Title:A form of Autoimmune Diabetes in Adults Named LADA – An Update on Essential Features and Controversies
Volume: 15
Issue: 3
Author(s): Valdemar Grill*Bjørn O. Åsvold
Affiliation:
- Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, NO-7491 Trondheim,Norway
Keywords:
Autoantibodies, type 1 diabetes, type 2 diabetes, insulin secretion, glutamic acid decarboxylase, GADA.
Abstract: Latent Autoimmune Diabetes in the Adult, LADA has been investigated less than “classical”
type 1 and type 2 diabetes and the criteria for and the relevance of a LADA diagnosis has been challenged.
Despite the absence of a genetic background that is exclusive to LADA, this form of diabetes
displays phenotypic characteristics that distinguish it from other forms of diabetes. LADA is heterogeneous
in terms of the impact of autoimmunity and lifestyle factors, something that poses problems as to
therapy and follow-up perhaps particularly in those with marginal positivity. Yet, there appears to be
clear clinical utility in classifying individuals as LADA.
