization of N′-(2-bromophenyl)benzamidines. Chloroform cleanly generated CO under mild conditions. This method allows for the carbonylation-cyclization of N′-(2- bromophenyl)benzamidines in the presence of Pd(OAc)2 to give quinazolin-4(3H)-ones in good to excellent yields.

Keywords: Quinazolin-4(3H)-one, N′-(2-Bromophenyl)benzamidine, chloroform, palladium acetate, carbonylation, anti-ulcer agents.

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DOI https://dx.doi.org/10.2174/1570178616666190514085642	Print ISSN 1570-1786
Publisher Name Bentham Science Publisher	Online ISSN 1875-6255

Letters in Organic Chemistry

Pd-Catalyzed Carbonylation-cyclization of N′-(2-bromophenyl)benzamidines by Chloroform as a CO Precursor for the Synthesis of Quinazolin- 4(3H)-ones

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