Abstract
A prudent and scalable synthesis of (±)-Preclamol is described utilizing Michael addition and in-situ reduction/cyclization of an aryl-α-carbethoxy acetonitrile derivative as a key step.
Keywords: Michael addition, in-situ reduction/cyclization, preclamol, risperidone, alogliptin, ritalin.
Letters in Organic Chemistry
Title:An Efficient and Straightforward Total Synthesis of (±)-Preclamol
Volume: 15 Issue: 12
Author(s): Ravi Lakkakula, K. Mukkanti and Arnab Roy*
Affiliation:
- GVK Biosciences Private Limited, Plot No. 28 A, IDA Nacharam, Hyderabad - 500076,India
Keywords: Michael addition, in-situ reduction/cyclization, preclamol, risperidone, alogliptin, ritalin.
Abstract: A prudent and scalable synthesis of (±)-Preclamol is described utilizing Michael addition and in-situ reduction/cyclization of an aryl-α-carbethoxy acetonitrile derivative as a key step.
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Cite this article as:
Lakkakula Ravi, Mukkanti K. and Roy Arnab*, An Efficient and Straightforward Total Synthesis of (±)-Preclamol, Letters in Organic Chemistry 2018; 15 (12) . https://dx.doi.org/10.2174/1570178615666180518090406
DOI https://dx.doi.org/10.2174/1570178615666180518090406 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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