Title:Osteoarthritis: Potential for Herbal Medicines as Therapies in the Management of Chronic Inflammatory Damage
Volume: 14
Issue: 2
Author(s): Diana R. Cundell*Kathryn E. Mickle
Affiliation:
- College of Life Sciences, Jefferson University, 4201 Henry Avenue, Philadelphia, PA 19144,United States
Keywords:
Chronic inflammation, COX-2 (cyclooxygenase 2 inhibitor), curcumin, double-blind randomized placebocontrolled
trial, herbal medicine, NF-κβ (nuclear factor kappa beta) and NSAID (non-steroidal anti-inflammatory drug).
Abstract: Osteoarthritis results from a chronic inflammation-mediated destruction of synovial joints
particularly in the hand, hip, and knee. Intervention strategies primarily focus on reducing this
inflammation and its associated pain and involve a hierarchy of pharmaceuticals designed to prolong
activity and prevent early joint replacement. Unfortunately, side effects from these agents are
significant and their efficacy, especially in the later stages of the condition, variable. For this reason,
many patients are seeking out alternative interventions, including herbal medicines, which are natural
and safe. This review will evaluate the current understanding of the pathophysiology and
immunological changes that occur in osteoarthritis and identify areas where herbal medicines could
improve treatment strategies.