Title:Flavonoids and Anthranquinones as Xanthine Oxidase and Monoamine Oxidase Inhibitors: A New Approach Towards Inflammation and Oxidative Stress
Volume: 18
Issue: 25
Author(s): Neelam Malik, Priyanka Dhiman, Eduardo Sobarzo-Sanchez* Anurag Khatkar*
Affiliation:
- Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Campus Vida, 15782 Santiago de Compostela,Spain
- Faculty of Pharmaceutical Sciences, M.D. University, Rohtak 124001,India
Keywords:
Xanthine oxidase, Monoamine oxidase, Flavonoids, Anthraquinones, Oxidative stress, Herbal medicine.
Abstract: The development of xanthine oxidase and monoamine oxidase inhibitors led to important
breakthroughs in the therapy of oxidative damage, hyperuricemia, gout, neurological, neuropsychiatric
disorders and management of reperfusion injury. Drugs obtained from natural sources play an important
role in the treatment of various pathological disorders and act as a lead compound for the discovery of
new synthetic drug substances. In this review, various pharmacological effects produced by the inhibition
of xanthine oxidase and monoamine oxidase through natural and synthetic flavonoids as well as
anthraquinones are discussed in detail. Several methods have been designed for monitoring enzymatic
activity and its inhibitor screening of bioactive natural and synthetic flavonoids and anthraquinones. In
this review, all the in-vitro and other computational approaches are critically discussed which provided
the clue about structure activity requirements for further precise modifications on the basic scaffold.