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摘要
目的: 鉴于矛盾的结果和缺乏信息,这项综合研究检查了先兆子痫患者的关键抗氧化剂和氧化剂/促氧化剂的活性和水平。 方法: 测定了谷胱甘肽过氧化物酶、谷胱甘肽还原酶、谷胱甘肽-S-转移酶、超氧化物歧化酶、过氧化氢酶、还原谷胱甘肽、硒、锌、铜和锰等抗氧化剂和标记氧化剂/促氧化剂过氧化氢、超氧化物阴离子、丙二醛、蛋白质羰基和氧化谷胱甘肽。在血浆和胎盘中,未怀孕、健康怀孕和先兆子痫受试者的发生。 结果: 数据表明,与非妊娠受试者相比,健康孕妇的所有血浆抗氧化剂均出现中度但显著的下降(p<0.05),而先兆子痫患者的血浆抗氧化剂则显著下降(p<0.0001)。此外,与健康怀孕受试者相比,先兆子痫患者的所有血浆抗氧化剂均显著降低(p<0.001),但其胎盘活性和水平均显著降低(p<0.0001)。然而,所有研究组的血浆铜和胎盘水平均保持不变。相比之下,三个研究组中所有血浆和胎盘氧化剂/促氧化剂的量值和显著性均增加,导致谷胱甘肽降低/氧化比率同样显著降低。此外,与健康怀孕受试者相比,所有抗氧化酶的基因转录物在先兆子痫患者的胎盘发育过程中经历了显著的下调(p<0.0001)。 结论: 数据表明,与健康的怀孕/非怀孕受试者相比,在先兆子痫患者的胎盘发生过程中,有利于氧化应激的代谢变化更为明显。我们假设硒、锌和锰补充剂有助于减轻先兆子痫患者的明显氧化应激。
关键词: 子痫前期,胎盘t发生,氧化应激,微量营养素,抗氧化基因转录物,锌。
Current Molecular Medicine
Title:The Status of Biochemical and Molecular Markers of Oxidative Stress in Preeclamptic Saudi Patients
Volume: 18 Issue: 7
关键词: 子痫前期,胎盘t发生,氧化应激,微量营养素,抗氧化基因转录物,锌。
摘要: Purpose: In the light of contradictory results and paucity of information, this comprehensive study examines the activities and levels of key antioxidants and oxidants/pro-oxidants in preeclamptic patients.
Methods: Antioxidants including glutathione peroxidase, glutathione reductase, glutathione-S-transferase, superoxide dismutase, catalase, reduced glutathione, selenium, zinc, copper and manganese, as well as marker oxidants/pro-oxidants including hydrogen peroxide, superoxide anions, malondialdehyde, protein carbonyls and oxidized glutathione were determined in plasma and placental tissues of nonpregnant, healthy pregnant and preeclamptic subjects.
Results: Data indicated that all plasma antioxidants underwent moderate but significant decreases (p< 0.05) in healthy pregnant women, , and much more significant ones (p< 0.0001) in preeclamptic patients, when both were compared to non-pregnant subjects. Furthermore, whereas all plasma antioxidants underwent significant decreases (p< 0.001) in preeclamptic patients compared to healthy pregnant subjects, their placental activities and levels were very significantly decreased (p< 0.0001). However, copper plasma and placental levels were unchanged in all study groups. In contrast, there were increases similar in magnitude and significance of all plasma and placental oxidants/prooxidants compared among the three study groups leading to equally significant decreases in the reduced/oxidized glutathione ratios. In addition, gene transcripts of all antioxidant enzymes underwent marked downregulation (p< 0.0001) in placental tissue of preeclamptic patients compared to healthy pregnant subjects.
Conclusion: Data indicated a metabolic shift in favor of oxidative stress more pronounced in placental tissue of preeclamptic patients compared to healthy pregnant/non-pregnant subjects. We postulate that selenium, zinc and manganese supplements could be beneficial for alleviation of the noted oxidative stress in preeclamptic patients.
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Cite this article as:
The Status of Biochemical and Molecular Markers of Oxidative Stress in Preeclamptic Saudi Patients, Current Molecular Medicine 2018; 18 (7) . https://dx.doi.org/10.2174/1566524019666190104105843
DOI https://dx.doi.org/10.2174/1566524019666190104105843 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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