Title:The Unique Inhibitory IgG Receptor--FcγRIIb
Volume: 25
Issue: 11
Author(s): Zhenzhen Xu, Lipeng Liu, Zhe Cui, Kewei Bi, Nan Zhang, Yanfen Zhang*Zhongcheng Liu*
Affiliation:
- Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Baoding 071002,China
- Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Baoding 071002,China
Keywords:
FcγRIIb, IgG receptor, BCR, Fc receptor, biological function, ITIM.
Abstract: Background: FcγRIIb is the only inhibitory IgG receptor, which is divided into three
subtypes of FcγRIIb1, FcγRIIb2 and FcγRIIb3. It is mainly responsible for the immune balance in
vivo by cross-linking with the activated receptor to intracellular transduction inhibitory signals, and
it plays an important biological role in the negative regulation of innate immunity and adaptive
immunity. An abnormal expression of FcγRIIb on cells would result in autoimmune diseases, infectious
diseases, and so forth.
Conclusion: FcγRIIb modulates immune responses and further treats related diseases by inhibiting
the activation of B lymphocytes, monocytes, mast cells, and basophils induced by activating receptors.
It can be used in biotherapeutic methods such as monoclonal antibodies, chimeric recombinant
proteins, bispecific antibodies, etc. Our increased understanding of FcγRIIb function also has a
foundation for further research and development of FcγRIIb, which also provides potentially farreaching
therapeutic implications.
