沙特阿拉伯先兆子痫患者氧化应激生化及分子标志物的研究现状

Title:The Status of Biochemical and Molecular Markers of Oxidative Stress in Preeclamptic Saudi Patients

Volume: 18 Issue: 7

关键词: 子痫前期，胎盘t发生，氧化应激，微量营养素，抗氧化基因转录物，锌。

摘要: Purpose: In the light of contradictory results and paucity of information, this comprehensive study examines the activities and levels of key antioxidants and oxidants/pro-oxidants in preeclamptic patients.

Methods: Antioxidants including glutathione peroxidase, glutathione reductase, glutathione-S-transferase, superoxide dismutase, catalase, reduced glutathione, selenium, zinc, copper and manganese, as well as marker oxidants/pro-oxidants including hydrogen peroxide, superoxide anions, malondialdehyde, protein carbonyls and oxidized glutathione were determined in plasma and placental tissues of nonpregnant, healthy pregnant and preeclamptic subjects.

Results: Data indicated that all plasma antioxidants underwent moderate but significant decreases (p< 0.05) in healthy pregnant women, , and much more significant ones (p< 0.0001) in preeclamptic patients, when both were compared to non-pregnant subjects. Furthermore, whereas all plasma antioxidants underwent significant decreases (p< 0.001) in preeclamptic patients compared to healthy pregnant subjects, their placental activities and levels were very significantly decreased (p< 0.0001). However, copper plasma and placental levels were unchanged in all study groups. In contrast, there were increases similar in magnitude and significance of all plasma and placental oxidants/prooxidants compared among the three study groups leading to equally significant decreases in the reduced/oxidized glutathione ratios. In addition, gene transcripts of all antioxidant enzymes underwent marked downregulation (p< 0.0001) in placental tissue of preeclamptic patients compared to healthy pregnant subjects.

Conclusion: Data indicated a metabolic shift in favor of oxidative stress more pronounced in placental tissue of preeclamptic patients compared to healthy pregnant/non-pregnant subjects. We postulate that selenium, zinc and manganese supplements could be beneficial for alleviation of the noted oxidative stress in preeclamptic patients.

Cite this article as:

The Status of Biochemical and Molecular Markers of Oxidative Stress in Preeclamptic Saudi Patients, Current Molecular Medicine 2018; 18 (7) . https://dx.doi.org/10.2174/1566524019666190104105843