Title:Hydrotalcites in Organic Synthesis: Multicomponent Reactions
Volume: 15
Issue: 8
Author(s): Eliana Nope, Gabriel Sathicq, José Martinez, Hugo Rojas, Rafael Luque and Gustavo Romanelli*
Affiliation:
- Centro de Investigación y Desarrollo en Ciencias Aplicadas “Dr. Jorge J. Ronco” CINDECA – Facultad de Ciencias Exactas – Universidad Nacional de La Plata, 47 Nº 257, La Plata 1900,Argentina
Keywords:
Hydrotalcite, multicomponent reaction, basic, catalyst, organic synthesis, bifuntional catalyst, solvent-free.
Abstract: Background: The use of solid bases as heterogeneous catalysts allows the replacement of conventional
bases in Organic Chemistry, being of outmost importance. Lamellar double hydroxides or hydrotalcites
are materials having excellent basic properties and high surface areas. As their surface properties have been
used as bifunctional catalysts allowing the incorporation of metals and depending on the calcination temperature,
these materials may exhibit Lewis or Brönsted basic sites. Additionally, they are widely used in various
organic synthesis reactions.
Objective: This contribution has been aimed to provide a compilation of the application of hydrotalcites as basic
materials in organic synthesis, with a particular emphasis on multicomponent reactions.
Conclusion: Hydrotalcites act as heterogeneous catalysts that conduct highly efficient processes in short reaction
times and with the advantage of their easy recovery and reuse without significant loss of their catalytic activity.
In addition, due to the modification of their structural and chemical properties, they are catalysts with
multiple applications in organic synthesis such as Michael addition reactions, dehydrogenation reactions of alcohols,
Knoevenagel condensations, reduction reactions, oxidations, epoxidations, multicomponent reactions,
among others. Multicomponent reactions are of major interest since they allow obtaining compounds that have
high biological activity and are generated through processes in a single step by combining three or more starting
reagents under solvent-free conditions.
