Title:Nucleophagy Plays a Major Role in Human Diseases
Volume: 19
Issue: 15
关键词:
细胞核吞噬、核层、微管相关蛋白1轻链3(LC3)、自噬相关基因(ATG)、自噬、角化病和银屑病。
摘要: Nucleophagy is a selective autophagy, which selectively removes damaged or non-essential
nuclear material from a cell by the autophagy pathway. Additionally, nucleophagy is crucial for promoting
cell longevity and ensure body proper function. Increasing evidence has shown that nucleophagy may
play a major role in such human diseases as degenerative disorders, tumorigenesis, malnutrition and
metabolic disorders, parakeratosis and psoriasis. Studies indicated that nucleophagy can improve degenerative
disorders by delaying premature cell senescence, prevent malnutrition and metabolic disorder via
maintaining nuclear structure and releasing nutrients for energy production, and alleviate parakeratosis
and psoriasis. But the activation of nucleophagy appears to be a double-edged sword. Some studies indicated
that overexpression of lamin B1 delays cell senescence. During the process of nucleophagy, appropriate
nucleophagy can drive RAS-induced cell senescence and DNA damage-induced cell senescence so
as to restrain cell proliferation. Besides, appropriate nucleophagy can degrade excessive amount of DNA
content in polyploid tumor cells. Hence, selective nucleophagy may effectively protect cells from tumorigenesis
and maintain cell and tissue integrity. However, excessive nucleophagy can attack normal
cells and lead to an unforeseen cytotoxicity. In this paper, some signal pathways of nucleophagy occurrence
were explained and the role of nucleophagy in these human diseases was analyzed. Our review indicates
that nucleophagy may be a potential target in human diseases.
