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Review Article

基于乙酰胆碱酯酶和丁酰胆碱酯酶的病理状态的诊断

卷 27, 期 18, 2020

页: [2994 - 3011] 页: 18

弟呕挨: 10.2174/0929867326666190130161202

价格: $65

摘要

两种胆碱酯酶存在:乙酰胆碱酯酶(AChE)和丁酰胆碱酯酶(BChE)。AChE在神经传递中起着至关重要的作用，而BChE除了可以解毒一些药物和植物的次生代谢产物外，并没有特殊的功能。因此，AChE和BChE都可以作为多种病理的生化标志物。神经毒剂如沙林、索曼、塔本、VX、诺维乔克的中毒，以及阿尔茨海默病、重症肌无力等神经退行性疾病的药物过量，以及有机磷农药中毒，都与这个问题有关。但这些酶的变化似乎发生在其他过程中，包括氧化应激、炎症、某些类型的癌症和遗传性疾病。本文介绍了胆碱酯酶的研究进展，阐述了胆碱酯酶抑制剂的作用机理，并阐述了胆碱酯酶与疾病的关系。

关键词: 乙酰胆碱酯酶，麻醉，丁酰胆碱酯酶，诊断，肝功能检查，肌松药，神经毒剂，神经传递，农药，中毒。

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