Abstract
The number of people who are overweight and obese are continuously increasing both in the adult and adolescent populations. Coinciding with this is the increased prevalence of health problems such as type 2 diabetes (T2D). Bariatric surgery is the only proven long-term treatment of obesity and may induce remission of T2D, although the underlying mechanisms are unknown. The translational studies presented here might provide insight on the mechanism of steady-state energy balance of the obese phenotype using a special time-restricted feeding regimen for weight loss during the steady-state energy balance; mechanism by vagal blocking therapy (vBLoc® therapy) as a new treatment for obesity; and possible mechanism behind the remission of T2D following gastric bypass surgery.
Keywords: Energy balance, PYY, time-restricted feeding, vagus nerve, obese, bariatric surgery.
Current Pharmaceutical Design
Title:New Approaches for Weight Loss: Experiments Using Animal Models
Volume: 24 Issue: 18
Author(s): Magnus K. Olsen*, Helene Johannessen, Reshma Ramracheya, Chun-Mei Zhao and Duan Chen
Affiliation:
- Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim,Norway
Keywords: Energy balance, PYY, time-restricted feeding, vagus nerve, obese, bariatric surgery.
Abstract: The number of people who are overweight and obese are continuously increasing both in the adult and adolescent populations. Coinciding with this is the increased prevalence of health problems such as type 2 diabetes (T2D). Bariatric surgery is the only proven long-term treatment of obesity and may induce remission of T2D, although the underlying mechanisms are unknown. The translational studies presented here might provide insight on the mechanism of steady-state energy balance of the obese phenotype using a special time-restricted feeding regimen for weight loss during the steady-state energy balance; mechanism by vagal blocking therapy (vBLoc® therapy) as a new treatment for obesity; and possible mechanism behind the remission of T2D following gastric bypass surgery.
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Cite this article as:
Olsen K. Magnus *, Johannessen Helene , Ramracheya Reshma , Zhao Chun-Mei and Chen Duan , New Approaches for Weight Loss: Experiments Using Animal Models, Current Pharmaceutical Design 2018; 24 (18) . https://dx.doi.org/10.2174/1381612824666180614075412
DOI https://dx.doi.org/10.2174/1381612824666180614075412 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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