Title:Neurological Involvement as the Initial Manifestation in Primary Sjögren's Syndrome - A Case Report
Volume: 15
Issue: 3
Author(s): Iván Posso-Osorio, Juan Naranjo-Escobar, Diana Marcela Loaiza, Marcela Polo, Alex Echeverri and Gabriel J. Tobón*
Affiliation:
- GIRAT (Grupo de Investigacion en Reumatologia, Autoinmunidad y Medicina Traslacional) Fundacion Valle del Lili and Universidad Icesi, Cali,Colombia
Keywords:
Neurological involvement, primary Sjögren's syndrome, autoimmune disease, sicca symptoms, exocrinopathy, peripheral
neuropathy.
Abstract:
Background: Sjögren's syndrome is an autoimmune disease characterised by
exocrinopathy mainly involving the salivary and lacrimal glands. In addition, it is a multisystemic
condition (i.e., affecting multiple organs and systems). Neurological involvement has been reported
in ~20% of cases, with peripheral manifestations being the most frequent.
Methods: We analysed four cases in which neurological manifestations were the first symptoms of
Sjögren's syndrome.
Results: In all four cases, neurological symptoms preceded sicca symptoms. In addition, immunosuppressive
treatment with steroids and, in some cases, cyclophosphamide showed improvement.
Conclusion: Neurological involvement in Sjögren's syndrome is common and often occurs as the
first clinical manifestation. Since evidence is limited, more studies are required in order to determine
appropriate diagnostic methods and treatments for each manifestation of Sjögren's syndrome.
