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摘要
越来越多的证据表明,肥胖和代谢综合征是肾脏疾病发生发展的独立危险因素。除了炎症、脂肪毒性和血流动力学因素外,脂肪因子被认为在肾脏疾病和代谢紊乱之间的关系中发挥重要作用。脂肪酸结合蛋白4 (fatty acid binding protein 4, FABP4)是关键的脂肪因子之一,主要在脂肪细胞和巨噬细胞中表达,最近被证实与肾功能不全和肾损伤有关。临床和实验研究均提出循环FABP4作为肾脏损伤的一种新的预测因子,它也可能是终末期肾脏疾病(ESRD)患者心血管事件的预测因子。在小鼠和人肾脏的肾小球细胞和上皮管细胞中也检测到FABP4,这些细胞中FABP4的表达参与了肾脏疾病的发病机制。此外,实验研究表明抑制FABP4对肾脏损伤具有保护作用。在这里,我们综述了有关FABP4在病理生理学方面作用,以及它作为肾脏疾病的预测因子和治疗靶点潜在功能的最新研究进展。
关键词: 脂肪酸结合蛋白4,肾脏疾病,脂肪因子,靶向药物,预测因子,终末期肾脏疾病。
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