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Review Article

动物毒肽作为抗神经退行性疾病新疗法的宝藏

卷 26, 期 25, 2019

页: [4749 - 4774] 页: 26

弟呕挨: 10.2174/0929867325666181031122438

价格: $65

摘要

背景：神经退行性疾病，例如阿尔茨海默氏病，帕金森氏病和脑缺血性中风，给患者和医疗系统带来了巨大的社会经济负担。 然而，针对这些疾病的药物仍然不能令人满意，因此迫切需要开发新颖和有效的候选药物。 方法：动物毒素在蛋白质和多肽上均表现出丰富的多样性，在生物医学药物开发中起着至关重要的作用。 作为一种分子工具，动物毒素肽不仅有助于阐明许多关键的生理过程，而且还导致了新药和临床疗法的发现。 结果：最近，从有毒动物中鉴定出毒素肽，例如有毒动物。 已显示蜘蛛毒液中的艾塞那肽，齐考诺肽，Hi1a和PcTx1可以阻断特定的离子通道，减轻炎症，减少蛋白质聚集，调节谷氨酸和神经递质水平并增加神经保护因子。 结论：因此，毒液的成分作为缓解或减少神经变性的候选药物具有相当大的能力。 这篇综述重点介绍了评估不同动物毒素（尤其是肽）作为治疗不同神经退行性疾病和病症的有前途的治疗工具的研究。

关键词: 动物毒素，小肽，分子机制，治疗方法，神经退行性疾病，兴奋性毒性

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