Title:A Summary of Electrospun Nanofibers as Drug Delivery System: Drugs Loaded and Biopolymers Used as Matrices
Volume: 15
Issue: 10
Author(s): Erick José Torres-Martinez, José Manuel Cornejo Bravo*, Aracely Serrano Medina, Graciela Lizeth Pérez González and Luis Jesús Villarreal Gómez*
Affiliation:
- Universidad Autonoma de Baja California, Calzada Universidad 14418, Parque Industrial Internacional, Tijuana Baja California C.P. 22390,Mexico
- Universidad Autonoma de Baja California, Calzada Universidad 14418, Parque Industrial Internacional, Tijuana Baja California C.P. 22390,Mexico
Keywords:
Biopolymers, electrospinning, nanofibers, drug release, fast release, controlled release.
Abstract: Recently, electrospun polymeric nanofibers have proven to be an interesting strategy for
drug delivery systems application. The high surface-to-volume ratio of the fibers can improve some
processes, such as cell binding and proliferation, drug loading, and mass transfer processes. One of the
most important and studied areas of electrospinning is in the drug delivery field, for the controlled release
of active substances ranging from antibiotics and anticancer agents to macromolecules such as
proteins and DNA. The advantage of this method is that a wide variety of low solubility drugs can be
loaded into the fibers to improve their bioavailability or to attain controlled release. This review presents
an overview of the reported drugs loaded into polymeric nanofibers, to be used as drug delivery
systems. For instance, it presents the reports on drugs with different bioactivities such as antiinflammatory,
anti-microbial, anticancer, cardiovascular, anti-histamine, gastrointestinal, palliative and
contraceptive drugs, etc. It also analyzes the electrospinning techniques used in each system, as well as
the polymers used as matrices for the preparation of the nanofibers; unfolding the advantages of electrospun
polymeric nanofibers over other drug delivery systems. This review intends to enlist and summarize
the reported literature concerning this topic. In addition, it proposes future research in the field.
