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General Review Article

细菌脂蛋白的生物合成途径作为基于结构的抗菌剂设计的潜在目标

卷 27, 期 7, 2020

页: [1132 - 1150] 页: 19

弟呕挨: 10.2174/0929867325666181008143411

价格: $65

摘要

背景：抗生素耐药性目前是全球公共卫生的严重问题。为此，发现与新型靶标相互作用的新型抗菌药物很重要。脂蛋白的生物合成对细菌生存至关重要，其抑制剂已显示出对多种细菌的功效，因此细菌脂蛋白的生物合成途径是潜在的靶标。 方法：首先，综述了涵盖细菌脂蛋白生物合成途径的基本概念以及三种关键酶的生化特性的文献。然后，从蛋白质数据库（PDB）中检索了这三种酶最近解析的晶体结构，并分析了活性位点中的必需残基。最后，讨论了靶向该途径的所有可用特异性抑制剂及其结构活性关系（SAR）。 结果：我们简要介绍了细菌脂蛋白的生物合成途径，并详细描述了三种关键酶的结构和功能。此外，我们介绍了许多有关配体识别的知识，这些知识可能有助于基于结构的药物设计。此外，我们专注于LspA抑制剂的SAR，并讨论它们的效力和药物相似性。 结论：这篇综述提供了脂蛋白生物合成途径的清晰背景，并为基于结构的药物设计提供了实用的线索。特别是，针对靶向该途径的先导化合物的SAR的最新知识将为发现新型抗菌剂提供很好的参考。

关键词: 抗生素抗药性，细菌脂蛋白，Lgt，LspA，Lnt，球霉素，粘菌素，苯甲酰胺。

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