摘要
背景:中枢神经系统(CNS)肿瘤由于具有侵袭性和异质性,而且对多种治疗方法均耐药,因此其生存预后较差。 目的:本文综述了脑肿瘤生物学和发病机制的主要方面,包括脑原发性肿瘤(神经胶质瘤)以及其他恶性肿瘤(包括肺癌,乳腺癌和恶性黑色素瘤)的转移整体恶性脑肿瘤的比例很高。我们回顾了抗氧化系统,即硫氧还蛋白和谷胱甘肽系统,在脑肿瘤的发生和/或进展中的作用。 方法:尽管硫氧还蛋白还原酶(TrxR)和硫氧还蛋白(Trx)的过表达通常与脑肿瘤的恶性程度增加有关,而谷胱甘肽(GSH)和谷胱甘肽S-转移酶(GST)的高表达与治疗耐药性相关,关于例如过氧化物酶(Prx)和戊二醛(Grx)的作用,知识差距仍然存在。 结论:由于氧化还原系统在氧化还原稳态和ROS清除中起着重要作用,因此它们是新型抗肿瘤药物的潜在靶标,并讨论了旨在提高脑肿瘤治疗成功率的创新疗法的实例。
关键词: 脑肿瘤,硫氧还蛋白,谷胱甘肽,神经胶质瘤,抗氧化剂系统,中枢神经系统。
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