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Review Article

神经系统肿瘤中的硫氧还蛋白，谷胱甘肽和相关分子

卷 27, 期 12, 2020

页: [1878 - 1900] 页: 23

弟呕挨: 10.2174/0929867326666190201113004

价格: $65

摘要

背景：中枢神经系统（CNS）肿瘤由于具有侵袭性和异质性，而且对多种治疗方法均耐药，因此其生存预后较差。 目的：本文综述了脑肿瘤生物学和发病机制的主要方面，包括脑原发性肿瘤（神经胶质瘤）以及其他恶性肿瘤（包括肺癌，乳腺癌和恶性黑色素瘤）的转移整体恶性脑肿瘤的比例很高。我们回顾了抗氧化系统，即硫氧还蛋白和谷胱甘肽系统，在脑肿瘤的发生和/或进展中的作用。 方法：尽管硫氧还蛋白还原酶（TrxR）和硫氧还蛋白（Trx）的过表达通常与脑肿瘤的恶性程度增加有关，而谷胱甘肽（GSH）和谷胱甘肽S-转移酶（GST）的高表达与治疗耐药性相关，关于例如过氧化物酶（Prx）和戊二醛（Grx）的作用，知识差距仍然存在。 结论：由于氧化还原系统在氧化还原稳态和ROS清除中起着重要作用，因此它们是新型抗肿瘤药物的潜在靶标，并讨论了旨在提高脑肿瘤治疗成功率的创新疗法的实例。

关键词: 脑肿瘤，硫氧还蛋白，谷胱甘肽，神经胶质瘤，抗氧化剂系统，中枢神经系统。

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