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Review Article

FTY720 (Fingolimod)通过多种机制改善脑损伤，是中风治疗的有力候选药物

卷 27, 期 18, 2020

页: [2979 - 2993] 页: 15

弟呕挨: 10.2174/0929867326666190308133732

open access plus

摘要

FTY720 (Fingolimod)是一种已知的具有强烈抗炎作用的鞘糖苷-1-磷酸(S1P)受体激动剂，于2010年被美国食品和药物管理局(FDA)批准为第一种治疗多发性硬化症的口服药物。FTY720主要与独特的功能性“拮抗剂”和“激动剂”机制有关。其功能拮抗机制是通过淋巴细胞上的S1P受体短暂的下调和降解，阻止淋巴细胞从淋巴结进入血流。这随后导致淋巴细胞减少和减少淋巴细胞炎症的发展。功能激动机制是通过表达在神经元、星形胶质细胞、小胶质细胞和血管内皮细胞等多种细胞表面的S1P受体来实现的。这些功能可能在调节抗凋亡系统、调节脑免疫和吞噬活性、维持血脑屏障(BBB)和神经前体细胞的增殖等方面发挥重要作用。最近，FTY720显示出了不依赖受体的作用，包括细胞内目标结合和表观遗传调节。许多研究人员已经认识到FTY720的积极作用，并开展了基础和临床实验来测试该制剂对中风的使用。虽然FTY720的作用机制尚未完全阐明，但其对脑卒中的疗效正在逐渐明确，不仅在动物模型中，在缺血性脑卒中患者中也通过临床试验得到证实。在本文中，我们回顾了使用FTY720治疗中风的实验室结果和初步临床试验的数据。

关键词: FTY720

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