Title:Role of Morin in Neurodegenerative Diseases: A Review
Volume: 18
Issue: 11
Author(s): Ritu Kataria, Eduardo Sobarzo-Sanchez*Anurag Khatkar*
Affiliation:
- Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Campus Vida, 15782 Santiago de Compostela,Spain
- Faculty of Pharmaceutical Sciences, M. D. University, Rohtak, Haryana 124001,India
Keywords:
Morin, Neurodegenerative disease, Herbal, Polyphenolic compound, Flavonoid, Alzheimer`s disease.
Abstract: Neurodegenerative diseases are likely to emerge as the second cause of mortality in the world
in coming years. NDDs cause tremendous financial burden on the healthcare system along with profound
effect on families and patient. Disease-modifying treatment strategies with proven efficacy for
these disorders are still lacking. Documentation proved that oxidative stress plays a leading role in the
pathophysiology of many neurodegenerative disorders. Molecules with good antioxidant profile could
be explored for the doctoring of these conditions. Neuroprotective effects of bioflavonoid morin have
been well recognized in the literature. Morin being super antioxidant compound helped in preventing
and curing these disorders by suppression of ROS and by inhibition of multiple targets. In this review,
we tried to explain various neuropathological conditions with their target sites and neurobiological
mechanisms of morin.
