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Review Article

乳铁蛋白在骨组织再生中的作用

卷 27, 期 6, 2020

页: [838 - 853] 页: 16

弟呕挨: 10.2174/0929867326666190503121546

价格: $65

摘要

在乳铁蛋白（Lf）表现出的多种特性中，目前它在骨骼再生过程中的参与备受关注。一系列的体外和体内研究表明，Lf具有促进成骨细胞存活，增殖和分化以及抑制破骨细胞介导的骨吸收的能力。尽管尚不能完全阐明Lf在骨细胞中的作用机理，但已证明其导致成骨细胞存活的作用方式被其促有丝分裂作用所补充。已经确定了依赖LRP或独立的方式激活了几种信号传导途径和基因表达。与对成骨细胞的影响不同，对破骨细胞的作用有所不同，Lf导致完全破骨细胞生成。由于Lf对成骨细胞具有积极作用，因此Lf单独或与不同生物活性化合物组合用于骨组织再生和治疗骨疾病的潜在用途引起了极大的兴趣。由于Lf在体内的生物利用度较差，因此开发了一种基于纳米技术的策略来改善Lf的生物学特性。研究的制剂包括将Lf掺入胶原蛋白膜，明胶水凝胶，脂质体，加载到纳米纤维，多孔微球上或涂覆在基于二氧化硅/钛的植入物上。 Lf还与其他生物活性化合物（如仿生羟基磷灰石）偶联，以提高用于调节骨稳态的生物材料的功效。这篇综述旨在提供有关Lf参与骨生长和愈合及其在骨组织再生中作为潜在治疗因子的应用研究的最新综述。

关键词: 乳铁蛋白，成骨细胞，破骨细胞，骨，纳米制剂，再生。

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