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当代阿耳茨海默病研究

Editor-in-Chief

ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Research Article

上海轻度认知障碍队列一年的研究结果

卷 16, 期 2, 2019

页: [156 - 165] 页: 10

弟呕挨: 10.2174/1567205016666181128151144

价格: $65

Open Access Journals Promotions 2
摘要

背景与目的:本研究的目的是确定与轻度认知障碍(MCI)转变为阿尔茨海默病(AD)痴呆相关的风险因素,以便早期发现AD。 方法:该研究包括一项前瞻性队列研究,其中包括400名MCI受试者,每年随访3年。 结果:在前12个月的随访期间,42名受试者转为阿尔茨海默氏症痴呆(21例可能的AD和21例可能的AD),两名受试者转为其他类型的痴呆症,56名受试者失访。与从MCI转变为AD的更大风险相关的因素包括性别,全脑容量和右海马体积(rt.HV),以及阿尔茨海默氏病评估量表 - 认知子量表13的修订中文版本的得分( ADAS-Cog-C),时钟绘图测试(CDT),符号数字模态测试(SDMT)和Rey-Osterrieth复杂图测试(ROCFT)。 ADAS-Cog-C和阿尔茨海默病认知综合征(ACC)组合的风险分类与rt。 HV和左内嗅皮质体积(lt.ECV)显示各组之间的转换差异。 结论:早期发现AD和临床试验设计的潜在选择应该使用rt。 HV,以及神经心理学测试分数,包括ADAS-Cog-C和ACC的分数。

关键词: 轻度认知障碍,阿尔茨海默病,危险因素,阿尔茨海默病认知综合评分,选择性提醒测试,神经心理学测试

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