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Review Article

多核钌络合物DNA结合剂/结构探针及抗癌剂的研究进展

卷 27, 期 22, 2020

页: [3735 - 3752] 页: 18

弟呕挨: 10.2174/0929867326666181203143422

价格: $65

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摘要

钌配合物在几种进入临床试验的单核配合物中脱颖而出，如咪唑鎓[反式RuCl4（1H-咪唑）（DMSO-S）]（NAMI-A）和（[Ru（II）（4,4''-二甲基-2,2''-联吡啶）2-（2（2'' -，2''''：5''''，2''''-对噻吩）-咪唑并[4,5-f] [1,10]菲咯啉）] 2+）（TLD-1433），为开发有前景的替代顺铂的钌基抗癌药物开辟了新途径。据报道，多核钌配合物表现出协同和/或互补作用：增强的DNA结构识别和DNA结合以及体外抗癌活性。 这篇综述概述了作为DNA结构探针，DNA结合物和体外抗癌剂的一些代表性多核钌配合物，这些复合物是在过去几十年中开发的。 根据同多核和异多核复合物的两个主要类别对这些配合物进行了综述，每种复合物都进一步明确了由刚性和柔性桥联配体连接的金属中心。 指出或提出了研究这些令人兴奋的复合体的观点，挑战和未来的努力。

关键词: 钌，DNA，DNA结构探针，细胞毒性，结合模式，顺铂类药物，抗癌药物。

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