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当代肿瘤药物靶点

Editor-in-Chief

ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Review Article

糖酵解抑制是肝癌治疗的一种策略?

卷 19, 期 1, 2019

页: [26 - 40] 页: 15

弟呕挨: 10.2174/1568009618666180430144441

价格: $65

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摘要

肝细胞癌(Hepatocellularcarcinoma,HCC)是最常见的原发性肝癌,以其高发病率和高死亡率代表着世界范围内的公共卫生问题。肝癌通常在晚期发现,排除使用治疗的意图。因此,寻找有效的治疗肝癌的方法是至关重要的。癌细胞对g有很高的依赖性。用于产生ATP的溶解,特别是在低氧环境下。这种依赖提供了一个可靠的可能的策略,专门针对癌症细胞的基础上,抑制糖酵解。肝癌,如其他类型的癌症,出现了一个临床知名的上调几个糖酵解关键酶和蛋白质,包括葡萄糖转运蛋白,特别是葡萄糖转运蛋白1(GLUT 1)。斯UCH酶和蛋白质是治疗的潜在靶点。事实上,对于其中的一些目标,已经有一些抑制剂的报道,如2-脱氧葡萄糖,伊马替尼或类黄酮。尽管糖酵解的抑制具有很大的抗癌潜力,糖酵解抑制剂作为一类新的抗癌药物的开发还有待进一步探索。在此,我们综述、讨论和介绍抑制肝癌细胞糖酵解代谢的不同途径,这些方法在肝癌的治疗中可能是非常有效的。

关键词: 糖酵解,肝细胞癌,癌症,GLOBOCAN,EGFR,过剩。

图形摘要
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